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  1. Article: Epsilon-sarcoglycan is not involved in sporadic Gilles de la Tourette syndrome.

    Asmus, Friedrich / Schoenian, Sarah / Lichtner, Peter / Munz, Marita / Mayer, Petra / Muller-Myhsok, Bertram / Zimprich, Alexander / Remschmidt, Helmut / Hebebrand, Johannes / Bandmann, Oliver / Gasser, Thomas

    Neurogenetics

    2005  Volume 6, Issue 1, Page(s) 55–56

    MeSH term(s) DNA Mutational Analysis ; Humans ; Sarcoglycans/genetics ; Tourette Syndrome/genetics
    Chemical Substances Sarcoglycans
    Language English
    Publishing date 2005-02
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1339887-8
    ISSN 1364-6753 ; 1364-6745
    ISSN (online) 1364-6753
    ISSN 1364-6745
    DOI 10.1007/s10048-004-0206-z
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5295: Show issues Location:
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  2. Article ; Online: Anticancer platinum-based photo-oxidants in a new light.

    Vigueras, Gloria / Gasser, Gilles

    Nature chemistry

    2023  Volume 15, Issue 7, Page(s) 896–898

    MeSH term(s) Platinum ; Antineoplastic Agents/pharmacology ; Prodrugs ; Light
    Chemical Substances Platinum (49DFR088MY) ; Antineoplastic Agents ; Prodrugs
    Language English
    Publishing date 2023-07-05
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2464596-5
    ISSN 1755-4349 ; 1755-4330
    ISSN (online) 1755-4349
    ISSN 1755-4330
    DOI 10.1038/s41557-023-01250-w
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  3. Article ; Online: Strategies for the Nuclear Delivery of Metal Complexes to Cancer Cells.

    Huynh, Marie / Vinck, Robin / Gibert, Benjamin / Gasser, Gilles

    Advanced materials (Deerfield Beach, Fla.)

    2024  Volume 36, Issue 16, Page(s) e2311437

    Abstract: The nucleus is an essential organelle for the function of cells. It holds most of the genetic material and plays a crucial role in the regulation of cell growth and proliferation. Since many antitumoral therapies target nucleic acids to induce cell death, ...

    Abstract The nucleus is an essential organelle for the function of cells. It holds most of the genetic material and plays a crucial role in the regulation of cell growth and proliferation. Since many antitumoral therapies target nucleic acids to induce cell death, tumor-specific nuclear drug delivery could potentiate therapeutic effects and prevent potential off-target side effects on healthy tissue. Due to their great structural variety, good biocompatibility, and unique physico-chemical properties, organometallic complexes and other metal-based compounds have sparked great interest as promising anticancer agents. In this review, strategies for specific nuclear delivery of metal complexes are summarized and discussed to highlight crucial parameters to consider for the design of new metal complexes as anticancer drug candidates. Moreover, the existing opportunities and challenges of tumor-specific, nucleus-targeting metal complexes are emphasized to outline some new perspectives and help in the design of new cancer treatments.
    MeSH term(s) Humans ; Coordination Complexes/therapeutic use ; Organometallic Compounds/chemistry ; Antineoplastic Agents/chemistry ; Neoplasms/drug therapy ; Drug Delivery Systems
    Chemical Substances Coordination Complexes ; Organometallic Compounds ; Antineoplastic Agents
    Language English
    Publishing date 2024-01-18
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1474949-X
    ISSN 1521-4095 ; 0935-9648
    ISSN (online) 1521-4095
    ISSN 0935-9648
    DOI 10.1002/adma.202311437
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  4. Article ; Online: N

    Mahe, Capucine / Blacque, Olivier / Gasser, Gilles / Gandon, Vincent / Cariou, Kevin

    Organic letters

    2023  Volume 25, Issue 4, Page(s) 624–629

    Abstract: The first synthesis of ... ...

    Abstract The first synthesis of various
    Language English
    Publishing date 2023-01-23
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.2c04169
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  5. Article ; Online: Metal-Based Photosensitizers as Inducers of Regulated Cell Death Mechanisms.

    Zhang, Yiyi / Doan, Bich-Thuy / Gasser, Gilles

    Chemical reviews

    2023  Volume 123, Issue 16, Page(s) 10135–10155

    Abstract: Over the last few decades, various forms of regulated cell death (RCD) have been discovered and were found to improve cancer treatment. Although there are several reviews on RCD induced by photodynamic therapy (PDT), a comprehensive summary covering ... ...

    Abstract Over the last few decades, various forms of regulated cell death (RCD) have been discovered and were found to improve cancer treatment. Although there are several reviews on RCD induced by photodynamic therapy (PDT), a comprehensive summary covering metal-based photosensitizers (PSs) as RCD inducers has not yet been presented. In this review, we systematically summarize the works on metal-based PSs that induce different types of RCD, including ferroptosis, immunogenic cell death (ICD), and pyroptosis. The characteristics and mechanisms of each RCD are explained. At the end of each section, a summary of the reported commonalities between different metal-based PSs inducing the same RCD is emphasized, and future perspectives on metal-based PSs inducing novel forms of RCD are discussed at the end of the review. Considering the essential roles of metal-based PSs and RCD in cancer therapy, we hope that this review will provide the stage for future advances in metal-based PSs as RCD inducers.
    MeSH term(s) Humans ; Photosensitizing Agents/pharmacology ; Photosensitizing Agents/therapeutic use ; Regulated Cell Death ; Photochemotherapy ; Metals ; Neoplasms/drug therapy
    Chemical Substances Photosensitizing Agents ; Metals
    Language English
    Publishing date 2023-08-03
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 207949-5
    ISSN 1520-6890 ; 0009-2665
    ISSN (online) 1520-6890
    ISSN 0009-2665
    DOI 10.1021/acs.chemrev.3c00161
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    In stock of ZB MED Bonn / Germany

    Z 4' 49/78: Show issues
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  6. Article ; Online: Theranostics with photodynamic therapy for personalized medicine: to see and to treat.

    Wang, Youchao / Staudinger, Johannes Nikodemus / Mindt, Thomas L / Gasser, Gilles

    Theranostics

    2023  Volume 13, Issue 15, Page(s) 5501–5544

    Abstract: Photodynamic Therapy (PDT) is an approved treatment modality, which is presently receiving great attention due to its limited invasiveness, high selectivity and limited susceptibility to drug resistance. Another related research area currently expanding ... ...

    Abstract Photodynamic Therapy (PDT) is an approved treatment modality, which is presently receiving great attention due to its limited invasiveness, high selectivity and limited susceptibility to drug resistance. Another related research area currently expanding rapidly is the development of novel theranostic agents based on the combination of PDT with different imaging technologies, which allows for both therapy and diagnosis. This combination can help to address issues of suboptimal biodistribution and selectivity through regional imaging, while therapeutic agents enable an effective and personalized therapy. In this review, we describe compounds, whose structures combine PDT photosensitizers with different imaging probes - including examples for near-infrared optical imaging, magnetic resonance imaging (MRI) and nuclear imaging (PET or SPECT), generating novel theranostic drug candidates. We have intentionally focused our attention on novel compounds, which have already been investigated preclinically
    MeSH term(s) Precision Medicine ; Photochemotherapy/methods ; Tissue Distribution ; Photosensitizing Agents/therapeutic use ; Photosensitizing Agents/chemistry ; Magnetic Resonance Imaging/methods ; Theranostic Nanomedicine/methods
    Chemical Substances Photosensitizing Agents
    Language English
    Publishing date 2023-10-09
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 2592097-2
    ISSN 1838-7640 ; 1838-7640
    ISSN (online) 1838-7640
    ISSN 1838-7640
    DOI 10.7150/thno.87363
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  7. Article ; Online: The beneficial effect of cyclohexyl substituent on the

    Benetti, Sara / Dalla Pozza, Maria / Biancalana, Lorenzo / Zacchini, Stefano / Gasser, Gilles / Marchetti, Fabio

    Dalton transactions (Cambridge, England : 2003)

    2023  Volume 52, Issue 17, Page(s) 5724–5741

    Abstract: Novel diiron vinyliminium complexes, [ ... ...

    Abstract Novel diiron vinyliminium complexes, [Fe
    MeSH term(s) Animals ; Mice ; Humans ; Neoplasms ; Methylation
    Language English
    Publishing date 2023-05-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d3dt00186e
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  8. Article ; Online: Towards Copper(I) Clusters for Photo-Induced Oxidation of Biological Thiols in Living Cells.

    Gourdon-Grünewaldt, Lisa / Blacque, Olivier / Gasser, Gilles / Cariou, Kevin

    Chembiochem : a European journal of chemical biology

    2023  Volume 24, Issue 23, Page(s) e202300496

    Abstract: The cell redox balance can be disrupted by the oxidation of biological peptides, eventually leading to cell death, which provides opportunities to develop cytotoxic drugs. With the aim of developing compounds capable of specifically inducing fatal redox ... ...

    Abstract The cell redox balance can be disrupted by the oxidation of biological peptides, eventually leading to cell death, which provides opportunities to develop cytotoxic drugs. With the aim of developing compounds capable of specifically inducing fatal redox reactions upon light irradiation, we have developed a library of copper compounds. This metal is abundant and considered essential for human health, making it particularly attractive for the development of new anticancer drugs. Copper(I) clusters with thiol ligands (including 5 novel ones) have been synthesized and characterized. Structures were elucidated by X-ray diffraction and showed that the compounds are oligomeric clusters. The clusters display high photooxidation capacity towards cysteine - an essential amino acid - upon light irradiation in the visible range (450 nm), while remaining completely inactive in the dark. This photoredox activity against a biological thiol is very encouraging for the development of anticancer photoredox drugs.The in vitro assay on murine colorectal cancer cells (CT26) did not show any toxicity - whether in the dark or when exposed to 450 nm light, likely because of the poor solubility of the complexes in biological medium.
    MeSH term(s) Humans ; Animals ; Mice ; Sulfhydryl Compounds/chemistry ; Copper/chemistry ; Oxidation-Reduction ; Cysteine/chemistry ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry
    Chemical Substances Sulfhydryl Compounds ; Copper (789U1901C5) ; Cysteine (K848JZ4886) ; Antineoplastic Agents
    Language English
    Publishing date 2023-10-16
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2020469-3
    ISSN 1439-7633 ; 1439-4227
    ISSN (online) 1439-7633
    ISSN 1439-4227
    DOI 10.1002/cbic.202300496
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  9. Article ; Online: Phototherapeutic anticancer strategies with first-row transition metal complexes: a critical review.

    Gourdon, Lisa / Cariou, Kevin / Gasser, Gilles

    Chemical Society reviews

    2022  Volume 51, Issue 3, Page(s) 1167–1195

    Abstract: Photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) are therapeutic techniques based on a photosensitizer (PS) and light. These techniques allow the spatial and temporal control of the activation of drugs with light. Transition metal ... ...

    Abstract Photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) are therapeutic techniques based on a photosensitizer (PS) and light. These techniques allow the spatial and temporal control of the activation of drugs with light. Transition metal complexes are attractive compounds as photoactivatable prodrugs since their excited states can be appropriately designed by subtle modifications of the ligands, the metal centre, or the oxidation state. However, most metal-based PSs contain heavy metals such as Ru, Os, Ir, Pt or Au, which are expensive and non-earth-abundant, contrary to first-row transition metals. In this context, the exploration of the photochemical properties of complexes based on first-row transition metals appears to be extremely promising. This did encourage several groups to develop promising PSs based on these metals. This review presents up-to-date state-of-the-art information on first-row-transition metal complexes, from titanium to zinc in regard to their application as PSs for phototherapeutic applications.
    MeSH term(s) Coordination Complexes ; Metals, Heavy ; Photochemotherapy ; Photosensitizing Agents/therapeutic use ; Transition Elements
    Chemical Substances Coordination Complexes ; Metals, Heavy ; Photosensitizing Agents ; Transition Elements
    Language English
    Publishing date 2022-02-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1472875-8
    ISSN 1460-4744 ; 0306-0012
    ISSN (online) 1460-4744
    ISSN 0306-0012
    DOI 10.1039/d1cs00609f
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  10. Article ; Online: Stimuli-Responsive Metal Complexes for Biomedical Applications.

    Amarsy, Ivanna / Papot, Sébastien / Gasser, Gilles

    Angewandte Chemie (International ed. in English)

    2022  Volume 61, Issue 40, Page(s) e202205900

    Abstract: Metal-based compounds have been widely used for biomedical applications. Their unique characteristics make them attractive for both therapeutic and diagnostic purposes. However, numerous issues including toxicity, poor aqueous solubility, and unfavorable ...

    Abstract Metal-based compounds have been widely used for biomedical applications. Their unique characteristics make them attractive for both therapeutic and diagnostic purposes. However, numerous issues including toxicity, poor aqueous solubility, and unfavorable biodistribution hamper their widespread use. To overcome these drawbacks, the concept of metal-based prodrugs emerged. This field is particularly developed for applications in oncology. More precisely, tumor-associated stimuli (e.g., pH variation, redox activity, enzyme overexpression, etc.) have been exploited to trigger the selective delivery of active metal-based drugs to the tumor site. The main advances in this area are discussed in this Review.
    MeSH term(s) Coordination Complexes/chemistry ; Drug Delivery Systems ; Humans ; Metals/chemistry ; Neoplasms/drug therapy ; Prodrugs/chemistry ; Tissue Distribution
    Chemical Substances Coordination Complexes ; Metals ; Prodrugs
    Language English
    Publishing date 2022-09-01
    Publishing country Germany
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202205900
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