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Article: Completion pneumonectomy via sternotomy and complete intrathoracic liver migration in metastatic osteosarcoma.

Chang, Shantel / Kirk, Frazer / Fuller, Robert / Provenzano, Sylvio

2023 Volume 2023, Issue 10, Page(s) rjad552

Abstract: Pulmonary metastasectomy is the well-accepted surgical management for recurrent osteosarcoma in the lung. A pneumonectomy is seldom performed, even more so via a sternotomy. We report an unusual case of a pneumonectomy via median sternotomy for a ... ...

Abstract	Pulmonary metastasectomy is the well-accepted surgical management for recurrent osteosarcoma in the lung. A pneumonectomy is seldom performed, even more so via a sternotomy. We report an unusual case of a pneumonectomy via median sternotomy for a pulmonary metastasis with complete migration of the liver into the intrathoracic space, a complication rarely observed. The patient remains disease-free on follow-up, 21 years following the initial diagnosis. Aggressive approaches for metastasectomy, despite clinician hesitation in the age of minimally invasive surgery, can yield excellent outcomes for a cancer with otherwise poor prognosis.
Language	English
Publishing date	2023-10-15
Publishing country	England
Document type	Case Reports
ZDB-ID	2580919-2
ISSN	2042-8812
ISSN	2042-8812
DOI	10.1093/jscr/rjad552
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Article: Viewpoint: Is there a nephrologist shortage or just poor deployment?

Provenzano, Robert

Nephrology news & issues

2016 Volume 30, Issue 4, Page(s) 34–36

MeSH term(s)	Health Manpower/statistics & numerical data ; Humans ; Nephrology/organization & administration ; Nephrology/statistics & numerical data ; Physicians/statistics & numerical data ; Physicians/supply & distribution ; Professional Role ; United States
Language	English
Publishing date	2016-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	1077629-1
ISSN	1944-7493 ; 0896-1263
ISSN (online)	1944-7493
ISSN	0896-1263
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Zs.A 3266: Show issues

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Article ; Online: The Economics of Late-Stage Chronic Kidney Disease.

Provenzano, Robert

Advances in chronic kidney disease

2016 Volume 23, Issue 4, Page(s) 222–226

Abstract: Health care reimbursement is undergoing a fundamental change from volume-driven to value-driven care. The Patient Protection and Affordable Care Act is marshaling this change and empowering hospitals through Accountable Care Organizations to accept risk. ...

Abstract	Health care reimbursement is undergoing a fundamental change from volume-driven to value-driven care. The Patient Protection and Affordable Care Act is marshaling this change and empowering hospitals through Accountable Care Organizations to accept risk. ESRD care/nephrology was awarded the only disease-specific Accountable Care Organization, ESRD Seamless Care Organizations. Dialysis providers in partnership with nephrologists will be exploring how ESRD Seamless Care Organizations will drive improvement in care. CKD care and economics will no longer be isolated from ESRD but possibly more closely linked to global patient outcomes. Preparation for these changes will require unique co-operation and collaboration between nephrologists, dialysis providers, payers, and hospitals/health care systems. Early pilot trials, demonstration projects, and special need programs have suggested value care can be delivered. Whether these results are scalable needs to be determined.
Language	English
Publishing date	2016
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1548-5609 ; 1548-5595
ISSN (online)	1548-5609
ISSN	1548-5595
DOI	10.1053/j.ackd.2015.12.002
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Zs.A 4627: Show issues

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Article ; Online: Optimal cell traction forces in a generalized motor-clutch model.

Alonso-Matilla, Roberto / Provenzano, Paolo P / Odde, David J

Biophysical journal

2023 Volume 122, Issue 16, Page(s) 3369–3385

Abstract: Cells exert forces on mechanically compliant environments to sense stiffness, migrate, and remodel tissue. Cells can sense environmental stiffness via myosin-generated pulling forces acting on F-actin, which is in turn mechanically coupled to the ... ...

Abstract	Cells exert forces on mechanically compliant environments to sense stiffness, migrate, and remodel tissue. Cells can sense environmental stiffness via myosin-generated pulling forces acting on F-actin, which is in turn mechanically coupled to the environment via adhesive proteins, akin to a clutch in a drivetrain. In this "motor-clutch" framework, the force transmitted depends on the complex interplay of motor, clutch, and environmental properties. Previous mean-field analysis of the motor-clutch model identified the conditions for optimal stiffness for maximal force transmission via a dimensionless number that combines motor-clutch parameters. However, in this and other previous mean-field analyses, the motor-clutch system is assumed to have balanced motors and clutches and did not consider force-dependent clutch reinforcement and catch bond behavior. Here, we generalize the motor-clutch analytical framework to include imbalanced motor-clutch regimes, with clutch reinforcement and catch bonding, and investigate optimality with respect to all parameters. We found that traction force is strongly influenced by clutch stiffness, and we discovered an optimal clutch stiffness that maximizes traction force, suggesting that cells could tune their clutch mechanical properties to perform a specific function. The results provide guidance for maximizing the accuracy of cell-generated force measurements via molecular tension sensors by designing their mechanosensitive linker peptide to be as stiff as possible. In addition, we found that, on rigid substrates, the mean-field analysis identifies optimal motor properties, suggesting that cells could regulate their myosin repertoire and activity to maximize force transmission. Finally, we found that clutch reinforcement shifts the optimum substrate stiffness to larger values, whereas the optimum substrate stiffness is insensitive to clutch catch bond properties. Overall, our work reveals novel features of the motor-clutch model that can affect the design of molecular tension sensors and provide a generalized analytical framework for predicting and controlling cell adhesion and migration in immunotherapy and cancer.
MeSH term(s)	Biomechanical Phenomena ; Traction ; Actins/metabolism ; Actin Cytoskeleton/metabolism ; Cell Adhesion
Chemical Substances	Actins
Language	English
Publishing date	2023-07-20
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	218078-9
ISSN	1542-0086 ; 0006-3495
ISSN (online)	1542-0086
ISSN	0006-3495
DOI	10.1016/j.bpj.2023.07.012
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Zs.A 235: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: AKI moves into the outpatient dialysis setting. What the new law means for patients, staff.

Provenzano, Robert / Payne, Glenda

Nephrology news & issues

2018 Volume 31, Issue 2, Page(s) 27–29

MeSH term(s)	Acute Kidney Injury/economics ; Acute Kidney Injury/therapy ; Aged ; Female ; Health Care Costs/legislation & jurisprudence ; Humans ; Kidney Failure, Chronic/economics ; Kidney Failure, Chronic/therapy ; Male ; Medicare/legislation & jurisprudence ; Middle Aged ; Outpatients ; Renal Dialysis/economics ; Risk Factors ; United States
Language	English
Publishing date	2018-11-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1077629-1
ISSN	1944-7493 ; 0896-1263
ISSN (online)	1944-7493
ISSN	0896-1263
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Article ; Online: Association of risk stratification score with dialysis vascular access stenosis.

Kumbar, Lalathaksha / Astor, Brad C / Besarab, Anatole / Provenzano, Robert / Yee, Jerry

The journal of vascular access

2022 , Page(s) 11297298221136592

Abstract: Backgrounds: Clinical monitoring is the recommended standard for identifying dialysis access dysfunction; however, clinical monitoring requires skill and training, which is challenging for understaffed clinics and overburdened healthcare personnel. A ... ...

Abstract	Backgrounds: Clinical monitoring is the recommended standard for identifying dialysis access dysfunction; however, clinical monitoring requires skill and training, which is challenging for understaffed clinics and overburdened healthcare personnel. A vascular access risk stratification score was recently proposed to assist in detecting dialysis access dysfunction. Purpose: Our objective was to evaluate the utility of using vascular access risk scores to assess venous stenosis in hemodialysis vascular accesses. Methods: We prospectively enrolled adult patients who were receiving hemodialysis through an arteriovenous access and who had a risk score ⩽3 (low-risk) or ⩾8 (high-risk). We compared the occurrence of access stenosis (>50% on ultrasonography or angiography) between low-risk and high-risk groups and assessed clinical monitoring results for each group. Results: Of the 38 patients analyzed (18 low-risk; 20 high-risk), 16 (42%) had significant stenosis. Clinical monitoring results were positive in 39% of the low-risk and 60% of the high-risk group ( Conclusions: A calculated risk score may help predict the development of hemodialysis vascular access stenosis and may provide a simple and reliable objective measure for risk stratification.
Language	English
Publishing date	2022-11-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2252820-9
ISSN	1724-6032 ; 1129-7298
ISSN (online)	1724-6032
ISSN	1129-7298
DOI	10.1177/11297298221136592
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Zs.A 6414: Show issues

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Article ; Online: Treating refractory posterior sacroiliac joint complex pain in the current healthcare ecosystem: a call to action.

Sherwood, David / Yang, Aaron / Hunt, Christine / Provenzano, David / Kohan, Lynn / Hurley, Robert W / Cohen, Steven P / Shah, Vinil / McCormick, Zachary L

Pain medicine (Malden, Mass.)

2023 Volume 24, Issue 10, Page(s) 1131–1132

MeSH term(s)	Humans ; Sacroiliac Joint ; Ecosystem ; Arthralgia ; Low Back Pain ; Pelvic Pain
Language	English
Publishing date	2023-06-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2015903-1
ISSN	1526-4637 ; 1526-2375
ISSN (online)	1526-4637
ISSN	1526-2375
DOI	10.1093/pm/pnad071
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Article ; Online: Dapagliflozin and Blood Pressure in Patients with Chronic Kidney Disease and Albuminuria.

Heerspink, Hiddo Jl / Provenzano, Michele / Vart, Priya / Jongs, Niels / Correa-Rotter, Ricardo / Rossing, Peter / Mark, Patrick B / Pecoits-Filho, Roberto / McMurray, John Jv / Langkilde, Anna Maria / Wheeler, David C / Toto, Robert B / Chertow, Glenn M

American heart journal

2024 Volume 270, Page(s) 125–135

Abstract: Background and aims: Sodium-glucose cotransporter 2 inhibitors decrease blood pressure in patients with type 2 diabetes, but the consistency and magnitude of blood pressure lowering with dapagliflozin in patients with chronic kidney disease (CKD) is ... ...

Abstract	Background and aims: Sodium-glucose cotransporter 2 inhibitors decrease blood pressure in patients with type 2 diabetes, but the consistency and magnitude of blood pressure lowering with dapagliflozin in patients with chronic kidney disease (CKD) is unknown. We conducted a prespecified analysis of the DAPA-CKD trial to investigate the effect of dapagliflozin on systolic blood pressure (SBP) in patients with CKD, with and without type 2 diabetes. Methods: A total of 4304 adults with baseline estimated glomerular filtration rate (eGFR) 25-75 mL/min/1.73m Results: Baseline mean (SD) SBP was 137.1 mmHg (17.4). By Week 2, dapagliflozin compared to placebo reduced SBP by 3.6 mmHg (95% CI 2.8-4.4 mmHg), an effect maintained over the duration of the trial (2.9 mmHg, 2.3-3.6 mmHg). Time-averaged reductions in SBP were 3.2 mmHg (2.5-4.0 mmHg) in patients with diabetes and 2.3 mmHg (1.2-3.4 mmHg) in patients without diabetes. The time-averaged effect of dapagliflozin on diastolic blood pressure (DBP) was 1.0 mmHg (0.6-1.4 mmHg); 0.8 mmHg (0.4-1.3 mmHg) in patients with diabetes and 1.4 mmHg (0.7-2.1 mmHg) in patients without diabetes. Benefits of dapagliflozin on the primary composite and secondary endpoints were evident across the spectrum of baseline SBP and DBP. Conclusion: In patients with CKD and albuminuria, randomization to dapagliflozin was associated with modest reductions in systolic and diastolic BP.
MeSH term(s)	Adult ; Humans ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Blood Pressure ; Albuminuria/etiology ; Albuminuria/complications ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Sodium-Glucose Transporter 2 Inhibitors/pharmacology ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/drug therapy ; Glomerular Filtration Rate ; Benzhydryl Compounds ; Glucosides
Chemical Substances	dapagliflozin (1ULL0QJ8UC) ; Sodium-Glucose Transporter 2 Inhibitors ; Benzhydryl Compounds ; Glucosides
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	80026-0
ISSN	1097-6744 ; 0002-8703
ISSN (online)	1097-6744
ISSN	0002-8703
DOI	10.1016/j.ahj.2024.02.006
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Article ; Online: Retraction notice to "Pooled Analysis of Roxadustat for Anemia in Patients With Kidney Failure Incident to Dialysis."

Provenzano, Robert / Fishbane, Steven / Szczech, Lynda / Leong, Robert / Saikali, Khalil G / Zhong, Ming / Lee, Tyson T / Houser, Mark T / Frison, Lars / Houghton, John / Little, Dustin J / Peony Yu, Kin-Hung / Neff, Thomas B

Kidney international reports

2022 Volume 7, Issue 3, Page(s) 665

Abstract: This retracts the article DOI: 10.1016/j.ekir.2020.12.018.]. ...

Abstract	[This retracts the article DOI: 10.1016/j.ekir.2020.12.018.].
Language	English
Publishing date	2022-02-05
Publishing country	United States
Document type	Retraction of Publication
ISSN	2468-0249
ISSN (online)	2468-0249
DOI	10.1016/j.ekir.2022.01.1069
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Article ; Online: Elucidating the signal for contact guidance contained in aligned fibrils with a microstructural-mechanical model.

Bersie-Larson, Lauren M / Lai, Victor K / Dhume, Rohit Y / Provenzano, Paolo P / Barocas, Victor H / Tranquillo, Robert T

Journal of the Royal Society, Interface

2022 Volume 19, Issue 190, Page(s) 20210951

Abstract: Despite its importance in physiological processes and tissue engineering, the mechanism underlying cell contact guidance in an aligned fibrillar network has defied elucidation due to multiple interdependent signals that such a network presents to cells, ... ...

Abstract	Despite its importance in physiological processes and tissue engineering, the mechanism underlying cell contact guidance in an aligned fibrillar network has defied elucidation due to multiple interdependent signals that such a network presents to cells, namely, anisotropy of adhesion, porosity and mechanical behaviour. A microstructural-mechanical model of fibril networks was used to assess the relative magnitudes of these competing signals in networks of varied alignment strength based on idealized cylindrical pseudopods projected into the aligned and orthogonal directions and computing the anisotropy of metrics chosen for adhesion, porosity and mechanical behaviour: cylinder-fibre contact area for adhesion, persistence length of pores for porosity and total force to displace fibres from the cylindrical volume as well as network stiffness experienced upon cylinder retraction for mechanical behaviour. The signals related to mechanical anisotropy are substantially higher than adhesion and porosity anisotropy, especially at stronger network alignments, although their signal to noise (S/N) values are substantially lower. The former finding is consistent with a recent report that fibroblasts can sense fibril alignment via anisotropy of network mechanical resistance, and the model reveals this can be due to either mechanical resistance to pseudopod protrusion or retraction given their signal and S/N values are similar.
MeSH term(s)	Anisotropy ; Cell Communication ; Fibroblasts ; Porosity ; Tissue Engineering
Language	English
Publishing date	2022-05-18
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2156283-0
ISSN	1742-5662 ; 1742-5689
ISSN (online)	1742-5662
ISSN	1742-5689
DOI	10.1098/rsif.2021.0951
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