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  1. Article ; Online: GATA4 as a maestro of gut regionalization.

    Torres, Licia / Faria, Ana M C

    Immunity

    2023  Volume 56, Issue 1, Page(s) 1–3

    Abstract: How gut regionalization impacts microbiota and immunity is unclear. In this issue of Immunity, Earley et al. show that jejumal GATA4 expression controls bacteria colonization through retinol metabolism and IgA production. This metabolic-immune axis ... ...

    Abstract How gut regionalization impacts microbiota and immunity is unclear. In this issue of Immunity, Earley et al. show that jejumal GATA4 expression controls bacteria colonization through retinol metabolism and IgA production. This metabolic-immune axis limits intestinal Th17 responses and immunopathology.
    MeSH term(s) Gastrointestinal Microbiome ; Microbiota ; GATA4 Transcription Factor ; Th17 Cells/metabolism ; Th17 Cells/microbiology
    Chemical Substances GATA4 protein, human ; GATA4 Transcription Factor
    Language English
    Publishing date 2023-01-09
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2022.12.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4227: Show issues Location:
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  2. Article ; Online: Drug Delivery from PCL/Chitosan Multilayer Coatings for Metallic Implants.

    Soares, Íris / Faria, Jaime / Marques, Ana / Ribeiro, Isabel A C / Baleizão, Carlos / Bettencourt, Ana / Ferreira, Isabel M M / Baptista, Ana Catarina

    ACS omega

    2022  Volume 7, Issue 27, Page(s) 23096–23106

    Abstract: Implant-related infections, mainly caused ... ...

    Abstract Implant-related infections, mainly caused by
    Language English
    Publishing date 2022-06-28
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.2c00504
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  3. Article ; Online: The bioprospecting potential of Clusia fluminensis Planch. & Triana: a scoping review.

    Faria, Giselle M / Lemos, Ana Patricia A / Anholeti, Maria C / Paiva, Selma R / Amorim, Lidia M F

    Anais da Academia Brasileira de Ciencias

    2023  Volume 95, Issue 1, Page(s) e20211605

    Abstract: ... knowledge of C. fluminensis from a bioprospecting standpoint. "Clusia fluminensis" search term was applied ...

    Abstract Many biological activities are described for the Clusiaceae family. Clusia fluminensis, a species from Brazilian flora, is mainly employed for ornamental purposes. This review aimed to depict the current knowledge of C. fluminensis from a bioprospecting standpoint. "Clusia fluminensis" search term was applied in Scopus, Web of Science, PubMed and Bireme databases according to PRISMA-ScR statement. Selected papers on Phytochemistry or Bioactivity followed hand searching procedures. Bioactivity preclinical studies considered in vitro or in vivo biological systems, treated with plant extracts or isolated compounds. The outcomes were compared with standard or no treatment control groups. Critical appraisal of individual trials considered completeness in the research fields. Our results showed that 81% of the selected papers presented high level of completeness, 69% revealed phytochemical parameters and 31% biological applications of plant extracts and isolated compounds. Polyisoprenylated benzophenones, terpenoids, sterols and phenolic compounds were identified. Antiviral, insecticidal and snake antivenom activities were reported. In conclusion, the phytochemical data reinforce the reported activities. Potential applications in personal care, nutritional supplementation and pharmaceutical, food, chemical or textile industries were also identified. Toxicological and phytochemical complementary studies may be required.
    MeSH term(s) Clusia/chemistry ; Bioprospecting ; Plant Extracts/chemistry ; Phytochemicals/pharmacology ; Dietary Supplements
    Chemical Substances Plant Extracts ; Phytochemicals
    Language English
    Publishing date 2023-05-01
    Publishing country Brazil
    Document type Systematic Review ; Review ; Journal Article
    ZDB-ID 2046885-4
    ISSN 1678-2690 ; 0001-3765
    ISSN (online) 1678-2690
    ISSN 0001-3765
    DOI 10.1590/0001-3765202320211605
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  4. Article ; Online: Early life stage mechanisms of an active fish species to cope with ocean warming and hypoxia as interacting stressors.

    Lima, André R A / Booms, Emily M / Lopes, Ana Rita / Martins-Cardoso, Sara / Novais, Sara C / Lemos, Marco F L / Ribeiro, Laura / Castanho, Sara / Candeias-Mendes, Ana / Pousão-Ferreira, Pedro / Faria, Ana M

    Environmental pollution (Barking, Essex : 1987)

    2023  Volume 341, Page(s) 122989

    Abstract: ... life stages of fish. We assessed whether the chronic effects of warming (24 °C) and hypoxia (<2-2.5 mg L ...

    Abstract Ocean's characteristics are rapidly changing, modifying environmental suitability for early life stages of fish. We assessed whether the chronic effects of warming (24 °C) and hypoxia (<2-2.5 mg L
    MeSH term(s) Animals ; Temperature ; Hypoxia ; Sea Bream/metabolism ; Larva ; Oceans and Seas
    Language English
    Publishing date 2023-11-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2023.122989
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2599: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  5. Article ; Online: Oxygen-dependent histone lysine demethylase 4 restricts hepatitis B virus replication.

    Harris, James M / Magri, Andrea / Faria, Ana Rita / Tsukuda, Senko / Balfe, Peter / Wing, Peter A C / McKeating, Jane A

    The Journal of biological chemistry

    2024  Volume 300, Issue 3, Page(s) 105724

    Abstract: Mammalian cells have evolved strategies to regulate gene expression when oxygen is limited. Hypoxia-inducible factors (HIF) are the major transcriptional regulators of host gene expression. We previously reported that HIFs bind and activate hepatitis B ... ...

    Abstract Mammalian cells have evolved strategies to regulate gene expression when oxygen is limited. Hypoxia-inducible factors (HIF) are the major transcriptional regulators of host gene expression. We previously reported that HIFs bind and activate hepatitis B virus (HBV) DNA transcription under low oxygen conditions; however, the global cellular response to low oxygen is mediated by a family of oxygenases that work in concert with HIFs. Recent studies have identified a role for chromatin modifiers in sensing cellular oxygen and orchestrating transcriptional responses, but their role in the HBV life cycle is as yet undefined. We demonstrated that histone lysine demethylase 4 (KDM4) can restrict HBV, and pharmacological or oxygen-mediated inhibition of the demethylase increases viral RNAs derived from both episomal and integrated copies of the viral genome. Sequencing studies demonstrated that KDM4 is a major regulator of the hepatic transcriptome, which defines hepatocellular permissivity to HBV infection. We propose a model where HBV exploits cellular oxygen sensors to replicate and persist in the liver. Understanding oxygen-dependent pathways that regulate HBV infection will facilitate the development of physiologically relevant cell-based models that support efficient HBV replication.
    MeSH term(s) Humans ; DNA, Viral/genetics ; Genome, Viral/genetics ; Hepatitis B/enzymology ; Hepatitis B/metabolism ; Hepatitis B/virology ; Hepatitis B virus/genetics ; Hepatitis B virus/growth & development ; Hepatitis B virus/metabolism ; Jumonji Domain-Containing Histone Demethylases/metabolism ; Liver/enzymology ; Liver/metabolism ; Liver/virology ; Oxygen/metabolism ; Plasmids/genetics ; Transcriptome ; Virus Replication/genetics
    Chemical Substances DNA, Viral ; Jumonji Domain-Containing Histone Demethylases (EC 1.14.11.-) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2024.105724
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    Uc I Zs.108: Show issues Location:
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  6. Article: Evaluation of

    Peixoto, Ana / Cirnes, Luís / Carvalho, Ana Luísa / Andrade, Maria João / Brito, Maria José / Borralho, Paula / Borralho, Pedro M / Carneiro, Ana Sofia / Castro, Lisandra / Correia, Lurdes / Dionísio, Maria Rita / Faria, Carlos / Figueiredo, Paulo / Gomes, Ana / Paixão, Joana / Pinheiro, Manuela / Prazeres, Hugo / Ribeiro, Joana / Salgueiro, Natália /
    Schmitt, Fernando C / Silva, Fátima / Silvestre, Ana Rita / Sousa, Ana Carla / Almeida-Tavares, Joana / Teixeira, Manuel R / André, Saudade / Machado, José Carlos

    Frontiers in molecular biosciences

    2023  Volume 10, Page(s) 1082915

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-02-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2023.1082915
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  7. Article ; Online: Poly I:C elicits broader and stronger humoral and cellular responses to a

    Costa-Gouvea, Tiffany B L / Françoso, Katia S / Marques, Rodolfo F / Gimenez, Alba Marina / Faria, Ana C M / Cariste, Leonardo M / Dominguez, Mariana R / Vasconcelos, José Ronnie C / Nakaya, Helder I / Silveira, Eduardo L V / Soares, Irene S

    Frontiers in immunology

    2024  Volume 15, Page(s) 1331474

    Abstract: Malaria remains a global health challenge, necessitating the development of effective vaccines. The RTS,S vaccination ... ...

    Abstract Malaria remains a global health challenge, necessitating the development of effective vaccines. The RTS,S vaccination prevents
    MeSH term(s) Animals ; Malaria Vaccines/immunology ; Protozoan Proteins/immunology ; Protozoan Proteins/genetics ; Mice ; Plasmodium vivax/immunology ; Antibodies, Protozoan/immunology ; Poly I-C/immunology ; Malaria, Vivax/immunology ; Malaria, Vivax/prevention & control ; Aluminum Hydroxide/immunology ; Immunoglobulin G/immunology ; Immunoglobulin G/blood ; Female ; Adjuvants, Immunologic ; Immunity, Humoral ; Immunity, Cellular ; Mice, Inbred BALB C
    Chemical Substances Malaria Vaccines ; Protozoan Proteins ; Antibodies, Protozoan ; Poly I-C (O84C90HH2L) ; circumsporozoite protein, Protozoan ; Aluminum Hydroxide (5QB0T2IUN0) ; Immunoglobulin G ; Adjuvants, Immunologic
    Language English
    Publishing date 2024-04-08
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1331474
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  8. Article ; Online: Improved L-Asparaginase Properties and Reusability by Immobilization onto Functionalized Carbon Xerogels.

    Barros, Rita A M / Cristóvão, Raquel O / Carneiro, Inês G / Barros, Maria A / Pereira, Matheus M / Carabineiro, Sónia A C / Freire, Mara G / Faria, Joaquim L / Santos-Ebinuma, Valéria C / Tavares, Ana P M / Silva, Cláudia G

    ChemPlusChem

    2024  , Page(s) e202400025

    Abstract: ... flow at 600 °C (CX-OX-600). Under the optimal conditions (81 min of contact time, pH 6.2 and 0.36 g/L ...

    Abstract Enzyme immobilization can offer a range of significant advantages, including reusability, and increased selectivity, stability, and activity. In this work, a central composite design (CCD) of experiments and response surface methodology (RSM) were used to study, for the first time, the L-asparaginase (ASNase) immobilization onto functionalized carbon xerogels (CXs). The best results were achieved using CXs obtained by hydrothermal oxidation with nitric acid and subsequent heat treatment in a nitrogen flow at 600 °C (CX-OX-600). Under the optimal conditions (81 min of contact time, pH 6.2 and 0.36 g/L of ASNase), an immobilization yield (IY) of 100 % and relative recovered activity (RRA) of 103 % were achieved. The kinetic parameters obtained also indicate a 1.25-fold increase in the affinity of ASNase towards the substrate after immobilization. Moreover, the immobilized enzyme retained 97 % of its initial activity after 6 consecutive reaction cycles. All these outcomes confirm the promising properties of functionalized CXs as support for ASNase, bringing new insights into the development of an efficient and stable immobilization platform for use in the pharmaceutical industry, food industry, and biosensors.
    Language English
    Publishing date 2024-03-04
    Publishing country Germany
    Document type Journal Article
    ISSN 2192-6506
    ISSN (online) 2192-6506
    DOI 10.1002/cplu.202400025
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  9. Article ; Online: Synergy between 3D-extruded electroconductive scaffolds and electrical stimulation to improve bone tissue engineering strategies.

    Silva, João C / Marcelino, Pedro / Meneses, João / Barbosa, Frederico / Moura, Carla S / Marques, Ana C / Cabral, Joaquim M S / Pascoal-Faria, Paula / Alves, Nuno / Morgado, Jorge / Ferreira, Frederico Castelo / Garrudo, Fábio F F

    Journal of materials chemistry. B

    2024  Volume 12, Issue 11, Page(s) 2771–2794

    Abstract: In this work, we propose a simple, reliable, and versatile strategy to create 3D electroconductive scaffolds suitable for bone tissue engineering (TE) applications with electrical stimulation (ES). The proposed scaffolds are made of 3D-extruded poly(ε- ... ...

    Abstract In this work, we propose a simple, reliable, and versatile strategy to create 3D electroconductive scaffolds suitable for bone tissue engineering (TE) applications with electrical stimulation (ES). The proposed scaffolds are made of 3D-extruded poly(ε-caprolactone) (PCL), subjected to alkaline treatment, and of poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS), anchored to PCL with one of two different crosslinkers: (3-glycidyloxypropyl)trimethoxysilane (GOPS) and divinyl sulfone (DVS). Both cross-linkers allowed the formation of a homogenous and continuous coating of PEDOT:PSS to PCL. We show that these PEDOT:PSS coatings are electroconductive (11.3-20.1 S cm
    MeSH term(s) Humans ; Tissue Engineering/methods ; Tissue Scaffolds ; Osteogenesis ; Sodium Hydroxide ; Gelatin ; Electric Stimulation
    Chemical Substances Sodium Hydroxide (55X04QC32I) ; Gelatin (9000-70-8)
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2702241-9
    ISSN 2050-7518 ; 2050-750X
    ISSN (online) 2050-7518
    ISSN 2050-750X
    DOI 10.1039/d3tb02673f
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  10. Article ; Online: Predicting the ecological impact of a recent range expansion in the structure of intertidal biofilms.

    Martins, Gustavo M / Prestes, Afonso C L / Faria, João / Neto, Ana I

    Marine environmental research

    2021  Volume 169, Page(s) 105332

    Abstract: Predicting the consequences of recent changes in species distributional ranges is paramount. The trochid Phorcus sauciatus has recently colonised the Azores and is the only intertidal trochid in these islands. In this study we used experimental mesocosms ...

    Abstract Predicting the consequences of recent changes in species distributional ranges is paramount. The trochid Phorcus sauciatus has recently colonised the Azores and is the only intertidal trochid in these islands. In this study we used experimental mesocosms to examine whether its addition to the remainder of the intertidal assemblage of grazers composed of littorinids and patellids affects the structure of epilithic biofilms growing on experimental plates. We also examined if its presence can compensate the loss of patellid limpets to simulate areas where these are chronically harvested. Results showed that when the native assemblage of grazers (littorinids and patellids) are present, the addition of P. sauciatus had little influence on the overall structure of epilithic biofilms. However, when patellids were absent, and in contrast to expectations, biofilm standing stock on experimental plates decreased significantly. Results suggest that patellids may negatively affect the foraging activities of P. sauciatus via interference competition and are further discussed in face of ecological knowledge of these organisms.
    MeSH term(s) Animals ; Azores ; Biofilms ; Environment ; Gastropoda
    Language English
    Publishing date 2021-04-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1502505-6
    ISSN 1879-0291 ; 0141-1136
    ISSN (online) 1879-0291
    ISSN 0141-1136
    DOI 10.1016/j.marenvres.2021.105332
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