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  1. Article ; Online: Two paradoxical reactions in a patient with psoriasis and psoriatic arthritis: Adalimumab-induced hidradenitis suppurativa and secukinumab-induced alopecia areata.

    Öğüt, Neslihan Demirel

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2022  Volume 37, Issue 4, Page(s) e468–e469

    MeSH term(s) Humans ; Adalimumab/adverse effects ; Arthritis, Psoriatic/drug therapy ; Hidradenitis Suppurativa/chemically induced ; Hidradenitis Suppurativa/drug therapy ; Alopecia Areata/chemically induced ; Psoriasis/drug therapy ; Psoriasis/chemically induced
    Chemical Substances Adalimumab (FYS6T7F842) ; secukinumab (DLG4EML025)
    Language English
    Publishing date 2022-10-01
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.18601
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Acquired plantar port-wine stain (Fegeler syndrome) following prolonged standing.

    Demirel Öğüt, Neslihan

    Journal of cosmetic dermatology

    2022  Volume 21, Issue 10, Page(s) 5234–5235

    MeSH term(s) Humans ; Port-Wine Stain/diagnosis ; Hemangioma, Capillary ; Skin ; Syndrome
    Language English
    Publishing date 2022-02-06
    Publishing country England
    Document type Letter
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.14822
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Impulsivity in patients with acne excoriee.

    Öğüt, Çağrı / Öğüt, Neslihan Demirel

    Journal of cosmetic dermatology

    2022  Volume 22, Issue 3, Page(s) 1099–1104

    Abstract: Background: Impulsivity is the tendency to make decisions and act quickly without adequate planning and anticipating risks. Impulsivity is among the core symptoms of many psychiatric disorders. In addition, impulsivity can affect the course of various ... ...

    Abstract Background: Impulsivity is the tendency to make decisions and act quickly without adequate planning and anticipating risks. Impulsivity is among the core symptoms of many psychiatric disorders. In addition, impulsivity can affect the course of various diseases shaped by behaviors.
    Aims: This study aimed to evaluate the relationship between the presence of acne excoriee and different impulsivity dimensions.
    Study design: A case-control study.
    Methods: Thirty patients with acne excoriee (AE+) and 30 acne vulgaris patients without excoriated lesions (AE-) enrolled in this study. Impulsivity was evaluated by The Barratt Impulsivity Scale (BIS). In addition, The Beck Anxiety Inventory, The Beck Depression Inventory, and The Skin Picking Scale were applied to assess the clinical characteristics of the participants.
    Results: AE+ patients had higher non-planning subscale scores of BIS than AE- patients in this study. In addition, the acne-picking severity score determined by The Skin Picking Scale was positively correlated with non-planning subscale scores of BIS. There was no significant difference between the groups regarding the Beck Depression Inventory and Beck Anxiety Inventory.
    Conclusions: These results indicate that AE patients have a lack of forethought. In other words, it has been shown that impulsive personality traits, which indicate a lack of planning for the future, may be associated with the acne-picking behavior of the patients.
    MeSH term(s) Humans ; Case-Control Studies ; Impulsive Behavior ; Acne Vulgaris/psychology ; Skin Diseases ; Dermabrasion
    Language English
    Publishing date 2022-11-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.15535
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Possible ruxolitinib-induced acquired epidermodysplasia verruciformis and multiple non-melanoma skin cancers in a patient with polycythemia vera.

    Demirel Öğüt, Neslihan / Mızrak, Bülent

    Journal of cosmetic dermatology

    2022  

    Language English
    Publishing date 2022-07-22
    Publishing country England
    Document type Letter
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.15253
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  5. Article: Scabies Affects Quality of Life in Correlation with Depression and Anxiety.

    Koç Yıldırım, Sema / Demirel Öğüt, Neslihan / Erbağcı, Ece / Öğüt, Çağrı

    Dermatology practical & conceptual

    2023  Volume 13, Issue 2

    Abstract: Introduction: Scabies is a highly contagious disease affects many people worldwide each year and a major public health problem. A small number of studies have shown that scabies causes impairment in the quality of life in adult patients.: Objectives: ...

    Abstract Introduction: Scabies is a highly contagious disease affects many people worldwide each year and a major public health problem. A small number of studies have shown that scabies causes impairment in the quality of life in adult patients.
    Objectives: The aims of this study are to assess the impact of scabies on adult patients quality of life (QoL) and evaluate the relationship between depression and anxiety levels and impairment in life quality.
    Methods: This cross-sectional study included adult patients diagnosed with scabies in our dermatology outpatient clinic. The effect of scabies on QoL was evaluated by Dermatology Life Quality Index (DLQI), and the levels of depression and anxiety were evaluated by Beck Depression Scale (BDS) and Beck Anxiety Scale (BAS).
    Results: Totally, 85 patients included to the study. QoL of 72.2% of the patients was moderate to extremely large affected. There was a positive correlation between the duration of the disease, the total DLQI score and the severity of the disease impact on QoL (r
    Conclusions: Scabies has a moderate to severe effect on QoL. There was a positive correlation between impairment QoL and anxiety and depression scores.
    Language English
    Publishing date 2023-04-01
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 2685397-8
    ISSN 2160-9381
    ISSN 2160-9381
    DOI 10.5826/dpc.1302a144
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Pain type and neuropathic pain components in acute herpes zoster.

    Ünal, Hanzade Aybüke / Demirel Öğüt, Neslihan / Güler, Emel / Alptekin, Alp

    Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology

    2024  Volume 36, Issue 2, Page(s) 100–105

    Abstract: Objectives: The aim of this study was to investigate the pain type (nociceptive or neuropathic) and neuropathic pain components in patients with acute herpes zoster (HZ).: Methods: Patients with acute HZ referred to the outpatient Dermatology and ... ...

    Title translation Akut herpes zoster'de ağrı tipi ve nöropatik ağrı bileşenleri.
    Abstract Objectives: The aim of this study was to investigate the pain type (nociceptive or neuropathic) and neuropathic pain components in patients with acute herpes zoster (HZ).
    Methods: Patients with acute HZ referred to the outpatient Dermatology and Venereology clinic between January 2021 and January 2022 were retrospectively detected. The demographic data including gender and age, rash localization, pain severity, and neuropathic pain components were recorded. Pain severity and neuropathic pain components were evaluated using a Visual Analog Scale (VAS) and Douleur Neuropathique 4 (DN4), respectively.
    Results: The study included a total of 58 patients, comprising 33 females and 25 males. Of these patients, 35 (60.3%) were found to have neuropathic pain. Itching, burning, pins and needles, and tingling were the most frequently reported neuropathic pain signs and symptoms. The proportion of female patients with neuropathic pain was found to be significantly higher than that of male patients (p=0.021). No significant differences were observed in the distribution of pain across different body sites or in the age of patients with neuropathic pain (p>0.05). Itching was significantly more common in younger patients (p=0.02).
    Conclusion: In conclusion, the study found that over half of the patients with acute HZ experienced neuropathic pain, and this was more frequently observed in female patients. Analysis of different components of neuropathic pain showed significant differences in age, gender, and site distribution. The findings of this study may have important implications for the manage-ment and treatment of acute HZ.
    MeSH term(s) Humans ; Male ; Female ; Retrospective Studies ; Neuralgia/diagnosis ; Herpes Zoster/complications ; Pain Measurement ; Pruritus
    Language English
    Publishing date 2024-04-01
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 1283669-2
    ISSN 2458-9446 ; 1300-0012
    ISSN (online) 2458-9446
    ISSN 1300-0012
    DOI 10.14744/agri.2023.03743
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Long-term effects of omalizumab on peripheral blood cells and C-reactive protein levels in patients with chronic spontaneous urticaria.

    Akdogan, Neslihan / Demirel Ogut, Neslihan / Dogan, Sibel / Atakan, Nilgun

    Dermatologic therapy

    2019  Volume 32, Issue 4, Page(s) e12966

    Abstract: Omalizumab's mechanism of action is not well-understood yet despite its strong therapeutic efficacy in chronic spontaneous urticaria (CSU). To determine the overall effect of omalizumab on peripheral blood cell counts and serum C-reactive protein levels ( ...

    Abstract Omalizumab's mechanism of action is not well-understood yet despite its strong therapeutic efficacy in chronic spontaneous urticaria (CSU). To determine the overall effect of omalizumab on peripheral blood cell counts and serum C-reactive protein levels (sCRP) during a 1-year follow-up in patients with CSU. Data of 74 patients (male/female: 20/54) were reviewed from medical charts. Leucocyte counts, percentages of peripheral blood cells(lymphocyte, monocyte, neutrophil [PPBN], eosinophil, basophil [PPBB]) and sCRP were recorded at baseline, 3rd, 6th, 12th months of omalizumab treatment. Although a dramatic increase in the mean PPBB (±SD) was observed at the 3rd month, PPBB (%) gradually decreased after the 3rd month (PPBB: 0.38 ± 0.21 [baseline] vs. 0.59 ± 0.3 [3rd month], p = .002). However, 12th month PPBB remained higher than baseline (PPBB:0.38 ± 0.21 [baseline] vs. 0.46 ± 0.27 [12th month], p = .03). A dramatic decrease in the mean PPBN (%) was noticed within the first 3 months (PPBN:62.85 ± 8.97 [baseline] vs. 58.37 ± 9.07 [3rd month], p = .04), and 12th month PPBN remained lower than baseline values (PPBN: 62.85 ± 8.97 [baseline] vs. 60.31 ± 8.02 [12th month], p = .045).Mean sCRP (mg/dL) decreased rapidly within the first 3 months (sCRP: 1.09 ± 1.53 [baseline] vs. 0.56 ± 0.45 [3rd month], p = .17) and 12th month sCRP still remained lower than baseline levels (sCRP: 1.09 ± 1.53 [baseline] vs. 0.83 ± 1.06 [12th month], p = .01). Omalizumab substantially increases PPBB,and reduces PPBN accompanied by a reduction in sCRP especially in the first 3 months; however, these effects may continue in the long-term. The alterations in peripheral blood cell ratios and sCRP may contribute to the therapeutic effect of omalizumab in CSU.
    MeSH term(s) Adult ; Aged ; Anti-Allergic Agents/administration & dosage ; Blood Cell Count ; C-Reactive Protein/metabolism ; Chronic Urticaria/drug therapy ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Omalizumab/administration & dosage ; Retrospective Studies ; Time Factors ; Treatment Outcome ; Young Adult
    Chemical Substances Anti-Allergic Agents ; Omalizumab (2P471X1Z11) ; C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2019-06-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1354801-3
    ISSN 1529-8019 ; 1396-0296
    ISSN (online) 1529-8019
    ISSN 1396-0296
    DOI 10.1111/dth.12966
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The role of online consultation requests to personal social media accounts and instant messaging services of dermatologists in occupational burnout: An emerging problem.

    Demirel Öğüt, Neslihan / Öğüt, Çağrı / Eşme, Pelin

    Journal of cosmetic dermatology

    2021  Volume 21, Issue 6, Page(s) 2542–2549

    Abstract: Background: Burnout affects all physicians, including dermatologists. Long working hours, high workload, and work-related activities outside working hours are common risk factors for burnout that disrupt the work-life balance. This study aimed to ... ...

    Abstract Background: Burnout affects all physicians, including dermatologists. Long working hours, high workload, and work-related activities outside working hours are common risk factors for burnout that disrupt the work-life balance. This study aimed to evaluate dermatologists' approach to online consultation requests via social media (SM) and instant messaging services (IMS), the psychological effects of these consultations on dermatologists, and their relationship with burnout syndrome.
    Materials and methods: A cross-sectional, descriptive research was conducted as an online survey using Google Forms. The survey consisted of 55 items and was sent to dermatologists through a closed Facebook group of the Turkish Society of Dermatology. The burnout levels of dermatologists were evaluated using three subscales of the Maslach Burnout Inventory (MBI): emotional exhaustion (EE), depersonalization (DP), and personal achievement (PA).
    Results: Out of the total 270 participants, 268 (99.3%) participants reported using SM and IMS, whereas 263 (98.1%) received personal consultation requests on these applications. Among all IMS, WhatsApp (n=258, 98.1%) was the most common IMS for online consultation requests. Median (IQR) scores for EE, DP, and PA subscales were 18 (11), 6 (5), and 21 (6), respectively. A positive correlation was observed between the frequency of online consultation requests and MBI-EE subscale scores (r = 0.136; 95% CI, 0.013-0.254; p = 0.026). Fatigue (95.1%), anger (66.6%), and unhappiness (45.2%) were among the most common adverse effects of online consultations on dermatologists.
    Conclusion: Online consultation requests to dermatologists' personal IMS and SM accounts can lead to burnout. The current study findings raise the awareness of the risks of burnout among dermatologists. There is an implicit need for further research, mobile apps other than frequently used IMS and SM apps, and regulations to avoid problems related to the consequences of online dermatology consultations through IMS and SM.
    MeSH term(s) Burnout, Professional/diagnosis ; Burnout, Professional/etiology ; Burnout, Professional/psychology ; Cross-Sectional Studies ; Dermatologists ; Humans ; Referral and Consultation ; Social Media ; Surveys and Questionnaires
    Language English
    Publishing date 2021-08-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.14417
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Evaluation of patients with telogen effluvium during the pandemic: May the monocytes be responsible for post COVID-19 telogen effluvium?

    Koç Yıldırım, Sema / Erbağcı, Ece / Demirel Öğüt, Neslihan

    Journal of cosmetic dermatology

    2022  Volume 21, Issue 5, Page(s) 1809–1815

    Abstract: Introduction: Telogen effluvium (TE) is one of the causes of non-scarring hair loss that occurred commonly 2-3 months after a triggering factor. It was reported that the incidence of TE increased during the COVID-19 (coronavirus disease 2019) pandemic. ... ...

    Abstract Introduction: Telogen effluvium (TE) is one of the causes of non-scarring hair loss that occurred commonly 2-3 months after a triggering factor. It was reported that the incidence of TE increased during the COVID-19 (coronavirus disease 2019) pandemic. However, to date, there is no study evaluating the status of COVID-19 before the onset of hair loss in patients with TE. The aim of this study is to evaluate the patients with TE whether they had COVID-19 or not before the onset of their hair loss and to compare the demographic and clinical characteristics and laboratory parameters of those with and without a history of COVID-19.
    Method: We conducted an observational cohort study of TE patients. The diagnosis of TE depended on anamnesis and physical examination of the patients. Also, hair pull test was performed. Demographic data and the results of COVID-19 real-time polymerase chain reaction (RT-PCR) were recorded from the electronic medical records.
    Results: Totally, 181 patients with TE were included in the study. Sixty-four of patients (35.4%) had been diagnosed with COVID-19 before the hair loss started. The median duration of development of hair loss was 2 months (range 1-11 months, IQR 3) after COVID-19 diagnosis. In this group, 87.5% of patients (n = 56) had acute TE and 12.5% of patients (n = 8) had chronic TE. The rate of acute TE and the use of vitamin supplements were ignificantly higher (p < 0.001 and p = 0.027, respectively) and the monocyte count in peripheral blood was lower (p = 0.041) in the group diagnosed with COVID-19.
    Discussion and conclusion: It was stated that monocytes and macrophages infected by SARS-CoV-2 can produce pro-inflammatory cytokines that play a crucial role in the development of COVID-19-related complications. Also, it was suggested that the number of monocytes tends to be lower in the late recovery stage. The lower monocyte count in patients with a history of COVID-19 in our study may be related to evaluating the patients in the late period of recovery and the migration of circulating monocytes to hair follicles. The history of COVID-19 must be questioned in patients with TE. It should be kept in mind that hair loss that develops after COVID-19 may be presented as chronic TE form too. The exact mechanisms of hair loss induced by COVID-19 are not fully explained; the roles of monocytes on the hair follicles may be one of the responsible mechanisms.
    MeSH term(s) Alopecia Areata ; COVID-19/epidemiology ; COVID-19 Testing ; Cohort Studies ; Humans ; Monocytes ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2022-02-28
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.14883
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Retrospective evaluation of patients with chronic spontaneous urticaria using omalizumab during the COVID-19 pandemic.

    Koç Yıldırım, Sema / Demirel Öğüt, Neslihan / Erbağcı, Ece

    Journal of cosmetic dermatology

    2022  Volume 21, Issue 2, Page(s) 431–434

    Abstract: Introduction: Omalizumab (OMZ) is a monoclonal anti-immunoglobulin E antibody used in patients with chronic spontaneous urticaria (CSU). The data about using OMZ during the coronavirus disease 19 (COVID-19) pandemic are limited. The aim of this study ... ...

    Abstract Introduction: Omalizumab (OMZ) is a monoclonal anti-immunoglobulin E antibody used in patients with chronic spontaneous urticaria (CSU). The data about using OMZ during the coronavirus disease 19 (COVID-19) pandemic are limited. The aim of this study was to evaluate the status of having COVID-19 and relationships between COVID-19, vaccination, and urticaria symptoms of CSU patients on OMZ.
    Method: We conducted a retrospective cohort study of 36 adult CSU patients treated with OMZ. Demographic data, the results of COVID-19 real-time polymerase chain reaction (RT-PCR), and vaccination status were recorded from the electronic medical records.
    Results: Thirty-six patients, 23 women, and 13 men were evaluated. The mean age was 45.81 years. Two patients were diagnosed with COVID-19 while using OMZ. Four patients interrupted their OMZ treatment during the pandemic, and OMZ treatments were restarted in all patients. There were 28 patients who had at least one dose of vaccine (inactive and/or mRNA vaccine). Only one patient had an urticaria exacerbation after the first dose of mRNA vaccine.
    Conclusion: As a result, our findings have shown that omalizumab treatment in CSU patients during the COVID-19 pandemic does not increase the risk of COVID-19 infection and omalizumab can be used safely.
    MeSH term(s) Adult ; Anti-Allergic Agents/therapeutic use ; COVID-19/complications ; COVID-19 Vaccines ; Chronic Disease ; Chronic Urticaria/complications ; Chronic Urticaria/drug therapy ; Female ; Humans ; Male ; Middle Aged ; Omalizumab/therapeutic use ; Pandemics ; Retrospective Studies ; Treatment Outcome ; Vaccines, Synthetic ; mRNA Vaccines
    Chemical Substances Anti-Allergic Agents ; COVID-19 Vaccines ; Vaccines, Synthetic ; mRNA Vaccines ; Omalizumab (2P471X1Z11)
    Language English
    Publishing date 2022-01-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.14725
    Database MEDical Literature Analysis and Retrieval System OnLINE

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