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Article ; Online: Assessing the methodological quality of studies included in systematic reviews: Interpretation of scores.

Büchler, Andrea C / Voor In 't Holt, Anne F

Infection control and hospital epidemiology

2022 Volume 44, Issue 1, Page(s) 169–170

MeSH term(s)	Humans ; Systematic Reviews as Topic ; Quality Control ; Research Design
Language	English
Publishing date	2022-07-14
Publishing country	United States
Document type	Letter
ZDB-ID	639378-0
ISSN	1559-6834 ; 0195-9417 ; 0899-823X
ISSN (online)	1559-6834
ISSN	0195-9417 ; 0899-823X
DOI	10.1017/ice.2022.176
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Article ; Online: Diabetes and infection: review of the epidemiology, mechanisms and principles of treatment.

Holt, Richard I G / Cockram, Clive S / Ma, Ronald C W / Luk, Andrea O Y

Diabetologia

2024

Abstract: An association between diabetes and infection has been recognised for many years, with infection being an important cause of death and morbidity in people with diabetes. The COVID-19 pandemic has re-kindled an interest in the complex relationship between ...

Abstract	An association between diabetes and infection has been recognised for many years, with infection being an important cause of death and morbidity in people with diabetes. The COVID-19 pandemic has re-kindled an interest in the complex relationship between diabetes and infection. Some infections occur almost exclusively in people with diabetes, often with high mortality rates without early diagnosis and treatment. However, more commonly, diabetes is a complicating factor in many infections. A reciprocal relationship occurs whereby certain infections and their treatments may also increase the risk of diabetes. People with diabetes have a 1.5- to 4-fold increased risk of infection. The risks are the most pronounced for kidney infection, osteomyelitis and foot infection, but are also increased for pneumonia, influenza, tuberculosis, skin infection and general sepsis. Outcomes from infection are worse in people with diabetes, with the most notable example being a twofold higher rate of death from COVID-19. Hyperglycaemia has deleterious effects on the immune response. Vascular insufficiency and neuropathy, together with altered skin, mucosal and gut microbial colonisation, contribute to the increased risk of infection. Vaccination is important in people with diabetes although the efficacy of certain immunisations may be compromised, particularly in the presence of hyperglycaemia. The principles of treatment largely follow those of the general population with certain notable exceptions.
Language	English
Publishing date	2024-02-20
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1694-9
ISSN	1432-0428 ; 0012-186X
ISSN (online)	1432-0428
ISSN	0012-186X
DOI	10.1007/s00125-024-06102-x
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Zs.A 279: Show issues

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Article: Interprofessional simulation with nursing and occupational therapy students: Comparing a virtual and in-person event.

Hughesdon, Kathryn / Zakrajsek, Andrea / Washington, Vicki L / Seurynck, Kathleen / Myler, Linda / Holt, Sharon

Journal of interprofessional education & practice

2023 Volume 32, Page(s) 100660

Language	English
Publishing date	2023-06-01
Publishing country	United States
Document type	Journal Article
ISSN	2405-4526
ISSN	2405-4526
DOI	10.1016/j.xjep.2023.100660
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Article ; Online: In vitro

Miller-Holt, Jacqueline / Baskerville-Abraham, Irene / Sakimura, Masanori / Fukushima, Toshiro / Puglisi, Andrea / Gafner, Jeremie

Toxicology reports

2022 Volume 9, Page(s) 1316–1324

Abstract: Non-clinical in vitro studies were conducted to investigate the characteristics of extracts from tobacco free nicotine pouches alongside a reference snus product and/or 1R6F reference cigarette. ...

Abstract	Non-clinical in vitro studies were conducted to investigate the characteristics of extracts from tobacco free nicotine pouches alongside a reference snus product and/or 1R6F reference cigarette.
Language	English
Publishing date	2022-06-15
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	2805786-7
ISSN	2214-7500 ; 2214-7500
ISSN (online)	2214-7500
ISSN	2214-7500
DOI	10.1016/j.toxrep.2022.06.008
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Article ; Online: Impact of diabetes on COVID-19 and other infection: Report from the 22nd Hong Kong Diabetes and Cardiovascular Risk Factors-East Meets West Symposium.

Luk, Andrea O Y / Ng, Susanna S S / Holt, Richard I G

Diabetic medicine : a journal of the British Diabetic Association

2021 Volume 38, Issue 5, Page(s) e14547

Abstract: The coronavirus disease 2019 (COVID-19) pandemic has posed enormous challenges to healthcare systems worldwide. The negative impact of COVID-19 is widespread and includes not only people who contracted the disease but also those with chronic morbidities ... ...

Abstract	The coronavirus disease 2019 (COVID-19) pandemic has posed enormous challenges to healthcare systems worldwide. The negative impact of COVID-19 is widespread and includes not only people who contracted the disease but also those with chronic morbidities such as diabetes whose care is compromised due to diversion of medical resources. People with diabetes are generally more susceptible to infection as a result of altered immunity. People with diabetes have a worse prognosis from COVID-19 and there is evidence to suggest that severe acute respiratory syndrome coronavirus 2 may directly affect pancreatic function precipitating hyperglycaemic crises. In the United Kingdom, one of the most heavily affected countries, guidelines are in place to unify the management of people with diabetes hospitalized for COVID-19. Diabetes services are re-organized to ensure that medical care of people with diabetes is maintained despite resource and other practical constraints. Public health measures including social distancing, hand hygiene and the use of face masks are crucial in containing community transmission of the virus. Hong Kong, one of the most densely populated city in the world, is particularly vulnerable and has in place a stringent containment policy and aggressive contact tracing to ensure public safety during this pandemic.
MeSH term(s)	COVID-19/epidemiology ; COVID-19/immunology ; COVID-19/metabolism ; COVID-19/therapy ; Communicable Disease Control/methods ; Comorbidity ; Delivery of Health Care/organization & administration ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/immunology ; Diabetes Mellitus/metabolism ; Diabetes Mellitus/therapy ; Glycemic Control ; Hand Hygiene ; Hong Kong/epidemiology ; Humans ; Immunocompromised Host/immunology ; Infections/epidemiology ; Infections/immunology ; Influenza, Human/epidemiology ; Influenza, Human/immunology ; Masks ; Physical Distancing ; Practice Guidelines as Topic ; Public Policy ; Risk ; Risk Factors ; SARS-CoV-2 ; Severity of Illness Index ; United Kingdom/epidemiology
Language	English
Publishing date	2021-03-02
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	605769-x
ISSN	1464-5491 ; 0742-3071 ; 1466-5468
ISSN (online)	1464-5491
ISSN	0742-3071 ; 1466-5468
DOI	10.1111/dme.14547
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Zs.A 1954: Show issues

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Article ; Online: Bictegravir Use During Pregnancy: A Multi-Center Retrospective Analysis Evaluating HIV Viral Suppression and Perinatal Outcomes.

Holt, Lauren M / Short, William R / Momplaisir, Florence / Hyun, Eleanor / McKinney, Jennifer / Lugo Morales, Andrea / Duque, Alejandra / Druyan, Brian / Ndubizu, Chima / Duthely, Luthita / Joseph, Naima / Sheth, Anandi / Badell, Martina L

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2024

Abstract: This study describes the largest cohort to date (n=147) of pregnant patients living with HIV on bictegravir (BIC). BIC in pregnancy was associated with high levels of viral suppression and similar perinatal outcomes to published literature. These ... ...

Abstract	This study describes the largest cohort to date (n=147) of pregnant patients living with HIV on bictegravir (BIC). BIC in pregnancy was associated with high levels of viral suppression and similar perinatal outcomes to published literature. These findings support consideration for use of BIC in management of HIV during pregnancy.
Language	English
Publishing date	2024-04-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciae218
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Zs.A 1505: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 480: Show issues

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Article ; Online: Grading system for medullary thyroid carcinoma; an institutional experience.

Podany, Peter / Meiklejohn, Karleen / Garritano, James / Holt, Elizabeth H / Barbieri, Andrea / Prasad, Manju / Gilani, Syed M

Annals of diagnostic pathology

2023 Volume 64, Page(s) 152112

Abstract: Objective: Medullary thyroid carcinoma (MTC) is a rare type of thyroid malignancy. Recently, a two-tier grading system (GS) for MTC has been suggested. We conducted this study to evaluate the generalizability, as well as application of recently proposed ...

Abstract	Objective: Medullary thyroid carcinoma (MTC) is a rare type of thyroid malignancy. Recently, a two-tier grading system (GS) for MTC has been suggested. We conducted this study to evaluate the generalizability, as well as application of recently proposed GS to our cohort of Medullary thyroid carcinoma (MTC) cases. Methods: We assigned grades to MTC cases and divided them into two groups by using morphologic criteria only as suggested by recent studies: low-grade (LG, <5 mitosis per 2 mm Results: A total of 59 MTC cases were evaluated and of those 52 (88 %) were LG and 7 (12 %) were HG. Vascular invasion (VI) (p = 0.017), distant metastasis (DM) (p < 0.0001), nuclear pleomorphism (NP) (p = 0.017) and prominent nucleoli (p = 0.03) were prominently noted in the HG group. After controlling for demographics using multivariate cox regression, tumor grade and necrosis remained significantly associated with the overall survival (HR = 22.7, p < 0.01 and HR = 11.1, p = 0.008, respectively). Upon comparing the cases with and without nodal disease, we found that nodal disease is more strongly associated with NP (p = 0.029), tumor fibrosis (p = 0.0001), VI (p = 0.001) and DM (p = 0.005). Conclusions: We applied the two-tier GS for MTC to our cohort of cases and found statistically significant differences in the overall survival among the two groups. Adding the grading to the pathology report communicates additional information regarding risk stratification in MTC.
MeSH term(s)	Humans ; Thyroid Neoplasms/pathology ; Carcinoma, Neuroendocrine/diagnosis ; Carcinoma, Neuroendocrine/pathology ; Prognosis
Language	English
Publishing date	2023-01-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	1440011-x
ISSN	1532-8198 ; 1092-9134
ISSN (online)	1532-8198
ISSN	1092-9134
DOI	10.1016/j.anndiagpath.2023.152112
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Zs.A 5463: Show issues

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Article ; Online: Outbreak investigations after identifying carbapenem-resistant Pseudomonas aeruginosa: a systematic review.

Büchler, Andrea C / Shahab, Selvi N / Severin, Juliëtte A / Vos, Margreet C / Voor In 't Holt, Anne F

Antimicrobial resistance and infection control

2023 Volume 12, Issue 1, Page(s) 28

Abstract: Background: Carbapenem-resistant Pseudomonas aeruginosa (CRPA) are a serious cause of healthcare-associated infections. Part of the infection prevention and control measures are outbreak investigations (OI) of patients, healthcare workers (HCW), and the ...

Abstract	Background: Carbapenem-resistant Pseudomonas aeruginosa (CRPA) are a serious cause of healthcare-associated infections. Part of the infection prevention and control measures are outbreak investigations (OI) of patients, healthcare workers (HCW), and the environment after identifying a CRPA in order to identify carriers and environmental reservoirs, so that targeted actions can be taken to prevent further transmission. However, little is known on when and how to perform such OI. Therefore, this systematic review aims to summarize OI performed after detection of CRPA in the endemic and epidemic hospital setting. Main text: Articles related to our research question were identified through a literature research in multiple databases (Embase, Medline Ovid, Cochrane, Scopus, Cinahl, Web of Science, and Google Scholar) until January 12, 2022 (Prospero registration number CRD42020194165). Hundred-twenty-six studies were included. In both the endemic and the epidemic setting, a median number of two out of seven predefined components of OI were identified. In the endemic setting, the most frequent component of OI was screening of the environment (28 studies, 62.2%). In the epidemic setting, screening of the environment (72 studies, 88.9%), and screening of patients during hospitalization (30 studies, 37%) were most frequently performed. Only 19 out of 126 studies (15.1%) reported screening of contact patients, and 37 studies reported screening of healthcare workers (HCW, 29.4%). Conclusion: Due to probable underreporting of OI in the literature, the available evidence for the usefulness of the individual components of OI is scarce. This could lead to inhomogeneous performance of OI after detection of CRPA in the healthcare setting, and with this, potential under- or overscreening. While we could show evidence for the usefulness for environmental screening in order to identify the mode of transmission, evidence for HCW screening is scarce and might not lead to the identification of modes of transmission. Further studies are needed to better understand CI in different settings and, finally, develop guidance on when and how to best perform OI.
MeSH term(s)	Humans ; Carbapenems/pharmacology ; Anti-Bacterial Agents/pharmacology ; Pseudomonas aeruginosa/genetics ; Risk Factors ; Disease Outbreaks
Chemical Substances	Carbapenems ; Anti-Bacterial Agents
Language	English
Publishing date	2023-04-03
Publishing country	England
Document type	Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2666706-X
ISSN	2047-2994 ; 2047-2994
ISSN (online)	2047-2994
ISSN	2047-2994
DOI	10.1186/s13756-023-01223-1
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Article ; Online: The care of the colorectal cancer survivor.

Cercek, Andrea / Holt, Peter R

Current opinion in gastroenterology

2017 Volume 33, Issue 1, Page(s) 26–33

Abstract: Purpose of review: The gastroenterology literature emphasizes factors that increase colorectal cancer (CRC) incidence but presents little about management after initial CRC treatments. The purpose of this review is to describe the remarkably increasing ... ...

Abstract	Purpose of review: The gastroenterology literature emphasizes factors that increase colorectal cancer (CRC) incidence but presents little about management after initial CRC treatments. The purpose of this review is to describe the remarkably increasing numbers of CRC survivors in whom surveillance guidelines are often not followed and patient care is fragmented. The gastroenterologist can play an important role in this care to improve prognosis and overall health. Recent findings: Existing surveillance recommendations by specialty societies for CRC survivors are fairly consistent but implementation occurs in less than half. The gastroenterologist can help to coordinate care to ensure appropriate surveillance and also can help to diagnose and treat chemotherapy and radiotherapy complications in survivors which can affect the quality of life long after the initial treatment. The gastroenterologist also can focus on host factors, including management of obesity, exercise programs, and the diet and can introduce potential chemopreventive agents such as nonsteroidal anti-inflammatory drugs when positive prospective studies are forthcoming. Interested gastroenterologists also have a role in participating in such prospective studies. Summary: The gastroenterologist should enhance her/his role for coordinated management of CRC survivors to improve patient surveillance care, to treat posttherapy complications and encourage preventive measures to improve prognosis and quality of life.
MeSH term(s)	Cancer Survivors ; Colorectal Neoplasms/therapy ; Continuity of Patient Care ; Humans ; Patient Care ; Patient Care Management ; Prognosis ; Quality of Life
Language	English
Publishing date	2017-01-30
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	632571-3
ISSN	1531-7056 ; 0267-1379
ISSN (online)	1531-7056
ISSN	0267-1379
DOI	10.1097/MOG.0000000000000321
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Zs.A 2072: Show issues

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Article ; Online: Are Negative Symptoms Merely the "Real World" Consequences of Deficits in Social Cognition?

Pelletier-Baldelli, Andrea / Holt, Daphne J

Schizophrenia bulletin

2019 Volume 46, Issue 2, Page(s) 236–241

Abstract: Many investigations have demonstrated that negative symptoms and social cognitive deficits in schizophrenia play a large role in determining functional outcomes and ultimately long-term prognosis. Given this, there is increasing interest in understanding ...

Abstract	Many investigations have demonstrated that negative symptoms and social cognitive deficits in schizophrenia play a large role in determining functional outcomes and ultimately long-term prognosis. Given this, there is increasing interest in understanding the relationship between these two symptom domains, particularly since studies have consistently found moderate to large associations between them. This shared variance raises a key question: to what degree do these two categories of symptoms arise from overlapping or identical changes in brain function? In other words, do some or all negative symptoms represent merely the downstream effects of social cognition deficits on daily functioning? In this commentary, the evidence for and against this possibility, limitations of currently validated empirical measurements of these symptoms, and directions for further investigation of this hypothesis are discussed. Understanding the shared and distinct mechanisms of these disabling deficits will have important implications for the design of novel, personalized treatments for psychotic illness.
MeSH term(s)	Cognitive Dysfunction/etiology ; Cognitive Dysfunction/physiopathology ; Humans ; Schizophrenia/complications ; Schizophrenia/physiopathology ; Social Cognition
Language	English
Publishing date	2019-10-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	439173-1
ISSN	1745-1701 ; 0586-7614
ISSN (online)	1745-1701
ISSN	0586-7614
DOI	10.1093/schbul/sbz095
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