Article ; Online: M
2022 Volume 23, Issue 1, Page(s) 341
Abstract: ... Prophylaxis trial (M: Discussion: The results of this study have the potential to demonstrate ...
Abstract | Background: Opioid use is escalating in North America and comes with a multitude of health consequences, including HIV and hepatitis C virus (HCV) outbreaks among persons who inject drugs (PWID). HIV pre-exposure prophylaxis (PrEP) and HCV treatment regimens have transformative potential to address these co-occurring epidemics. Evaluation of innovative multi-modal approaches, integrating harm reduction, opioid agonist therapy (OAT), PrEP, and HCV treatment is required. The aim of this study is to assess the effectiveness of an on-site integrated care model where delivery of PrEP and HCV treatment for PWID takes places at syringe service programs (SSP) and OAT programs compared with referring PWID to clinical services in the community through a patient navigation model and to examine how structural factors interact with HIV prevention adherence and HCV treatment outcomes. Methods: The Miami-Montreal Hepatitis C and Pre-Exposure Prophylaxis trial (M Discussion: The results of this study have the potential to demonstrate the effectiveness and cost-effectiveness of offering PrEP and HCV treatment in healthcare venues frequently attended by PWID. Testing the intervention in two urban centers with high disease burden among PWID, but with different healthcare system dynamics, will increase generalizability of findings. Trial registration: Clinicaltrials.gov NCT03981445 . Trial registry name: Integrated HIV Prevention and HCV Care for PWID (M2HepPrEP). Registration date: June 10, 201. |
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MeSH term(s) | Analgesics, Opioid/therapeutic use ; Drug Users ; HIV Infections/diagnosis ; HIV Infections/drug therapy ; HIV Infections/prevention & control ; Hepacivirus ; Hepatitis C/diagnosis ; Hepatitis C/drug therapy ; Hepatitis C/prevention & control ; Humans ; Multicenter Studies as Topic ; Pharmaceutical Preparations ; Randomized Controlled Trials as Topic ; Substance Abuse, Intravenous/complications ; Substance Abuse, Intravenous/drug therapy |
Chemical Substances | Analgesics, Opioid ; Pharmaceutical Preparations |
Language | English |
Publishing date | 2022-04-23 |
Publishing country | England |
Document type | Clinical Trial Protocol ; Journal Article |
ZDB-ID | 2040523-6 |
ISSN | 1745-6215 ; 1468-6694 ; 1745-6215 |
ISSN (online) | 1745-6215 |
ISSN | 1468-6694 ; 1745-6215 |
DOI | 10.1186/s13063-022-06085-3 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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