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  1. Book: Cancer

    Tanaka, Takuji

    disease progression and chemoprevention

    2007  

    Author's details ed.: Takuji Tanaka
    Language English
    Size 344 S. : Ill., graph. Darst.
    Publisher Research Signpost
    Publishing place Trivandrum
    Publishing country India
    Document type Book
    HBZ-ID HT015489059
    ISBN 81-308-0150-7 ; 978-81-308-0150-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2008 A 2103 order for loan Magazin

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  2. Book ; Online: Inflammation and Cancer

    Shimizu, Masahito / Tanaka, Takuji

    2017  

    Abstract: Based on the most recent clinical and epidemiologic information, one out of seven newly diagnosed epithelial malignancies worldwide result from infection and chronic inflammation in conjunction with cancer. This book draws contributions from ... ...

    Abstract Based on the most recent clinical and epidemiologic information, one out of seven newly diagnosed epithelial malignancies worldwide result from infection and chronic inflammation in conjunction with cancer. This book draws contributions from international expert researchers from diverse disciplines, who addressed various aspects of experimental and clinical cancer biology, by selectively focusing on inflammation-mediated oncogenesis to debate these and related issues. Topics covered include the epidemiological links between cancer and inflammation, the parallels between inflammation and cancer, the role of inflammation in cancer, inflammatory genes as risk factors for cancer initiation and progression, inflammation and cancer angiogenesis, and preventative/therapeutic strategies. This comprehensive and cutting-edge Special Issue "Inflammation and Cancer" promises to serve as a vital guide and resource for investigators and clinicians working toward the goal of fighting the estimated 2200 inflammation-related oncogenesis fatalities occurring every day
    Keywords Biology (General)
    Size 1 electronic resource (VIII, 248 p.)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020096792
    ISBN 9783038426080 ; 9783038426097 ; 3038426083 ; 3038426091
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: Pathogenesis of Warthin's Tumor: Neoplastic or Non-Neoplastic?

    Aoki, Ryogo / Tanaka, Takuji

    Cancers

    2024  Volume 16, Issue 5

    Abstract: Warthin's tumor is the second most frequent neoplasm next to pleomorphic adenoma in the salivary gland, mostly in the parotid gland. The epithelial cells constituting a tumor are characterized by the presence of mitochondria that undergo structural and ... ...

    Abstract Warthin's tumor is the second most frequent neoplasm next to pleomorphic adenoma in the salivary gland, mostly in the parotid gland. The epithelial cells constituting a tumor are characterized by the presence of mitochondria that undergo structural and functional changes, resulting in the development of oncocytes. In addition to containing epithelial cells, Warthin's tumors contain abundant lymphocytes with lymph follicles (germinal centers) that are surrounded by epithelial cells. The pathogenesis of Warthin's tumor is not fully understood, and several hypotheses have been proposed. The risk factors for the development of Warthin's tumor, which predominantly occurs in males, include aging, smoking, and radiation exposure. Recently, it has been reported that chronic inflammation and aging cells promote the growth of Warthin's tumor. Several reports regarding the origin of the tumor have suggested that (1) Warthin's tumor is an IgG4-related disease, (2) epithelial cells that compose Warthin's tumor accumulate mitochondria, and (3) Warthin's tumor is a metaplastic lesion in the lymph nodes. It is possible that the pathogenesis of Warthin's tumor includes mitochondrial metabolic abnormalities, accumulation of aged cells, chronic inflammation, and senescence-associated secretory phenotype (SASP). In this short review, we propose that DNA damage, metabolic dysfunction of mitochondria, senescent cells, SASP, human papillomavirus, and IgG4 may be involved in the development of Warthin's tumor.
    Language English
    Publishing date 2024-02-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16050912
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Discovery of α-(1→6)-linked mannan structures resembling yeast

    Kadooka, Chihiro / Tanaka, Yutaka / Kishida, Rintaro / Hira, Daisuke / Oka, Takuji

    mSphere

    2024  , Page(s) e0010024

    Abstract: The cellular surface of the pathogenic filamentous fungus : Importance: This study unravels the complexities of mannan biosynthesis ... ...

    Abstract The cellular surface of the pathogenic filamentous fungus
    Importance: This study unravels the complexities of mannan biosynthesis in
    Language English
    Publishing date 2024-04-23
    Publishing country United States
    Document type Journal Article
    ISSN 2379-5042
    ISSN (online) 2379-5042
    DOI 10.1128/msphere.00100-24
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Structural basis for the allosteric behaviour and substrate specificity of Lactococcus lactis Prolidase.

    Xu, Shangyi / Grochulski, Pawel / Tanaka, Takuji

    Biochimica et biophysica acta. Proteins and proteomics

    2024  Volume 1872, Issue 3, Page(s) 141000

    Abstract: Prolidase (EC 3.4.13.9) is an enzyme that specifically hydrolyzes Xaa-Pro dipeptides into free amino acids. We previously studied kinetic behaviours and solved the crystal structure of wild-type (WT) Lactococcus lactis prolidase (Llprol), showing that ... ...

    Abstract Prolidase (EC 3.4.13.9) is an enzyme that specifically hydrolyzes Xaa-Pro dipeptides into free amino acids. We previously studied kinetic behaviours and solved the crystal structure of wild-type (WT) Lactococcus lactis prolidase (Llprol), showing that this homodimeric enzyme has unique characteristics: allosteric behaviour and substrate inhibition. In this study, we focused on solving the crystal structures of three Llprol mutants (D36S, H38S, and R293S) which behave differently in v-S plots. The D36S and R293S Llprol mutants do not show allosteric behaviour, and the Llprol mutant H38S has allosteric behaviour comparable to the WT enzyme (Hill constant 1.52 and 1.58, respectively). The crystal structures of Llprol variants suggest that the active site of Llprol formed with amino acid residues from both monomers, i.e., located in an interfacial area of dimer. The comparison between the structure models of Llprol indicated that the two monomers in the dimers of Llprol variants have different relative positions among Llprol variants. They showed different interatomic distances between the amino acid residues bridging the two monomers and varied sizes of the solvent-accessible interface areas in each Llprol variant. These observations indicated that Llprol could adapt to different conformational states with distinctive substrate affinities. It is strongly speculated that the domain movements required for productive substrate binding are restrained in allosteric Llprol (WT and H38S). At low substrate concentrations, only one out of the two active sites at the dimer interface could accept substrate; as a result, the asymmetrical activated dimer leads to allosteric behaviour.
    MeSH term(s) Allosteric Regulation ; Lactococcus lactis/genetics ; Lactococcus lactis/metabolism ; Substrate Specificity ; Models, Molecular ; Amino Acids/metabolism ; Dipeptidases
    Chemical Substances proline dipeptidase (EC 3.4.13.9) ; Amino Acids ; Dipeptidases (EC 3.4.13.-)
    Language English
    Publishing date 2024-01-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2918798-9
    ISSN 1878-1454 ; 1570-9639
    ISSN (online) 1878-1454
    ISSN 1570-9639
    DOI 10.1016/j.bbapap.2024.141000
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: Improving the techno‐functionality of air‐classified pea flour fine fraction by enzymatic proteolysis, followed by Maillard‐induced conjugation with available carbohydrates in the flour

    Mookerjee, Abhiroop / Nickerson, Michael / Tanaka, Takuji

    Cereal Chemistry. 2024 , v. 101, no. 1 p.99-119

    2024  

    Abstract: BACKGROUND AND OBJECTIVES: Air‐classified pea protein‐enriched flour (PPEF) was hydrolyzed with trypsin and papain and heat conjugated with the carbohydrate fraction of the flour via the Maillard reaction to form protein–carbohydrate conjugates. The ... ...

    Abstract BACKGROUND AND OBJECTIVES: Air‐classified pea protein‐enriched flour (PPEF) was hydrolyzed with trypsin and papain and heat conjugated with the carbohydrate fraction of the flour via the Maillard reaction to form protein–carbohydrate conjugates. The surface and functional properties of the conjugates were assessed thereafter. FINDINGS: The surface charge of the conjugates (trypsin and papain conjugates) (−27.5 to −32.2 mV and −33.1 to −37.5 mV) was higher than that of PPEF (−24.2 ± 0.5 mV and −27.3 ± 1.1 mV) at pH 7 and 10. Low degrees of trypsin hydrolysis, followed by conjugation resulted in enhanced foam capacity (109.2% ± 2.0%), and heated trypsin controls had the highest foam stability (76.9%) at pH 4. The emulsion activity index of the hydrolyzed protein–carbohydrate conjugates (hydrolyzed proteins conjugated with starch) was higher at pH 4 (15.9–22.2 min) as compared to pH 7 (16.5–21.3 min). Trypsin conjugates showed the highest emulsion stability (ES) at pH 4 (96.4%–98%), whereas the ES at pH 7 and 10 was almost comparable. Both oil‐holding (OHC: 1.9–3.9 g/g) and water‐holding capacities (WHC: 1.7–2.4 g/g) were significantly improved. CONCLUSIONS: Maillard conjugated proteins have enhanced functional properties at pH 4, 7, and 10 as compared to PPEF. Most of the conjugates show high functionality at pH 4. It was also observed that only heating the low‐cost, raw materials produced conjugates with enhanced functional properties. SIGNIFICANCE AND NOVELTY: Enhanced functional properties at acidic pH are indicative of their use in beverage emulsions like fruit juices and processed drinks. High WHC and OHC show their potential use in the food industry as an alternative to animal proteins.
    Keywords Maillard reaction ; animals ; beverages ; emulsions ; flour ; foams ; food industry ; fruits ; heat ; hydrolysis ; pH ; papain ; peas ; proteolysis ; starch ; trypsin
    Language English
    Dates of publication 2024-01
    Size p. 99-119.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 242360-1
    ISSN 0009-0352
    ISSN 0009-0352
    DOI 10.1002/cche.10727
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 937: Show issues

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  7. Article ; Online: A case of gas gangrene caused by Clostridium septicum with undiagnosed advanced colon cancer.

    Sumigama, Anna / Goto, Yusuke / Ohno, Yoshiyuki / Ohata, Hiroto / Okuno, Mitsuru / Onogi, Akane / Watanabe, Naoki / Tanaka, Takuji / Kanoh, Hiroyuki

    The Journal of dermatology

    2024  

    Language English
    Publishing date 2024-03-03
    Publishing country England
    Document type Letter
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.17167
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Correction: Use of contrast-enhanced harmonic endoscopic ultrasonography for the diagnosis of pancreatic cystic lesions.

    Ohno, Eizaburo / Kuzuya, Teiji / Kawabe, Naoto / Nakaoka, Kazunori / Tanaka, Hiroyuki / Nakano, Takuji / Miyachi, Yohei / Hashimoto, Senju / Hirooka, Yoshiki

    Journal of medical ultrasonics (2001)

    2024  

    Language English
    Publishing date 2024-03-13
    Publishing country Japan
    Document type Published Erratum
    ZDB-ID 1396630-3
    ISSN 1613-2254 ; 0287-0592 ; 1346-4523
    ISSN (online) 1613-2254
    ISSN 0287-0592 ; 1346-4523
    DOI 10.1007/s10396-024-01431-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Structuring pathologic reports containing Japanese language for integration into an endoscopy database.

    Kawamura, Takuji / Saito, Yutaka / Tanaka, Kiyohito

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society

    2022  Volume 34, Issue 6, Page(s) 1259

    MeSH term(s) Databases, Factual ; Endoscopy, Gastrointestinal ; Humans ; Japan ; Language
    Language English
    Publishing date 2022-07-31
    Publishing country Australia
    Document type Letter
    ZDB-ID 1171589-3
    ISSN 1443-1661 ; 0915-5635
    ISSN (online) 1443-1661
    ISSN 0915-5635
    DOI 10.1111/den.14392
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  10. Article: Potential Chemopreventive Effects of Dietary Combination of Phytochemicals against Cancer Development.

    Tanaka, Takuji / Aoki, Ryogo / Terasaki, Masaru

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 11

    Abstract: Cancer remains a major cause of cancer-related death worldwide. Over 70% of epithelial malignancies are sporadic and are related to lifestyle. Epidemiological studies suggest an inverse correlation between cancer incidence and fruit and vegetable intake. ...

    Abstract Cancer remains a major cause of cancer-related death worldwide. Over 70% of epithelial malignancies are sporadic and are related to lifestyle. Epidemiological studies suggest an inverse correlation between cancer incidence and fruit and vegetable intake. Numerous preclinical studies using in vitro (cell lines) and in vivo animal models of oncogenesis have reported the chemopreventive effects of dietary phytochemical agents through alterations in different biomarkers and signaling pathways. However, there is contrasting evidence from preclinical studies and clinical trials. To date, the most studied compounds include curcumin, resveratrol, isoflavones, green tea extract (epigallocatechin gallate), black raspberry powder (anthocyanins and ellagitannins), bilberry extract (anthocyanins), ginger extract (gingerol derivatives), and pomegranate extract (ellagitannins and ellagic acid). Overall, the clinical evidence of the preventive effects of dietary phytochemicals against cancer development is still weak, and the amount of these phytochemicals needed to exert chemopreventive effects largely exceeds the common dietary doses. Therefore, we propose a combination treatment of natural compounds that are used clinically for another purpose in order to obtain excess inhibitory efficacy via low-dose administration and discuss the possible reasons behind the gap between preclinical research and clinical trials.
    Language English
    Publishing date 2023-11-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16111591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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