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  1. Article ; Online: Internationalization of the Brazilian groups dedicated to oral pathology and oral medicine.

    Farias, Lucyana Conceição / Trezena, Samuel / de Souza, Hebert Cleiton Ferreira / Coletta, Ricardo D / Martelli-Junior, Hercílio

    Oral diseases

    2024  

    Language English
    Publishing date 2024-01-15
    Publishing country Denmark
    Document type Letter
    ZDB-ID 1290529-x
    ISSN 1601-0825 ; 1354-523X
    ISSN (online) 1601-0825
    ISSN 1354-523X
    DOI 10.1111/odi.14850
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    Zs.A 4427: Show issues Location:
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  2. Article ; Online: Relationship between non-syndromic oral clefts and cancer: A systematic review and meta-analysis.

    Machado, Renato Assis / Popoff, Daniela Araújo Veloso / Martelli-Júnior, Hercílio

    Oral diseases

    2022  Volume 28, Issue 5, Page(s) 1369–1386

    Abstract: Objective: To summarize the clinical evidence on the relationship between cancer and non-syndromic oral cleft (NSOC).: Methods: The review was reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist, and ...

    Abstract Objective: To summarize the clinical evidence on the relationship between cancer and non-syndromic oral cleft (NSOC).
    Methods: The review was reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist, and a literature search was conducted in six databases and gray literature. Studies published in any language mentioning cancer in patients with NSOC and their relatives and NSOC in patients with cancer and their relatives were included. Risk of bias was assessed using the Joanna Briggs Institute appraisal tool. The certainty of the evidence was evaluated using the GRADE (Grading of Recommendation, Assessment, Development, and Evaluation) assessment. After a 2-step selection process, 33 studies were included: 17 case-control studies, 13 cross-sectional studies, and 3 case reports.
    Results: The study evaluated 206,096 patients from 20 countries. Of these, 0.35% of patients with cancer (95% CI: 0.0%-1.1%; I
    Conclusion: Our findings demonstrate an increased risk of cancer in relatives of patients with NSOC and that relatives of patients with leukemia were more frequently affected by NSOC. Together, these findings can help guide cancer screening in patients with NSOC and their relatives and shed light on the risk of NSOC in families with a history of cancer.
    MeSH term(s) Cleft Lip/epidemiology ; Cleft Palate/epidemiology ; Cross-Sectional Studies ; Genetic Predisposition to Disease ; Genotype ; Humans ; Leukemia ; Neoplasms/epidemiology ; Polymorphism, Single Nucleotide
    Language English
    Publishing date 2022-03-22
    Publishing country Denmark
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ZDB-ID 1290529-x
    ISSN 1601-0825 ; 1354-523X
    ISSN (online) 1601-0825
    ISSN 1354-523X
    DOI 10.1111/odi.14179
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  3. Article ; Online: Dental anomalies in syndromes displaying hypertrichosis in the clinical spectrum.

    Carneiro, Vinícius Figueiredo / Machado, Renato Assis / Barbosa, Mauro Costa / Dias, Verônica Oliveira / Martelli, Daniella Reis Barbosa / Martelli-Júnior, Hercílio

    Brazilian oral research

    2023  Volume 37, Page(s) e030

    Abstract: Hypertrichosis and dental anomalies may occur alone or in combination in the spectrum of many syndromes. To identify genetic entities characterized by hypertrichosis and dental anomalies, a search was performed in the Mendelian Inheritance in Man ... ...

    Abstract Hypertrichosis and dental anomalies may occur alone or in combination in the spectrum of many syndromes. To identify genetic entities characterized by hypertrichosis and dental anomalies, a search was performed in the Mendelian Inheritance in Man database with the terms "hypertrichosis" or "hirsutism" and "tooth" or "dental abnormalities." Nondependent androgen metabolism disturbances were classified as hypertrichosis. Genetic entities with hypertrichosis and dental anomalies were included in the study. Additional searches were performed in the PubMed and Orphanet databases, when necessary, in order to include data from scientific articles. An integrative analysis of the genes associated with the identified syndromes was conducted using STRING to characterize biological processes, pathways, and interactive networks. The p-values were subjected to the false discovery rate for the correction of multiple tests. Thirty-nine syndromes were identified, and dental agenesis was the most frequent dental anomaly present in 41.02% (n = 16) of the syndromes. Causative genes were identified in 33 out of 39 genetic syndromes. Among them, 39 genes were identified, and 38 were analyzed by STRING, which showed 148 biological processes and three pathways that were statistically significant. The most significant biological processes were the disassembly of the nucleosome (GO:0006337, p = 1.09e-06), chromosomal organization (GO:0051276, p = 1.09e-06) and remodeling of the chromatin (GO: 0006338, p = 7.86e-06), and the pathways were hepatocellular carcinoma (hsa05225, p = 5.77e-05), thermogenesis (hsa04714, p = 0.00019), and cell cycle (hsa04110, p = 0.0433). Our results showed that the identification of hypertrichosis and dental anomalies may raise the suspicion of one of the thirty-nine syndromes with both phenotypes.
    MeSH term(s) Humans ; Hypertrichosis/genetics ; Phenotype
    Language English
    Publishing date 2023-03-31
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2179332-3
    ISSN 1807-3107 ; 1806-8324 ; 1517-7491
    ISSN (online) 1807-3107
    ISSN 1806-8324 ; 1517-7491
    DOI 10.1590/1807-3107bor-2023.vol37.0030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Postgraduate employment outcomes of Brazilian oral medicine and oral pathology programs.

    Bezerra, Hélen Kaline Farias / da Cruz Perez, Danyel Elias / Bonan, Paulo Rogério Ferreti / Moret, Marcelo Albano / Santos-Silva, Alan Roger / Martelli-Júnior, Hercílio

    Oral diseases

    2023  

    Language English
    Publishing date 2023-03-17
    Publishing country Denmark
    Document type Letter
    ZDB-ID 1290529-x
    ISSN 1601-0825 ; 1354-523X
    ISSN (online) 1601-0825
    ISSN 1354-523X
    DOI 10.1111/odi.14564
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: In Reply to: Alawi F. "Using rare diseases as teaching models to increase awareness".

    Martelli Júnior, Hercílio

    Oral surgery, oral medicine, oral pathology and oral radiology

    2019  Volume 128, Issue 6, Page(s) 690–691

    MeSH term(s) Awareness ; Humans ; Rare Diseases ; Surveys and Questionnaires
    Language English
    Publishing date 2019-07-17
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2650843-6
    ISSN 2212-4411 ; 2212-4403
    ISSN (online) 2212-4411
    ISSN 2212-4403
    DOI 10.1016/j.oooo.2019.07.002
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  6. Article ; Online: Outcomes of SARS-CoV-2 and Seasonal Viruses Among Children Hospitalized in Brazil.

    Dias, Cristiane S / Diniz, Lilian M / Oliveira, Maria Christina L / Simões E Silva, Ana Cristina / Colosimo, Enrico A / Mak, Robert H / Pinhati, Clara C / Galante, Stella C / Veloso, Isadora Y / Martelli-Júnior, Hercílio / Oliveira, Eduardo A

    Pediatrics

    2024  Volume 153, Issue 2

    Abstract: Background and objectives: Understanding how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) interacts with other respiratory viruses is crucial for developing effective public health strategies in the postpandemic era. This study aimed to ... ...

    Abstract Background and objectives: Understanding how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) interacts with other respiratory viruses is crucial for developing effective public health strategies in the postpandemic era. This study aimed to compare the outcomes of SARS-CoV-2 and seasonal viruses in children and adolescents hospitalized with severe acute respiratory infection (SARI).
    Methods: This population-based, retrospective cohort study included children and adolescents hospitalized with SARI from February 2020 to February 2023 in Brazil. The main exposure of interest was viral etiology. The primary outcome was in-hospital mortality. Competing risk analysis was used to account for time dependency and competing events.
    Results: A total of 235 829 patients had available results of the viral tests, with SARS-CoV-2 predominance. According to the competing-risk survival analysis, the estimated probability of a fatal outcome at 30 days of hospitalization according to the viral strain was 6.5%, 3.4%, 2.9%, 2.3%, 2.1%, and 1.8%, for SARS-CoV-2, coinfection, adenovirus, influenza, other viruses, and respiratory syncytial virus, respectively. Individuals with a positive test for SARS-CoV-2 had hazard of death 3 times higher than subjects with a negative test (hazard ratio, 3.3; 95% confidence interval, 3.1-3.5). After adjustment by the competing-risk multivariable analysis, admission in Northeast and North regions, oxygen saturation <95%, and the presence of comorbidities were risk factors for death in all viral strains.
    Conclusions: SARS-CoV-2 infection had the highest hazard of in-hospital mortality in this pediatric cohort hospitalized with SARI. Regardless of viral etiology, the presence of underlying medical conditions was a risk factor for death.
    MeSH term(s) Adolescent ; Humans ; Child ; SARS-CoV-2 ; COVID-19 ; Brazil/epidemiology ; Retrospective Studies ; Seasons ; Viruses ; Influenza, Human
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2023-064326
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  7. Article ; Online: The continuous increase in the number of systemic lupus erythematosus cases in Brazil in the COVID-19 era.

    Marques, Nelson Pereira / Marques, Nádia Carolina Teixeira / Lucena, Edson Hilan Gomes de / Martelli, Daniella Reis Barbosa / Oliveira, Eduardo Araújo / Martelli-Junior, Hercílio

    Brazilian oral research

    2023  Volume 37, Page(s) e066

    Abstract: This study aims to reevaluate and compare the data from the Brazilian Unified Health System (SUS) on the number of diagnoses of systemic lupus erythematosus (SLE) in the pre-pandemic period with those in the pandemic period, as well as to compare the ... ...

    Abstract This study aims to reevaluate and compare the data from the Brazilian Unified Health System (SUS) on the number of diagnoses of systemic lupus erythematosus (SLE) in the pre-pandemic period with those in the pandemic period, as well as to compare the first year (2020) of the COVID-19 pandemic in Brazil with the last year (2021), to update the data, and to verify whether SLE disease control measures were effective in 2021. There was a consistent and significant increase in the incidence of SLE cases all over Brazil between the first and second pandemic years and between the pre-pandemic triennium and the second pandemic year. Therefore, it is inescapable to have larger clinical studies with different populations to better understand the relationship between these two conditions and find measures to improve the control of this disease.
    MeSH term(s) Humans ; Brazil/epidemiology ; COVID-19/epidemiology ; Pandemics/prevention & control ; Lupus Erythematosus, Systemic/epidemiology
    Language English
    Publishing date 2023-06-19
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2179332-3
    ISSN 1807-3107 ; 1806-8324 ; 1517-7491
    ISSN (online) 1807-3107
    ISSN 1806-8324 ; 1517-7491
    DOI 10.1590/1807-3107bor-2023.vol37.0066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Global scientific production in the pre-Covid-19 Era: An analysis of 53 countries for 22 years.

    Oliveira, Eduardo A / Oliveira, Maria Christina L / Colosimo, Enrico A / Martelli, Daniella B / Silva, Ludmila R / Silva, Ana Cristina Simões E / Martelli-Júnior, Hercílio

    Anais da Academia Brasileira de Ciencias

    2022  Volume 94, Issue suppl 3, Page(s) e20201428

    Abstract: Based on an extensive analysis of public databases, we provide an overview of the global scientific output and describe the dynamics of the profound changes in the scientific enterprise during the last decades. The analysis included the scientific ... ...

    Abstract Based on an extensive analysis of public databases, we provide an overview of the global scientific output and describe the dynamics of the profound changes in the scientific enterprise during the last decades. The analysis included the scientific production of 53 countries over the 1996-2018 period. During this period, the production of articles per year has tripled. There was a strong correlation between the growth of the global gross domestic product and the increase in the number of articles (R2 = 0.973, P<0.001). Six countries showed a robust increment of their scientific production and are currently among the top 20 in the ranking of world scientific production (China, India, South Korea, Brazil, Turkey, and Iran). The mean annual growth rate was about 12.7% for these six countries. The share of the global scientific production of these countries increased from 7% in 1996 to 27.8% in 2018. Conversely, the participation of the 10 most traditional countries has dropped from 73% to 45% during the same period. In conclusion, we believe that our findings may contribute to further studies aiming to evaluate the impact and changes of the scientific endeavor over the next years in light of the forthcoming new world framework.
    MeSH term(s) Humans ; COVID-19 ; Brazil ; China ; Databases, Factual ; India
    Language English
    Publishing date 2022-11-21
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2046885-4
    ISSN 1678-2690 ; 0001-3765
    ISSN (online) 1678-2690
    ISSN 0001-3765
    DOI 10.1590/0001-3765202220201428
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Revaluation of the COVID-19 pandemic impact on the epidemiology of syphilis in Brazil

    Nelson Pereira Marques / Nádia Carolina Teixera Marques / Denise Maria Silveira / Daniella Reis Barbosa Martelli / Eduardo Araújo Oliveira / Hercílio Martelli-Junior

    DST, Vol

    2023  Volume 35

    Abstract: Introduction: Due to the coronavirus 2019 disease (COVID-19) pandemic, health systems worldwide have suffered interferences, with the interruption of sexual health clinics, limitation of ambulatory consults, prevention, diagnosis, and treatment of ... ...

    Abstract Introduction: Due to the coronavirus 2019 disease (COVID-19) pandemic, health systems worldwide have suffered interferences, with the interruption of sexual health clinics, limitation of ambulatory consults, prevention, diagnosis, and treatment of several diseases, especially syphilis, altering their epidemiology. Objective: To investigate the impact of the pandemic on syphilis diagnosis in Brazil, the main goal of this study was to update and reevaluate data from the Brazilian Unified Health System on the number of syphilis cases reported in all five Brazilian geographic regions and verify the response of the Brazilian health care to the COVID-19 pandemic. Methods: The data were retrieved from the National Disease Notification System and the Department of Chronic Conditions Diseases and Sexually Transmitted Infections and represent syphilis diagnosis in Brazil, from March to December 2017 to 2019, 2020, and 2021. Results: The increase in the number of syphilis cases was minor compared to 2020, keeping the Southeast region as the most impacted (+146.1%) and an increase of 22,633 cases throughout Brazil (+54.3%). Conclusion: Syphilis disease control measures were ineffective in 2021 as the drop in the number of cases was irrelevant compared to the years before the pandemic. The association between the increase in syphilis cases in Brazil and the COVID-19 pandemic should be further investigated to assist in decision-making processes and in the programming of health actions in addition to finding measures to raise the control of this disease.
    Keywords COVID-19 ; Syphilis ; Epidemiology ; Medicine ; R
    Subject code 360
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher Zeppelini Editorial e Comunicacao
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Craniofacial findings in syndromes associated with cafe-au-lait spots: a literature review.

    Carvalho, Adriana Amaral / Ferraz, Lorena Daiza Aquino / Martelli, Daniella Reis Barbosa / Machado, Renato Assis / Martelli Júnior, Hercílio

    Revista da Associacao Medica Brasileira (1992)

    2023  Volume 69, Issue 1, Page(s) 195–202

    MeSH term(s) Humans ; Cafe-au-Lait Spots/complications ; Syndrome ; Skin ; Neurofibromatosis 1/complications ; Bone and Bones
    Language English
    Publishing date 2023-01-09
    Publishing country Brazil
    Document type Review ; Journal Article
    ZDB-ID 731969-1
    ISSN 1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
    ISSN (online) 1806-9282
    ISSN 0104-4230 ; 0004-5241 ; 0102-843X
    DOI 10.1590/1806-9282.20220866
    Database MEDical Literature Analysis and Retrieval System OnLINE

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