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  1. Article ; Online: Organisation d’un service de radiothérapie pendant l’épidémie de COVID-19 : expérience du centre hospitalier de Mulhouse.

    Ohnleiter, T / Piot, L / Rogenmuser, A / Noirclerc, M / Hamlaoui, R / Grandgirard, A

    Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique

    2020  Volume 24, Issue 3, Page(s) 188–193

    Abstract: The COVID-19 outbreak grows exponentially in our country. Despite most of patients develops benign symptoms, cancer patients are at risk of a severe form of the disease. Radiotherapy centres are a potential contamination place due to the number of ... ...

    Title translation Management of a radiotherapy center during the COVID-19 outbreak: The experience of the Mulhouse hospital centre (France).
    Abstract The COVID-19 outbreak grows exponentially in our country. Despite most of patients develops benign symptoms, cancer patients are at risk of a severe form of the disease. Radiotherapy centres are a potential contamination place due to the number of patients treated and staff present. Their organization during the outbreak period aims to ensure continuity of care while limiting the risk of death from COVID-19. In the radiotherapy department of Mulhouse hospital (France), we pointed five points out: protection of medical and paramedical staff, protection of patients undergoing treatment, detection of patients suspected of being infected by SARS-CoV-2 and their management, reorganization of the patient circuit and measures regarding the quality management. This reflection, which began at the beginning of the outbreak in our city, allows us to preserve the access to radiotherapy treatments by anticipating the risk of spreading the virus. Through biweekly meetings, we continue to adapt to the epidemic in our department, considering our material resources. The ability to perform diagnostic tests in all suspect patients would also allow us to refine our procedures.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Cancer Care Facilities/organization & administration ; Clinical Protocols ; Continuity of Patient Care/organization & administration ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; France/epidemiology ; Health Services Accessibility/organization & administration ; Humans ; Neoplasms/radiotherapy ; Occupational Diseases/prevention & control ; Pandemics/prevention & control ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Quality of Health Care/organization & administration ; SARS-CoV-2
    Keywords covid19
    Language French
    Publishing date 2020-04-17
    Publishing country France
    Document type Journal Article
    ZDB-ID 1397169-4
    ISSN 1769-6658 ; 1278-3218
    ISSN (online) 1769-6658
    ISSN 1278-3218
    DOI 10.1016/j.canrad.2020.04.002
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  2. Article ; Online: Organisation d’un service de radiothérapie pendant l’épidémie de COVID-19

    Ohnleiter, T. / Piot, L. / Rogenmuser, A. / Noirclerc, M. / Hamlaoui, R. / Grandgirard, A.

    Cancer/Radiothérapie

    expérience du centre hospitalier de Mulhouse

    2020  Volume 24, Issue 3, Page(s) 188–193

    Keywords Oncology ; Radiology Nuclear Medicine and imaging ; covid19
    Language French
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1397169-4
    ISSN 1278-3218
    ISSN 1278-3218
    DOI 10.1016/j.canrad.2020.04.002
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: [Management of a radiotherapy center during the COVID-19 outbreak: The experience of the Mulhouse hospital centre (France)]

    Ohnleiter, T. / Piot, L. / Rogenmuser, A. / Noirclerc, M. / Hamlaoui, R. / Grandgirard, A.

    Cancer Radiother

    Abstract: The COVID-19 outbreak grows exponentially in our country Despite most of patients develops benign symptoms, cancer patients are at risk of a severe form of the disease Radiotherapy centres are a potential contamination place due to the number of patients ...

    Abstract The COVID-19 outbreak grows exponentially in our country Despite most of patients develops benign symptoms, cancer patients are at risk of a severe form of the disease Radiotherapy centres are a potential contamination place due to the number of patients treated and staff present Their organization during the outbreak period aims to ensure continuity of care while limiting the risk of death from COVID-19 In the radiotherapy department of Mulhouse hospital (France), we pointed five points out: protection of medical and paramedical staff, protection of patients undergoing treatment, detection of patients suspected of being infected by SARS-CoV-2 and their management, reorganization of the patient circuit and measures regarding the quality management This reflection, which began at the beginning of the outbreak in our city, allows us to preserve the access to radiotherapy treatments by anticipating the risk of spreading the virus Through biweekly meetings, we continue to adapt to the epidemic in our department, considering our material resources The ability to perform diagnostic tests in all suspect patients would also allow us to refine our procedures
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #128694
    Database COVID19

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  4. Article: Organisation d'un service de radiothérapie pendant l'épidémie de COVID-19 : expérience du centre hospitalier de Mulhouse./ [Management of a radiotherapy center during the COVID-19 outbreak: The experience of the Mulhouse hospital centre (France)]

    Ohnleiter, T / Piot, L / Rogenmuser, A / Noirclerc, M / Hamlaoui, R / Grandgirard, A

    Cancer Radiother

    Abstract: The COVID-19 outbreak grows exponentially in our country. Despite most of patients develops benign symptoms, cancer patients are at risk of a severe form of the disease. Radiotherapy centres are a potential contamination place due to the number of ... ...

    Abstract The COVID-19 outbreak grows exponentially in our country. Despite most of patients develops benign symptoms, cancer patients are at risk of a severe form of the disease. Radiotherapy centres are a potential contamination place due to the number of patients treated and staff present. Their organization during the outbreak period aims to ensure continuity of care while limiting the risk of death from COVID-19. In the radiotherapy department of Mulhouse hospital (France), we pointed five points out: protection of medical and paramedical staff, protection of patients undergoing treatment, detection of patients suspected of being infected by SARS-CoV-2 and their management, reorganization of the patient circuit and measures regarding the quality management. This reflection, which began at the beginning of the outbreak in our city, allows us to preserve the access to radiotherapy treatments by anticipating the risk of spreading the virus. Through biweekly meetings, we continue to adapt to the epidemic in our department, considering our material resources. The ability to perform diagnostic tests in all suspect patients would also allow us to refine our procedures.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32334905
    Database COVID19

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  5. Article ; Online: Facteurs pronostiques de la ré-irradiation des cancers des voies aérodigestives supérieures : revue de la littérature.

    Ohnleiter, T / Truntzer, P / Antoni, D / Guihard, S / Elgard, A-M / Noël, G

    Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique

    2017  Volume 21, Issue 4, Page(s) 316–338

    Abstract: Purpose: To specify the effectiveness of head and neck cancer reirradiation and make a synthesis of prognostic factors established by published series of patients.: Materials and methods: Original series of external reirradiation of head and neck ... ...

    Title translation Prognostic factors for head and neck cancer reirradiation: A systematic review.
    Abstract Purpose: To specify the effectiveness of head and neck cancer reirradiation and make a synthesis of prognostic factors established by published series of patients.
    Materials and methods: Original series of external reirradiation of head and neck cancer with at least ten patients were sought in Medline database.
    Results: Exclusive reirradiation with or without concurrent chemotherapy offers 11 months of median overall survival, versus 6 months for chemotherapy alone, and 20 to 40% of the patients are still alive two years after treatment. Postoperative reirradiation allows 3 years overall survival from 40 to 60%. However, side effects of grade 3 or more arise in more than half of patients. Patient-related good prognostic factors are male, young age, good performance status without comorbidities. Those related to the disease are low rT and rN stage, poor differentiation, other than squamous cell carcinomas and a nasopharyngeal, oropharyngeal or laryngeal location. Concerning the treatment, surgical resection, a dose higher than 50 to 60Gy in a smaller-irradiated volume, an interval between the two treatments of more than 2 years and the use of an innovating technology are the most commonly highlighted prognostic factors. Concurrent chemotherapy is often associated with higher toxicity rates, without improving overall survival, unless using cisplatin for selected patients.
    Conclusions: Head and neck cancer reirradiation achieves long-term survival outcomes. However, regarding to its associated side effects, patients need to be carefully selected based on prognostic factors.
    MeSH term(s) Combined Modality Therapy ; Head and Neck Neoplasms/radiotherapy ; Head and Neck Neoplasms/therapy ; Humans ; Prognosis ; Re-Irradiation
    Language French
    Publishing date 2017-06
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 1397169-4
    ISSN 1769-6658 ; 1278-3218
    ISSN (online) 1769-6658
    ISSN 1278-3218
    DOI 10.1016/j.canrad.2017.02.004
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  6. Article ; Online: Organisation d’un service de radiothérapie pendant l’épidémie de COVID-19 : expérience du centre hospitalier de Mulhouse

    Ohnleiter, Thomas / Piot, Luc / Rogenmuser, Agathe / Noirclerc, Monique / Hamlaoui, Rabah / Grandgirard, Alain

    Cancer/Radiothérapie

    Abstract: Résumé L’épidémie de COVID-19 continue de croître de manière exponentielle dans notre pays. Si la majorité des formes sont bénignes, les patients atteints de cancer sont à risque de voir se développer une forme grave de la maladie. Les services de ... ...

    Abstract Résumé L’épidémie de COVID-19 continue de croître de manière exponentielle dans notre pays. Si la majorité des formes sont bénignes, les patients atteints de cancer sont à risque de voir se développer une forme grave de la maladie. Les services de radiothérapie sont un lieu à potentiel de contamination en raison du nombre de patients traités et de personnels présent. Leur organisation pendant la période épidémique vise à assurer la continuité des soins tout en limitant le risque de décès dû à une contamination par le SARS-CoV-2 (virus responsable de la COVID-19). Dans le service de radiothérapie du groupe hospitalier de la région de Mulhouse et Sud-Alsace, cette organisation s’articule en cinq points : la protection des personnels médicaux et paramédicaux, la protection des patients en cours de traitement, la détection des patients suspects d’être atteints de COVID-19 et leur prise en charge, la réorganisation du circuit patient et les mesures concernant l’organisation du système qualité du service. Nos pistes de réflexion, débutée dès le début de l’épidémie dans notre département, nous permettent de préserver au maximum l’accès aux soins radiothérapiques en anticipant le risque de diffusion du virus. Grâce à des réunions bihebdomadaires, nous continuons à nous adapter à l’évolution épidémique dans notre service, en tenant compte de nos moyens matériels. La possibilité de réaliser des tests de diagnostic chez tous les patients suspects nous permettrait également d’affiner nos procédures. Summary The COVID-19 outbreak grows exponentially in our country. Despite most of patients develops benign symptoms, cancer patients are at risk of a severe form of the disease. Radiotherapy centres are a potential contamination place due to the number of patients treated and staff present. Their organization during the outbreak period aims to ensure continuity of care while limiting the risk of death from COVID-19. In the radiotherapy department of Mulhouse hospital (France), we pointed five points out: protection of medical and paramedical staff, protection of patients undergoing treatment, detection of patients suspected of being infected by SARS-CoV-2 and their management, reorganization of the patient circuit and measures regarding the quality management. This reflection, which began at the beginning of the outbreak in our city, allows us to preserve the access to radiotherapy treatments by anticipating the risk of spreading the virus. Through biweekly meetings, we continue to adapt to the epidemic in our department, considering our material resources. The ability to perform diagnostic tests in all suspect patients would also allow us to refine our procedures.
    Keywords covid19
    Publisher Elsevier
    Document type Article ; Online
    DOI 10.1016/j.canrad.2020.04.002
    Database COVID19

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  7. Article ; Online: Factors improving the outcome of patients re-irradiated with intensity-modulated radiotherapy (IMRT) for relapse or new head and neck cancer developed in irradiated areas.

    Ohnleiter, Thomas / Antoni, Delphine / Lefebvre, François / Truntzer, Pierre / Schultz, Philippe / Burgy, Mickael / Borel, Christian / Noël, Georges

    Chinese clinical oncology

    2018  Volume 7, Issue 6, Page(s) 60

    Abstract: Background: Patients with secondary/recurrent squamous cell head and neck cancer have poor prognoses. Re-irradiation is a treatment option. However, best technique to re-irradiate is not known. This study aims to evaluate the outcome of patients treated ...

    Abstract Background: Patients with secondary/recurrent squamous cell head and neck cancer have poor prognoses. Re-irradiation is a treatment option. However, best technique to re-irradiate is not known. This study aims to evaluate the outcome of patients treated with curative-intent intensity-modulated radiotherapy (IMRT) re-irradiation (re-RT) for head and neck (H&N) cancers.
    Methods: Fifty patients with recurrent H&N cancers underwent fractionated IMRT re-RT. The median time between the two courses of radiotherapy was 22 months. The median dose of re-RT was 66 Gy.
    Results: The median follow-up of surviving patients was 13.6 months. The median overall survival (OS) was 15.7 months, and the 1- and 2-year OS rates were 62.4% and 33.9%, respectively. On multivariate analysis, performance status (PS) 0-1 (HR, 0.518; 95% CI: 0.292-0.917; P=0.024) and 3D-RT use during the first irradiation course technique (HR, 0.415; 95% CI: 0.183-0.938; P=0.035) were favorable, independent of significant prognostic factors of OS. The median loco-regional progression-free survival (LRPFS) was 8.3 months, and, the 1- and 2-year LRPFS rates were 46.6% and 35.9%, respectively. On multivariate analysis, a surgical resection before re-RT (HR, 0.107; 95% CI: 0.027-0.428; P=0.002), a higher age (HR, 0.894; 95% CI: 0.833-0.960; P=0.002), a PS 0-1 (HR, 0.316; 95% CI: 0.140-0.715; P=0.006), and a long re-RT interval (HR, 0.970; 95% CI: 0.945-0.996; P=0.024) were favorable independent significant prognostic factors of LRPFS. The median progression-free survival (PFS) was 7.0 months and, the 1- and 2-year PFS rates were 45.0% and 30.4%, respectively. On multivariate analysis, a surgical resection before re-RT (HR, 0.129; 95% CI: 0.036-0.466; P=0.002), a PS 0-1 (HR, 0.399; 95% CI: 0.208-0.764; P=0.006) and, a long re-RT interval (HR, 0.958; 95% CI: 0.927-0.989; P=0.009) were favorable, independent significant prognostic factors. The early and late toxicities rates were 28% and 34%, respectively.
    Conclusions: Re-RT for H&N cancers can be curative, and the complications can be manageable but patients need to be strictly selected. Surgery before re-RT could improve the patient outcome. Dose and irradiation schedules should be prospectively evaluated.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Female ; Head and Neck Neoplasms/mortality ; Head and Neck Neoplasms/pathology ; Head and Neck Neoplasms/radiotherapy ; Humans ; Male ; Middle Aged ; Radiotherapy, Intensity-Modulated/methods ; Re-Irradiation/methods ; Recurrence ; Retrospective Studies ; Survival Analysis ; Treatment Outcome
    Language English
    Publishing date 2018-06-27
    Publishing country China
    Document type Journal Article
    ZDB-ID 2828547-5
    ISSN 2304-3873 ; 2304-3865
    ISSN (online) 2304-3873
    ISSN 2304-3865
    DOI 10.21037/cco.2018.06.07
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  8. Article ; Online: [Frameless set-up with ExacTrac

    Ohnleiter, T / Mahé, M-A / Biau, J / Wdowczyk, D / Clavier, J-B / Antoni, D / Noël, G

    Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique

    2016  Volume 20, Issue 8, Page(s) 768–775

    Abstract: Purpose: This study aimed to analyse the positioning protocols with the ExacTrac: Materials and methods: A survey, including three questions about the prescription of irradiation and twenty-one questions about how the ExacTrac: Results: All ... ...

    Title translation Repositionnement par le système ExacTrac
    Abstract Purpose: This study aimed to analyse the positioning protocols with the ExacTrac
    Materials and methods: A survey, including three questions about the prescription of irradiation and twenty-one questions about how the ExacTrac
    Results: All centres checked the positioning before each treatment's bow, with residual mismatch tolerances of 0.5 to 0.7mm for the translations and 0.5 to 1° for the rotations. All centres except one also realised orthogonal planar images of classic incidences to help operators ensure proper isocentre positioning. Prescribed doses were 20Gy in one fraction, 30Gy and 33Gy in three fractions or 34Gy in four fractions, mainly depending on the size of the lesion. Finally, a physician validated the images at the treatment station before starting the irradiation.
    Conclusions: The practices of the different centres concerning the positioning protocols were rather homogeneous, in agreement with the literature data on ExacTrac
    MeSH term(s) Brain Neoplasms/radiotherapy ; Brain Neoplasms/secondary ; Cranial Irradiation/instrumentation ; France ; Health Care Surveys ; Humans ; Neuronavigation/instrumentation ; Particle Accelerators ; Patient Positioning ; Radiosurgery/instrumentation ; Radiosurgery/methods ; Radiotherapy Planning, Computer-Assisted/methods ; Surveys and Questionnaires
    Language French
    Publishing date 2016-12
    Publishing country France
    Document type Journal Article ; Multicenter Study
    ZDB-ID 1397169-4
    ISSN 1769-6658 ; 1278-3218
    ISSN (online) 1769-6658
    ISSN 1278-3218
    DOI 10.1016/j.canrad.2016.04.007
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