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  1. Article: [Effects of pingyu capsule on signal transduction of rats with chronic stress-induced depression].

    Wu, Li-kun / Zhang, Jian-jun / Wang, Jing-xia / Li, Wei / Deng, Xiao-ying / Tong, Hai-ying / Zhou, Peng / Xi, Sheng-yan

    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

    2008  Volume 33, Issue 14, Page(s) 1743–1746

    Abstract: Objective: To observe the effects of Pingyu capsule on such important regulatory factors as cAMP ... Wistar male rats were randomly divided into control group, model group, paroxetine group, and Pingyu ... in the model group were lower than those in the normal group. Pingyu capsule and paroxetine can increase ...

    Abstract Objective: To observe the effects of Pingyu capsule on such important regulatory factors as cAMP, PKA and PKC of the signal transduction in rats with chronic stress-induced depression.
    Method: Wistar male rats were randomly divided into control group, model group, paroxetine group, and Pingyu capsule low, middle and high doses groups; rats in all groups but the control group were fed in single cage for 21 days and were given such irritations as lightening stroke on pelma, ice water swimming, pyretic fumigation and tail clipping during this period; lobe cortex and hippocampus of all rats were taken out for detection of the cAMP content by means of radioactive immunization, PKA and PKC content by Elisa, and the PKA and PKC activity by radioactive isotope.
    Result: Content of cAMP in lobe cortex and hippocampus, content and activity of PKA in hippocampus, and content of PKC in lobe cortex of rats in the model group were lower than those in the normal group. Pingyu capsule and paroxetine can increase them.
    Conclusion: The anti-depression effect of Pingyu capsule maybe related to its function of adjusting the signal transduction of cAMP-PKA.
    MeSH term(s) Animals ; Capsules/administration & dosage ; Capsules/pharmacology ; Cyclic AMP/metabolism ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Depression/metabolism ; Disease Models, Animal ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/pharmacology ; Enzyme-Linked Immunosorbent Assay ; Male ; Protein Kinase C/metabolism ; Radioimmunoassay ; Rats ; Rats, Wistar ; Signal Transduction/drug effects
    Chemical Substances Capsules ; Drugs, Chinese Herbal ; Cyclic AMP (E0399OZS9N) ; Cyclic AMP-Dependent Protein Kinases (EC 2.7.11.11) ; Protein Kinase C (EC 2.7.11.13)
    Language Chinese
    Publishing date 2008-07
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 1004649-5
    ISSN 1001-5302 ; 0254-0029
    ISSN 1001-5302 ; 0254-0029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3056: Show issues Location:
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  2. Article ; Online: Editorial: Syphilis infection: clinical, epidemiology, basic science, and behavioral research.

    Zhou, Pingyu / Ye, Meiping / Tucker, Joseph D / Zhang, Lei / Radolf, Justin David

    Frontiers in immunology

    2023  Volume 14, Page(s) 1182069

    MeSH term(s) Humans ; Syphilis/epidemiology ; Behavioral Research ; Risk Factors ; Research
    Language English
    Publishing date 2023-04-06
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1182069
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  3. Article ; Online: A Photoisomerizable Zinc (II) Complex Inhibits Microtubule Polymerization for Photoactive Therapy.

    Cao, Fengshu / Wang, Haobing / Lu, Nong / Zhang, Pingyu / Huang, Huaiyi

    Angewandte Chemie (International ed. in English)

    2023  Volume 62, Issue 14, Page(s) e202301344

    Abstract: The photoisomerization-induced cytotoxicity in photopharmacology provides a unique pathway for phototherapy because it is independent of endogenous oxygen. In this study, we developed a biosafe photoisomerizable zinc(II) complex (Zn1), which releases its ...

    Abstract The photoisomerization-induced cytotoxicity in photopharmacology provides a unique pathway for phototherapy because it is independent of endogenous oxygen. In this study, we developed a biosafe photoisomerizable zinc(II) complex (Zn1), which releases its trans ligand (trans-L1) after being irradiated with blue light. This causes the complex to undergo photoisomerization and produce the toxic cis product (cis-L1) and generate singlet oxygen (
    MeSH term(s) Zinc ; Polymerization ; Phototherapy ; Oxygen ; Microtubules ; Photochemotherapy
    Chemical Substances Zinc (J41CSQ7QDS) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2023-02-21
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202301344
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  4. Article ; Online: SCPL acyltransferases catalyze the metabolism of chlorogenic acid during purple coneflower seed germination.

    Huang, Yuqing / Wang, Hsihua / Zhang, Yuting / Zhang, Pingyu / Xiang, Yuting / Zhang, Yang / Fu, Rao

    The New phytologist

    2024  

    Abstract: The metabolism of massively accumulated chlorogenic acid is crucial for the successful germination of purple coneflower (Echinacea purpurea (L.) Menoch). A serine carboxypeptidase-like (SCPL) acyltransferase (chicoric acid synthase, CAS) utilizes ... ...

    Abstract The metabolism of massively accumulated chlorogenic acid is crucial for the successful germination of purple coneflower (Echinacea purpurea (L.) Menoch). A serine carboxypeptidase-like (SCPL) acyltransferase (chicoric acid synthase, CAS) utilizes chlorogenic acid to produce chicoric acid during germination. However, it seems that the generation of chicoric acid lags behind the decrease in chlorogenic acid, suggesting an earlier route of chlorogenic acid metabolism. We discovered another chlorogenic acid metabolic product, 3,5-dicaffeoylquinic acid, which is produced before chicoric acid, filling the lag phase. Then, we identified two additional typical clade IA SCPL acyltransferases, named chlorogenic acid condensing enzymes (CCEs), that catalyze the biosynthesis of 3,5-dicaffeoylquinic acid from chlorogenic acid with different kinetic characteristics. Chlorogenic acid inhibits radicle elongation in a dose-dependent manner, explaining the potential biological role of SCPL acyltransferases-mediated continuous chlorogenic acid metabolism during germination. Both CCE1 and CCE2 are highly conserved among Echinacea species, supporting the observed metabolism of chlorogenic acid to 3,5-dicaffeoylquinic acid in two Echinacea species without chicoric acid accumulation. The discovery of SCPL acyltransferase involved in the biosynthesis of 3,5-dicaffeoylquinic acid suggests convergent evolution. Our research clarifies the metabolism strategy of chlorogenic acid in Echinacea species and provides more insight into plant metabolism.
    Language English
    Publishing date 2024-04-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 208885-x
    ISSN 1469-8137 ; 0028-646X
    ISSN (online) 1469-8137
    ISSN 0028-646X
    DOI 10.1111/nph.19776
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    In stock of ZB MED Bonn / Germany

    Z 868: Show issues

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  5. Article ; Online: Editorial

    Pingyu Zhou / Meiping Ye / Joseph D. Tucker / Lei Zhang / Justin David Radolf

    Frontiers in Immunology, Vol

    Syphilis infection: clinical, epidemiology, basic science, and behavioral research

    2023  Volume 14

    Keywords syphilis ; clinical research ; epidemiology ; basic science ; behavioral research ; Immunologic diseases. Allergy ; RC581-607
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Cost-effectiveness of edaravone dexborneol versus human urinary kallidinogenase for acute ischemic stroke in China.

    Chen, Pingyu / Luo, Mengjie / Chen, Yanqiu / Zhang, Yanlei / Wang, Chao / Li, Hongchao

    Health economics review

    2024  Volume 14, Issue 1, Page(s) 7

    Abstract: Background: Clinical trials have demonstrated the efficacy of edaravone dexborneol in the treatment of acute ischemic stroke. This study aims to determine the cost-effectiveness of edaravone dexborneol compared with human urinary kallidinogenase from ... ...

    Abstract Background: Clinical trials have demonstrated the efficacy of edaravone dexborneol in the treatment of acute ischemic stroke. This study aims to determine the cost-effectiveness of edaravone dexborneol compared with human urinary kallidinogenase from China's healthcare system perspective.
    Methods: A combination of the decision tree and Markov model was constructed to evaluate the cost-effectiveness of edaravone dexborneol versus human urinary kallidinogenase in the treatment of acute ischemic stroke over a lifetime horizon. Efficacy data were derived from pivotal clinical trials of edaravone dexborneol and human urinary kallidinogenase (TASTE trial and RESK trial, respectively) and adjusted using matching-adjusted indirect comparison. Cost and health utility inputs were extracted from published literature and open databases. One-way deterministic sensitivity and probabilistic sensitivity analyses were performed to examine the robustness of the results.
    Results: Compared with human urinary kallidinogenase, edaravone dexborneol generated 0.153 incremental quality-adjusted life years (QALYs) with an incremental cost of ¥856, yielding an incremental cost-effectiveness ratio of ¥5,608 per QALY gained under the willingness-to-pay threshold (one-time gross domestic product per capita). Both one-way deterministic sensitivity analysis and probabilistic sensitivity analysis demonstrated the robustness of the base case results.
    Conclusions: Edaravone dexborneol is a cost-effective treatment choice for acute ischemic stroke patients compared with human urinary kallidinogenase in China.
    Language English
    Publishing date 2024-01-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2634483-X
    ISSN 2191-1991
    ISSN 2191-1991
    DOI 10.1186/s13561-024-00479-6
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  7. Article ; Online: Self-Assembly of Erlotinib-Platinum(II) Complexes for Epidermal Growth Factor Receptor-Targeted Photodynamic Therapy.

    Wang, Haobing / Lai, Yidan / Li, Dan / Karges, Johannes / Zhang, Pingyu / Huang, Huaiyi

    Journal of medicinal chemistry

    2024  Volume 67, Issue 2, Page(s) 1336–1346

    Abstract: Due to cell mutation and self-adaptation, the application of clinical drugs with early epidermal growth factor receptor (EGFR)-targeted inhibitors is severely limited. To overcome this limitation, herein, the synthesis and in-depth biological evaluation ... ...

    Abstract Due to cell mutation and self-adaptation, the application of clinical drugs with early epidermal growth factor receptor (EGFR)-targeted inhibitors is severely limited. To overcome this limitation, herein, the synthesis and in-depth biological evaluation of an erlotinib-platinum(II) complex as an EGFR-targeted anticancer agent is reported. The metal complex is able to self-assemble inside an aqueous solution and readily form nanostructures with strong photophysical properties. While being poorly toxic toward healthy cells and upon treatment in the dark, the compound was able to induce a cytotoxic effect in the very low micromolar range upon irradiation against EGFR overexpressing (drug resistant) human lung cancer cells as well as multicellular tumor spheroids. Mechanistic insights revealed that the compound was able to selectively degrade the EGFR using the lysosomal degradation pathway upon generation of singlet oxygen at the EGFR. We are confident that this work will open new avenues for the treatment of EGFR-overexpressing tumors.
    MeSH term(s) Humans ; Erlotinib Hydrochloride/pharmacology ; Erlotinib Hydrochloride/therapeutic use ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Platinum/pharmacology ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Lung Neoplasms/pathology ; ErbB Receptors/metabolism ; Mutation ; Photochemotherapy ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Drug Resistance, Neoplasm ; Cell Line, Tumor
    Chemical Substances Erlotinib Hydrochloride (DA87705X9K) ; Platinum (49DFR088MY) ; Antineoplastic Agents ; ErbB Receptors (EC 2.7.10.1) ; Protein Kinase Inhibitors
    Language English
    Publishing date 2024-01-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.3c01889
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    Zs.B 151: Show issues Location:
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  8. Article ; Online: Spatial Pattern of Farmland Transfer in Liaoning Province, China

    Ning, Jiachen / Zhang, Pingyu / Yang, Qifeng / Ma, Zuopeng

    Agriculture. 2023 July 23, v. 13, no. 7

    2023  

    Abstract: Farmland transfer (FT) is the key to achieving moderate agricultural scale management in China. Clarifying the spatial pattern of FT is important to improve FT strategies. In this study, the multinomial logit model was used to reveal the spatial pattern ... ...

    Abstract Farmland transfer (FT) is the key to achieving moderate agricultural scale management in China. Clarifying the spatial pattern of FT is important to improve FT strategies. In this study, the multinomial logit model was used to reveal the spatial pattern of FT in Liaoning Province, Northeast China. On this basis, the reasons for its formation were discussed, and suggestions were proposed. According to the statistical results, 39.7% of the sample peasant households participated in FT. Most of them live far from the regional core area. Regression analysis shows that the FT in Liaoning Province has a significant “core-periphery” spatial pattern. As the spatial distance between the residence and the regional core area (SDRRC) increases, the probability of FT rises for peasant households. Specifically, the odds ratios of farmland transfer out and farmland transfer in rise by 0.9% and 0.6% on average, respectively, for each 1 km increase in SDRRC. Widespread concurrent business and the increase in FT fees due to imperfect urbanization are the main reasons for the formation of the spatial pattern. We suggest that the promotion of FT requires high-quality urbanization in central cities, accelerating urbanization in medium and small cities and counties, implementing differentiated FT subsidy standards, and promoting new agricultural scale management models.
    Keywords agricultural land ; agriculture ; logit analysis ; peasantry ; probability ; urbanization ; China
    Language English
    Dates of publication 2023-0723
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2651678-0
    ISSN 2077-0472
    ISSN 2077-0472
    DOI 10.3390/agriculture13071453
    Database NAL-Catalogue (AGRICOLA)

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  9. Article: Ferroptosis promotes sonodynamic therapy: a platinum(ii)-indocyanine sonosensitizer.

    Lai, Yidan / Lu, Nong / Ouyang, Ai / Zhang, Qianling / Zhang, Pingyu

    Chemical science

    2022  Volume 13, Issue 34, Page(s) 9921–9926

    Abstract: Sonodynamic therapy (SDT) has unique advantages in deep tumour ablation due to its deep penetration depth, showing great preclinical and clinical potential. Herein, a platinum(ii)-cyanine complex has been designed to investigate its potential as a SDT ... ...

    Abstract Sonodynamic therapy (SDT) has unique advantages in deep tumour ablation due to its deep penetration depth, showing great preclinical and clinical potential. Herein, a platinum(ii)-cyanine complex has been designed to investigate its potential as a SDT anticancer agent. It generates singlet oxygen (
    Language English
    Publishing date 2022-08-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d2sc02597c
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  10. Article ; Online: An Electron Donor-Acceptor Structured Rhenium(I) Complex Photo-Sensitizer Evokes Mutually Reinforcing "Closed-Loop" Ferroptosis and Immunotherapy.

    Ren, Qingyan / Wang, Haobing / Li, Dan / Dao, Anyi / Luo, Jiajun / Wang, Deliang / Zhang, Pingyu / Huang, Huaiyi

    Advanced healthcare materials

    2024  , Page(s) e2304067

    Abstract: The hypoxic microenvironment of solid tumors severely lowers the efficacy of oxygen-dependent photodynamic therapy (PDT). The development of hypoxia-tolerant photosensitizers for PDT is an urgent requirement. In this study, a novel rhenium complex (Re- ... ...

    Abstract The hypoxic microenvironment of solid tumors severely lowers the efficacy of oxygen-dependent photodynamic therapy (PDT). The development of hypoxia-tolerant photosensitizers for PDT is an urgent requirement. In this study, a novel rhenium complex (Re-TTPY) to develop a "closed-loop" therapy based on PDT-induced ferroptosis and immune therapy is reported. Due to its electron donor-acceptor (D-A) structure, Re-TTPY undergoes energy transfer and electron transfer processes under 550 nm light irradiation and displays hypoxia-tolerant type I/II combined PDT capability, which can generate
    Language English
    Publishing date 2024-04-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2649576-4
    ISSN 2192-2659 ; 2192-2640
    ISSN (online) 2192-2659
    ISSN 2192-2640
    DOI 10.1002/adhm.202304067
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    Zs.A 6966: Show issues Location:
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