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Article: Case 5. Toe stump wound in arterial disease.

Koyama, Akio

2024 Volume 32, Issue Sup12a, Page(s) S16–S17

MeSH term(s)	Humans ; Amputation Stumps ; Toes ; Vascular Diseases
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Journal Article
ZDB-ID	1353951-6
ISSN	0969-0700
ISSN	0969-0700
DOI	10.12968/jowc.2023.32.Sup12a.S16
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Article ; Online: Staphylococcus aureus

Takayasu, Mamiko / Hirayama, Kouichi / Shimohata, Homare / Kobayashi, Masaki / Koyama, Akio

International journal of molecular sciences

2022 Volume 23, Issue 13

Abstract: Since 1995, when we reported the case of a patient with glomerulonephritis with IgA deposition that occurred after a methicillin- ... ...

Abstract	Since 1995, when we reported the case of a patient with glomerulonephritis with IgA deposition that occurred after a methicillin-resistant
MeSH term(s)	Glomerulonephritis/pathology ; Glomerulonephritis, IGA/complications ; Glomerulonephritis, IGA/pathology ; Humans ; Immunoglobulin A ; Methicillin-Resistant Staphylococcus aureus ; Staphylococcal Infections ; Staphylococcus aureus
Chemical Substances	Immunoglobulin A
Language	English
Publishing date	2022-07-05
Publishing country	Switzerland
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23137482
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Article ; Online: Zinc Deficiency and Clinical Outcome After Infrainguinal Bypass Grafting for Critical Limb Ischemia.

Koyama, Akio / Kodama, Akio / Tsuruoka, Takuya / Fujii, Takayuki / Sugimoto, Masayuki / Banno, Hiroshi / Komori, Kimihiro

Circulation reports

2020 Volume 2, Issue 3, Page(s) 167–173

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2020-02-26
Publishing country	Japan
Document type	Journal Article
ISSN	2434-0790
ISSN (online)	2434-0790
DOI	10.1253/circrep.CR-20-0003
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Article: Recurrent Mural Thrombosis of the Ascending Aorta in a Patient with Antiphospholipid Syndrome.

Otsuka, Ryohei / Saito, Shunei / Yamamoto, Toshikuni / Ohno, Tsukasa / Koyama, Akio / Morimae, Hirofumi / Matsushita, Masahiro / Yokota, Kaori / Miyahara, Ken / Matsuura, Akio

Annals of vascular diseases

2022 Volume 15, Issue 1, Page(s) 77–80

Abstract: A 38-year-old man presented with embolic occlusion of the brachial artery. As per his computed tomography results, a pedunculated mass in the proximal ascending aorta was detected. Since discrimination between a thrombus and a tumor was deemed difficult, ...

Abstract	A 38-year-old man presented with embolic occlusion of the brachial artery. As per his computed tomography results, a pedunculated mass in the proximal ascending aorta was detected. Since discrimination between a thrombus and a tumor was deemed difficult, the patient underwent replacement of the ascending aorta. Histopathology revealed the mass to be a thrombus. The diagnosis of antiphospholipid syndrome was then confirmed postoperatively. Six months post-surgery, a new thrombus was detected in the vascular prosthesis. The thrombus resolved after treatment with edoxaban and aspirin. To the best of our knowledge, this is the first report on graft thrombosis in antiphospholipid syndrome, highlighting the importance of seamless anticoagulation therapy.
Language	English
Publishing date	2022-04-06
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2394256-3
ISSN	1881-6428 ; 1881-641X
ISSN (online)	1881-6428
ISSN	1881-641X
DOI	10.3400/avd.cr.21-00138
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Article ; Online: Chronic Limb-Threatening Ischemia is a Residual Bleeding Risk Factor among Patients with Lower Extremity Artery Disease.

Tokuda, Takahiro / Yoshioka, Naoki / Koyama, Akio / Yamada, Takehiro / Shimamura, Kiyotaka / Nishikawa, Ryusuke

Journal of atherosclerosis and thrombosis

2023 Volume 31, Issue 1, Page(s) 100–108

Abstract: Aim: Lower-extremity artery disease (LEAD) is a high-risk factor for bleeding. However, the specific risk factors for bleeding in patients with LEAD remain unclear. We aimed to identify risk factors for bleeding in patients with LEAD after endovascular ... ...

Abstract	Aim: Lower-extremity artery disease (LEAD) is a high-risk factor for bleeding. However, the specific risk factors for bleeding in patients with LEAD remain unclear. We aimed to identify risk factors for bleeding in patients with LEAD after endovascular treatment (EVT). Methods: This multicenter, retrospective, observational study included 732 consecutive patients with LEAD who underwent EVT between January 2018 and December 2019. Patient characteristics, laboratory data, target lesions, and medications were compared between patients with and without chronic limb-threatening ischemia (CLTI). Predictive bleeding risk factors were explored using Cox regression analysis with differential models. Results: In model 1, a body mass index (BMI) ＜18.5 kg/m
MeSH term(s)	Humans ; Chronic Limb-Threatening Ischemia ; Warfarin ; Retrospective Studies ; Platelet Aggregation Inhibitors/adverse effects ; Endovascular Procedures/adverse effects ; Peripheral Arterial Disease/surgery ; Treatment Outcome ; Ischemia/surgery ; Risk Factors ; Lower Extremity/blood supply ; Limb Salvage ; Arteries ; Heart Failure/etiology ; Chronic Disease
Chemical Substances	Warfarin (5Q7ZVV76EI) ; Platelet Aggregation Inhibitors
Language	English
Publishing date	2023-08-02
Publishing country	Japan
Document type	Observational Study ; Multicenter Study ; Journal Article
ZDB-ID	2011474-6
ISSN	1880-3873 ; 1340-3478
ISSN (online)	1880-3873
ISSN	1340-3478
DOI	10.5551/jat.64242
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Article ; Online: Predictors of recurrence based on intravascular ultrasound findings after Eluvia placement in symptomatic peripheral arterial disease: A retrospective study.

Yamada, Takehiro / Tokuda, Takahiro / Yoshioka, Naoki / Koyama, Akio / Nishikawa, Ryusuke / Shimamura, Kiyotaka / Aoyama, Takuma

Health science reports

2023 Volume 6, Issue 8, Page(s) e1481

Abstract: Background and aims: Polymer-coated drug-eluting stents (Eluvia) have shown favorable clinical outcomes in real-world registries. There are no reports on recurrent predictors after Eluvia placement based on intravascular ultrasound (IVUS) findings.: ... ...

Abstract	Background and aims: Polymer-coated drug-eluting stents (Eluvia) have shown favorable clinical outcomes in real-world registries. There are no reports on recurrent predictors after Eluvia placement based on intravascular ultrasound (IVUS) findings. Methods: We analyzed clinical data from the ASIGARU PAD registry, a retrospective, multicenter, observational study that enrolled patients who underwent endovascular therapy for superficial femoral and proximal popliteal arteries lesions using Eluvia or drug-coated balloon. The primary outcome was the identification of recurrent predictors, including IVUS parameters at 12 months. The rate of target lesion recurrence was also assessed. Results: IVUS images were obtained in 54 of 65 cases. Seven recurrent cases (13.0%) were observed within 12 months. The random survival forest method presented eight predictive variables of recurrence: Clinical Frailty Scale (CFS), distal stent edge area, distal plaque burden, age, sex, distal external elastic membrane (EEM) area, minimum stent area (MSA), and distal lumen area. Furthermore, the partial dependence plot showed that frailty (CFS ≥ 6), smaller distal stent edge area, higher and lower distal plaque burden, older and younger age, female sex, smaller distal EEM area, smaller MSA, and smaller and larger distal lumen area predicted recurrence after Eluvia placement within 12 months. Conclusion: CFS, distal stent edge area, distal plaque burden, age, sex, distal EEM area, MSA, and distal lumen area were significant recurrent predictors after Eluvia placement.
Language	English
Publishing date	2023-08-03
Publishing country	United States
Document type	Journal Article
ISSN	2398-8835
ISSN (online)	2398-8835
DOI	10.1002/hsr2.1481
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Article ; Online: Staphylococcus aureus Infection-Related Glomerulonephritis with Dominant IgA Deposition

Mamiko Takayasu / Kouichi Hirayama / Homare Shimohata / Masaki Kobayashi / Akio Koyama

International Journal of Molecular Sciences, Vol 23, Iss 7482, p

2022 Volume 7482

Abstract: Since 1995, when we reported the case of a patient with glomerulonephritis with IgA deposition that occurred after a methicillin-resistant Staphylococcus aureus (MRSA) infection, many reports of MRSA infection-associated glomerulonephritis have ... ...

Abstract	Since 1995, when we reported the case of a patient with glomerulonephritis with IgA deposition that occurred after a methicillin-resistant Staphylococcus aureus (MRSA) infection, many reports of MRSA infection-associated glomerulonephritis have accumulated. This disease is being systematized as Staphylococcus infection-associated glomerulonephritis (SAGN) in light of the apparent cause of infection, and as immunoglobulin A-dominant deposition infection-related glomerulonephritis (IgA-IRGN) in light of its histopathology. This glomerulonephritis usually presents as rapidly progressive glomerulonephritis or acute kidney injury with various degrees of proteinuria and microscopic hematuria along with an ongoing infection. Its renal pathology has shown several types of mesangial and/or endocapillary proliferative glomerulonephritis with various degrees of crescent formation and tubulointerstitial nephritis. IgA, IgG, and C 3 staining in the mesangium and along the glomerular capillary walls have been observed on immunofluorescence examinations. A marked activation of T cells, an increase in specific variable regions of the T-cell receptor β-chain-positive cells, hypercytokinemia, and increased polyclonal immune complexes have also been observed in this glomerulonephritis. In the development of this disease, staphylococcal enterotoxin may be involved as a superantigen, but further investigations are needed to clarify the mechanisms underlying this disease. Here, we review 336 cases of IgA-IRGN and 218 cases of SAGN.
Keywords	Staphylococcus aureus ; rapidly progressive glomerulonephritis ; IgA-dominant glomerulonephritis ; Staphylococcus infection-associated glomerulonephritis ; bacterial superantigen ; T-cell receptor ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	616
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Comparison of clinical outcomes, including the wound healing rate, between inframalleolar bypass to the pedal artery and that to the pedal branch artery in the modern endovascular era.

Kodama, Akio / Kobayashi, Taira / Guntani, Atsushi / Yamada, Tetsuya / Koyama, Akio / Mii, Shinsuke / Ishibashi, Hiroyuki / Matsushita, Masahiro / Komori, Kimihiro

Journal of vascular surgery

2022 Volume 75, Issue 6, Page(s) 2019–2029.e2

Abstract: Objective: Inframalleolar (IM) bypass has been reported to demonstrate acceptable patency and limb salvage in patients with chronic limb-threatening ischemia. However, wound healing after IM bypass and comparisons between pedal artery (PA) bypass and ... ...

Abstract	Objective: Inframalleolar (IM) bypass has been reported to demonstrate acceptable patency and limb salvage in patients with chronic limb-threatening ischemia. However, wound healing after IM bypass and comparisons between pedal artery (PA) bypass and pedal branch artery (PBA) bypass are lacking. Methods: We reviewed prospectively collected data from 208 consecutive patients after IM bypass performed over a period of 6 years. Patients were divided into two groups based on the distal anastomotic artery: the PA group (dorsal pedis artery or common plantar artery) and the PBA group (medial tarsal, lateral tarsal, medial plantar, and lateral plantar artery). The primary outcome was wound healing, and secondary outcomes included loss of patency and limb and life prognosis. Results: Of the 208 patients, 174 (74%) had PA bypass, whereas 34 (16%) had PBA bypass. Patients in the PBA group were significantly younger than those in the PA group (69 ± 7 vs 73 ± 9; P = .03). Although early (30-day) graft failure was more common in the PBA group, late clinical outcomes, including the wound healing rate (79% in the PA group and 84% in the PBA group; P = .74), were similar between the two groups. The Global Limb Anatomic Staging System IM grade (hazard ratio [HR], 0.73; 95% confidence interval [CI], 0.58-0.93; P = .006); wound, ischemia, and foot infection wound grade (HR, 0.67; 95% CI, 0.51-0.89; P < .01); and wound, ischemia, and foot infection foot infection grade (HR, 0.79; 95% CI, 0.65-0.96; P = .02) were independent predictors of wound healing. Conclusions: The current study revealed that wound healing in patients after PBA bypass was acceptable and comparable with that after PA bypass. In the modern era, including a high prevalence of infrapopliteal angioplasty, our results could provide useful information to clinicians in actual clinical settings. Moreover, PBA bypass may be an alternative revascularization procedure to avoid major amputation when the PA is occluded, such as in the global vascular guideline IM P2 grade. Prospective multicenter larger studies are warranted to confirm the findings of this study and to compare PBA bypass and IM endovascular treatment in patients with anatomical no-option chronic limb-threatening ischemia.
MeSH term(s)	Amputation ; Humans ; Ischemia/diagnostic imaging ; Ischemia/surgery ; Limb Salvage ; Multicenter Studies as Topic ; Prospective Studies ; Risk Factors ; Tibial Arteries ; Treatment Outcome ; Vascular Patency ; Wound Healing
Language	English
Publishing date	2022-02-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	605700-7
ISSN	1097-6809 ; 0741-5214
ISSN (online)	1097-6809
ISSN	0741-5214
DOI	10.1016/j.jvs.2022.01.138
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Article: An anomalous hyperplastic anterior choroidal artery associated with an unruptured internal carotid-posterior communicating artery aneurysm.

Nishino, Akio / Mori, Kousuke / Yano, Yoshihiro / Koyama, Takashi / Taniwaki, Kouichi / Fujita, Toshiaki / Taneda, Mamoru

Radiology case reports

2022 Volume 17, Issue 5, Page(s) 1745–1749

Abstract: The anterior choroidal artery (AChA) injuries can result in severe neurologic deficits, so requiring careful observation to avoid inadvertent damage during neuroendovascular procedures. In this case report, we present the unusual case of an anomalous ... ...

Abstract	The anterior choroidal artery (AChA) injuries can result in severe neurologic deficits, so requiring careful observation to avoid inadvertent damage during neuroendovascular procedures. In this case report, we present the unusual case of an anomalous hyperplastic AChA associated with a fetal-type posterior communicating artery (PCoA), and an unruptured internal carotid artery (ICA) -PCoA aneurysm. A 54-year-old woman presented with persistent headache. Brain magnetic resonance imaging (MRI) showed an unruptured cerebral aneurysm in the right ICA, and cerebral angiography revealed a proximal fetal-type PComA and a distal anomalous hyperplastic AChA. Coil embolization was performed with no neurologic deficits and the target lesion was embolized with a total of 6 coils. An anomalous hyperplastic AchA has a lengthy course with numerous choroidal and perforating branches, and therefore, an abundant perfusion region. Thorough knowledge of the development and anatomy of anomalous arteries is important for safely performing endovascular procedures without causing any ischemic complications.
Language	English
Publishing date	2022-03-25
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2406300-9
ISSN	1930-0433
ISSN	1930-0433
DOI	10.1016/j.radcr.2022.02.071
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Article ; Online: Association between High Bleeding Risk and 2-Year Mortality in Patients with Chronic Limb-Threatening Ischemia.

Yoshioka, Naoki / Tokuda, Takahiro / Koyama, Akio / Yamada, Takehiro / Shimamura, Kiyotaka / Nishikawa, Ryusuke / Morita, Yasuhiro / Morishima, Itsuro

Journal of atherosclerosis and thrombosis

2023 Volume 30, Issue 11, Page(s) 1674–1686

Abstract: Aim: Patients with chronic limb-threatening ischemia (CLTI) have a high bleeding risk (HBR) and mortality rate. The 2-year life expectancy is an important factor in deciding the appropriate treatment strategy. This study aimed to assess the influence of ...

Abstract	Aim: Patients with chronic limb-threatening ischemia (CLTI) have a high bleeding risk (HBR) and mortality rate. The 2-year life expectancy is an important factor in deciding the appropriate treatment strategy. This study aimed to assess the influence of HBR on the prognosis of patients with CLTI. Methods: A total of 259 patients with CLTI who underwent endovascular therapy (EVT) (mean age, 76.2 years; male, 62.9%) between January 2018 and December 2019 were evaluated. The Academic Research Consortium for HBR (ARC-HBR) criteria were applied to each patient, and the ARC-HBR scores were calculated. The cut-off score for predicting all-cause mortality within two years was derived using a survival classification and regression tree (CART) model. Causes of death and the association between ARC-HBR scores and major bleeding events within two years were also investigated. Results: Based on the CART model, patients were divided into three groups (low HBR score 0-1.0, 48 patients; moderate HBR score 1.5-3.0, 176 patients; and high HBR score ≥ 3.5, 35 patients). During the study period, 82 patients (39.6%) died due to cardiac (n=23) and non-cardiac causes (n=59). All-cause mortality increased significantly with increasing ARC-HBR scores. Cox multivariate analysis revealed a significant association between high ARC-HBR scores and the risk of all-cause mortality within two years. Major bleeding events increased significantly with increasing ARC-HBR scores. Conclusions: The ARC-HBR score could predict 2-year mortality in patients with CLTI who underwent EVT. Thus, this score can help determine the best revascularization strategy for patients with CLTI.
MeSH term(s)	Humans ; Aged ; Chronic Limb-Threatening Ischemia ; Ischemia/surgery ; Treatment Outcome ; Peripheral Arterial Disease/surgery ; Risk Factors ; Hemorrhage/complications ; Risk Assessment ; Retrospective Studies ; Limb Salvage ; Endovascular Procedures/adverse effects
Language	English
Publishing date	2023-03-22
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2011474-6
ISSN	1880-3873 ; 1340-3478
ISSN (online)	1880-3873
ISSN	1340-3478
DOI	10.5551/jat.64157
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