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  1. Article ; Online: Effects of paediatric intensive care due to congenital heart defects on maternal mental health.

    Brandt, J B / Golej, J / Irschik, S / Steiner, A / Voitl, P / Steiner, I / Höflich, A

    Acta paediatrica (Oslo, Norway : 1992)

    2023  Volume 112, Issue 8, Page(s) 1725–1733

    Abstract: Aim: Successful mother-child-bonding is a fundamental step for a healthy development of the child. Different factors like postpartum depression can hinder the bonding process. This study aimed to investigate how intensive care treatment due to ... ...

    Abstract Aim: Successful mother-child-bonding is a fundamental step for a healthy development of the child. Different factors like postpartum depression can hinder the bonding process. This study aimed to investigate how intensive care treatment due to congenital heart diseases of the infant alters bonding and how mothers cope with the situation.
    Methods: Validated questionnaires were used to analyse postpartum depression, mother-child bonding, stress factors and coping strategies for mothers at a paediatric intensive care unit (PICU; n = 38) and a group of mothers without known psychiatric disorders attending a babywell visit with their child (n = 91). Descriptive statistics and interaction models were calculated.
    Results: The PICU group showed on average higher total scores on the postpartum bonding questionnaire indicating mother-child bonding impairment and a higher proportion of mothers with depression was observed (76% vs 11%). The model showed a significant interaction between effective coping strategies and mother infant bonding (p = 0.04). Ineffective coping had no effect on bonding or depression in the PICU group.
    Conclusion: Mothers of children treated at an ICU due a congenital heart disease are at increased risk for the development of depression and difficulties in different aspects of postpartum bonding. Our results show that coping mechanisms might significantly influence postpartum bonding. Implementation of tailored support is needed to optimise maternal outcomes.
    MeSH term(s) Infant ; Female ; Humans ; Depression, Postpartum/epidemiology ; Depression, Postpartum/psychology ; Mental Health ; Mother-Child Relations/psychology ; Mothers/psychology ; Postpartum Period ; Heart Defects, Congenital ; Critical Care ; Object Attachment
    Language English
    Publishing date 2023-05-30
    Publishing country Norway
    Document type Journal Article
    ZDB-ID 203487-6
    ISSN 1651-2227 ; 0365-1436 ; 0803-5253
    ISSN (online) 1651-2227
    ISSN 0365-1436 ; 0803-5253
    DOI 10.1111/apa.16843
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Risk factors for mortality in infants with congenital diaphragmatic hernia: a single center experience.

    Brandt, Jennifer Bettina / Werther, Tobias / Groth, Erika / Küng, Erik / Golej, Johann / Berger, Angelika

    Wiener klinische Wochenschrift

    2021  Volume 133, Issue 13-14, Page(s) 674–679

    Abstract: Background: Despite current progress in research of congenital diaphragmatic hernia, its management remains challenging, requiring an interdisciplinary team for optimal treatment.: Objective: Aim of the present study was to evaluate potential risk ... ...

    Abstract Background: Despite current progress in research of congenital diaphragmatic hernia, its management remains challenging, requiring an interdisciplinary team for optimal treatment.
    Objective: Aim of the present study was to evaluate potential risk factors for mortality of infants with congenital diaphragmatic hernia.
    Methods: A single-center chart review of all patients treated with congenital diaphragmatic hernia over a period of 16 years, at the Medical University of Vienna, was performed. A comparison of medical parameters between survivors and non-survivors, as well as to published literature was conducted.
    Results: During the observational period 66 patients were diagnosed with congenital diaphragmatic hernia. Overall survival was 84.6%. Left-sided hernia occurred in 51 patients (78.5%) with a mortality of 7.8%. In comparison, right-sided hernia occurred less frequently (n = 12) but showed a higher mortality (33.3%, p = 0.000). Critically instable patients were provided with venoarterial extracorporeal membrane oxygenation (ECMO, 32.3%, n = 21). Survival rate among these patients was 66.7%. Right-sided hernia, treatment with inhaled nitric oxide (iNO) over 15 days and the use of ECMO over 10 days were significant risk factors for mortality.
    Conclusion: The survival rate in this cohort is comparable to the current literature. Parameters such as the side of the diaphragmatic defect, duration of ECMO and inhaled nitric oxide were assessed as mortality risk factors. This analysis of patients with congenital diaphragmatic hernia enhances understanding of risk factors for mortality, helping to improve management and enabling further evaluation in prospective clinical trials.
    MeSH term(s) Extracorporeal Membrane Oxygenation ; Hernias, Diaphragmatic, Congenital/therapy ; Humans ; Infant ; Nitric Oxide ; Prospective Studies ; Retrospective Studies ; Risk Factors
    Chemical Substances Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2021-03-30
    Publishing country Austria
    Document type Journal Article ; Observational Study
    ZDB-ID 200462-8
    ISSN 1613-7671 ; 0043-5325 ; 0300-5178
    ISSN (online) 1613-7671
    ISSN 0043-5325 ; 0300-5178
    DOI 10.1007/s00508-021-01843-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Hemadsorption as rescue therapy for patients with multisystem organ failure in pediatric intensive care-Report of two cases reports and review of the literature.

    Steurer, Lisa-Maria / Schlager, Gerald / Sadeghi, Kambis / Golej, Johann / Wiedemann, Dominik / Hermon, Michael

    Artificial organs

    2021  Volume 45, Issue 12, Page(s) 1582–1593

    Abstract: Hemadsorption via the cytokine-adsorber CytoSorb (CytoSorbents Europe, Berlin, Germany) has successfully been used as an adjunctive method in adults, mainly for the purpose of immunomodulation under acute inflammatory conditions such as sepsis and ... ...

    Abstract Hemadsorption via the cytokine-adsorber CytoSorb (CytoSorbents Europe, Berlin, Germany) has successfully been used as an adjunctive method in adults, mainly for the purpose of immunomodulation under acute inflammatory conditions such as sepsis and cardiac surgery. In recent years, there has been growing interest in its use in pediatric intensive care to improve outcomes in patients with multiple organ failure following an inflammatory illness. Literature on the application of CytoSorb in neonatal and pediatric patients is scarce, though the implication is that it could be an effective last-resort treatment option in critically ill pediatric patients. Herein we present the clinical cases of two pediatric patients successfully treated with a combination of the CytoSorb hemadsorber, continuous renal replacement therapy, and extracorporeal membrane oxygenation due to multiple organ failure following different underlying medical conditions. Patient 1 was a 7-month-old male child with Down's syndrome admitted to the Pediatric Intensive Care Unit (PICU) after congenital heart surgery, who developed antimicrobial-resistant septic shock and severe acute respiratory distress syndrome. Patient 2 was a 2-year-old male child admitted to the PICU with influenza A-associated acute liver failure resulting in hyperammonemia, lactate acidosis, hemodynamic instability, and acute kidney failure. In both patients, hemadsorption with CytoSorb was initiated as an adjunctive rescue therapy to treat refractory multisystem organ failure. Improvement of laboratory and clinical parameters was observed within hours of treatment initiation. The application of the hemadsorber-developed for use in adults-proved simple and safe for use in both of our low-weight pediatric patients.
    MeSH term(s) Child, Preschool ; Continuous Renal Replacement Therapy/methods ; Down Syndrome ; Extracorporeal Membrane Oxygenation/methods ; Heart Defects, Congenital/surgery ; Hemadsorption ; Humans ; Infant ; Influenza A virus ; Influenza, Human/therapy ; Liver Failure, Acute/therapy ; Male ; Multiple Organ Failure/therapy ; Respiratory Distress Syndrome/therapy ; Shock, Septic/therapy ; Treatment Outcome
    Language English
    Publishing date 2021-08-12
    Publishing country United States
    Document type Case Reports
    ZDB-ID 441812-8
    ISSN 1525-1594 ; 0160-564X
    ISSN (online) 1525-1594
    ISSN 0160-564X
    DOI 10.1111/aor.14047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Pediatric infection and sepsis in five age subgroups: single-center registry.

    Hermon, Michael M / Etmayr, Theresa / Brandt, Jennifer Bettina / Sadeghi, Kambis / Burda, Gudrun / Golej, Johann

    Wiener medizinische Wochenschrift (1946)

    2020  Volume 171, Issue 1-2, Page(s) 29–35

    Abstract: Background: Sepsis is, worldwide, one of the leading causes of death among infants and children. Over the past two decades, mortality rates have declined due to advanced treatment options; however, the incidence of sepsis and septic shock is still on ... ...

    Title translation Pädiatrische Infektion und Sepsis in 5 Altersuntergruppen: Einzelzentrumsregister.
    Abstract Background: Sepsis is, worldwide, one of the leading causes of death among infants and children. Over the past two decades, mortality rates have declined due to advanced treatment options; however, the incidence of sepsis and septic shock is still on the rise in many hospital settings. The objective of this study was to evaluate the course of this disease in pediatric intensive care patients.
    Methods: An evaluation of pediatric patients in the intensive care unit diagnosed with infections or sepsis between 2005 and 2015 was performed via a retrospective exploratory data analysis.
    Results: During the observational period, 201 patients were diagnosed with infection or sepsis. The study population was divided into five age subgroups. The majority of patients were newborns, infants, and toddlers. Forty percent had sepsis; 6% had septic shock. Viral infection was the most prevalent (59%). The overall survival rate was 83%; newborns and adolescents had the lowest survival rates.
    Conclusion: With this registry, children divided into five age subgroups with infection or sepsis were evaluated and treatment strategies were examined. We have shown that our findings on children treated in our pediatric intensive care unit conform with current literature about pediatric sepsis. In addition to maintaining strict hygiene standards, optimal aspects of sepsis care should be stringently observed, such as the quick administration of empirical broad-spectrum antibiotics, initial adequate fluid resuscitation, and a reliable and frequent routine of source control.
    MeSH term(s) Adolescent ; Child ; Child, Preschool ; Humans ; Infant ; Infant, Newborn ; Intensive Care Units ; Registries ; Retrospective Studies ; Sepsis ; Shock, Septic
    Language English
    Publishing date 2020-10-27
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 123613-1
    ISSN 1563-258X ; 0254-7945 ; 0043-5341
    ISSN (online) 1563-258X
    ISSN 0254-7945 ; 0043-5341
    DOI 10.1007/s10354-020-00787-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Pediatric Simplified Acute Physiology Score II: Establishment of a New, Repeatable Pediatric Mortality Risk Assessment Score.

    Irschik, Stefan / Veljkovic, Jelena / Golej, Johann / Schlager, Gerald / Brandt, Jennifer B / Krall, Christoph / Hermon, Michael

    Frontiers in pediatrics

    2021  Volume 9, Page(s) 757822

    Abstract: Objectives: ...

    Abstract Objectives:
    Language English
    Publishing date 2021-10-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2021.757822
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Ketogenic Diet in the Treatment of Super-Refractory Status Epilepticus at a Pediatric Intensive Care Unit: A Single-Center Experience.

    Breu, Markus / Häfele, Chiara / Glatter, Sarah / Trimmel-Schwahofer, Petra / Golej, Johann / Male, Christoph / Feucht, Martha / Dressler, Anastasia

    Frontiers in neurology

    2021  Volume 12, Page(s) 669296

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-06-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2021.669296
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Chylothorax and Chylous-Like Diseases in Children: Clinical Management.

    Hermon, Michael / Tenner, Elias / Burda, Gudrun / Strohmaier, Wolfgang / Schlager, Gerald / Golej, Johann

    Frontiers in pediatrics

    2019  Volume 7, Page(s) 258

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2019-06-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2019.00258
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  8. Article: An adolescent with herpes simplex encephalitis, presenting with mild symptoms and rapid deterioration: A case report.

    Stepien, Natalia / Weseslindtner, Lukas / Seidl, Rainer / Geldner, Julia / Golej, Johann / Schmook, Maria-Theresa / Peyrl, Andreas

    SAGE open medical case reports

    2020  Volume 8, Page(s) 2050313X20977142

    Abstract: Headaches in children are a common, but unspecific symptom that can have many underlying causes, ranging from unspecific tension headache through migraine and up to encephalitis and intracranial hypertension. We present the case of a 14-year-old boy who ... ...

    Abstract Headaches in children are a common, but unspecific symptom that can have many underlying causes, ranging from unspecific tension headache through migraine and up to encephalitis and intracranial hypertension. We present the case of a 14-year-old boy who presented to our emergency department with headache, nausea as well as vomiting and developed seizures later on. The initial diagnosis was complicated by a magnetic resonance imaging which did not show any signs of inflammation, but was of limited informative value due to orthodontic appliances. Despite the unremarkable imaging, prophylactic antiviral and antibiotic treatment was started after lumbar puncture. Herpes simplex virus as well as human herpes virus 7 were confirmed in the cerebrospinal fluid. Although both viruses are ubiquitous, severe infections are a rare complication. Immunodeficiency syndromes are predisposing factors for serious complications and genetic analysis of UNC93B and TLR-3 might be helpful for decision-making. No genetic or immunologic predisposition was found in our patient. The patient's condition deteriorated rapidly, so he had to be admitted to the pediatric intensive care unit, where he was intubated and his antiviral treatment with acyclovir was extended by foscarnet. After prolonged mechanical ventilation, he slowly improved. With intensive neurorehabilitation, he could finally return to his daily life activities 3 months after diagnosis. Despite headaches being an unspecific symptom, the possibility of a herpes simplex virus encephalitis should always kept in mind, especially in patients presenting with additional symptoms such as vomiting, altered mental status and/or focal neurological deficits. An initial magnetic resonance imaging might be misleading if orthodontic appliances are in place. Initiation of treatment without delay is crucial for neurologic outcome of herpes simplex virus encephalitis.
    Language English
    Publishing date 2020-12-06
    Publishing country England
    Document type Case Reports
    ZDB-ID 2736953-5
    ISSN 2050-313X
    ISSN 2050-313X
    DOI 10.1177/2050313X20977142
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Necessity of early and continuous monitoring for possible infectious complications in children undergoing therapeutic hypothermia.

    Brandt, Jennifer B / Steiner, Sabine / Schlager, Gerald / Sadeghi, Kambis / Vargha, Regina / Golej, Johann / Hermon, Michael

    Acta paediatrica (Oslo, Norway : 1992)

    2020  Volume 110, Issue 3, Page(s) 805–810

    Abstract: Aim: Since therapeutic hypothermia (TH) is known for its inhibitory effects on leucocyte migration and cytokine synthesis, our aim was to underline the necessity of early monitoring for potential immunomodulatory risks.: Methods: Using a 13-year ... ...

    Abstract Aim: Since therapeutic hypothermia (TH) is known for its inhibitory effects on leucocyte migration and cytokine synthesis, our aim was to underline the necessity of early monitoring for potential immunomodulatory risks.
    Methods: Using a 13-year retrospective case-control study at the paediatric intensive care unit (PICU) of the Medical University in Vienna, all newborn infants and children receiving TH were screened and compared with a diagnosis-matched control group undergoing conventional normothermic treatment (NT). TH was accomplished by using a non-invasive cooling device. Target temperature was 32-34°C. Children with evident infections, a medical history of an immunodeficiency or undergoing immunosuppressive therapy, were excluded.
    Results: During the observational period, 108 patients were screened, 27 of which underwent TH. Culture-proven infections occurred in 22% of the TH group compared with 4% of the normothermic controls (P = .1). From the second day following PICU admission, median C-reactive protein (CRP) values were higher in the TH group (day two P = .002, day three P = .0002, day six P = .008).
    Conclusion: Children undergoing TH showed earlier and higher increases in CRP levels when compared to normothermic controls. These data underline the necessity of early and continuous monitoring for possible infectious complications.
    MeSH term(s) Case-Control Studies ; Child ; Cold Temperature ; Humans ; Hypothermia, Induced/adverse effects ; Infant ; Infant, Newborn ; Intensive Care Units, Pediatric ; Retrospective Studies
    Language English
    Publishing date 2020-08-12
    Publishing country Norway
    Document type Journal Article
    ZDB-ID 203487-6
    ISSN 1651-2227 ; 0365-1436 ; 0803-5253
    ISSN (online) 1651-2227
    ISSN 0365-1436 ; 0803-5253
    DOI 10.1111/apa.15506
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Extended use of the modified Berlin Definition based on age-related subgroup analysis in pediatric ARDS.

    Hermon, Michael / Dotzler, Sophia / Brandt, Jennifer Bettina / Strohmaier, Wolfgang / Golej, Johann

    Wiener medizinische Wochenschrift (1946)

    2018  Volume 169, Issue 3-4, Page(s) 93–98

    Abstract: Background: Pediatric acute respiratory distress syndrome (pARDS) is a rare but very severe condition. Management of the condition remains a major challenge for pediatric intensive care specialists.: Objective: To perform a descriptive assessment of ... ...

    Title translation Erweiterte Anwendung der modifizierten Berlin-Definition auf der Basis einer altersbezogenen Subgruppenanalyse beim kindlichen ARDS.
    Abstract Background: Pediatric acute respiratory distress syndrome (pARDS) is a rare but very severe condition. Management of the condition remains a major challenge for pediatric intensive care specialists.
    Objective: To perform a descriptive assessment of pARDS based on the modified Berlin Definition by using the SpO
    Methods: The data of all children on mechanical ventilation for respiratory failure admitted between 2005 and 2012 were reviewed retrospectively for this study. The age of patients ranged from newborns >37 weeks, up to children <18 years. Inclusion criteria were based on the modified Berlin Definition of pARDS. The following data were collected: demographic data, primary diagnosis, ventilation settings, and use of supportive treatment, in addition to mechanical ventilation (inhaled nitric oxide, surfactant, corticosteroids, prone positioning, and extracorporeal membrane oxygenation).
    Results: In all, 93 children where included: 35% were newborns, 29% infants, 24% toddlers, and 12% school children; 66% were male and 34% were female patients. The most common primary diagnosis was viral pneumonia (21%) and 55% of the children were diagnosed with severe ARDS. The median duration of stay on the pediatric intensive care unit was 16 days (10/27). In total, 66 children (71%) had direct lung injury and 18 (19%) had indirect lung injury. More than 80% of all children needed more than one supportive care therapy. The overall survival rate was 77%.
    Conclusion: This study is a valuable report about pediatric patients with ARDS and allows for an important extension of the application of the modified Berlin Definition in all age groups.
    MeSH term(s) Adolescent ; Berlin ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Practice Guidelines as Topic ; Respiration, Artificial/methods ; Respiratory Distress Syndrome, Adult ; Retrospective Studies
    Language English
    Publishing date 2018-09-19
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 123613-1
    ISSN 1563-258X ; 0254-7945 ; 0043-5341
    ISSN (online) 1563-258X
    ISSN 0254-7945 ; 0043-5341
    DOI 10.1007/s10354-018-0659-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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