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  1. Article ; Online: Generation and use of renal cells for replacement therapies.

    Hammerman, Marc R

    Current opinion in organ transplantation

    2015  Volume 20, Issue 2, Page(s) 159

    MeSH term(s) Cell Transplantation ; Humans ; Kidney/cytology ; Periodicals as Topic ; Renal Replacement Therapy
    Language English
    Publishing date 2015-04
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1390429-2
    ISSN 1531-7013 ; 1087-2418
    ISSN (online) 1531-7013
    ISSN 1087-2418
    DOI 10.1097/MOT.0000000000000178
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5609: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Underpinnings of cellular organ replacement therapies.

    Hammerman, Marc R

    Current opinion in organ transplantation

    2014  Volume 19, Issue 2, Page(s) 131–132

    MeSH term(s) Bioartificial Organs ; Cell- and Tissue-Based Therapy/methods ; Cell- and Tissue-Based Therapy/trends ; Humans ; Organ Culture Techniques/methods ; Organogenesis/physiology ; Tissue Engineering/methods ; Tissue Scaffolds
    Language English
    Publishing date 2014-02-19
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1390429-2
    ISSN 1531-7013 ; 1087-2418
    ISSN (online) 1531-7013
    ISSN 1087-2418
    DOI 10.1097/MOT.0000000000000056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5609: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Classic and current opinion in embryonic organ transplantation.

    Hammerman, Marc R

    Current opinion in organ transplantation

    2014  Volume 19, Issue 2, Page(s) 133–139

    Abstract: Purpose of review: Here, we review the rationale for the use of organs from embryonic donors, antecedent investigations and recent work from our own laboratory, exploring the utility for transplantation of embryonic kidney and pancreas as an organ ... ...

    Abstract Purpose of review: Here, we review the rationale for the use of organs from embryonic donors, antecedent investigations and recent work from our own laboratory, exploring the utility for transplantation of embryonic kidney and pancreas as an organ replacement therapy.
    Recent findings: Ultrastructurally precise kidneys differentiate in situ in rats following xenotransplantation in mesentery of embryonic pig renal primordia. The developing organ attracts its blood supply from the host. Engraftment of pig renal primordia requires host immune suppression. However, beta cells originating from embryonic pig pancreas obtained very early following initiation of organogenesis [embryonic day 28 (E28)] engraft long term in nonimmune-suppressed diabetic rats or rhesus macaques. Engraftment of morphologically similar cells originating from adult porcine islets of Langerhans occurs in animals previously transplanted with E28 pig pancreatic primordia.
    Summary: Organ primordia engraft, attract a host vasculature and differentiate following transplantation to ectopic sites. Attempts have been made to exploit these characteristics to achieve clinically relevant endpoints for end-stage renal disease and diabetes mellitus using animal models. We and others have focused on use of the embryonic pig as a donor.
    MeSH term(s) Animals ; Fetal Tissue Transplantation ; Humans ; Kidney/embryology ; Kidney Failure, Chronic/surgery ; Organogenesis ; Renal Replacement Therapy ; Tissue Donors ; Transplantation, Heterologous
    Language English
    Publishing date 2014-02-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1390429-2
    ISSN 1531-7013 ; 1087-2418
    ISSN (online) 1531-7013
    ISSN 1087-2418
    DOI 10.1097/MOT.0000000000000054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5609: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Xenotransplantation of embryonic pig pancreas for treatment of diabetes mellitus in non-human primates.

    Hammerman, Marc R

    Journal of biomedical science and engineering

    2012  Volume 6, Issue 5A

    Abstract: Transplantation therapy for diabetes in humans is limited by the low availability of human donor whole pancreas or islets. Outcomes are complicated by immunosuppressive drug toxicity. Xenotransplantation is a strategy to overcome supply problems. ... ...

    Abstract Transplantation therapy for diabetes in humans is limited by the low availability of human donor whole pancreas or islets. Outcomes are complicated by immunosuppressive drug toxicity. Xenotransplantation is a strategy to overcome supply problems. Implantation of tissue obtained early during embryogenesis is a way to reduce transplant immunogenicity. Pig insulin is biologically active in humans. In that regard the pig is an appropriate xenogeneic organ donor. Insulin-producing cells originating from embryonic pig pancreas obtained very early following pancreatic primordium formation [embryonic day 28 (E28)] engraft long-term in rhesus macaques. Endocrine cells originating from embryonic pig pancreas transplanted in host mesentery migrate to mesenteric lymph nodes, engraft, differentiate and improve glucose tolerance in rhesus macaques without the need for immune suppression. Transplantation of embryonic pig pancreas is a novel approach towards beta cell replacement therapy that could be applicable to humans.
    Language English
    Publishing date 2012-12-06
    Publishing country United States
    Document type Journal Article
    ISSN 1937-6871
    ISSN 1937-6871
    DOI 10.4236/jbise.2013.65A002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Development of a novel xenotransplantation strategy for treatment of diabetes mellitus in rat hosts and translation to non-human primates.

    Hammerman, Marc R

    Organogenesis

    2012  Volume 8, Issue 2, Page(s) 41–48

    Abstract: Transplantation therapy for diabetes is limited by unavailability of donor organs and outcomes complicated by immunosuppressive drug toxicity. Xenotransplantation is a strategy to overcome supply problems. Implantation of tissue obtained early during ... ...

    Abstract Transplantation therapy for diabetes is limited by unavailability of donor organs and outcomes complicated by immunosuppressive drug toxicity. Xenotransplantation is a strategy to overcome supply problems. Implantation of tissue obtained early during embryogenesis is a way to reduce transplant immunogenicity. Insulin-producing cells originating from embryonic pig pancreas obtained very early following pancreatic primordium formation [embryonic day 28 (E28)] engraft long-term in inbred diabetic Lewis or Zucker Diabetic Fatty (ZDF) rats or rhesus macaques. Endocrine cells originating from embryonic pig pancreas transplanted in host mesentery migrate to mesenteric lymph nodes, engraft, normalize glucose tolerance in rats and improve glucose tolerance in rhesus macaques without the need for immune suppression. Engraftment of primordia is permissive for engraftment of an insulin-expressing cell component from porcine islets implanted subsequently without immune suppression. Similarities between findings in inbred rat and non-human primate hosts bode well for successful translation to humans of what could be a novel xenotransplantation strategy for the treatment of diabetes.
    MeSH term(s) Animals ; Blood Glucose/metabolism ; Cell Movement ; Diabetes Mellitus/pathology ; Diabetes Mellitus/therapy ; Embryo, Mammalian ; Glucose Tolerance Test ; Graft Survival ; Humans ; Immunosuppression ; Islets of Langerhans/cytology ; Islets of Langerhans Transplantation ; Lymph Nodes/pathology ; Macaca mulatta ; Mesentery/immunology ; Mesentery/pathology ; Rats ; Rats, Zucker ; Swine ; Transplantation, Heterologous
    Chemical Substances Blood Glucose
    Language English
    Publishing date 2012-04-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2159583-5
    ISSN 1555-8592 ; 1555-8592
    ISSN (online) 1555-8592
    ISSN 1555-8592
    DOI 10.4161/org.20930
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Organogenetic tolerance.

    Hammerman, Marc R

    Organogenesis

    2011  Volume 6, Issue 4, Page(s) 270–275

    Abstract: Transplantation therapy for humans is limited by insufficient availability of donor organs and outcomes are complicated by the toxicity of immunosuppressive drugs. Xenotransplantation is a strategy to overcome supply problems. Implantation of tissue ... ...

    Abstract Transplantation therapy for humans is limited by insufficient availability of donor organs and outcomes are complicated by the toxicity of immunosuppressive drugs. Xenotransplantation is a strategy to overcome supply problems. Implantation of tissue obtained early during embryogenesis is a way to reduce immunogenicity of transplants. Insulin-producing cells originating from embryonic pig pancreas obtained very early following initiation of organogenesis [embryonic day 28 (E28)] engraft long-term in non-immune suppressed diabetic rats or rhesus macaques. Recently, we demonstrated engraftment of morphologically similar cells originating from adult porcine islets of Langerhans (islets) in rats previously transplanted with E28 pig pancreatic primordia. Our findings are consistent with induction of tolerance to a cell component of porcine islets induced by previous transplantation of embryonic pig pancreas, a phenomenon we designate organogenetic tolerance. Induction of organogenetic tolerance to porcine islets in humans with diabetes mellitus would enable the use of pigs as islet donors with no host immune suppression requirement. Adaptation of methodology for transplanting embryonic organs other than pancreas so as to induce organogenetic tolerance would revolutionize transplantation therapy.
    MeSH term(s) Animals ; Humans ; Immune Tolerance ; Organogenesis ; Rats ; Swine ; Transplantation, Heterologous
    Language English
    Publishing date 2011-01-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2159583-5
    ISSN 1555-8592 ; 1555-8592
    ISSN (online) 1555-8592
    ISSN 1555-8592
    DOI 10.4161/org.6.4.13283
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Engraftment of insulin-producing cells from porcine islets in non-immune-suppressed rats or nonhuman primates transplanted previously with embryonic pig pancreas.

    Hammerman, Marc R

    Journal of transplantation

    2011  Volume 2011, Page(s) 261352

    Abstract: Transplantation therapy for diabetes is limited by unavailability of donor organs and outcomes complicated by immunosuppressive drug toxicity. Xenotransplantation is a strategy to overcome supply problems. Implantation of tissue obtained early during ... ...

    Abstract Transplantation therapy for diabetes is limited by unavailability of donor organs and outcomes complicated by immunosuppressive drug toxicity. Xenotransplantation is a strategy to overcome supply problems. Implantation of tissue obtained early during embryogenesis is a way to reduce transplant immunogenicity. Insulin-producing cells originating from embryonic pig pancreas obtained very early following pancreatic primordium formation (embryonic day 28 (E28)) engraft long-term in non-immune, suppressed diabetic rats or rhesus macaques. Morphologically, similar cells originating from adult porcine islets of Langerhans (islets) engraft in non-immune-suppressed rats or rhesus macaques previously transplanted with E28 pig pancreatic primordia. Our data are consistent with induction of tolerance to an endocrine cell component of porcine islets induced by previous transplantation of embryonic pig pancreas, a novel finding we designate organogenetic tolerance. The potential exists for its use to enable the use of pigs as islet cell donors for humans with no immune suppression requirement.
    Language English
    Publishing date 2011-09-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2503421-2
    ISSN 2090-0015 ; 2090-0007
    ISSN (online) 2090-0015
    ISSN 2090-0007
    DOI 10.1155/2011/261352
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Xenotransplantation of embryonic pig kidney or pancreas to replace the function of mature organs.

    Hammerman, Marc R

    Journal of transplantation

    2010  Volume 2011, Page(s) 501749

    Abstract: Lack of donor availability limits the number of human donor organs. The need for host immunosuppression complicates transplantation procedures. Ultrastructurally precise kidneys differentiate in situ following xenotransplantation in mesentery of ... ...

    Abstract Lack of donor availability limits the number of human donor organs. The need for host immunosuppression complicates transplantation procedures. Ultrastructurally precise kidneys differentiate in situ following xenotransplantation in mesentery of embryonic pig renal primordia. The developing organ attracts its blood supply from the host, obviating humoral rejection. Engraftment of pig renal primordia transplanted directly into rats requires host immune suppression. However, insulin-producing cells originating from embryonic pig pancreas obtained very early following initiation of organogenesis [embryonic day 28 (E28)] engraft long term in nonimmune-suppressed diabetic rats or rhesus macaques. Engraftment of morphologically similar cells originating from adult porcine islets of Langerhans (islets) occurs in rats previously transplanted with E28 pig pancreatic primordia. Here, we review recent findings germane to xenotransplantation of pig renal or pancreatic primordia as a novel organ replacement strategy.
    Language English
    Publishing date 2010-12-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2503421-2
    ISSN 2090-0015 ; 2090-0007
    ISSN (online) 2090-0015
    ISSN 2090-0007
    DOI 10.1155/2011/501749
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Pancreas and kidney transplantation using embryonic donor organs.

    Hammerman, Marc R

    Organogenesis

    2009  Volume 1, Issue 1, Page(s) 3–13

    Abstract: One novel solution to the shortage of human organs available for transplantation envisions 'growing' new organs in situ. This can be accomplished by transplantation of developing organ anlagen/primordia. We and others have shown that renal anlagen ( ... ...

    Abstract One novel solution to the shortage of human organs available for transplantation envisions 'growing' new organs in situ. This can be accomplished by transplantation of developing organ anlagen/primordia. We and others have shown that renal anlagen (metanephroi) transplanted into animal hosts undergo differentiation and growth, become vascularized by blood vessels of host origin and exhibit excretory function. Metanephroi can be stored for up to 3 days in vitro prior to transplantation with no impairment in growth or function post-implantation. Metanephroi can be transplanted across both concordant (rat to mouse) and highly disparate (pig to rodent) xenogeneic barriers. Similarly, pancreatic anlagen can be transplanted across concordant and highly disparate barriers, and undergo growth, differentiation and secrete insulin in a physiological manner following intra-peritoneal placement. Implantation of the embryonic pancreas, is followed by selective differentiation of islet components. Here we review studies exploring the potential therapeutic applicability for organogenesis of the kidney or endocrine pancreas.
    Language English
    Publishing date 2009-06-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2159583-5
    ISSN 1555-8592 ; 1547-6278
    ISSN (online) 1555-8592
    ISSN 1547-6278
    DOI 10.4161/org.1.1.1008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Organogenesis of kidney and endocrine pancreas: the window opens.

    Hammerman, Marc R

    Organogenesis

    2009  Volume 3, Issue 2, Page(s) 59–66

    Abstract: Growing new organs in situ by implanting developing animal organ primordia (organogenesis) represents a novel solution to the problem of limited supply for human donor organs that offers advantages relative to transplanting embryonic stem (ES) cells or ... ...

    Abstract Growing new organs in situ by implanting developing animal organ primordia (organogenesis) represents a novel solution to the problem of limited supply for human donor organs that offers advantages relative to transplanting embryonic stem (ES) cells or xenotransplantation of developed organs. Successful transplantation of organ primordia depends on obtaining them at defined windows during embryonic development within which the risk of teratogenicity is eliminated, growth potential is maximized, and immunogenicity is reduced. We and others have shown that renal primordia transplanted into the mesentery undergo differentiation and growth, become vascularized by blood vessels of host origin, exhibit excretory function and support life in otherwise anephric hosts. Renal primordia can be transplanted across isogeneic, allogeneic or xenogeneic barriers. Pancreatic primordia can be transplanted across the same barriers undergo growth, and differentiation of endocrine components only and secrete insulin in a physiological manner following mesenteric placement. Insulin-secreting cells originating from embryonic day (E) 28 (E28) pig pancreatic primordia transplanted into the mesentery of streptozotocin-diabetic (type 1) Lewis rats or ZDF diabetic (type 2) rats or STZ-diabetic rhesus macaques engraft without the need for host immune-suppression. Our findings in diabetic macaques represent the first steps in the opening of a window for a novel treatment of diabetes in humans.
    Language English
    Publishing date 2009-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2159583-5
    ISSN 1555-8592 ; 1547-6278
    ISSN (online) 1555-8592
    ISSN 1547-6278
    DOI 10.4161/org.3.2.5382
    Database MEDical Literature Analysis and Retrieval System OnLINE

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