LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 7 of total 7

Search options

  1. Article: Orexins in the brain-gut axis.

    Kirchgessner, Annette L

    Endocrine reviews

    2002  Volume 23, Issue 1, Page(s) 1–15

    Abstract: Orexins (hypocretins) are a novel pair of neuropeptides implicated in the regulation of energy balances and arousal. Previous reports have indicated that orexins are produced only in the lateral hypothalamic area, although orexin-containing nerve fibers ... ...

    Abstract Orexins (hypocretins) are a novel pair of neuropeptides implicated in the regulation of energy balances and arousal. Previous reports have indicated that orexins are produced only in the lateral hypothalamic area, although orexin-containing nerve fibers were observed throughout the neuroaxis. Recent evidence shows that orexins and functional orexin receptors are found in the periphery. Vagal and spinal primary afferent neurons, enteric neurons, and endocrine cells in both the gut and pancreas display orexin- and orexin receptor-like immunoreactivity. Orexins excite secretomotor neurons in the guinea pig gut and modulate gastric and intestinal motility and secretion. In addition, orexins modulate hormone release from pancreatic endocrine cells. Moreover, fasting up-regulates the phosphorylated form of cAMP response element binding protein in orexin-immunoreactive enteric neurons, indicating a functional response to food status in these cells. The purpose of this article is to summarize evidence for the existence of a brain-gut network of orexin-containing cells that appears to play a role in the acute regulation of energy homeostasis.
    MeSH term(s) Animals ; Brain/physiology ; Carrier Proteins/physiology ; Feeding Behavior/physiology ; Humans ; Intestines/physiology ; Intracellular Signaling Peptides and Proteins ; Neuropeptides/physiology ; Orexins ; Pancreas/physiology
    Chemical Substances Carrier Proteins ; Intracellular Signaling Peptides and Proteins ; Neuropeptides ; Orexins
    Language English
    Publishing date 2002-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 603096-8
    ISSN 1945-7189 ; 0163-769X
    ISSN (online) 1945-7189
    ISSN 0163-769X
    DOI 10.1210/edrv.23.1.0454
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1562: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Localization and function of metabotropic glutamate receptor 8 in the enteric nervous system.

    Tong, Qingchun / Kirchgessner, Annette L

    American journal of physiology. Gastrointestinal and liver physiology

    2003  Volume 285, Issue 5, Page(s) G992–G1003

    Abstract: ... because CPPG inhibited it. Moreover, in the presence of hexamethonium or Nomega-nitro-l-arginine methyl ester ...

    Abstract The enteric nervous system (ENS) contains glutamatergic neurons, transporters, and functional ionotropic and groups I and II metabotropic glutamate receptors (mGluRs). The aim of this study was to determine whether the ENS contains functional group III mGluRs. RT-PCR demonstrated the expression of mGluR7 and mGluR8 mRNA in rat myenteric ganglia. Western blot analysis confirmed the presence of mGluR8 protein. Immunocytochemistry, in conjunction with confocal microscopy, demonstrated mGluR8 immunoreactivity in the ENS of several species, including humans. mGluR8 immunoreactivity was localized to the membrane of nerve cell bodies that received glutamatergic input. Significant receptor internalization of mGluR8 was observed on activation, and localization to membrane was observed on blocking with the mGluR III antagonist (RS)-cyclopropyl-4-phosphonophenylglycine (CPPG). mGluR8-positive myenteric neurons contained glutamate or nitric oxide synthase (NOS), a marker of inhibitory motorneurons. Enteric group III mGluRs are functional because mGluR8 agonists inhibited forskolin-induced accumulation of cAMP in isolated myenteric ganglia, and CPPG reduced this effect. In addition, an accelerating effect on guinea pig colonic motility was observed after the application of mGluR8 agonists. Increase in motility was specific, because CPPG inhibited it. Moreover, in the presence of hexamethonium or Nomega-nitro-l-arginine methyl ester, an inhibitor of NOS, responses caused by mGluR8 agonists were abolished. mGluR8 agonists also increased longitudinal muscle contractions. These findings suggest that mGluR8 agonists increase motility by inhibiting nitrergic relaxation and possibly by facilitating cholinergic contractions.
    MeSH term(s) Animals ; Blotting, Western ; Colforsin/pharmacology ; Cyclic AMP/antagonists & inhibitors ; Cyclic AMP/biosynthesis ; Electric Stimulation ; Enteric Nervous System/cytology ; Enteric Nervous System/metabolism ; Enteric Nervous System/physiology ; Female ; Ganglia/metabolism ; Gastrointestinal Motility/physiology ; Immunohistochemistry ; Microscopy, Confocal ; Muscle, Smooth/physiology ; Myenteric Plexus/metabolism ; RNA, Messenger/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, Metabotropic Glutamate/agonists ; Receptors, Metabotropic Glutamate/genetics ; Receptors, Metabotropic Glutamate/metabolism ; Receptors, Metabotropic Glutamate/physiology ; Reverse Transcriptase Polymerase Chain Reaction ; Tissue Distribution
    Chemical Substances RNA, Messenger ; Receptors, Metabotropic Glutamate ; metabotropic glutamate receptor 8 ; Colforsin (1F7A44V6OU) ; Cyclic AMP (E0399OZS9N)
    Language English
    Publishing date 2003-11
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 603840-2
    ISSN 1522-1547 ; 0193-1857
    ISSN (online) 1522-1547
    ISSN 0193-1857
    DOI 10.1152/ajpgi.00118.2003
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Activation of group II mGlu receptors inhibits voltage-gated Ca2+ currents in myenteric neurons.

    Chen, Wei-Ping / Kirchgessner, Annette L

    American journal of physiology. Gastrointestinal and liver physiology

    2002  Volume 283, Issue 6, Page(s) G1282–9

    Abstract: ... by L-glutamate and the group II mGlu receptor agonists, (2S,2'R,3'R)-2-(2',3'-dicarboxycyclopropyl ... glycine (DCG-IV) and (2S,1'S,2'S)-2-(2-carboxycyclopropyl)glycine (L-CCG-I), with a rank order potency ... of 2R,4R-APDC > DCG-IV > L-glutamate > L-CCG-I, and was reduced by the group II mGlu receptor antagonist ...

    Abstract The enteric nervous system (ENS) contains functional ionotropic and group I metabotropic glutamate (mGlu) receptors. In this study, we determined whether enteric neurons express group II mGlu receptors and the effects of mGlu receptor activation on voltage-gated Ca(2+) currents in these cells. (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate (2R,4R-APDC), a group II mGlu receptor agonist, reversibly suppressed the Ba(2+) current in myenteric neurons isolated from the guinea pig ileum. Significant inhibition was also produced by L-glutamate and the group II mGlu receptor agonists, (2S,2'R,3'R)-2-(2',3'-dicarboxycyclopropyl)glycine (DCG-IV) and (2S,1'S,2'S)-2-(2-carboxycyclopropyl)glycine (L-CCG-I), with a rank order potency of 2R,4R-APDC > DCG-IV > L-glutamate > L-CCG-I, and was reduced by the group II mGlu receptor antagonist LY-341495. Pretreatment of neurons with pertussis toxin (PTX) reduced the action of mGlu receptor agonists, suggesting participation of G(i)/G(o) proteins. Finally, omega-conotoxin GVIA blocked current suppression by DCG-IV, suggesting modulation of N-type calcium channels. mGlu2/3 receptor immunoreactivity was displayed by neurons in culture and in the submucosal and myenteric plexus of the ileum. A subset of these cells displayed a glutamatergic phenotype as shown by the expression of vesicular glutamate transporter 2. These results provide the first evidence for functional group II mGlu receptors in the ENS and show that these receptors are PTX sensitive and negatively coupled to N-type calcium channels. Inhibition of N-type calcium channels produced by activation of group II mGlu receptors may modulate enteric neurotransmission.
    MeSH term(s) Animals ; Barium/metabolism ; Cadmium/pharmacology ; Calcium/pharmacology ; Calcium Channel Blockers/pharmacology ; Calcium Channels/physiology ; Cyclopropanes/pharmacology ; Electric Conductivity ; GTP-Binding Proteins/physiology ; Glutamic Acid/pharmacology ; Glycine/analogs & derivatives ; Glycine/pharmacology ; Guinea Pigs ; Ion Channel Gating ; Male ; Myenteric Plexus/physiology ; Neurons/chemistry ; Neurons/physiology ; Nifedipine/pharmacology ; Pertussis Toxin/pharmacology ; Proline/analogs & derivatives ; Proline/pharmacology ; Receptors, Metabotropic Glutamate/agonists ; Receptors, Metabotropic Glutamate/analysis ; Receptors, Metabotropic Glutamate/physiology ; omega-Conotoxin GVIA/pharmacology
    Chemical Substances 4-aminopyrrolidine-2,4-dicarboxylic acid ; Calcium Channel Blockers ; Calcium Channels ; Cyclopropanes ; Receptors, Metabotropic Glutamate ; metabotropic glutamate receptor 2 ; Cadmium (00BH33GNGH) ; 2-(2,3-dicarboxycyclopropyl)glycine (147782-19-2) ; Barium (24GP945V5T) ; Glutamic Acid (3KX376GY7L) ; omega-Conotoxin GVIA (92078-76-7) ; Proline (9DLQ4CIU6V) ; Pertussis Toxin (EC 2.4.2.31) ; GTP-Binding Proteins (EC 3.6.1.-) ; Nifedipine (I9ZF7L6G2L) ; Calcium (SY7Q814VUP) ; Glycine (TE7660XO1C)
    Language English
    Publishing date 2002-12
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 603840-2
    ISSN 1522-1547 ; 0193-1857
    ISSN (online) 1522-1547
    ISSN 0193-1857
    DOI 10.1152/ajpgi.00216.2002
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Glucose regulates the release of orexin-a from the endocrine pancreas.

    Ouedraogo, Raogo / Näslund, Erik / Kirchgessner, Annette L

    Diabetes

    2002  Volume 52, Issue 1, Page(s) 111–117

    Abstract: ... glucose (2.8 mmol/l), similar to glucagon secretion, and inhibited by high glucose (16.7 mmol/l). Fasting ...

    Abstract Orexins (hypocretins) are novel neuropeptides that appear to play a role in the regulation of energy balances. Orexin-A (OXA) increases food intake in rodents, and fasting activates OXA neurons in both the lateral hypothalamic area and gut. OXA is also found in the endocrine pancreas; however, little is known about its release or functional significance. In this study, we show that depolarizing stimuli evoke the release of OXA from rat pancreatic islets in a calcium-dependent manner. Moreover, OXA release is stimulated by low glucose (2.8 mmol/l), similar to glucagon secretion, and inhibited by high glucose (16.7 mmol/l). Fasting increases plasma OXA, supporting the idea that orexin is released in response to hypoglycemia. Cells that secrete glucagon and insulin contain OXA and both cell types express orexin receptors. OXA increases glucagon secretion and decreases glucose-stimulated insulin release from isolated islets. OXA infusion increases plasma glucagon and glucose levels and decreases plasma insulin in fasted rats. We conclude that orexin-containing islet cells, like those in the brain and gut, are glucosensitive and part of a network of glucose "sensing" cells that becomes activated when blood glucose levels fall. OXA may modulate islet hormone secretion to maintain blood glucose levels during fasting.
    MeSH term(s) Animals ; Blood Glucose/analysis ; Carrier Proteins/metabolism ; Carrier Proteins/pharmacology ; Culture Techniques ; Fasting/blood ; Female ; Glucagon/blood ; Glucagon/metabolism ; Glucose/pharmacology ; Glucose/physiology ; Immunohistochemistry ; Insulin/blood ; Insulin/metabolism ; Insulin Secretion ; Intracellular Signaling Peptides and Proteins ; Islets of Langerhans/drug effects ; Islets of Langerhans/metabolism ; Male ; Neuropeptides/metabolism ; Neuropeptides/pharmacology ; Orexin Receptors ; Orexins ; Rats ; Rats, Sprague-Dawley ; Receptors, G-Protein-Coupled ; Receptors, Neuropeptide/metabolism ; Stimulation, Chemical
    Chemical Substances Blood Glucose ; Carrier Proteins ; Insulin ; Intracellular Signaling Peptides and Proteins ; Neuropeptides ; Orexin Receptors ; Orexins ; Receptors, G-Protein-Coupled ; Receptors, Neuropeptide ; Glucagon (9007-92-5) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2002-12-13
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 80085-5
    ISSN 1939-327X ; 0012-1797
    ISSN (online) 1939-327X
    ISSN 0012-1797
    DOI 10.2337/diabetes.52.1.111
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.175: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Localization and function of group III metabotropic glutamate receptors in rat pancreatic islets.

    Tong, Qingchun / Ouedraogo, Raogo / Kirchgessner, Annette L

    American journal of physiology. Endocrinology and metabolism

    2002  Volume 282, Issue 6, Page(s) E1324–33

    Abstract: Pancreatic islets contain ionotropic glutamate receptors that can modulate hormone secretion. The purpose of this study was to determine whether islets express functional group III metabotropic glutamate (mGlu) receptors. RT-PCR analysis showed that rat ... ...

    Abstract Pancreatic islets contain ionotropic glutamate receptors that can modulate hormone secretion. The purpose of this study was to determine whether islets express functional group III metabotropic glutamate (mGlu) receptors. RT-PCR analysis showed that rat islets express the mGlu8 receptor subtype. mGlu8 receptor immunoreactivity was primarily displayed by glucagon-secreting alpha-cells and intrapancreatic neurons. By demonstrating the immunoreactivities of both glutamate and the vesicular glutamate transporter 2 (VGLUT2) in these cells, we established that alpha-cells express a glutamatergic phenotype. VGLUT2 was concentrated in the secretory granules of islet cells, suggesting that glutamate might play a role in the regulation of glucagon processing. The expression of mGlu8 by glutamatergic cells also suggests that mGlu8 may function as an autoreceptor to regulate glutamate release. Pancreatic group III mGlu receptors are functional because mGlu8 receptor agonists inhibited glucagon release and forskolin-induced accumulation of cAMP in isolated islets, and (R,S)-cyclopropyl-4-phosphonophenylglycine, a group III mGlu receptor antagonist, reduced these effects. Because excess glucagon secretion causes postprandial hyperglycemia in patients with type 2 diabetes, group III mGlu receptor agonists could be of value in the treatment of these patients.
    MeSH term(s) Animals ; Benzoates/pharmacology ; Cell Membrane/chemistry ; Colforsin/pharmacology ; Cyclic AMP/metabolism ; Cytoplasmic Granules/chemistry ; DNA Primers ; Excitatory Amino Acid Antagonists/pharmacology ; Female ; Gene Expression ; Glucagon/secretion ; Glutamic Acid/analysis ; Glycine/analogs & derivatives ; Glycine/pharmacology ; Islets of Langerhans/chemistry ; Islets of Langerhans/physiology ; Microscopy, Immunoelectron ; Rats ; Rats, Sprague-Dawley ; Receptors, Metabotropic Glutamate/analysis ; Receptors, Metabotropic Glutamate/genetics ; Receptors, Metabotropic Glutamate/physiology ; Reverse Transcriptase Polymerase Chain Reaction ; Synaptophysin/analysis ; Tissue Distribution
    Chemical Substances 3,4-dicarboxyphenylglycine ; Benzoates ; DNA Primers ; Excitatory Amino Acid Antagonists ; Receptors, Metabotropic Glutamate ; Synaptophysin ; metabotropic glutamate receptor 8 ; Colforsin (1F7A44V6OU) ; Glutamic Acid (3KX376GY7L) ; Glucagon (9007-92-5) ; Cyclic AMP (E0399OZS9N) ; Glycine (TE7660XO1C)
    Language English
    Publishing date 2002-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 603841-4
    ISSN 1522-1555 ; 0193-1849
    ISSN (online) 1522-1555
    ISSN 0193-1849
    DOI 10.1152/ajpendo.00460.2001
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: Stimulatory effect of endogenous orexin A on gastric emptying and acid secretion independent of gastrin.

    Ehrström, Marcus / Levin, Fredrik / Kirchgessner, Annette L / Schmidt, Peter T / Hilsted, Linda M / Grybäck, Per / Jacobsson, Hans / Hellström, Per M / Näslund, Erik

    Regulatory peptides

    2005  Volume 132, Issue 1-3, Page(s) 9–16

    Abstract: Orexin A (OXA) increases food intake and inhibits fasting small bowel motility in rats. The aim of this study was to examine the effect of exogenous OXA and endogenous OXA on gastric emptying, acid secretion, glucose metabolism and distribution of orexin ...

    Abstract Orexin A (OXA) increases food intake and inhibits fasting small bowel motility in rats. The aim of this study was to examine the effect of exogenous OXA and endogenous OXA on gastric emptying, acid secretion, glucose metabolism and distribution of orexin immunoreactivity in the stomach. Rats equipped with a gastric fistula were subjected to intravenous (IV) infusion of OXA or the selective orexin-1 receptor (OX1R) antagonist SB-334867-A during saline or pentagastrin infusion. Gastric emptying was studied with a liquid non-nutrient or nutrient, using 51Cr as radioactive marker. Gastric retention was measured after a 20-min infusion of OXA or SB-334867-A. Plasma concentrations of OXA, insulin, glucagon, glucose and gastrin were studied. Immunohistochemistry against OXA, OX1R and gastrin in gastric tissue was performed. OXA alone had no effect on either acid secretion or gastric emptying. SB-334867-A inhibited both basal and pentagastrin-induced gastric acid secretion and increased gastric retention of the liquid nutrient, but not PEG 4000. Plasma gastrin levels were unchanged by IV OXA or SB-334867-A. Plasma OXA levels decreased after intake of the nutrient meal and infusion of the OX1R antagonist. Only weak effects were seen on plasma glucose and insulin by OXA. Immunoreactivity to OXA and OX1R were found in the mucosa, myenteric cells bodies and varicose nerve fibers in ganglia and circular muscle of the stomach. In conclusion, endogenous OXA influences gastric emptying of a nutrient liquid and gastric acid secretion independent of gastrin. This indicates a role for endogenous OXA, not only in metabolic homeostasis, but also in the pre-absorptive processing of nutrients in the gut.
    MeSH term(s) Animals ; Blood Glucose/metabolism ; Gastric Acid/secretion ; Gastric Emptying/physiology ; Gastrins/blood ; Glucagon/blood ; Immunohistochemistry ; Insulin/blood ; Intracellular Signaling Peptides and Proteins/blood ; Intracellular Signaling Peptides and Proteins/pharmacology ; Intracellular Signaling Peptides and Proteins/physiology ; Male ; Neuropeptides/blood ; Neuropeptides/pharmacology ; Neuropeptides/physiology ; Nitric Oxide Synthase Type I/metabolism ; Orexins ; Rats ; Rats, Sprague-Dawley
    Chemical Substances Blood Glucose ; Gastrins ; Insulin ; Intracellular Signaling Peptides and Proteins ; Neuropeptides ; Orexins ; Glucagon (9007-92-5) ; Nitric Oxide Synthase Type I (EC 1.14.13.39)
    Language English
    Publishing date 2005-12-15
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 225685-x
    ISSN 1873-1686 ; 0167-0115
    ISSN (online) 1873-1686
    ISSN 0167-0115
    DOI 10.1016/j.regpep.2005.07.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1593: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Impairments in Analgesic, Hypothermic, and Glucoprivic Stress Responses following Neonatal Monosodium Glutamate

    Badillo-Martinez, Diana / Nicotera, Nora / Butler, Pamela D. / Kirchgessner, Annette L. / Bodnar, Richard J.

    Neuroendocrinology - International Journal for Basic and Clinical Studies on Neuroendocrine Relationships

    1984  Volume 38, Issue 6, Page(s) 438–446

    Abstract: Neonatal administration of monosodium glutamate (MSG) produces in rats neurotoxic degeneration of the circumventricular system, including the medial-basal hypothalamus, depleting several neuropeptides and neurotransmitters in this area. In addition, a ... ...

    Abstract Neonatal administration of monosodium glutamate (MSG) produces in rats neurotoxic degeneration of the circumventricular system, including the medial-basal hypothalamus, depleting several neuropeptides and neurotransmitters in this area. In addition, a number of behavioral and neuroendocrine responses are impaired, including a significant decrease in the analgesic response to cold-water swims (CWS). The present study examined whether the alterations in the analgesic responses following CWS and 2-deoxy-D-glucose (2-DG) induced by neonatal MSG treatment were due either to direct alterations in a pain-inhibitory system, or alternatively, to alterations in a system that processes the stressful consequences or properties of a stimulus. To accomplish this, the analgesic, hypothermic, and locomotor responses following CWS and the analgesic, hyperphagic, and locomotor responses following 2-DG were assessed in rats treated neonatally (days 2, 4, 6, 8, and 10) with either MSG or a vehicle solution. MSG-treated rats displayed significant reductions in both their analgesic and hypothermic responses following CWS, suggesting that MSG treatment impairs an animal’s ability to process sufficiently the stimulus properties of the swim as stressful. While MSG treatment potentiated 2-DG analgesia, it reduced 2-DG hyperphagia, suggesting that MSG treatment also impairs coping responses to glucoprivation. These data indicate the importance of the circumventricular system in the coding of stimuli as potential stressors and in the subsequent activation of requisite systems necessary to provide a sustained, coordinated, and synchronous coping response.
    Keywords Monosodium glutamate ; Pain ; Stress ; Analgesia ; Hypothermia ; Glucoprivation ; Coping responses
    Language English
    Publisher S. Karger AG
    Publishing place Basel
    Publishing country Switzerland
    Document type Article ; Online
    ZDB-ID 123303-8
    ISSN 1423-0194 ; 0028-3835 ; 0028-3835
    ISSN (online) 1423-0194
    ISSN 0028-3835
    DOI 10.1159/000123932
    Database Karger publisher's database

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 531: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top