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  1. Book: Orphan G protein coupled receptors and novel neuropeptides

    Civelli, Olivier

    (Results and problems in cell differentiation ; 46)

    2008  

    Author's details Olivier Civelli ... (ed.)
    Series title Results and problems in cell differentiation ; 46
    Collection
    Keywords Neuropeptide ; ECHO-Viren ; GTP-bindende Proteine ; Rezeptor
    Subject Guaninnucleotidbindende Proteine ; G-Proteine ; Enteric cytopathogenic human orphan viruses ; Orphan-Viruses ; Orphan-Viren ; Neuromodulator
    Language English
    Size XV, 259 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT015574759
    ISBN 978-3-540-78350-3 ; 9783540783510 ; 3-540-78350-4 ; 3540783512
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2008 A 3541 order for loan Magazin

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  2. Article: Editorial: Neuropeptide GPCRs in neuroendocrinology, Volume II.

    Vaudry, Hubert / Schoofs, Liliane / Civelli, Olivier / Kojima, Masayasu

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1219530

    MeSH term(s) Neuroendocrinology ; Neuropeptides ; Receptors, G-Protein-Coupled
    Chemical Substances Neuropeptides ; Receptors, G-Protein-Coupled
    Language English
    Publishing date 2023-06-21
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1219530
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Humanized dopamine D

    Alachkar, Amal / Phan, Alvin / Dabbous, Travis / Alhassen, Sammy / Alhassen, Wedad / Reynolds, Bryan / Rubinstein, Marcelo / Ferré, Sergi / Civelli, Olivier

    Journal of neuroscience research

    2024  Volume 102, Issue 2, Page(s) e25299

    Abstract: The dopamine ... ...

    Abstract The dopamine D
    MeSH term(s) Humans ; Male ; Mice ; Animals ; Memory, Short-Term ; Dopamine ; Receptors, Dopamine D4/genetics ; Attention Deficit Disorder with Hyperactivity/genetics ; Memory Disorders ; Risk-Taking
    Chemical Substances Dopamine (VTD58H1Z2X) ; Receptors, Dopamine D4 (137750-34-6)
    Language English
    Publishing date 2024-01-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 195324-2
    ISSN 1097-4547 ; 0360-4012
    ISSN (online) 1097-4547
    ISSN 0360-4012
    DOI 10.1002/jnr.25299
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1232: Show issues Location:
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  4. Article ; Online: Ophthalmate is a new regulator of motor functions via CaSR: Implications for movement disorders.

    Alhassen, Sammy / Hogenkamp, Derk / Nguyen, Hung Anh / Al Masri, Saeed / Abbott, Geoffrey W / Civelli, Olivier / Alachkar, Amal

    Brain : a journal of neurology

    2024  

    Abstract: Dopamine's role as the principal neurotransmitter in motor functions has long been accepted. We broaden this conventional perspective by demonstrating the involvement of non-dopaminergic mechanisms. In mouse models of Parkinson's Disease (PD), we ... ...

    Abstract Dopamine's role as the principal neurotransmitter in motor functions has long been accepted. We broaden this conventional perspective by demonstrating the involvement of non-dopaminergic mechanisms. In mouse models of Parkinson's Disease (PD), we observed that L-DOPA elicited a substantial motor response even when its conversion to dopamine was blocked by inhibiting the enzyme aromatic amino acid decarboxylase (AADC). Remarkably, the motor activity response to L-DOPA in the presence of an AADC inhibitor (NSD1015) showed a delayed onset, yet greater intensity and longer duration, peaking at 7 hours, compared to when L-DOPA was administered alone. This suggests an alternative pathway or mechanism, independent of dopamine signaling, mediating the motor functions. We sought to determine the metabolites associated with the pronounced hyperactivity observed, using comprehensive metabolomics analysis. Our results revealed that the peak in motor activity induced by NSD1015/L-DOPA in PD mice is associated with a surge (20-fold) in brain levels of the tripeptide ophthalmic acid (OA, also known as ophthalmate in its anionic form). Interestingly, we found that administering ophthalmate directly to the brain rescued motor deficits in PD mice in a dose-dependent manner. We investigated the molecular mechanisms underlying ophthalmate's action and discovered, through radioligand binding and cAMP-luminescence assays, that ophthalmate binds to and activates the calcium-sensing receptor (CaSR). Additionally, our findings demonstrated that a CaSR antagonist inhibits the motor-enhancing effects of ophthalmate, further solidifying the evidence that ophthalmate modulates motor functions through the activation of the CaSR. The discovery of ophthalmate as a novel regulator of motor function presents significant potential to transform our understanding of brain mechanisms of movement control and the therapeutic management of related disorders.
    Language English
    Publishing date 2024-03-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 80072-7
    ISSN 1460-2156 ; 0006-8950
    ISSN (online) 1460-2156
    ISSN 0006-8950
    DOI 10.1093/brain/awae097
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    Ui II Zs.26: Show issues Location:
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  5. Article ; Online: Dehydroepiandrosterone Sulfate (DHEAS) Is an Endogenous Kv7 Channel Modulator That Reduces Kv7/M-Current Suppression and Inflammatory Pain.

    Alhassen, Lamees / Alhassen, Wedad / Wong, Cindy / Sun, Yuxuan / Xia, Zelin / Civelli, Olivier / Hoshi, Naoto

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2023  Volume 43, Issue 43, Page(s) 7073–7083

    Abstract: Neuronal Kv7 voltage-gated potassium channels generate the M-current and regulate neuronal excitability. Here, we report that dehydroepiandrosterone sulfate (DHEAS) is an endogenous Kv7 channel modulator that attenuates Gq-coupled receptor-induced M- ... ...

    Abstract Neuronal Kv7 voltage-gated potassium channels generate the M-current and regulate neuronal excitability. Here, we report that dehydroepiandrosterone sulfate (DHEAS) is an endogenous Kv7 channel modulator that attenuates Gq-coupled receptor-induced M-current suppression. DHEAS reduced muscarinic agonist-induced Kv7-current suppression of Kv7.1, Kv7.2, Kv7.4, or Kv7.5 homomeric currents and endogenous M-currents in rat sympathetic ganglion neurons. However, DHEAS per se did not alter the voltage dependence of these Kv7 homomeric channels or the m1 receptor-induced activation of phospholipase C or protein kinase C. DHEAS-treated Kv7.2 homomeric currents became resistant to depletion of phosphatidylinositol 4,5-bisphosphate (PIP2) induced by voltage-activated phosphatase, Ci-VSP or eVSP. Our computational models predicted a novel binding site for DHEAS in the cytoplasmic domain of Kv7 subunits. A single-point mutation of the predicted key histidine into cysteine in the rat Kv7.2 subunit, rKv7.2(H558C), resulted in a loss of effects of DHEAS on muscarinic Kv7 current suppression. Furthermore,
    MeSH term(s) Male ; Female ; Mice ; Rats ; Animals ; Dehydroepiandrosterone Sulfate ; KCNQ2 Potassium Channel/metabolism ; Muscarinic Agonists/pharmacology ; Pain/drug therapy ; Formaldehyde ; KCNQ3 Potassium Channel/genetics ; KCNQ3 Potassium Channel/metabolism
    Chemical Substances Dehydroepiandrosterone Sulfate (57B09Q7FJR) ; KCNQ2 Potassium Channel ; Muscarinic Agonists ; Formaldehyde (1HG84L3525) ; KCNQ3 Potassium Channel
    Language English
    Publishing date 2023-08-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.2307-22.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1668: Show issues Location:
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  6. Article: The History of N/OFQ and the NOP Receptor.

    Reinscheid, Rainer K / Civelli, Olivier

    Handbook of experimental pharmacology

    2019  Volume 254, Page(s) 3–16

    Abstract: The discovery of nociceptin/orphanin FQ (N/OFQ) marks the genuine start of the reverse pharmacology era, when systematic hunting for ligands of orphan receptors began. The choice of this particular target was no coincidence as the orphan receptor ORL-1 ... ...

    Abstract The discovery of nociceptin/orphanin FQ (N/OFQ) marks the genuine start of the reverse pharmacology era, when systematic hunting for ligands of orphan receptors began. The choice of this particular target was no coincidence as the orphan receptor ORL-1 displayed high similarity to known opioid receptors, and thus its elusive ligand held promise to find more than a ligand but a missing opioid peptide. N/OFQ indeed turned out to belong to the opioid peptide family, but with significant pharmacological and functional distinctions. The quest for understanding N/OFQ's physiological functions has produced some novel insights into stress regulation and many other body functions but is still ongoing almost 25 years after its discovery. This chapter highlights the early steps of orphan receptor research and some of the protagonists who helped to advance the field.
    MeSH term(s) Ligands ; Opioid Peptides/pharmacology ; Receptors, Opioid ; Nociceptin
    Chemical Substances Ligands ; Opioid Peptides ; Receptors, Opioid
    Language English
    Publishing date 2019-01-28
    Publishing country Germany
    Document type Journal Article
    ISSN 0171-2004
    ISSN 0171-2004
    DOI 10.1007/164_2018_195
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Sign. bis Bd. 125 (1997): 1982 A 2146: Show issues
     danach: Sign. bei den Einzelbänden: Show issues

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  7. Article ; Online: Orphan GPCRs and neuromodulation.

    Civelli, Olivier

    Neuron

    2012  Volume 76, Issue 1, Page(s) 12–21

    Abstract: Most G protein-coupled receptors (GPCRs) started as orphan GPCRs. Matching them to known neuromodulators led to the elucidation of the broad diversity of the neuroreceptor families. Moreover, orphan GPCRs have also been used as targets to discover novel ... ...

    Abstract Most G protein-coupled receptors (GPCRs) started as orphan GPCRs. Matching them to known neuromodulators led to the elucidation of the broad diversity of the neuroreceptor families. Moreover, orphan GPCRs have also been used as targets to discover novel neuromodulators. These discoveries have had profound impact on our understanding of brain function. Here, I present an overview of how some of the novel neuropeptides have enlarged our comprehension of responses that direct sleep/wakefulness, the onset of obesity and the feeding response. I also discuss other advances gained from orphan GPCR studies such as the concept of specificity in neuromodulation or of receptors acting as sensors instead of synaptic transmitters. Finally, I suggest that the recently discovered neuromodulators may hold the keys to our understanding of higher brain functions and psychiatric disorders.
    MeSH term(s) Animals ; Brain/physiology ; Humans ; Neurotransmitter Agents/physiology ; Receptors, G-Protein-Coupled/physiology
    Chemical Substances Neurotransmitter Agents ; Receptors, G-Protein-Coupled
    Language English
    Publishing date 2012-10-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2012.09.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2496: Show issues Location:
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    Zs.MG 92: Show issues

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  8. Article: Behavioral and neuro-functional consequences of eliminating the KCNQ3 GABA binding site in mice.

    Chen, Kiki J / Yoshimura, Ryan / Edmundo, Clarissa Adriana / Truong, Tri Minh / Civelli, Olivier / Alachkar, Amal / Abbott, Geoffrey W

    Frontiers in molecular neuroscience

    2023  Volume 16, Page(s) 1192628

    Abstract: Voltage-gated potassium (Kv) channels formed by α subunits KCNQ2-5 are important in regulating neuronal excitability. We previously found that GABA directly binds to and activates channels containing KCNQ3, challenging the traditional understanding of ... ...

    Abstract Voltage-gated potassium (Kv) channels formed by α subunits KCNQ2-5 are important in regulating neuronal excitability. We previously found that GABA directly binds to and activates channels containing KCNQ3, challenging the traditional understanding of inhibitory neurotransmission. To investigate the functional significance and behavioral role of this direct interaction, mice with a mutated KCNQ3 GABA binding site (Kcnq3-W266L) were generated and subjected to behavioral studies. Kcnq3-W266L mice exhibited distinctive behavioral phenotypes, of which reduced nociceptive and stress responses were profound and sex-specific. In female Kcnq3-W266L mice, the phenotype was shifted towards more nociceptive effects, while in male Kcnq3-W266L mice, it was shifted towards the stress response. In addition, female Kcnq3-W266L mice exhibited lower motor activity and reduced working spatial memory. The neuronal activity in the lateral habenula and visual cortex was altered in the female Kcnq3-W266L mice, suggesting that GABAergic activation of KCNQ3 in these regions may play a role in the regulation of the responses. Given the known overlap between the nociceptive and stress brain circuits, our data provide new insights into a sex-dependent role of KCNQ3 in regulating neural circuits involved in nociception and stress,
    Language English
    Publishing date 2023-05-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452967-9
    ISSN 1662-5099
    ISSN 1662-5099
    DOI 10.3389/fnmol.2023.1192628
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: The Extract of

    Alhassen, Lamees / Nuseir, Khawla / Ha, Allyssa / Phan, Warren / Marmouzi, Ilias / Shah, Shalini / Civelli, Olivier

    Pharmaceuticals (Basel, Switzerland)

    2021  Volume 14, Issue 10

    Abstract: The opioid epidemic was triggered by an overprescription of opioid analgesics. In the treatment of chronic pain, repeated opioid administrations are required which ultimately lead to tolerance, physical dependence, and addiction. A possible way to ... ...

    Abstract The opioid epidemic was triggered by an overprescription of opioid analgesics. In the treatment of chronic pain, repeated opioid administrations are required which ultimately lead to tolerance, physical dependence, and addiction. A possible way to overcome this conundrum consists of a co-medication that maintains the analgesic benefits of opioids while preventing their adverse liabilities. YHS, the extract of the plant
    Language English
    Publishing date 2021-10-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph14101034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The Analgesic Properties of

    Alhassen, Lamees / Dabbous, Travis / Ha, Allyssa / Dang, Leon Hoang Lam / Civelli, Olivier

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 24

    Abstract: Corydalis ... ...

    Abstract Corydalis yanhusuo
    MeSH term(s) Alkaloids/chemistry ; Alkaloids/isolation & purification ; Alkaloids/therapeutic use ; Analgesics/chemistry ; Analgesics/isolation & purification ; Analgesics/therapeutic use ; Corydalis/chemistry ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/isolation & purification ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Molecular Structure ; Pain/drug therapy ; Plant Extracts/chemistry ; Plant Extracts/isolation & purification ; Plant Extracts/therapeutic use
    Chemical Substances Alkaloids ; Analgesics ; Drugs, Chinese Herbal ; Plant Extracts
    Language English
    Publishing date 2021-12-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26247498
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    Zs.MO 81: Show issues

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