Artikel ; Online: Bao Yuan decoction alleviates fatigue by restraining inflammation and oxidative stress via the AMPK/CRY2/PER1 signaling pathway.
2024 Band 328, Seite(n) 118058
Abstract: Ethnopharmacological relevance: Baoyuan Decoction (BYD) was initially recorded in the classic of "Bo Ai Xin Jian" in the Ming dynasty. It is traditionally used for treating weakness and cowardice, and deficiency of vital energy. In researches related to ...
| Abstract | Ethnopharmacological relevance: Baoyuan Decoction (BYD) was initially recorded in the classic of "Bo Ai Xin Jian" in the Ming dynasty. It is traditionally used for treating weakness and cowardice, and deficiency of vital energy. In researches related to anti-fatigue effects, the reciprocal regulation of AMPK and circadian clocks likely plays an important role in anti-fatigue mechanism, while it has not yet been revealed. Therefore, we elucidated the anti-fatigue mechanism of BYD through AMPK/CRY2/PER1 pathway. Aim of the study: To investigate the effect and mechanism of BYD in reducing fatigue, using pharmacodynamics, network pharmacology and transcriptomics through the AMPK/CRY2/PER1 signaling pathway. Materials and methods: Firstly, the chemical constituents of BYD were qualitatively identified by UHPLC-Q-Exactive Orbitrap/MS, establishing a comprehensive strategy with an in-house library, Xcalibur software and Pubchem combined. Secondly, a Na Results: In total, 114 compounds from the water extract of BYD were identified as major compounds. Na₂SO₃-induced fatigue model and AAPH-induced oxidative stress model indicated that BYD has significant anti-fatigue and antioxidant effects. Meanwhile, BYD showed significant anti-inflammatory effects on CuSO Conclusion: Herein, we identified 114 chemical constituents of BYD, performed zebrafish activity validation, while demonstrated that BYD can relieve fatigue by AMPK/CRY2/PER1 signaling pathway through network pharmacology and transcriptome. |
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| Mesh-Begriff(e) | Animals ; AMP-Activated Protein Kinases ; Zebrafish ; Oxidative Stress ; Fatigue/drug therapy ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Inflammation/drug therapy ; Antioxidants ; Signal Transduction ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Amidines |
| Chemische Substanzen | AMP-Activated Protein Kinases (EC 2.7.11.31) ; 2,2'-azobis(2-amidinopropane) (7381JDR72F) ; Drugs, Chinese Herbal ; Antioxidants ; Anti-Inflammatory Agents ; Amidines |
| Sprache | Englisch |
| Erscheinungsdatum | 2024-03-20 |
| Erscheinungsland | Ireland |
| Dokumenttyp | Journal Article |
| ZDB-ID | 134511-4 |
| ISSN | 1872-7573 ; 0378-8741 |
| ISSN (online) | 1872-7573 |
| ISSN | 0378-8741 |
| DOI | 10.1016/j.jep.2024.118058 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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