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Article: PAI-1 4G-4G, MTHFR 677TT, V Leiden 506Q, and Prothrombin 20210A in Splanchnic Vein Thrombosis: Analysis of Individual Patient Data From Three Prospective Studies.

Pasta, Linda / Pasta, Francesca / D'Amico, Mario

Journal of clinical and experimental hepatology

2015 Volume 6, Issue 1, Page(s) 10–14

Abstract: ... THRGFs): PAI-1 4G-4G, MTHFR 677TT, V Leiden 506Q, and prothrombin 20210A.: Objectives: To evaluate ... MTHFR 677TT were significantly more frequent in patients with SVT (P values <0.005), whereas V Leiden ...

Abstract	Background: There are no univocal opinions on the role of genetic thrombophilia on splanchnic vein thrombosis (SVT). We defined genetic thrombophilia the presence of one of these thrombophilic genetic factors (THRGFs): PAI-1 4G-4G, MTHFR 677TT, V Leiden 506Q, and prothrombin 20210A. Objectives: To evaluate the frequencies of these THRGFs in SVT patients, we analyzed individual data of 482 Caucasian patients, recruited from 2000 to 2014 in three prospective studies. SVT was defined as the presence of thrombosis of portal (PVT), mesenteric (MVT), splenic (SPVT), cava (CT), and hepatic vein (Budd Chiari syndrome, BCS). Pre-hepatic SVT (pre-HSVT) was defined as PVT with or without MVT/SPVT, without BCS. Post-hepatic SVT (post-HSVT) was BCS with or without PVT/MVT/SPVT. Methods: We compared 350 patients with liver cirrhosis (LC), 47 hepatocellular carcinoma (HCC), 37 myeloproliferative neoplasm (MPN), 38 associated disease (AD), 10 without any associated disease (WAD), vs 150 healthy controls (HC); 437 patients showed pre-HSVT and 45 post-HSVT. Results: Thrombophilia was present in 294/482 (60.9%) patients: 189/350 LC (54.0%), 31/47 (66.0%) HCC, 29/39 (74.4%) MPN, 35/38 AD (92.1%), and 10/10 (100%) WAD, and 54/150 (36.0%) in HC. In the total group, we found 175 PAI-1 4G-4G, 130 MTHFR 677TT, 42V Leiden 506Q, and 27 prothrombin 20210A; 75 patients showed presence of >1 TRHGF; the more frequent association was PAI-1 4G-4G/MTHFR 677TT, in 36 patients. PAI-1 4G-4G and MTHFR 677TT were significantly more frequent in patients with SVT (P values <0.005), whereas V Leiden Q506 and prothrombin G20210A were not. PAI-1 4G-4G and MTHFR 677TT distributions deviated significantly from that expected from a population in Hardy-Weinberg equilibrium. Thrombophilia was significantly less frequent in patients with pre-HSVT (250/437, 57.2%) than in patients with post-HSVT (44/45, 97.8%). Conclusions: Our study shows the significant prevalence of PAI-1 4G-4G and MTHFR 677TT in SVT, mainly in post-HSVT.
Language	English
Publishing date	2015-12-06
Publishing country	India
Document type	Journal Article
ISSN	0973-6883
ISSN	0973-6883
DOI	10.1016/j.jceh.2015.11.002
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Article: Thrombophilic Genetic Factors PAI-1, MTHFRC677T, V Leiden 506Q, and Prothrombin 20210A in Noncirrhotic Portal Vein Thrombosis and Budd-Chiari Syndrome in a Caucasian Population.

D'Amico, Mario / Sammarco, Pietro / Pasta, Linda

International journal of vascular medicine

2013 Volume 2013, Page(s) 717480

Abstract: Thrombophilic genetic factors PAI-1, MTHFRC677T, V Leiden 506Q, and Prothrombin 20210A were studied ... 4G, MTHFR677TT, and V Leiden 506Q were significantly frequent (OR 95% CI and χ (2) test with P value ... whereas the equilibrium was respected in healthy controls. V Leiden Q506 and Prothrombin 20210A were in the Hardy-Weinberg ...

Abstract	Thrombophilic genetic factors PAI-1, MTHFRC677T, V Leiden 506Q, and Prothrombin 20210A were studied as risk factors in 235 Caucasian subjects: 85 patients with abdominal thrombosis (54 with portal vein thrombosis (PVT) and 31 with Budd-Chiari syndrome (BCS) without liver cirrhosis or hepatocellular carcinoma) and 150 blood bank donors. Seventy-five patients with PVT/BCS showed associated disease or particular clinical status (46 PVT/29 BCS): 37 myeloproliferative neoplasm (20 PVT/17 BCS), 12 abdominal surgery (10 PVT/2 BCS), 10 contraception or pregnancy (6 PVT/4 BCS), 7 abdominal acute disease (6 PVT/1 BCS), and 9 chronic disease (4 PVT/5 BCS); ten patients did not present any association (8 PVT/2 BCS). PAI-14G-4G, MTHFR677TT, and V Leiden 506Q were significantly frequent (OR 95% CI and χ (2) test with P value) in abdominal thrombosis; in these patients PAI-14G-4G and MTHFR677TT distributions deviated from that expected from a population in the Hardy-Weinberg equilibrium (PAI-1: χ (2) = 13.8, P < 0.001; MTHFR677: χ (2) = 7.1, P < 0.01), whereas the equilibrium was respected in healthy controls. V Leiden Q506 and Prothrombin 20210A were in the Hardy-Weinberg equilibrium both in patients with abdominal thrombosis and healthy controls. Our study shows an important role of PAI-14G-4G and MTHFR677TT in abdominal thrombosis without liver cirrhosis or hepatocellular carcinoma.
Language	English
Publishing date	2013-12-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2573977-3
ISSN	2090-2832 ; 2090-2824
ISSN (online)	2090-2832
ISSN	2090-2824
DOI	10.1155/2013/717480
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Article ; Online: MTHFR C677TT, PAI1 4G-4G, V Leiden Q506, and prothrombin G20210A in hepatocellular carcinoma with and without portal vein thrombosis.

D'Amico, Mario / Pasta, Linda / Sammarco, Piero

Journal of thrombosis and thrombolysis

2008 Volume 28, Issue 1, Page(s) 70–73

Abstract: We studied thrombophilic genetic factors (TGFs) MTHFR C677TT, PAI1 4G-4G, V Leiden Q506 ... in patients with PVT, while V Leiden factor was equally distributed among HCC and HC. Differences were more ...

Abstract	We studied thrombophilic genetic factors (TGFs) MTHFR C677TT, PAI1 4G-4G, V Leiden Q506, prothrombin G20210A as risk factors in 94 patients with HCC with and without portal vein thrombosis (PVT), compared with 214 patients with liver cirrhosis (LC) with and without PVT and 94 healthy controls (HC). The OR (95% CI) for MTHFR C677TT with HCC was 3.85 (1.55-7.39) vs. HC. The OR for PAI1 4G-4G in HCC, was 2.87 (1.27-6.55) vs. HC. Also prothrombin G20210A was significantly more frequent among HCC, mainly in patients with PVT, while V Leiden factor was equally distributed among HCC and HC. Differences were more significant in patients with associated PVT. These findings suggest that frequently TGFs are needed for patients to be at risk of HCC and PVT. We conclude that in all patients with chronic liver disease TGF screening should be performed to individuate patients at risk of HCC and PVT.
MeSH term(s)	Carcinoma, Hepatocellular/complications ; Carcinoma, Hepatocellular/genetics ; Factor V/genetics ; Female ; Humans ; Liver Cirrhosis/complications ; Liver Cirrhosis/genetics ; Male ; Methylenetetrahydrofolate Reductase (NADPH2)/genetics ; Plasminogen Activator Inhibitor 1/genetics ; Portal Vein ; Prothrombin/genetics ; Thrombosis/complications ; Thrombosis/genetics
Chemical Substances	Plasminogen Activator Inhibitor 1 ; SERPINE1 protein, human ; factor V Leiden ; Factor V (9001-24-5) ; Prothrombin (9001-26-7) ; Methylenetetrahydrofolate Reductase (NADPH2) (EC 1.5.1.20)
Language	English
Publishing date	2008-07-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1230645-9
ISSN	1573-742X ; 0929-5305
ISSN (online)	1573-742X
ISSN	0929-5305
DOI	10.1007/s11239-008-0246-6
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Article: A Population-Based 3D Atlas of the Pathological Lumbar Spine Segment.

Sciortino, Vincenza / Pasta, Salvatore / Ingrassia, Tommaso / Cerniglia, Donatella

Bioengineering (Basel, Switzerland)

2022 Volume 9, Issue 8

Abstract: The spine is the load-bearing structure of human beings and may present several disorders, with low back pain the most frequent problem during human life. Signs of a spine disorder or disease vary depending on the location and type of the spine condition. ...

Abstract	The spine is the load-bearing structure of human beings and may present several disorders, with low back pain the most frequent problem during human life. Signs of a spine disorder or disease vary depending on the location and type of the spine condition. Therefore, we aim to develop a probabilistic atlas of the lumbar spine segment using statistical shape modeling (SSM) and then explore the variability of spine geometry using principal component analysis (PCA). Using computed tomography (CT), the human spine was reconstructed for 24 patients with spine disorders and then the mean shape was deformed upon specific boundaries (e.g., by ±3 or ±1.5 standard deviation). Results demonstrated that principal shape modes are associated with specific morphological features of the spine segment such as Cobb's angle, lordosis degree, spine width and height. The lumbar spine atlas here developed has evinced the potential of SSM to investigate the association between shape and morphological parameters, with the goal of developing new treatments for the management of patients with spine disorders.
Language	English
Publishing date	2022-08-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2746191-9
ISSN	2306-5354
ISSN	2306-5354
DOI	10.3390/bioengineering9080408
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Article: Vyuzití laserů v oftalmologii. Cást druhá: fotodisruptivní terapie.

Pasta, J

Ceskoslovenska oftalmologie

1993 Volume 49, Issue 3, Page(s) 189–192

Title translation	Use of lasers in ophthalmology. II. Photodisruptive therapy.
MeSH term(s)	Eye Diseases/surgery ; Humans ; Laser Therapy
Language	Czech
Publishing date	1993-06
Publishing country	Czech Republic
Document type	Journal Article
ZDB-ID	423593-9
ISSN	0009-059X
ISSN	0009-059X
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Article ; Online: Thrombophilic Genetic Factors PAI-1, MTHFRC677T, V Leiden 506Q, and Prothrombin 20210A in Noncirrhotic Portal Vein Thrombosis and Budd-Chiari Syndrome in a Caucasian Population

Mario D’Amico / Pietro Sammarco / Linda Pasta

International Journal of Vascular Medicine , Vol

2013 Volume 2013

Keywords	Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Cardiovascular ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	English
Publishing date	2013-01-01T00:00:00Z
Publisher	Hindawi Publishing Corporation
Document type	Article ; Online
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Article ; Online: The IXI/V motif in the C-terminal extension of alpha-crystallins: alternative interactions and oligomeric assemblies.

Pasta, Saloni Yatin / Raman, Bakthisaran / Ramakrishna, Tangirala / Rao, Ch Mohan

Molecular vision

2004 Volume 10, Page(s) 655–662

Abstract: ... a conserved IXI/V motif. The purpose of this study was to investigate the role of this conserved motif, IPV ... at 25 degrees C. FRET experiments show that the region spanning the IPI/V motif comes in proximity ... either to the beta-strands of the "alpha-crystallin" domain or the corresponding IPI/V region of another subunit ...

Abstract	Purpose: Alpha-crystallin, a hetero-oligomer of alphaA- and alphaB-crystallin, is involved in maintaining eye lens transparency, primarily by its structural packing and chaperone activity. alphaA- and alphaB-crystallin share significant sequence homology, which is almost exclusively restricted to the central, conserved "alphaA-crystallin domain". The flanking N-terminal domain and C-terminal extension are highly variable both in sequence and length. Mutations and age-related post-translational modifications of these proteins are associated with congenital and age-onset cataracts. Interestingly, most mutations or truncations in the C-terminal extensions of the alpha-crystallins and other alpha-sHsps like Hsp27 lead to pathology. It is therefore important to understand the structure/function relationship of this region. Sequence alignment of the C-terminal extensions of alphaA- and alphaB-crystallin with other homologues shows a conserved IXI/V motif. The purpose of this study was to investigate the role of this conserved motif, IPV in alphaA-crystallin and IPI in alphaB-crystallin (corresponding to residues 159-161 in both crystallins), in the structure and chaperone activity. Methods: The isoleucine/valine residues in the IPV motif of alphaA-crystallin and the IPI motif of alphaB-crystallin were mutated to glycine and studied the secondary and tertiary structure of the mutant proteins using circular dichroism and fluorescence spectroscopy, and the quaternary structure using glycerol density gradient centrifugation and dynamic light scattering. Chaperone activity was studied at 37 degrees C and 25 degrees C using DTT induced aggregation of insulin as a model system. We have performed fluorescence resonance energy transfer (FRET) experiments to investigate the interactions of this motif in homo- and hetero-oligomers. Since alphaB-crystallin is devoid of Cys residues, we have introduced a Cys residue flanking the IPI motif (T162CalphaB-crystallin) to facilitate fluorescence labeling studies. Results: Unlike in other homologues from plants or prokaryotes, mutation of the isoleucine/valine residues in alpha-crystallins does not result in oligomer dissociation or loss of chaperone activity. On the contrary, the mutant proteins retain their capacity to oligomerize and show enhanced chaperone activity at 37 degrees C. The mutants also exhibit significantly higher chaperone-like activity at 25 degrees C. FRET experiments show that the region spanning the IPI/V motif comes in proximity either to the beta-strands of the "alpha-crystallin" domain or the corresponding IPI/V region of another subunit. Conclusions: Our mutational studies show that the IPI/V motif has a propensity to participate in inter-subunit interactions, either with regions in the alpha-crystallin domain or with the corresponding IPI/V region on another monomer. These interactions are important in the structure and function of alpha-crystallins. This motif also appears to be important in the temperature dependent chaperone-like activity of the alpha-crystallins. The propensity of the IPI/V motif to form multiple inter-subunit interactions may contribute to the diversity in structure and function seen in the alpha-crystallin/sHsp family.
MeSH term(s)	Amino Acid Motifs ; Centrifugation, Density Gradient ; Circular Dichroism ; Humans ; Light ; Molecular Chaperones/chemistry ; Molecular Chaperones/genetics ; Point Mutation ; Protein Structure, Quaternary ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Recombinant Proteins ; Scattering, Radiation ; Spectrometry, Fluorescence ; alpha-Crystallin A Chain/chemistry ; alpha-Crystallin A Chain/genetics ; alpha-Crystallin B Chain/chemistry ; alpha-Crystallin B Chain/genetics
Chemical Substances	Molecular Chaperones ; Recombinant Proteins ; alpha-Crystallin A Chain ; alpha-Crystallin B Chain
Language	English
Publishing date	2004-09-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2017540-1
ISSN	1090-0535 ; 1090-0535
ISSN (online)	1090-0535
ISSN	1090-0535
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Article: On the Left Ventricular Remodeling of Patients with Stenotic Aortic Valve: A Statistical Shape Analysis.

Cutugno, Salvatore / Ingrassia, Tommaso / Nigrelli, Vincenzo / Pasta, Salvatore

Bioengineering (Basel, Switzerland)

2021 Volume 8, Issue 5

Abstract: The left ventricle (LV) constantly changes its shape and function as a response to pathological conditions, and this process is known as remodeling. In the presence of aortic stenosis (AS), the degenerative process is not limited to the aortic valve but ... ...

Abstract	The left ventricle (LV) constantly changes its shape and function as a response to pathological conditions, and this process is known as remodeling. In the presence of aortic stenosis (AS), the degenerative process is not limited to the aortic valve but also involves the remodeling of LV. Statistical shape analysis (SSA) offers a powerful tool for the visualization and quantification of the geometrical and functional patterns of any anatomic changes. In this paper, a SSA method was developed to determine shape descriptors of the LV under different degrees of AS and thus to shed light on the mechanistic link between shape and function. A total of n=86 patients underwent computed tomography (CT) for the evaluation of valvulopathy were segmented to obtain the LV surface and then were automatically aligned to a reference template by rigid registrations and transformations. Shape modes of the anatomical LV variation induced by the degree of AS were assessed by principal component analysis (PCA). The first shape mode represented nearly 50% of the total variance of LV shape in our patient population and was mainly associated to a spherical LV geometry. At Pearson's analysis, the first shape mode was positively correlated to both the end-diastolic volume (p<0.01, R=0.814) and end-systolic volume (p<0.01, and R=0.922), suggesting LV impairment in patients with severe AS. A predictive model built with PCA-related shape modes achieved better performance in stratifying the occurrence of adverse events with respect to a baseline model using clinical demographic data as risk predictors. This study demonstrated the potential of SSA approaches to detect the association of complex 3D shape features with functional LV parameters.
Language	English
Publishing date	2021-05-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2746191-9
ISSN	2306-5354
ISSN	2306-5354
DOI	10.3390/bioengineering8050066
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Article ; Online: Stent-Assisted Coil Embolization of a Saccular Visceral Aortic Aneurysm: Case Report and Review of the Literature.

Gibello, Lorenzo / Varetto, Gianfranco / Pasta, Vittorio / Ripepi, Matteo / Discalzi, Andrea / Verzini, Fabio

Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists

2023 , Page(s) 15266028231162259

Abstract: Purpose: We present the results of unconventional endovascular treatment of a voluminous (65 mm) saccular visceral aortic aneurysm in a 78-year-old woman. Patient was deemed unfit for open surgery due to comorbidities. Fenestrated or branched ... ...

Abstract	Purpose: We present the results of unconventional endovascular treatment of a voluminous (65 mm) saccular visceral aortic aneurysm in a 78-year-old woman. Patient was deemed unfit for open surgery due to comorbidities. Fenestrated or branched endografting was also excluded due to the small diameter of the aorta, the severe stenosis at the origin of celiac trunk, and the anomalous origin of superior mesenteric artery arising infrarenally. Case report: After a preliminary selective angiography of the superior mesenteric artery showing valid anastomotic network with celiac trunk branches, an aortic self-expandable bare stent (Jotec E-XL) was deployed in the visceral aorta. Aneurysm sac embolization (Penumbra detachable Ruby Coils) in a coil-jailing technique was performed. Finally, an aortic cuff endograft (Gore) was deployed immediately above the origin of the left renal artery to cover the wide neck of the saccular aneurysm and improve sac exclusion. Hospital stay was uneventful, computed tomography (CT) at 12-month demonstrated aneurysm shrinkage to 62 mm without images of endoleak. Literature review showed how this technique has successfully been applied to manage similar cases of postsurgical and posttraumatic saccular aortic aneurysms in high-risk patients; however, long-term results are still unknown. Conclusion: Coil-jail technique for the treatment of saccular aortic aneurysms can be considered an alternative when open surgery or conventional endovascular treatment is not feasible. Technical success and mid-term outcomes are promising but strict follow-up is recommended. Clinical impact: This study aims to share the unconventional endovascular treatment of a visceral aortic aneurysm in a patient unfit both for open and traditional endovascular surgery. To the best of our knowledge this is one of the first cases published in Literature, for this reason, a step-by-step video has been created to describe the procedure. Literature review was then performed to analyze midterm results of this technique. Despite being a treatment that is not recommended for conventional cases, the knowledge of endovascular devices and techniques may help to manage or simplify complex aortic diseases.
Language	English
Publishing date	2023-03-29
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2006618-1
ISSN	1545-1550 ; 1526-6028
ISSN (online)	1545-1550
ISSN	1526-6028
DOI	10.1177/15266028231162259
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Article ; Online: Breast density

L. Giannunzio / V. Pasta / A. Laganà / V. Unfer

International Journal of Medical Device and Adjuvant Treatments, Vol

towards new therapeutic strategies for breast cancer prevention

2021 Volume 4

Abstract: Breast cancer (BC) is the leading cause of cancer-related mortality worldwide, mostly occurred in United States andWestern Europe. Scientists progressed in diagnosis and treatments for BC, contributing to the significant drop in the mortality rate. ... ...

Abstract	Breast cancer (BC) is the leading cause of cancer-related mortality worldwide, mostly occurred in United States andWestern Europe. Scientists progressed in diagnosis and treatments for BC, contributing to the significant drop in the mortality rate. However, malignancy still accounts for more than 500,000 deaths annually worldwide. A major risk factor contributing to the breast cancer burden is mammographic density (MD) in breast tissue. In fact, more than 50% of women under 50 years of age exhibit high MD. Several studies revealed that women with high breast density have a 4-6-fold increased risk of breast cancer compared to women with less breast density. This review highlights some natural substances that may help in the prevention of breast cancer. Modern data suggest that women with high breast density experience significant clinical benefits when treated with a balanced composition including boswellic acid, betaine, and Myo-inositol. Without any side effects, this therapy is a valuable natural solution to ameliorate high breast density cases,preventing breast cancer and contributing to pain reduction.
Keywords	breast ; cancer ; breast density ; prevention ; myo-inositol ; Computer applications to medicine. Medical informatics ; R858-859.7
Subject code	610 ; 616
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	Verduci Editore
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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