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Article ; Online: Renal replacement therapy in the ICU: continued controversy despite recent advances.

Rimmelé, Thomas

2018 Volume 24, Issue 6, Page(s) 435–436

MeSH term(s)	Acute Kidney Injury/therapy ; Biomedical Research ; Humans ; Intensive Care Units/statistics & numerical data ; Patient Outcome Assessment ; Renal Dialysis/methods ; Renal Dialysis/statistics & numerical data ; Renal Replacement Therapy/statistics & numerical data ; Renal Replacement Therapy/trends
Language	English
Publishing date	2018-12-14
Publishing country	United States
Document type	Editorial
ZDB-ID	1235629-3
ISSN	1531-7072 ; 1070-5295
ISSN (online)	1531-7072
ISSN	1070-5295
DOI	10.1097/MCC.0000000000000565
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Article ; Online: Enhancing perioperative care through decontextualized simulation: A game-changer for non-technical skills training.

Abraham, Paul / Dubois, Nadège / Rimmelé, Thomas / Lilot, Marc / Balança, Baptiste

Journal of clinical anesthesia

2024 Volume 94, Page(s) 111428

MeSH term(s)	Humans ; Leadership ; Interprofessional Relations ; Perioperative Care ; Patient Care Team ; Simulation Training ; Clinical Competence ; Communication
Language	English
Publishing date	2024-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1011618-7
ISSN	1873-4529 ; 0952-8180
ISSN (online)	1873-4529
ISSN	0952-8180
DOI	10.1016/j.jclinane.2024.111428
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Zs.A 2622: Show issues

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Article ; Online: Hemoperfusion: Indications, Dose, Prescription.

Bidar, Frank / Abrard, Stanislas / Lamblin, Antoine / Rimmelé, Thomas

Contributions to nephrology

2023 Volume 200, Page(s) 88–97

Abstract: Recent advances in the development of sorbent materials have enabled the development of hemoperfusion (HP). However, HP dose and prescription are not standardized and there is no consensus in clinical practice guidelines. Adequate prescription and ... ...

Abstract	Recent advances in the development of sorbent materials have enabled the development of hemoperfusion (HP). However, HP dose and prescription are not standardized and there is no consensus in clinical practice guidelines. Adequate prescription and modality are of utmost importance to ensure HP effectiveness. Although the main indication of CytoSorb®, HA330/380, polymyxin B, and Seraph® is sepsis, these devices may be beneficial in many other situations such as liver failure, rhabdomyolysis, pancreatitis, cardiopulmonary bypass, extensive burns, and trauma or to ensure antiplatelet therapy drug removal. They can be applied as stand-alone therapies or combined with renal replacement therapy. The usual prescribed blood flow varies between 100 and 700 mL/min. CytoSorb® sessions usually last 24 h and may be repeated up to 7 days, whereas HA330/380, polymyxin B, and Seraph® sessions usually last between 2 and 4 h and are repeated up to 3 days. Current clinical data are lacking to establish the optimal operating conditions of HP and studies focusing on defining the optimal timing, dose, and duration of these therapies could help define future clinical applications.
MeSH term(s)	Humans ; Polymyxin B/therapeutic use ; Hemoperfusion ; Sepsis/therapy ; Hemodynamics ; Rhabdomyolysis
Chemical Substances	Polymyxin B (J2VZ07J96K)
Language	English
Publishing date	2023-06-01
Publishing country	Switzerland
Document type	Journal Article ; Review
ISSN	1662-2782 ; 0302-5144
ISSN (online)	1662-2782
ISSN	0302-5144
DOI	10.1159/000529294
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Article ; Online: Hemoperfusion in Burns.

Abraham, Paul / Monard, Céline / Lamblin, Antoine / Schneider, Antoine / Rimmelé, Thomas

Contributions to nephrology

2023 Volume 200, Page(s) 160–168

Abstract: Patients with severe thermal injury require urgent specialized care in burn units. These units assure good coordination of a bundle of care including fluid resuscitation, nutritional support, respiratory care, surgical care and wound care, infection ... ...

Abstract	Patients with severe thermal injury require urgent specialized care in burn units. These units assure good coordination of a bundle of care including fluid resuscitation, nutritional support, respiratory care, surgical care and wound care, infection prevention, and rehabilitation. When severely injured, burn patients present a systemic inflammatory response syndrome, associated with a dysregulated immune homeostasis. This complex host response exposes patients to prolonged hospitalization with suppressed immune function, increased susceptibility to secondary infections, longer organ support, and increased mortality. To date, several strategies, such as hemoperfusion techniques, have been developed to mitigate immune activation. We propose herein a review of the immune response to burn injury and the rationale and potential applications of extracorporeal blood purification techniques such as hemoperfusion for burn patients' management.
MeSH term(s)	Humans ; Resuscitation/methods ; Hemoperfusion ; Fluid Therapy
Language	English
Publishing date	2023-06-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ISSN	1662-2782 ; 0302-5144
ISSN (online)	1662-2782
ISSN	0302-5144
DOI	10.1159/000527709
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Article ; Online: Extracorporeal Blood Purification in Burns: For Whom, Why, and How?

Abraham, Paul / Monard, Céline / Schneider, Antoine / Rimmelé, Thomas

Blood purification

2022 Volume 52, Issue 1, Page(s) 17–24

Abstract: Patients with serious thermal burn injuries require immediate and specialized care in order to minimize morbidity and mortality. Optimal fluid resuscitation, nutritional support, pulmonary care, burn wound care, and infection control practices represent ... ...

Abstract	Patients with serious thermal burn injuries require immediate and specialized care in order to minimize morbidity and mortality. Optimal fluid resuscitation, nutritional support, pulmonary care, burn wound care, and infection control practices represent key aspects of patient care in burn centers. When severely burned, the patient usually presents a systemic inflammatory response syndrome, soon balanced by a counter anti-inflammatory response syndrome. These may lead to immune dysregulation/exhaustion favoring infectious complications that dramatically impair the prognosis of burn patients. This narrative review provides an overview of the main concepts, current understanding, and potential applications of extracorporeal blood purification techniques for burn patient management. Current understanding of burn patients' immune responses is reported. Hypotheses and data on the potential value of immunoregulation are reviewed. Finally, how extracorporeal blood purification may be of interest in this specific population is discussed.
MeSH term(s)	Humans ; Fluid Therapy ; Burns/immunology ; Burns/therapy ; Extracorporeal Circulation
Language	English
Publishing date	2022-06-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	605548-5
ISSN	1421-9735 ; 0253-5068
ISSN (online)	1421-9735
ISSN	0253-5068
DOI	10.1159/000525085
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Article ; Online: New Targets for Extracorporeal Blood Purification Therapies in Sepsis.

Monard, Céline / Abraham, Paul / Schneider, Antoine / Rimmelé, Thomas

Blood purification

2022 Volume 52, Issue 1, Page(s) 1–7

Abstract: As highlighted by the last international consensus definition for sepsis and septic shock (sepsis-3), sepsis comes from a complex relationship between a pathogen and a dysregulated host response. To date, the treatment of sepsis is based on antimicrobial ...

Abstract	As highlighted by the last international consensus definition for sepsis and septic shock (sepsis-3), sepsis comes from a complex relationship between a pathogen and a dysregulated host response. To date, the treatment of sepsis is based on antimicrobial treatment, source control, and organ support. Extracorporeal blood purification therapies have been proposed as adjuvant therapies to modulate the dysregulated inflammatory response. These therapies aim mostly at removing inflammatory mediators (cytokines) and endotoxins from the blood. However, so far, they failed to clearly demonstrate an improvement in patient survival when evaluated in randomized trials. Recently, new devices directly targeting the primary determinants of sepsis, e.g., the pathogen itself and the host immune cells, have been developed. This short review aimed at presenting new blood purification devices that have recently been developed to target pathogens and immune cells. For each, we will present the mechanism of action of the therapy and discuss the related literature.
MeSH term(s)	Humans ; Hemofiltration ; Sepsis/therapy ; Shock, Septic/therapy ; Cytokines ; Inflammation Mediators
Chemical Substances	Cytokines ; Inflammation Mediators
Language	English
Publishing date	2022-06-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	605548-5
ISSN	1421-9735 ; 0253-5068
ISSN (online)	1421-9735
ISSN	0253-5068
DOI	10.1159/000524973
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Article ; Online: Total-to-ionized calcium ratio, taken alone, is no longer valid to diagnose citrate accumulation! What additional parameters should we consider to strengthen the utility of this ratio?

Honore, Patrick M / Rimmelé, Thomas

Journal of critical care

2020 Volume 59, Page(s) 172–175

MeSH term(s)	Anticoagulants ; Calcium ; Citrates ; Citric Acid ; Humans ; Retrospective Studies
Chemical Substances	Anticoagulants ; Citrates ; Citric Acid (2968PHW8QP) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2020-07-04
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	632818-0
ISSN	1557-8615 ; 0883-9441
ISSN (online)	1557-8615
ISSN	0883-9441
DOI	10.1016/j.jcrc.2020.06.009
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Zs.A 2152: Show issues

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Article: Preoperative endothelial dysfunction for the prediction of acute kidney injury after cardiac surgery using cardiopulmonary bypass: a pilot study based on a second analysis of the MONS study.

Abrard, Stanislas / Streichenberger, Antoine / Riou, Jérémie / Hersant, Jeanne / Rineau, Emmanuel / Jacquet-Lagrèze, Matthias / Fouquet, Olivier / Henni, Samir / Rimmelé, Thomas

Perioperative medicine (London, England)

2024 Volume 13, Issue 1, Page(s) 12

Abstract: Background: Up to 42% of patients develop acute kidney injury (AKI) after cardiac surgery. The aim of this study was to describe the relationship between preoperative microcirculatory function and postoperative AKI after cardiac surgery using ... ...

Abstract	Background: Up to 42% of patients develop acute kidney injury (AKI) after cardiac surgery. The aim of this study was to describe the relationship between preoperative microcirculatory function and postoperative AKI after cardiac surgery using cardiopulmonary bypass (CPB). Methods: The prospective observational cohort MONS enrolled 60 patients scheduled for valvular (n = 30, 50%) or coronary (n = 30, 50%) surgery using CPB. Preoperative microcirculation was assessed during preoperative consultation from January 2019 to April 2019 at the University Hospital of Angers, France, using endothelium-dependent and endothelium-independent reactivity tests on the forearm (iontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP), respectively). Skin blood flow was measured by laser speckle contrast imaging. The primary endpoint was the occurrence of AKI according to the KDIGO classification during the hospital stay. Results: Forty-three (71.7%) patients developed AKI during the in-hospital follow-up, and 15 (25%) were classified as KDIGO stage 1, 20 (33%) KDIGO stage 2, and 8 (13%) KDIGO stage 3. Regarding preoperative microcirculation, a higher peak amplitude of vasodilation in response to iontophoresis of ACh was found in patients with postoperative occurrence of AKI (35 [20-49] vs 23 [9-44] LSPU, p = 0.04). Iontophoresis of SNP was not significantly different according to AKI occurrence (34 [22-49] vs 36 [20-50] LSPU, p = 0.95). In a multivariable model, the preoperative peak amplitude at iontophoresis of ACh was independently associated with postoperative AKI (OR 1.045 [1.001-1.092], p = 0.045). Conclusions: The preoperative peak amplitude of endothelium-dependent vasodilation is independently associated with the postoperative occurrence of AKI. Trial registration: Clinical-Trials.gov, NCT03631797. Registered 15 August 2018, https://clinicaltrials.gov/ct2/show/NCT03631797.
Language	English
Publishing date	2024-02-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2683800-X
ISSN	2047-0525
ISSN	2047-0525
DOI	10.1186/s13741-024-00364-0
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Article ; Online: A new standardized tool for quantification of closed-loop communication in trauma care: CAST Grid reliability study.

Schwindenhammer, Victor / Rimmelé, Thomas / Duclos, Antoine / Haesebaert, Julie / Lilot, Marc / Abraham, Paul

Injury

2023 Volume 54, Issue 9, Page(s) 110851

Abstract: Backround: The CAST Grid has been developed to evaluate the use of closed-loop communication (CLC) in the trauma bay.: Methods: The CAST Grid and two validated non-technical team performance assessment tools (the TEAM and T-NOTECHS grids) were ... ...

Abstract	Backround: The CAST Grid has been developed to evaluate the use of closed-loop communication (CLC) in the trauma bay. Methods: The CAST Grid and two validated non-technical team performance assessment tools (the TEAM and T-NOTECHS grids) were completed by 2 independent reviewers based on trauma care simulation videos from a French Level 1 trauma center. Intra- and inter-rater agreements were evaluated for CLC parameters and non-technical performance, and correlations between these parameters were analyzed. Results: The study analyzed 11 videos. The intra- and inter-rater agreement for the number of CLC per minute (CLC/min) was moderate and good, respectively, based on Lin's concordance correlation coefficient [95%CI] (0.57 [-0.40;0.94] and 0.77 [0.33;0.94]). However, the agreement was poor for the percentage of CLC (0.37 [-0.58;0.89] and -0.36 [-0.71;0.14], respectively). The study found that a lower number of CLC/min was correlated with an increased duration of the simulation (r = -0.75 [-0.93; -0.25]). Conclusion: The CAST Grid showed a relatively good inter-rater agreement to quantify the number of CLC/min which was inversely correlated with the duration of care. This tool opens up the possibility of quantifying CLC and allows for new analyses of team functioning and interactions.
MeSH term(s)	Humans ; Teach-Back Communication ; Reproducibility of Results ; Patient Care Team ; Trauma Centers ; Videotape Recording ; Clinical Competence
Language	English
Publishing date	2023-06-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	218778-4
ISSN	1879-0267 ; 0020-1383
ISSN (online)	1879-0267
ISSN	0020-1383
DOI	10.1016/j.injury.2023.110851
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Zs.A 778: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Economic burden of in-hospital AKI: a one-year analysis of the nationwide French hospital discharge database.

Monard, Céline / Rimmelé, Thomas / Blanc, Esther / Goguillot, Mélanie / Bénard, Stève / Textoris, Julien

BMC nephrology

2023 Volume 24, Issue 1, Page(s) 343

Abstract: Background: Although Acute Kidney Injury (AKI) incidence is increasing worldwide, data investigating its cost are lacking. This population-wide study aimed to describe the characteristics and costs of hospital stays with, and without AKI, and to ... ...

Abstract	Background: Although Acute Kidney Injury (AKI) incidence is increasing worldwide, data investigating its cost are lacking. This population-wide study aimed to describe the characteristics and costs of hospital stays with, and without AKI, and to estimate the AKI-associated increases in costs and length of stay (LOS) in three subgroups (major open visceral surgery (MOV), cardiovascular surgery with extracorporeal circulation (CVEC), and sepsis). Methods: All hospital stays that occurred in France in 2018 were included. Stay and patient characteristics were collected in the French hospital discharge database and described. Medical conditions were identified using the 10 Results: 26,917,832 hospital stays, of which 415,067 (1.5%) with AKI, were included. AKI was associated with 83,553 (19.8%), 7,165 (17.9%), and 15,387 (9.2%) of the stays with sepsis, CVEC, and MOV, respectively. Compared to stays without AKI, stays with AKI were more expensive (median [IQR] €4,719[€2,963-€7782] vs. €735[€383-€1,805]) and longer (median [IQR] 9[4-16] vs. 0[0-2] days). AKI was associated with a mean [95%CI] increase in hospitalization cost of 70% [69;72], 48% [45;50], and 68% [65;70] in the sepsis, CVEC, and MOV groups respectively, after adjustment. Conclusion: This study confirms the major economic burden of in-hospital AKI in a developed country. Interventions to prevent AKI are urgently needed and their cost should be balanced with AKI-related costs.
MeSH term(s)	Humans ; Patient Discharge ; Financial Stress ; Length of Stay ; Hospitals ; Acute Kidney Injury/epidemiology ; Sepsis/epidemiology ; Retrospective Studies
Language	English
Publishing date	2023-11-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041348-8
ISSN	1471-2369 ; 1471-2369
ISSN (online)	1471-2369
ISSN	1471-2369
DOI	10.1186/s12882-023-03396-8
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