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Article: The Use of

Derosa, Giuseppe / D'Angelo, Angela / Maffioli, Pamela / Cucinella, Laura / Nappi, Rossella Elena

2024 Volume 12, Issue 2

Abstract: ... Nigella ... ...

Abstract	Nigella sativa
Language	English
Publishing date	2024-02-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines12020405
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Article ; Online: The role of selected nutraceuticals in management of prediabetes and diabetes: An updated review of the literature.

Derosa, Giuseppe / D'Angelo, Angela / Maffioli, Pamela

Phytotherapy research : PTR

2022 Volume 36, Issue 10, Page(s) 3709–3765

Abstract: Dysglycemia is a disease state preceding the onset of diabetes and includes impaired fasting glycemia and impaired glucose tolerance. This review aimed to collect and analyze the literature reporting the results of clinical trials evaluating the effects ... ...

Abstract	Dysglycemia is a disease state preceding the onset of diabetes and includes impaired fasting glycemia and impaired glucose tolerance. This review aimed to collect and analyze the literature reporting the results of clinical trials evaluating the effects of selected nutraceuticals on glycemia in humans. The results of the analyzed trials, generally, showed the positive effects of the nutraceuticals studied alone or in association with other supplements on fasting plasma glucose and post-prandial plasma glucose as primary outcomes, and their efficacy in improving insulin resistance as a secondary outcome. Some evidences, obtained from clinical trials, suggest a role for some nutraceuticals, and in particular Berberis, Banaba, Curcumin, and Guar gum, in the management of prediabetes and diabetes. However, contradictory results were found on the hypoglycemic effects of Morus, Ilex paraguariensis, Omega-3, Allium cepa, and Trigonella faenum graecum, whereby rigorous long-term clinical trials are needed to confirm these data. More studies are also needed for Eugenia jambolana, as well as for Ascophyllum nodosum and Fucus vesiculosus which glucose-lowering effects were observed when administered in combination, but not alone. Further trials are also needed for quercetin.
MeSH term(s)	Blood Glucose ; Curcumin/pharmacology ; Curcumin/therapeutic use ; Diabetes Mellitus ; Diabetes Mellitus, Type 2/drug therapy ; Dietary Supplements ; Glucose Intolerance ; Humans ; Hypoglycemic Agents ; Prediabetic State/drug therapy ; Quercetin
Chemical Substances	Blood Glucose ; Hypoglycemic Agents ; Quercetin (9IKM0I5T1E) ; Curcumin (IT942ZTH98)
Language	English
Publishing date	2022-08-01
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	639136-9
ISSN	1099-1573 ; 0951-418X
ISSN (online)	1099-1573
ISSN	0951-418X
DOI	10.1002/ptr.7564
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Article ; Online: The role of selected nutraceuticals in management of prediabetes and diabetes: An updated review of the literature

Derosa, Giuseppe / D'Angelo, Angela / Maffioli, Pamela

Phytotherapy Research. 2022 Oct., v. 36, no. 10 p.3709-3765

2022

Abstract	Dysglycemia is a disease state preceding the onset of diabetes and includes impaired fasting glycemia and impaired glucose tolerance. This review aimed to collect and analyze the literature reporting the results of clinical trials evaluating the effects of selected nutraceuticals on glycemia in humans. The results of the analyzed trials, generally, showed the positive effects of the nutraceuticals studied alone or in association with other supplements on fasting plasma glucose and post‐prandial plasma glucose as primary outcomes, and their efficacy in improving insulin resistance as a secondary outcome. Some evidences, obtained from clinical trials, suggest a role for some nutraceuticals, and in particular Berberis, Banaba, Curcumin, and Guar gum, in the management of prediabetes and diabetes. However, contradictory results were found on the hypoglycemic effects of Morus, Ilex paraguariensis, Omega‐3, Allium cepa, and Trigonella faenum graecum, whereby rigorous long‐term clinical trials are needed to confirm these data. More studies are also needed for Eugenia jambolana, as well as for Ascophyllum nodosum and Fucus vesiculosus which glucose‐lowering effects were observed when administered in combination, but not alone. Further trials are also needed for quercetin.
Keywords	Allium cepa ; Ascophyllum nodosum ; Berberis ; Fucus vesiculosus ; Ilex paraguariensis ; Syzygium cumini ; Trigonella ; blood glucose ; carbohydrate metabolism disorders ; curcumin ; diabetes ; dietary supplements ; glucose tolerance ; guar gum ; insulin resistance ; phytotherapy ; quercetin ; research
Language	English
Dates of publication	2022-10
Size	p. 3709-3765.
Publishing place	John Wiley & Sons, Ltd.
Document type	Article ; Online
Note	REVIEW
ZDB-ID	639136-9
ISSN	1099-1573 ; 0951-418X
ISSN (online)	1099-1573
ISSN	0951-418X
DOI	10.1002/ptr.7564
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Article: Metabolic Actions of a Supplement of Ilex Paraguariensis (An Extract of the Leaf Standardized to 2% I-Deoxinojirimcina), White Mulberry and Chromium Picolinate in Nondiabetic Subects with Dysglycemia: A Randomized Trial.

Derosa, Giuseppe / D'Angelo, Angela / Maffioli, Pamela

Life (Basel, Switzerland)

2021 Volume 11, Issue 7

Abstract: Aim: To prove if a nutraceutical containing Ilex paraguariensis (: Methods: We randomized patients to consume placebo or the nutraceutical, self-administered once a day, one tablet at breakfast, for 3 months.: Results: A reduction in fasting ... ...

Abstract	Aim: To prove if a nutraceutical containing Ilex paraguariensis ( Methods: We randomized patients to consume placebo or the nutraceutical, self-administered once a day, one tablet at breakfast, for 3 months. Results: A reduction in fasting plasma glucose, postprandial glucose, and glycated hemoglobin was observed with the nutraceutical combination, both compared to baseline and placebo. Data suggested a decrease in the Homeostasis Model Assessment index with the nutraceutical, both compared to baseline and placebo. The M value, an index of insulin sensitivity, obtained after nutraceutical treatment was higher compared to baseline. We recorded a decrease in total cholesterol, low-density lipoprotein-cholesterol, and triglycerides with the nutraceutical combination compared to baseline and placebo. A decrease in high-sensitivity C-reactive protein was observed with the nutraceutical combination compared to baseline and placebo. Conclusions: A nutraceutical containing Ilex paraguariensis, white mulberry, and chromium picolinate can be helpful in improving glycemic status and lipid profile in dysglycemic subjects.
Language	English
Publishing date	2021-07-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life11070709
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Article: Evaluation of the Effect on Sexual Performance of a Nutraceutical Combination Containing Alpha Lipoic Acid,

Derosa, Giuseppe / D'Angelo, Angela / Preti, Paola Stefania / Maffioli, Pamela

Frontiers in endocrinology

2022 Volume 13, Page(s) 847240

Abstract: Aim: To evaluate if therapy with a nutraceutical combination of alpha lipoic acid, Vitis vinifera L. and Ginkgo biloba (Blunorm forte: Methods: The trial included 123 males with type 2 diabetic mellitus and with erectile dysfunction (ED), aged ≥18 ... ...

Abstract	Aim: To evaluate if therapy with a nutraceutical combination of alpha lipoic acid, Vitis vinifera L. and Ginkgo biloba (Blunorm forte Methods: The trial included 123 males with type 2 diabetic mellitus and with erectile dysfunction (ED), aged ≥18 years. Patients were divided in four different arms: 1 Results: A significant reduction of fasting plasma glucose, and homeostasis model assessment-insulin resistance index were recorded both in Avanafil + Blunorm forte and with Blunorm forte. Metalloproteinases-2, and -9 were reduced in the Avanafil + Blunorm forte group. High sensitivity-C-reactive protein was decreased by both Avanafil, and Avanafil + Blunorm forte group. No variations were recorded with the other treatments. The group treated with Blunorm forte and Avanafil reached a higher International Index of Erectile Function (IIEF) score after 3 months of therapy compared to baseline and placebo and compared to Avanafil and Blunorm forte taken alone. Conclusion: Blunorm forte
MeSH term(s)	Adolescent ; Adult ; Diabetes Mellitus, Type 2/complications ; Dietary Supplements ; Erectile Dysfunction/drug therapy ; Erectile Dysfunction/etiology ; Female ; Ginkgo biloba ; Humans ; Male ; Penile Erection ; Pyrimidines ; Thioctic Acid/pharmacology ; Thioctic Acid/therapeutic use ; Treatment Outcome ; Vitis
Chemical Substances	Pyrimidines ; Thioctic Acid (73Y7P0K73Y) ; avanafil (DR5S136IVO)
Language	English
Publishing date	2022-04-07
Publishing country	Switzerland
Document type	Clinical Trial ; Journal Article
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2022.847240
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Article ; Online: Nateglinide does not reduce the incidence of diabetes or cardiovascular outcomes in people with impaired glucose tolerance and cardiovascular disease or risk factors.

Derosa, Giuseppe

Evidence-based medicine

2011 Volume 16, Issue 1, Page(s) 7–8

Language	English
Publishing date	2011-02
Publishing country	England
Document type	Comment ; Journal Article
ZDB-ID	1324346-9
ISSN	1473-6810 ; 1356-5524
ISSN (online)	1473-6810
ISSN	1356-5524
DOI	10.1136/ebm1100
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Article: Ertugliflozin: a sodium-glucose cotransporter-2 (SGLT-2) inhibitor for glycemic control in type 2 diabetes.

Derosa, Giuseppe / Maffioli, Pamela

Therapeutics and clinical risk management

2018 Volume 14, Page(s) 1637–1640

Abstract: Recently, a new class of anti-diabetic drugs has found its way into the market: sodium-glucose cotransporters (SGLT) inhibitors. Two major SGLT isoforms have been identified: SGLT-2, mainly expressed in proximal renal tubules, and SGLT-1, mainly ... ...

Abstract	Recently, a new class of anti-diabetic drugs has found its way into the market: sodium-glucose cotransporters (SGLT) inhibitors. Two major SGLT isoforms have been identified: SGLT-2, mainly expressed in proximal renal tubules, and SGLT-1, mainly expressed in the small intestine, the proximal renal tubule, and the myocardium. SGLT-2 inhibitors increase urinary glucose excretion, lowering glycemia without inducing excessive insulin secretion. Marketed SGLT-2 inhibitors actually include dapagliflozin, canagliflozin, and empagliflozin; a new SGLT-2 inhibitor is being studied: ertugliflozin. Ertugliflozin is a potent inhibitor of SGLT-2 and possesses a high selectivity over glucose transport via SGLT-1 and several other glucose transporters GLUT-1-4. Ertugliflozin inhibits renal glucose reabsorption resulting in urinary glucose excretion and thereby reduces plasma glucose and glycated hemoglobin in subjects with type 2 diabetes mellitus. Ertugliflozin is being developed as an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus. The aim of this review is to evaluate the preliminary published data about this new molecule.
Language	English
Publishing date	2018-09-07
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2186560-7
ISSN	1178-203X ; 1176-6336
ISSN (online)	1178-203X
ISSN	1176-6336
DOI	10.2147/TCRM.S137068
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Article ; Online: Metabolic Actions of a Supplement of Ilex Paraguariensis (An Extract of the Leaf Standardized to 2% I-Deoxinojirimcina), White Mulberry and Chromium Picolinate in Nondiabetic Subects with Dysglycemia

Giuseppe Derosa / Angela D’Angelo / Pamela Maffioli

Life, Vol 11, Iss 709, p

A Randomized Trial

2021 Volume 709

Abstract: Aim: To prove if a nutraceutical containing Ilex paraguariensis ( Ilex L. spp. Aquifoliales) (an extract of the leaf standardized to 2% I-deoxinojirimcina), white mulberry ( Morus spp., Moraceae), and chromium picolinate can be effective in improving ... ...

Abstract	Aim: To prove if a nutraceutical containing Ilex paraguariensis ( Ilex L. spp. Aquifoliales) (an extract of the leaf standardized to 2% I-deoxinojirimcina), white mulberry ( Morus spp., Moraceae), and chromium picolinate can be effective in improving glycemic status in subject with dysglycemia. Methods: We randomized patients to consume placebo or the nutraceutical, self-administered once a day, one tablet at breakfast, for 3 months. Results: A reduction in fasting plasma glucose, postprandial glucose, and glycated hemoglobin was observed with the nutraceutical combination, both compared to baseline and placebo. Data suggested a decrease in the Homeostasis Model Assessment index with the nutraceutical, both compared to baseline and placebo. The M value, an index of insulin sensitivity, obtained after nutraceutical treatment was higher compared to baseline. We recorded a decrease in total cholesterol, low-density lipoprotein-cholesterol, and triglycerides with the nutraceutical combination compared to baseline and placebo. A decrease in high-sensitivity C-reactive protein was observed with the nutraceutical combination compared to baseline and placebo. Conclusions: A nutraceutical containing Ilex paraguariensis, white mulberry, and chromium picolinate can be helpful in improving glycemic status and lipid profile in dysglycemic subjects.
Keywords	Ilex paraguariensis ; white mulberry ; chromium picolinate ; impaired glycemia ; Science ; Q
Subject code	610
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Ilex paraguariensis, white mulberry and chromium picolinate in patients with pre-diabetes.

Derosa, Giuseppe / D'Angelo, Angela / Maffioli, Pamela

Phytotherapy research : PTR

2020 Volume 34, Issue 6, Page(s) 1377–1384

Abstract: Aim: to evaluate if a nutraceutical compound containing Ilex paraguariensis, White Mulberry and Chromium Picolinate can ameliorate glycemic status in patients with pre-diabetes.: Methods: we enrolled patients with IFG or IGT, not taking other ... ...

Abstract	Aim: to evaluate if a nutraceutical compound containing Ilex paraguariensis, White Mulberry and Chromium Picolinate can ameliorate glycemic status in patients with pre-diabetes. Methods: we enrolled patients with IFG or IGT, not taking other hypoglycemic compounds. Patients were randomized to take placebo or the nutraceutical compound for 3 months, in a randomized, double-blind, placebo-controlled design. Both treatments were self-administered once a day, 1 tablet during the breakfast. Results: a reduction of FPG was observed with the nutraceutical combination (-7.8%). Furthermore, there was a decrease of HOMA-IR with the nutraceutical combination (-7.9%). M value was higher (p < 0.05 vs baseline and p < 0.05 vs placebo) at the end of the treatment. We obtained a reduction of Tg with the nutraceutical combination (-8.3%). About 16.6% of patients treated with nutraceutical returned to have a normal glycemia (< 100 mg/dL), and all patients had an improvement of insulin-resistance, in particular 67% of patients returned to have a M value inside range of normal insulin sensitivity. Conclusions: a nutraceutical containing Ilex paraguariensis, White Mulberry and Chromium Picolinate at 500 mg can be helpful in improving glycemia and Tg value, in patients with pre-diabetes.
MeSH term(s)	Blood Glucose/drug effects ; Double-Blind Method ; Female ; Humans ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Ilex paraguariensis/chemistry ; Male ; Middle Aged ; Morus/chemistry ; Picolinic Acids/chemistry ; Prediabetic State/drug therapy
Chemical Substances	Blood Glucose ; Hypoglycemic Agents ; Picolinic Acids ; picolinic acid (QZV2W997JQ)
Language	English
Publishing date	2020-01-28
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	639136-9
ISSN	1099-1573 ; 0951-418X
ISSN (online)	1099-1573
ISSN	0951-418X
DOI	10.1002/ptr.6611
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Article ; Online: Nutraceutical Approach to Preventing Coronavirus Disease 2019 and Related Complications.

Derosa, Giuseppe / Maffioli, Pamela / D'Angelo, Angela / Di Pierro, Francesco

Frontiers in immunology

2021 Volume 12, Page(s) 582556

Abstract: Introduction: Several months ago, Chinese authorities identified an atypical pneumonia in Wuhan city, province of Hubei (China) caused by a novel coronavirus (2019-nCoV or SARS-CoV-2). The WHO announced this new disease was to be known as "COVID-19".: ...

Abstract	Introduction: Several months ago, Chinese authorities identified an atypical pneumonia in Wuhan city, province of Hubei (China) caused by a novel coronavirus (2019-nCoV or SARS-CoV-2). The WHO announced this new disease was to be known as "COVID-19". Evidence acquisition: Several approaches are currently underway for the treatment of this disease, but a specific cure remains to be established. Evidence synthesis: This review will describe how the use of selected nutraceuticals could be helpful, in addition to pharmacological therapy, in preventing some COVID-19-related complications in infected patients. Conclusions: Even if a specific and effective cure for COVID-19 still has some way to go, selected nutraceuticals could be helpful, in addition to pharmacological therapy, in preventing some COVID-19-related complications in infected patients.
MeSH term(s)	Berberine/therapeutic use ; COVID-19/complications ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/virology ; China/epidemiology ; Dietary Supplements ; Fatty Acids, Omega-3/therapeutic use ; Fungal Polysaccharides/therapeutic use ; Humans ; Lactoferrin/therapeutic use ; Minerals/therapeutic use ; Plant Lectins/therapeutic use ; Polyphenols/therapeutic use ; SARS-CoV-2 ; Soy Foods ; Vitamins/therapeutic use
Chemical Substances	Fatty Acids, Omega-3 ; Fungal Polysaccharides ; Minerals ; Plant Lectins ; Polyphenols ; Vitamins ; Berberine (0I8Y3P32UF) ; Lactoferrin (EC 3.4.21.-)
Language	English
Publishing date	2021-06-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.582556
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