LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Zurück zur letzten Suche Suchhistorie
Erweiterte Suche

Ihre letzten Suchen

  1. AU=Fra-Bido Sigrid
  2. AU="Delgado, Teresa Cardoso"
  3. AU="Judy Ly"
  4. AU="E Richtig"
  5. AU="Jones, D. C."
  6. AU="Revillet, Hélène" AU="Revillet, Hélène"
  7. AU="Lee, Ji Ye"
  8. AU="Yoshinaga, Kazuaki"
  9. AU="Moturi, Krishna"
  10. AU="Loizeau, J"
  11. AU="Gentry, Matthew S"
  12. AU="Drury, Lucy S"
  13. AU="Caraman, Irina"

Suchergebnis

Treffer 1 - 10 von insgesamt 11

Suchoptionen

  1. Artikel ; Online: Optimized immunofluorescence staining protocol for imaging germinal centers in secondary lymphoid tissues of vaccinated mice.

    Fra-Bido, Sigrid / Walker, Simon A / Innocentin, Silvia / Linterman, Michelle A

    STAR protocols

    2021  Band 2, Heft 3, Seite(n) 100499

    Abstract: Location of immune cells that form the germinal center reaction within secondary lymphoid tissues can be characterized using confocal microscopy. Here, we present an optimized immunofluorescence staining protocol to image germinal center structures in ... ...

    Abstract Location of immune cells that form the germinal center reaction within secondary lymphoid tissues can be characterized using confocal microscopy. Here, we present an optimized immunofluorescence staining protocol to image germinal center structures in fixed/frozen spleen sections from ChAdOx1 nCoV-19 immunized mice. This protocol can be adapted to identify other cell types within secondary lymphoid tissues. For complete information on the generation and use of this protocol to examine immune responses to the COVID vaccine ChAdOx1 nCoV-19, please refer to Silva-Cayetano et al. (2020).
    Mesh-Begriff(e) Animals ; COVID-19/diagnostic imaging ; COVID-19/immunology ; COVID-19/prevention & control ; COVID-19/virology ; ChAdOx1 nCoV-19/administration & dosage ; Fluorescent Antibody Technique/methods ; Fluorescent Antibody Technique/standards ; Germinal Center/drug effects ; Germinal Center/immunology ; Germinal Center/pathology ; Germinal Center/virology ; Immunization, Secondary/methods ; Immunogenicity, Vaccine ; Male ; Mice ; SARS-CoV-2/immunology ; Spleen/drug effects ; Spleen/immunology ; Spleen/pathology ; Spleen/virology
    Chemische Substanzen ChAdOx1 nCoV-19 (B5S3K2V0G8)
    Sprache Englisch
    Erscheinungsdatum 2021-06-18
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2021.100499
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  2. Artikel ; Online: B cell-intrinsic changes with age do not impact antibody-secreting cell formation but delay B cell participation in the germinal centre reaction.

    Lee, Jia Le / Fra-Bido, Sigrid C / Burton, Alice R / Innocentin, Silvia / Hill, Danika L / Linterman, Michelle A

    Aging cell

    2022  Band 21, Heft 9, Seite(n) e13692

    Abstract: Vaccines typically protect against (re)infections by generating pathogen-neutralising antibodies. However, as we age, antibody-secreting cell formation and vaccine-induced antibody titres are reduced. Antibody-secreting plasma cells differentiate from B ... ...

    Abstract Vaccines typically protect against (re)infections by generating pathogen-neutralising antibodies. However, as we age, antibody-secreting cell formation and vaccine-induced antibody titres are reduced. Antibody-secreting plasma cells differentiate from B cells either early post-vaccination through the extrafollicular response or from the germinal centre (GC) reaction, which generates long-lived antibody-secreting cells. As the formation of both the extrafollicular antibody response and the GC requires the interaction of multiple cell types, the impaired antibody response in ageing could be caused by B cell intrinsic or extrinsic factors, or a combination of the two. Here, we show that B cells from older people do not have intrinsic defects in their proliferation and differentiation into antibody-secreting cells in vitro compared to those from the younger donors. However, adoptive transfer of B cells from aged mice to young recipient mice showed that differentiation into extrafollicular plasma cells was favoured at the expense of B cells entering the GC during the early stages of GC formation. In contrast, by the peak of the GC response, GC B cells derived from the donor cells of aged mice had expanded to the same extent as those from the younger donors. This indicates that age-related intrinsic B cell changes delay the GC response but are not responsible for the impaired antibody-secreting response or smaller peak GC response in ageing. Collectively, this study shows that B cells from aged individuals are not intrinsically defective in responding to stimulation and becoming antibody-secreting cells, implicating B cell-extrinsic factors as the primary cause of age-associated impairment in the humoral immunity.
    Mesh-Begriff(e) Animals ; Antibody Formation ; Antibody-Producing Cells ; B-Lymphocytes ; Germinal Center ; Humans ; Mice ; Plasma Cells
    Sprache Englisch
    Erscheinungsdatum 2022-08-18
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2113083-8
    ISSN 1474-9726 ; 1474-9718
    ISSN (online) 1474-9726
    ISSN 1474-9718
    DOI 10.1111/acel.13692
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 6581: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  3. Artikel ; Online: Optimized immunofluorescence staining protocol for imaging germinal centers in secondary lymphoid tissues of vaccinated mice

    Sigrid Fra-Bido / Simon A. Walker / Silvia Innocentin / Michelle A. Linterman

    STAR Protocols, Vol 2, Iss 3, Pp 100499- (2021)

    2021  

    Abstract: Summary: Location of immune cells that form the germinal center reaction within secondary lymphoid tissues can be characterized using confocal microscopy. Here, we present an optimized immunofluorescence staining protocol to image germinal center ... ...

    Abstract Summary: Location of immune cells that form the germinal center reaction within secondary lymphoid tissues can be characterized using confocal microscopy. Here, we present an optimized immunofluorescence staining protocol to image germinal center structures in fixed/frozen spleen sections from ChAdOx1 nCoV-19 immunized mice. This protocol can be adapted to identify other cell types within secondary lymphoid tissues.For complete information on the generation and use of this protocol to examine immune responses to the COVID vaccine ChAdOx1 nCoV-19, please refer to Silva-Cayetano et al. (2020).
    Schlagwörter Antibody ; Cell Biology ; Immunology ; Microbiology ; Microscopy ; Model Organisms ; Science (General) ; Q1-390
    Sprache Englisch
    Erscheinungsdatum 2021-09-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  4. Artikel ; Online: Targeting TLR4 during vaccination boosts MAdCAM-1

    Denton, Alice E / Dooley, James / Cinti, Isabella / Silva-Cayetano, Alyssa / Fra-Bido, Sigrid / Innocentin, Silvia / Hill, Danika L / Carr, Edward J / McKenzie, Andrew N J / Liston, Adrian / Linterman, Michelle A

    Science immunology

    2022  Band 7, Heft 71, Seite(n) eabk0018

    Abstract: The failure to generate enduring humoral immunity after vaccination is a hallmark of advancing age. This can be attributed to a reduction in the germinal center (GC) response, which generates long-lived antibody-secreting cells that protect against (re) ... ...

    Abstract The failure to generate enduring humoral immunity after vaccination is a hallmark of advancing age. This can be attributed to a reduction in the germinal center (GC) response, which generates long-lived antibody-secreting cells that protect against (re)infection. Despite intensive investigation, the primary cellular defect underlying impaired GCs in aging has not been identified. Here, we used heterochronic parabiosis to demonstrate that GC formation was dictated by the age of the lymph node (LN) microenvironment rather than the age of the immune cells. Lymphoid stromal cells are a key determinant of the LN microenvironment and are also an essential component underpinning GC structure and function. Using mouse models, we demonstrated that mucosal adressin cell adhesion molecule-1 (MAdCAM-1)-expressing lymphoid stromal cells were among the first cells to respond to NP-KLH + Alum immunization, proliferating and up-regulating cell surface proteins such as podoplanin and cell adhesion molecules. This response was essentially abrogated in aged mice. By targeting TLR4 using adjuvants, we improved the MAdCAM-1
    Mesh-Begriff(e) Aged ; Aging/immunology ; Animals ; Cell Adhesion Molecules ; Germinal Center ; Humans ; Mice ; Stromal Cells ; Toll-Like Receptor 4 ; Vaccination
    Chemische Substanzen Cell Adhesion Molecules ; TLR4 protein, human ; Tlr4 protein, mouse ; Toll-Like Receptor 4
    Sprache Englisch
    Erscheinungsdatum 2022-05-06
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2470-9468
    ISSN (online) 2470-9468
    DOI 10.1126/sciimmunol.abk0018
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  5. Artikel ; Online: Ageing promotes early T follicular helper cell differentiation by modulating expression of RBPJ.

    Webb, Louise M C / Fra-Bido, Sigrid / Innocentin, Silvia / Matheson, Louise S / Attaf, Noudjoud / Bignon, Alexandre / Novarino, Julien / Fazilleau, Nicolas / Linterman, Michelle A

    Aging cell

    2021  Band 20, Heft 1, Seite(n) e13295

    Abstract: Ageing profoundly changes our immune system and is thought to be a driving factor in the morbidity and mortality associated with infectious disease in older people. We have previously shown that the impaired immunity to vaccination that occurs in aged ... ...

    Abstract Ageing profoundly changes our immune system and is thought to be a driving factor in the morbidity and mortality associated with infectious disease in older people. We have previously shown that the impaired immunity to vaccination that occurs in aged individuals is partly attributed to the effect of age on T follicular helper (Tfh) cell formation. In this study, we examined how age intrinsically affects Tfh cell formation in both mice and humans. We show increased formation of Tfh precursors (pre-Tfh) but no associated increase in germinal centre (GC)-Tfh cells in aged mice, suggesting age-driven promotion of only early Tfh cell differentiation. Mechanistically, we show that ageing alters TCR signalling which drives expression of the Notch-associated transcription factor, RBPJ. Genetic or chemical modulation of RBPJ or Notch rescues this age-associated early Tfh cell differentiation, and increased intrinsic Notch activity recapitulates this phenomenon in younger mice. Our data offer mechanistic insight into the age-induced changes in T-cell activation that affects the differentiation and ultimately the function of effector T cells.
    Mesh-Begriff(e) Aging ; Animals ; Cell Differentiation/immunology ; Female ; Humans ; Immunoglobulin J Recombination Signal Sequence-Binding Protein/metabolism ; Mice ; Receptors, CXCR5/metabolism ; T Follicular Helper Cells/immunology
    Chemische Substanzen CXCR5 protein, human ; Immunoglobulin J Recombination Signal Sequence-Binding Protein ; RBPJ protein, human ; Receptors, CXCR5
    Sprache Englisch
    Erscheinungsdatum 2021-01-02
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2113083-8
    ISSN 1474-9726 ; 1474-9718
    ISSN (online) 1474-9726
    ISSN 1474-9718
    DOI 10.1111/acel.13295
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 6581: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  6. Artikel ; Online: Follicular Regulatory T Cells Can Access the Germinal Center Independently of CXCR5.

    Vanderleyden, Ine / Fra-Bido, Sigrid C / Innocentin, Silvia / Stebegg, Marisa / Okkenhaug, Hanneke / Evans-Bailey, Nicola / Pierson, Wim / Denton, Alice E / Linterman, Michelle A

    Cell reports

    2020  Band 30, Heft 3, Seite(n) 611–619.e4

    Abstract: The germinal center (GC) response is critical for generating high-affinity humoral immunity and immunological memory, which forms the basis of successful immunization. Control of the GC response is thought to require follicular regulatory T (Tfr) cells, ... ...

    Abstract The germinal center (GC) response is critical for generating high-affinity humoral immunity and immunological memory, which forms the basis of successful immunization. Control of the GC response is thought to require follicular regulatory T (Tfr) cells, a subset of suppressive Foxp3
    Mesh-Begriff(e) Animals ; Forkhead Transcription Factors/metabolism ; Gene Deletion ; Germinal Center/immunology ; Lymphocyte Count ; Mice, Inbred C57BL ; Orthomyxoviridae Infections/immunology ; Receptors, CXCR5/metabolism ; T-Lymphocytes, Regulatory/immunology
    Chemische Substanzen Forkhead Transcription Factors ; Foxp3 protein, mouse ; Receptors, CXCR5
    Sprache Englisch
    Erscheinungsdatum 2020-01-22
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2019.12.076
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  7. Artikel ; Online: Spatial dysregulation of T follicular helper cells impairs vaccine responses in aging.

    Silva-Cayetano, Alyssa / Fra-Bido, Sigrid / Robert, Philippe A / Innocentin, Silvia / Burton, Alice R / Watson, Emily M / Lee, Jia Le / Webb, Louise M C / Foster, William S / McKenzie, Ross C J / Bignon, Alexandre / Vanderleyden, Ine / Alterauge, Dominik / Lemos, Julia P / Carr, Edward J / Hill, Danika L / Cinti, Isabella / Balabanian, Karl / Baumjohann, Dirk /
    Espeli, Marion / Meyer-Hermann, Michael / Denton, Alice E / Linterman, Michelle A

    Nature immunology

    2023  Band 24, Heft 7, Seite(n) 1124–1137

    Abstract: The magnitude and quality of the germinal center (GC) response decline with age, resulting in poor vaccine-induced immunity in older individuals. A functional GC requires the co-ordination of multiple cell types across time and space, in particular ... ...

    Abstract The magnitude and quality of the germinal center (GC) response decline with age, resulting in poor vaccine-induced immunity in older individuals. A functional GC requires the co-ordination of multiple cell types across time and space, in particular across its two functionally distinct compartments: the light and dark zones. In aged mice, there is CXCR4-mediated mislocalization of T follicular helper (T
    Mesh-Begriff(e) Animals ; Mice ; T-Lymphocytes, Helper-Inducer ; B-Lymphocytes ; T Follicular Helper Cells ; Germinal Center ; Aging ; Vaccines
    Chemische Substanzen Vaccines
    Sprache Englisch
    Erscheinungsdatum 2023-05-22
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-023-01519-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 5294: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 42: Hefte anzeigen

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  8. Artikel ; Online: A booster dose enhances immunogenicity of the COVID-19 vaccine candidate ChAdOx1 nCoV-19 in aged mice.

    Silva-Cayetano, Alyssa / Foster, William S / Innocentin, Silvia / Belij-Rammerstorfer, Sandra / Spencer, Alexandra J / Burton, Oliver T / Fra-Bidó, Sigrid / Le Lee, Jia / Thakur, Nazia / Conceicao, Carina / Wright, Daniel / Barrett, Jordan / Evans-Bailey, Nicola / Noble, Carly / Bailey, Dalan / Liston, Adrian / Gilbert, Sarah C / Lambe, Teresa / Linterman, Michelle A

    Med (New York, N.Y.)

    2020  Band 2, Heft 3, Seite(n) 243–262.e8

    Abstract: Background: The spread of SARS-CoV-2 has caused a worldwide pandemic that has affected almost every aspect of human life. The development of an effective COVID-19 vaccine could limit the morbidity and mortality caused by infection and may enable the ... ...

    Abstract Background: The spread of SARS-CoV-2 has caused a worldwide pandemic that has affected almost every aspect of human life. The development of an effective COVID-19 vaccine could limit the morbidity and mortality caused by infection and may enable the relaxation of social-distancing measures. Age is one of the most significant risk factors for poor health outcomes after SARS-CoV-2 infection; therefore, it is desirable that any new vaccine candidates elicit a robust immune response in older adults.
    Methods: Here, we use in-depth immunophenotyping to characterize the innate and adaptive immune response induced upon intramuscular administration of the adenoviral vectored ChAdOx1 nCoV-19 (AZD-1222) COVID-19 vaccine candidate in mice.
    Findings: A single vaccination generates spike-specific Th1 cells, Th1-like Foxp3
    Conclusions: This study shows that ChAdOx1 nCoV-19 induces both cellular and humoral immunity in adult and aged mice and suggests a prime-boost strategy is a rational approach to enhance immunogenicity in older persons.
    Funding: This study was supported by BBSRC, Lister institute of Preventative Medicine, EPSRC VaxHub, and Innovate UK.
    Mesh-Begriff(e) Aged ; Aged, 80 and over ; Animals ; CD8-Positive T-Lymphocytes ; COVID-19/prevention & control ; COVID-19 Vaccines ; ChAdOx1 nCoV-19 ; Humans ; Mice ; SARS-CoV-2
    Chemische Substanzen COVID-19 Vaccines ; ChAdOx1 nCoV-19 (B5S3K2V0G8)
    Sprache Englisch
    Erscheinungsdatum 2020-12-16
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2666-6340
    ISSN (online) 2666-6340
    DOI 10.1016/j.medj.2020.12.006
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  9. Artikel ; Online: Follicular Regulatory T Cells Can Access the Germinal Center Independently of CXCR5

    Ine Vanderleyden / Sigrid C. Fra-Bido / Silvia Innocentin / Marisa Stebegg / Hanneke Okkenhaug / Nicola Evans-Bailey / Wim Pierson / Alice E. Denton / Michelle A. Linterman

    Cell Reports, Vol 30, Iss 3, Pp 611-619.e

    2020  Band 4

    Abstract: Summary: The germinal center (GC) response is critical for generating high-affinity humoral immunity and immunological memory, which forms the basis of successful immunization. Control of the GC response is thought to require follicular regulatory T (Tfr) ...

    Abstract Summary: The germinal center (GC) response is critical for generating high-affinity humoral immunity and immunological memory, which forms the basis of successful immunization. Control of the GC response is thought to require follicular regulatory T (Tfr) cells, a subset of suppressive Foxp3+ regulatory T cells located within GCs. Relatively little is known about the exact role of Tfr cells within the GC and how they exert their suppressive function. A unique feature of Tfr cells is their reported CXCR5-dependent localization to the GC. Here, we show that the lack of CXCR5 on Foxp3+ regulatory T cells results in a reduced frequency, but not an absence, of GC-localized Tfr cells. This reduction in Tfr cells is not sufficient to alter the magnitude or output of the GC response. This demonstrates that additional, CXCR5-independent mechanisms facilitate Treg cell homing to the GC. : Vanderleyden et al. show that CXCR5-deficient Treg cells can migrate into the B cell follicle. In the absence of CXCR5, fewer Tfr cells participate in the germinal center reaction, but the reduction in Tfr cell number does not affect the magnitude of the germinal center response. Keywords: follicular regulatory T cells, germinal center response, CXCR5
    Schlagwörter Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2020-01-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  10. Artikel ; Online: A booster dose enhances immunogenicity of the COVID-19 vaccine candidate ChAdOx1 nCoV-19 in aged mice

    Silva-Cayetano, Alyssa / Foster, William S. / Innocentin, Silvia / Belij-Rammerstorfer, Sandra / Spencer, Alexandra J. / Burton, Oliver T. / Fra-Bidó, Sigrid / Lee, Jia Le / Thakur, Nazia / Conceicao, Carina / Wright, Daniel / Barett, Jordan / Evans-Bailey, Nicola / Noble, Carly / Bailey, Dalan / Liston, Adrian / Gilbert, Sarah C. / Lambe, Teresa / Linterman, Michelle A.

    bioRxiv

    Abstract: The spread of SARS-CoV-2 has caused a global pandemic that has affected almost every aspect of human life. The development of an effective COVID-19 vaccine could limit the morbidity and mortality caused by infection, and may enable the relaxation of ... ...

    Abstract The spread of SARS-CoV-2 has caused a global pandemic that has affected almost every aspect of human life. The development of an effective COVID-19 vaccine could limit the morbidity and mortality caused by infection, and may enable the relaxation of social distancing measures. Age is one of the most significant risk factors for poor health outcomes after SARS-CoV-2 infection, therefore it is desirable that any new vaccine candidates should elicit a robust immune response in older adults. Here, we test the immunogenicity of the adenoviral vectored vaccine ChAdOx1 nCoV-19 (AZD-1222) in aged mice. We find that a single dose of this vaccine induces cellular and humoral immunity in aged mice, but at a reduced magnitude than in younger adult mice. Furthermore, we report that a second dose enhances the immune response to this vaccine in aged mice, indicating that a primeboost strategy may be a rational approach to enhance immunogenicity in older persons.
    Schlagwörter covid19
    Verlag BioRxiv; WHO
    Dokumenttyp Artikel ; Online
    DOI 10.1101/2020.10.27.357426
    Datenquelle COVID19

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Zum Seitenanfang