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Article: Predicting Dominant Genotypes in Norovirus Seasons in Japan.

Suzuki, Yoshiyuki

2023 Volume 13, Issue 8

Abstract: Human noroviruses are an etiological agent of acute gastroenteritis. Since multiple genotypes co-circulate every season changing their proportions, it may be desirable to develop multivalent vaccines by formulating genotype composition of seed strains to ...

Abstract	Human noroviruses are an etiological agent of acute gastroenteritis. Since multiple genotypes co-circulate every season changing their proportions, it may be desirable to develop multivalent vaccines by formulating genotype composition of seed strains to match that of dominant strains. Here, performances of the models for predicting dominant genotypes, defined as the two most prevalent genotypes, were evaluated using observed genotype frequencies in Japan and genomic sequences for GI and GII strains. In the null model, genotype proportions in the target season were predicted to be the same as those in the immediately preceding season. In the fitness model, genotype proportions were predicted taking into account the acquisition of novel P-types through recombination and genotype-specific proliferation efficiency, as well as herd immunity to VP1 assuming the duration (
Language	English
Publishing date	2023-07-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life13081634
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Chaperone therapy for lysosomal and non-lysosomal protein misfolding diseases.

Suzuki, Yoshiyuki

Brain & development

2023 Volume 45, Issue 5, Page(s) 251–259

Abstract: Chaperone therapy was introduced first as a new molecular therapeutic approach to lysosomal diseases. In a recent article, I reviewed the development of chaperone therapy mainly for lysosomal diseases. Then, more data have been collected particularly on ... ...

Abstract	Chaperone therapy was introduced first as a new molecular therapeutic approach to lysosomal diseases. In a recent article, I reviewed the development of chaperone therapy mainly for lysosomal diseases. Then, more data have been collected particularly on non-lysosomal protein misfolding diseases. In this short review, I propose the concept of chaperone therapy to be classified into two different therapeutic approaches, for pH-dependent lysosomal, and pH-independent non-lysosomal protein misfolding diseases. The concept of lysosomal chaperone therapy is well established, but the non-lysosomal chaperone therapy is heterogeneous and to be investigated further for various individual diseases. As a whole, these two-types of new molecular therapeutic approaches will make an impact on the treatment of a wide range of pathological conditions caused by protein misfolding, not necessarily lysosomal but also many non-lysosomal diseases caused by gene mutations, metabolic diseases, malignancy, infectious diseases, and aging. The concept will open a completely new aspect of protein therapy in future.
MeSH term(s)	Humans ; Molecular Chaperones/metabolism ; Proteostasis Deficiencies/genetics ; Proteostasis Deficiencies/therapy ; Proteostasis Deficiencies/metabolism ; Mutation ; Lysosomes/metabolism
Chemical Substances	Molecular Chaperones
Language	English
Publishing date	2023-03-02
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	604822-5
ISSN	1872-7131 ; 0387-7604
ISSN (online)	1872-7131
ISSN	0387-7604
DOI	10.1016/j.braindev.2023.02.004
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Article: Methods for making multiple alignment of genomic sequences for severe acute respiratory syndrome coronavirus 2.

Suzuki, Yoshiyuki

Meta gene

2020 Volume 26, Page(s) 100785

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019 and caused a pandemic. To monitor the global transmission pattern of SARS-CoV-2, it is required to constantly update the phylogenetic tree of genomic sequences with 29 ... ...

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019 and caused a pandemic. To monitor the global transmission pattern of SARS-CoV-2, it is required to constantly update the phylogenetic tree of genomic sequences with 29.9 kb, which may be time consuming. Phylogenetic analysis of SARS-CoV-2 may be accelerated by making a multiple alignment of nucleotide sequences using the CPA (combining pairwise alignments) method, in which a pairwise alignment is made for a reference and each of other sequences, and the pairwise alignments are combined into a multiple alignment. Here it is shown from the analysis of 3729 genomic sequences for SARS-CoV-2 and outgroup strains that the CPA method can produce a multiple alignment with an elevated or a reduced number of variable sites depending on the reference compared to the OMA (ordinary multiple alignment) method, which was considered to be the most reliable. In particular, the topology of the phylogenetic tree constructed from the multiple alignment made using the CPA method adopting the outgroup sequence as the reference was considerably different from that using the OMA method, suggesting that the outgroup sequence may not be suitable as the reference in the CPA method.
Keywords	covid19
Language	English
Publishing date	2020-08-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2743632-9
ISSN	2214-5400
ISSN	2214-5400
DOI	10.1016/j.mgene.2020.100785
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Article ; Online: Chaperone therapy for molecular pathology in lysosomal diseases.

Suzuki, Yoshiyuki

Brain & development

2020 Volume 43, Issue 1, Page(s) 45–54

Abstract: In lysosomal diseases, enzyme deficiency is caused by misfolding of mutant enzyme protein with abnormal steric structure that is expressed by gene mutation. Chaperone therapy is a new molecular therapeutic approach primarily for lysosomal diseases. The ... ...

Abstract	In lysosomal diseases, enzyme deficiency is caused by misfolding of mutant enzyme protein with abnormal steric structure that is expressed by gene mutation. Chaperone therapy is a new molecular therapeutic approach primarily for lysosomal diseases. The misfolded mutant enzyme is digested rapidly or aggregated to induce endoplasmic reticulum stress. As a result, the catalytic activity is lost. The following sequence of events results in chaperone therapy to achieve correction of molecular pathology. An orally administered low molecular competitive inhibitor (chaperone) is absorbed into the bloodstream and reaches the target cells and tissues. The mutant enzyme is stabilized by the chaperone and subjected to normal enzyme proteinfolding (proteostasis). The first chaperone drug was developed for Fabry disease and is currently available in medical practice. At present three types of chaperones are available: competitive chaperone with enzyme inhibitory bioactivity (exogenous), non-competitive (or allosteric) chaperone without inhibitory bioactivity (exogenous), and molecular chaperone (heat shock protein; endogenous). The third endogenous chaperone would be directed to overexpression or activated by an exogenous low-molecular inducer. This new molecular therapeutic approach, utilizing the three types of chaperone, is expected to apply to a variety of diseases, genetic or non-genetic, and neurological or non-neurological, in addition to lysosomal diseases.
MeSH term(s)	Endoplasmic Reticulum Stress/physiology ; Fabry Disease/drug therapy ; Gangliosidosis, GM1/drug therapy ; Humans ; Lysosomal Storage Diseases/metabolism ; Lysosomal Storage Diseases/physiopathology ; Lysosomal Storage Diseases/therapy ; Lysosomes/metabolism ; Molecular Chaperones/metabolism ; Molecular Chaperones/therapeutic use ; Proteostasis Deficiencies/metabolism ; Proteostasis Deficiencies/physiopathology ; Proteostasis Deficiencies/therapy
Chemical Substances	Molecular Chaperones
Language	English
Publishing date	2020-07-29
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	604822-5
ISSN	1872-7131 ; 0387-7604
ISSN (online)	1872-7131
ISSN	0387-7604
DOI	10.1016/j.braindev.2020.06.015
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Article: [Ⅱ.Development of Anti-Neoplastic Agents for Prostate Cancer-Recent Trend and Perspectives].

Suzuki, Kazuhiro / Miyazawa, Yoshiyuki

Gan to kagaku ryoho. Cancer & chemotherapy

2021 Volume 48, Issue 1, Page(s) 35–40

MeSH term(s)	Antineoplastic Agents/therapeutic use ; Humans ; Male ; Prostatic Neoplasms/drug therapy
Chemical Substances	Antineoplastic Agents
Language	Japanese
Publishing date	2021-01-20
Publishing country	Japan
Document type	Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Article: Insomnia symptoms and related factors in a community-based population: The Yamagata Cohort study.

Suzuki, Miho / Suzuki, Natsuko / Sakurada, Kaori / Tsuchiya, Norihiko / Ueno, Yoshiyuki / Konta, Tsuneo

Heliyon

2024 Volume 10, Issue 6, Page(s) e28228

Abstract: Objective/background: Insomnia is prevalent and is a risk factor for the development of lifestyle-related diseases and early death. To improve insomnia, it is necessary to identify the factors that affect it. This study investigated the associations ... ...

Abstract	Objective/background: Insomnia is prevalent and is a risk factor for the development of lifestyle-related diseases and early death. To improve insomnia, it is necessary to identify the factors that affect it. This study investigated the associations between insomnia symptoms and mental, physical, and environmental factors in the general Japanese population. Patients/methods: The study participants were 7,873 individuals who responded to the Health and Lifestyle Survey questionnaire that included sleep-related items between December 2021 and March 2022. Insomnia symptoms were defined as a score of 6 or higher on the Athens Insomnia Scale (AIS). A multivariate logistic regression analysis was performed to identify factors independently associated with insomnia symptoms. Results: Of all subjects, 23.4% had insomnia symptoms. Factors associated with insomnia symptoms were older age, female sex, very difficult living conditions on current income, pain/discomfort, anxiety, lack of happiness, frequent nocturia, long duration from bathing time to bedtime, bedroom lighting, and short walking duration. The subgroup analysis showed stronger associations between walking time in men, higher body mass index in women, time from bathing time to bedtime, and daily walking duration in older adults. Conclusions: Insomnia symptoms were common in community-based populations and were independently associated with three different factor groups including physical, psychological, and environmental factors. Improvements in insomnia symptoms require appropriate practical support tailored to an individual's situation.
Language	English
Publishing date	2024-03-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e28228
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Article ; Online: Outstanding Robust Photo- and Thermo-Electric Applications with Stabilized n-Doped Carbon Nanotubes by Parylene Coating.

Suzuki, Daichi / Nonoguchi, Yoshiyuki / Shimamoto, Kazumasa / Terasaki, Nao

ACS applied materials & interfaces

2023

Abstract: Stabilization techniques for n-doped carbon nanotubes (CNTs) are essential for the practical use of CNT devices. However, none of the reported n-dopants have sufficient robustness in a practical environment. Herein, we report a highly stable technique ... ...

Abstract	Stabilization techniques for n-doped carbon nanotubes (CNTs) are essential for the practical use of CNT devices. However, none of the reported n-dopants have sufficient robustness in a practical environment. Herein, we report a highly stable technique for fabricating n-doped CNT films. We elucidate the mechanism by which air stability can be achieved by completely covering CNTs with n-dopants to prevent oxidation; consequently, the stability is lost when exposed to scratches or moisture. Therefore, we introduce parylene as a protective layer for n-doped CNTs and achieve air stability for more than 365 d. Moreover, we demonstrate outstanding robust thermo-electric power generation from strong acids, alkalis, and alcohols, which cannot be realized with conventional air-stable n-dopants. The proposed stabilization technique is versatile and can be applied to various n-dopants. Thus, it is expected to be a key technology in the practical application of CNT devices.
Language	English
Publishing date	2023-02-13
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.2c21347
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Article: Methods for making multiple alignment of genomic sequences for severe acute respiratory syndrome coronavirus 2

Suzuki, Yoshiyuki

Meta Gene

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019 and caused a pandemic To monitor the global transmission pattern of SARS-CoV-2, it is required to constantly update the phylogenetic tree of genomic sequences with 29 9 ...

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019 and caused a pandemic To monitor the global transmission pattern of SARS-CoV-2, it is required to constantly update the phylogenetic tree of genomic sequences with 29 9 kb, which may be time consuming Phylogenetic analysis of SARS-CoV-2 may be accelerated by making a multiple alignment of nucleotide sequences using the CPA (combining pairwise alignments) method, in which a pairwise alignment is made for a reference and each of other sequences, and the pairwise alignments are combined into a multiple alignment Here it is shown from the analysis of 3729 genomic sequences for SARS-CoV-2 and outgroup strains that the CPA method can produce a multiple alignment with an elevated or a reduced number of variable sites depending on the reference compared to the OMA (ordinary multiple alignment) method, which was considered to be the most reliable In particular, the topology of the phylogenetic tree constructed from the multiple alignment made using the CPA method adopting the outgroup sequence as the reference was considerably different from that using the OMA method, suggesting that the outgroup sequence may not be suitable as the reference in the CPA method
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #720653
Database	COVID19

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Article ; Online: Quantitative Analysis of Gastrointestinal Water Dynamics by Means of a Physiologically Based Fluid Kinetic Model.

Suzuki, Satoru / Inoue, Katsuhisa / Tamai, Ikumi / Shirasaka, Yoshiyuki

The AAPS journal

2023 Volume 25, Issue 3, Page(s) 42

Abstract: Since the processes of dissolution and membrane permeation are affected by the water content in the gastrointestinal (GI) tract, the water dynamics in the GI tract is expected to have a significant impact on the absorption of orally administered drugs. ... ...

Abstract	Since the processes of dissolution and membrane permeation are affected by the water content in the gastrointestinal (GI) tract, the water dynamics in the GI tract is expected to have a significant impact on the absorption of orally administered drugs. Here, we aimed to develop a physiologically based fluid kinetic (PBFK) model using GI water kinetic parameters obtained from in situ closed-loop studies in rats in order to quantitatively predict GI water dynamics. By incorporating the experimentally measured site-specific parameters of GI water absorption and secretion into a GI compartment model, we developed a bottom-up PBFK model that successfully simulates the reported GI fluid dynamics in rats and humans observed using positron emission tomography and magnetic resonance imaging, respectively. The simulations indicate that the water volume in both the stomach and duodenum is transiently increased by water ingestion, while that in the intestine below the jejunum is unchanged and remains in a steady state in both rats and humans. Furthermore, sensitivity analysis of the effect of ingested water volume on the volume-time profiles of water in the GI tract indicated that the impact of ingested water is limited to the proximal part of the GI tract. Simulations indicated that changes in water kinetic parameters may alter the impact of the ingested water on GI fluid dynamics, especially in the proximal part. Incorporating this PBFK model into a physiologically based pharmacokinetic (PBPK) absorption model has the potential to predict oral drug absorption in a variety of GI water environments.
MeSH term(s)	Humans ; Rats ; Animals ; Water ; Gastrointestinal Tract/metabolism ; Intestinal Absorption/physiology ; Positron-Emission Tomography ; Administration, Oral ; Models, Biological
Chemical Substances	Water (059QF0KO0R)
Language	English
Publishing date	2023-04-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1550-7416
ISSN (online)	1550-7416
DOI	10.1208/s12248-023-00809-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Outstanding Robust Photo- and Thermo-Electric Applications with Stabilized n‑Doped Carbon Nanotubes by Parylene Coating

Suzuki, Daichi / Nonoguchi, Yoshiyuki / Shimamoto, Kazumasa / Terasaki, Nao

ACS Applied Materials & Interfaces. 2023 Feb. 13, v. 15, no. 7 p.9873-9882

2023

Abstract	Stabilization techniques for n-doped carbon nanotubes (CNTs) are essential for the practical use of CNT devices. However, none of the reported n-dopants have sufficient robustness in a practical environment. Herein, we report a highly stable technique for fabricating n-doped CNT films. We elucidate the mechanism by which air stability can be achieved by completely covering CNTs with n-dopants to prevent oxidation; consequently, the stability is lost when exposed to scratches or moisture. Therefore, we introduce parylene as a protective layer for n-doped CNTs and achieve air stability for more than 365 d. Moreover, we demonstrate outstanding robust thermo-electric power generation from strong acids, alkalis, and alcohols, which cannot be realized with conventional air-stable n-dopants. The proposed stabilization technique is versatile and can be applied to various n-dopants. Thus, it is expected to be a key technology in the practical application of CNT devices.
Keywords	air ; carbon nanotubes ; oxidation ; power generation ; n-doped carbon nanotube films ; air stability ; stabilization technique ; parylene coating ; thermo-electric power generation
Language	English
Dates of publication	2023-0213
Size	p. 9873-9882.
Publishing place	American Chemical Society
Document type	Article ; Online
ISSN	1944-8252
DOI	10.1021/acsami.2c21347
Database	NAL-Catalogue (AGRICOLA)

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