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  1. Book: Optogenetis

    Yawo, Hiromu / Kandori, Hideki / Koizumi, Amane / Kageyama, Ryoichiro

    light-sensing proteins and their applications in neuroscience and beyond

    (Advances in experimental medicine and biology ; 1293)

    2021  

    Author's details Hiromu Yawo, Hideki Kandori, Amane Koizumi, Ryoichiro Kageyama editors
    Series title Advances in experimental medicine and biology ; 1293
    Collection
    Language English
    Size xii, 664 Seiten, Illustrationen
    Edition Second edition
    Publisher Springer
    Publishing place Singapore
    Publishing country Singapore
    Document type Book
    HBZ-ID HT020702585
    ISBN 978-981-15-8762-7 ; 9789811587634 ; 981-15-8762-0 ; 9811587639
    Database Catalogue ZB MED Medicine, Health

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    Zs A 3192 -1293- not available for loan Zeitschriften-Lesesaal

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  2. Article ; Online: 25 years of the segmentation clock gene.

    Kageyama, Ryoichiro

    Nature

    2022  Volume 611, Issue 7937, Page(s) 671–673

    Language English
    Publishing date 2022-11-09
    Publishing country England
    Document type News
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-022-03562-2
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  3. Article ; Online: The significance of ultradian oscillations in development.

    Maeda, Yuki / Kageyama, Ryoichiro

    Current opinion in genetics & development

    2024  Volume 86, Page(s) 102180

    Abstract: Genes regulating developmental processes have been identified, but the mechanisms underlying their expression with the correct timing are still under investigation. Several genes show oscillatory expression that regulates the timing of developmental ... ...

    Abstract Genes regulating developmental processes have been identified, but the mechanisms underlying their expression with the correct timing are still under investigation. Several genes show oscillatory expression that regulates the timing of developmental processes, such as somitogenesis and neurogenesis. These oscillations are also important for other developmental processes, such as cell proliferation and differentiation. In this review, we discuss the significance of oscillatory gene expression in developmental time and other forms of regulation.
    Language English
    Publishing date 2024-03-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1077312-5
    ISSN 1879-0380 ; 0959-437X
    ISSN (online) 1879-0380
    ISSN 0959-437X
    DOI 10.1016/j.gde.2024.102180
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  4. Article ; Online: Transcriptional control of neural stem cell activity.

    Kaise, Takashi / Kageyama, Ryoichiro

    Biochemical Society transactions

    2024  Volume 52, Issue 2, Page(s) 617–626

    Abstract: In the adult brain, neural stem cells (NSCs) are under the control of various molecular mechanisms to produce an appropriate number of neurons that are essential for specific brain functions. Usually, the majority of adult NSCs stay in a non- ... ...

    Abstract In the adult brain, neural stem cells (NSCs) are under the control of various molecular mechanisms to produce an appropriate number of neurons that are essential for specific brain functions. Usually, the majority of adult NSCs stay in a non-proliferative and undifferentiated state known as quiescence, occasionally transitioning to an active state to produce newborn neurons. This transition between the quiescent and active states is crucial for the activity of NSCs. Another significant state of adult NSCs is senescence, in which quiescent cells become more dormant and less reactive, ceasing the production of newborn neurons. Although many genes involved in the regulation of NSCs have been identified using genetic manipulation and omics analyses, the entire regulatory network is complicated and ambiguous. In this review, we focus on transcription factors, whose importance has been elucidated in NSCs by knockout or overexpression studies. We mainly discuss the transcription factors with roles in the active, quiescent, and rejuvenation states of adult NSCs.
    MeSH term(s) Neural Stem Cells/metabolism ; Neural Stem Cells/cytology ; Humans ; Animals ; Transcription Factors/metabolism ; Transcription Factors/genetics ; Transcription, Genetic ; Cell Differentiation ; Gene Expression Regulation ; Neurons/metabolism ; Neurons/cytology
    Chemical Substances Transcription Factors
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 184237-7
    ISSN 1470-8752 ; 0300-5127
    ISSN (online) 1470-8752
    ISSN 0300-5127
    DOI 10.1042/BST20230439
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  5. Book: Cortical development

    Kageyama, Ryoichiro / Yamamori, Tetsuo

    neural diversity and neocortical organization

    2013  

    Author's details Ryoichiro Kageyama ; Tetsuo Yamamori ed
    Language English
    Size VIII, 282 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Tokyo u.a.
    Publishing country Japan
    Document type Book
    HBZ-ID HT018101561
    ISBN 978-4-431-54495-1 ; 4-431-54495-X ; 9784431544968 ; 4431544968
    Database Catalogue ZB MED Medicine, Health

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    2013 A 4059 available for loan (reading room) Lesesaal EG

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  6. Article ; Online: Time-Lapse Bioluminescence Imaging of Hes7 Expression In Vitro and Ex Vivo.

    Sanaki-Matsumiya, Marina / Kageyama, Ryoichiro

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2525, Page(s) 321–332

    Abstract: Somites are formed sequentially by the segmentation of the anterior parts of the presomitic mesoderm (PSM), and such periodical somite formation is crucial to ensure the proper vertebrae. In the mouse embryo, Hes7, a segmentation clock gene, controls ... ...

    Abstract Somites are formed sequentially by the segmentation of the anterior parts of the presomitic mesoderm (PSM), and such periodical somite formation is crucial to ensure the proper vertebrae. In the mouse embryo, Hes7, a segmentation clock gene, controls this periodic event with new somites forming every 2 h. Hes7 oscillations are synchronized between neighboring PSM cells and propagate from the posterior to the anterior PSM in the form of traveling waves. However, the exact mechanisms that generate these oscillatory dynamics and control synchronization are still unclear. Given that the half-life of Hes7 is too short to be monitored with most fluorescent proteins, time-lapse bioluminescence imaging (BLI) is a suitable tool to monitor the chronological Hes7 expression dynamics. In this chapter, we introduce a ubiquitinated luciferase reporter which enables the visualization of Hes7 expression dynamics with high temporal and spatial resolution in living cells and tissues.
    MeSH term(s) Animals ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Embryo, Mammalian/metabolism ; Gene Expression Regulation, Developmental ; Mesoderm/metabolism ; Mice ; Somites/metabolism ; Time-Lapse Imaging
    Chemical Substances Basic Helix-Loop-Helix Transcription Factors ; Hes7 protein, mouse
    Language English
    Publishing date 2022-07-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2473-9_25
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Differential cell-cycle control by oscillatory versus sustained Hes1 expression via p21.

    Maeda, Yuki / Isomura, Akihiro / Masaki, Taimu / Kageyama, Ryoichiro

    Cell reports

    2023  Volume 42, Issue 5, Page(s) 112520

    Abstract: Oscillatory Hes1 expression activates cell proliferation, while high and sustained Hes1 expression induces quiescence, but the mechanism by which Hes1 differentially controls cell proliferation depending on its expression dynamics is unclear. Here, we ... ...

    Abstract Oscillatory Hes1 expression activates cell proliferation, while high and sustained Hes1 expression induces quiescence, but the mechanism by which Hes1 differentially controls cell proliferation depending on its expression dynamics is unclear. Here, we show that oscillatory Hes1 expression down-regulates the expression of the cyclin-dependent kinase inhibitor p21 (Cdkn1a), which delays cell-cycle progression, and thereby activates the proliferation of mouse neural stem cells (NSCs). By contrast, sustained Hes1 overexpression up-regulates p21 expression and inhibits NSC proliferation, although it initially down-regulates p21 expression. Compared with Hes1 oscillation, sustained Hes1 overexpression represses Dusp7, a phosphatase for phosphorylated Erk (p-Erk), and increases the levels of p-Erk, which can up-regulate p21 expression. These results indicate that p21 expression is directly repressed by oscillatory Hes1 expression, but indirectly up-regulated by sustained Hes1 overexpression, suggesting that depending on its expression dynamics, Hes1 differentially controls NSC proliferation via p21.
    MeSH term(s) Mice ; Animals ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Cell Line ; Nervous System/metabolism ; Neural Stem Cells/metabolism ; Cell Proliferation ; Transcription Factor HES-1/genetics ; Transcription Factor HES-1/metabolism
    Chemical Substances Cyclin-Dependent Kinase Inhibitor p21 ; Transcription Factor HES-1 ; Hes1 protein, mouse
    Language English
    Publishing date 2023-05-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.112520
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  8. Article ; Online: SUMOylation effects on neural stem cells self-renewal, differentiation, and survival.

    Queiroz, Letícia Yoshitome / Kageyama, Ryoichiro / Cimarosti, Helena I

    Neuroscience research

    2023  Volume 199, Page(s) 1–11

    Abstract: SUMO (small ubiquitin-like modifier) conjugation or SUMOylation, a post-translational modification, is a crucial regulator of protein function and cellular processes. In the context of neural stem cells (NSCs), SUMOylation has emerged as a key player, ... ...

    Abstract SUMO (small ubiquitin-like modifier) conjugation or SUMOylation, a post-translational modification, is a crucial regulator of protein function and cellular processes. In the context of neural stem cells (NSCs), SUMOylation has emerged as a key player, affecting their proliferation, differentiation, and survival. By modifying transcription factors, such as SOX1, SOX2, SOX3, SOX6, Bmi1, and Nanog, SUMOylation can either enhance or impair their transcriptional activity, thus impacting on NSCs self-renewal. Moreover, SUMOylation regulates neurogenesis and neuronal differentiation by modulating key proteins, such as Foxp1, Mecp2, MEF2A, and SOX10. SUMOylation is also crucial for the survival and proliferation of NSCs in both developing and adult brains. By regulating the activity of transcription factors, coactivators, and corepressors, SUMOylation acts as a molecular switch, inducing cofactor recruitment and function during development. Importantly, dysregulation of NSCs SUMOylation has been implicated in various disorders, including embryonic defects, ischemic cerebrovascular disease, glioma, and the harmful effects of benzophenone-3 exposure. Here we review the main findings on SUMOylation-mediated regulation of NSCs self-renewal, differentiation and survival. Better understanding NSCs SUMOylation mechanisms and its functional consequences might provide new strategies to promote neuronal differentiation that could contribute for the development of novel therapies targeting neurodegenerative diseases.
    MeSH term(s) Sumoylation ; Cell Differentiation ; Neural Stem Cells/metabolism ; Neurogenesis/physiology ; Transcription Factors/metabolism
    Chemical Substances Transcription Factors
    Language English
    Publishing date 2023-09-22
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 605842-5
    ISSN 1872-8111 ; 0168-0102 ; 0921-8696
    ISSN (online) 1872-8111
    ISSN 0168-0102 ; 0921-8696
    DOI 10.1016/j.neures.2023.09.006
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  9. Article ; Online: Oscillatory expression of Ascl1 in oligodendrogenesis.

    Sueda, Risa / Kageyama, Ryoichiro

    Gene expression patterns : GEP

    2021  Volume 41, Page(s) 119198

    Abstract: The proneural gene Ascl1 promotes formation of both neurons and oligodendrocytes from neural stem cells (NSCs), but it remains to be analyzed how its different functions are coordinated. It was previously shown that Ascl1 enhances proliferation of NSCs ... ...

    Abstract The proneural gene Ascl1 promotes formation of both neurons and oligodendrocytes from neural stem cells (NSCs), but it remains to be analyzed how its different functions are coordinated. It was previously shown that Ascl1 enhances proliferation of NSCs when its expression oscillates but induces differentiation into transit-amplifying precursor cells and neurons when its expression is up-regulated and sustained. By time-lapse imaging and immunohistological analyses, we found that Ascl1 expression oscillated in proliferating oligodendrocyte precursor cells (OPCs) at lower levels than in transit-amplifying precursor cells and was repressed when OPCs differentiated into mature oligodendrocytes. Induction of sustained overexpression of Ascl1 reduced oligodendrocyte differentiation and promoted neuronal differentiation. These results suggest that oscillatory expression of Ascl1 plays an important role in proliferating OPCs during oligodendrocyte formation.
    MeSH term(s) Basic Helix-Loop-Helix Transcription Factors/genetics ; Cell Differentiation ; Neural Stem Cells ; Neurogenesis ; Oligodendroglia
    Chemical Substances Basic Helix-Loop-Helix Transcription Factors
    Language English
    Publishing date 2021-06-25
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2058346-1
    ISSN 1872-7298 ; 1567-133X
    ISSN (online) 1872-7298
    ISSN 1567-133X
    DOI 10.1016/j.gep.2021.119198
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  10. Article ; Online: Dual activation of Shh and Notch signaling induces dramatic enlargement of neocortical surface area.

    Ohtsuka, Toshiyuki / Kageyama, Ryoichiro

    Neuroscience research

    2021  Volume 176, Page(s) 18–30

    Abstract: The expansion of the neocortex represents a characteristic event over the course of mammalian evolution. Gyrencephalic mammals that have the larger brains with many folds (gyri and sulci) seem to have acquired higher intelligence, reflective of the ... ...

    Abstract The expansion of the neocortex represents a characteristic event over the course of mammalian evolution. Gyrencephalic mammals that have the larger brains with many folds (gyri and sulci) seem to have acquired higher intelligence, reflective of the enlargement of the neocortical surface area. In this process, germinal layers containing neural stem cells (NSCs) and neural progenitors expanded in number, leading to an increase in the total number of cortical neurons. In this study, we sought to expand neural stem/progenitor cells and enlarge the neocortical surface area by the dual activation of Shh and Notch signaling in transgenic (Tg) mice, promoting the proliferation of neural stem/progenitor cells by the Shh signaling effector while maintaining the undifferentiated state of NSCs by the Notch signaling effector. In the neocortical region of the Tg embryos, NSCs increased in number, and the ventricles, ventricular zone, and neocortical surface area were dramatically expanded. Furthermore, we observed that folds/wrinkles on the neocortical surface were progressively formed, accompanied by the vascular formation. These findings suggest that Shh and Notch signaling may be key regulators of mammalian brain evolution.
    MeSH term(s) Animals ; Cell Differentiation/physiology ; Hedgehog Proteins/metabolism ; Mammals ; Mice ; Neocortex/metabolism ; Neural Stem Cells ; Neurons/metabolism ; Receptors, Notch/metabolism ; Signal Transduction/physiology
    Chemical Substances Hedgehog Proteins ; Receptors, Notch ; Shh protein, mouse
    Language English
    Publishing date 2021-09-30
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 605842-5
    ISSN 1872-8111 ; 0168-0102 ; 0921-8696
    ISSN (online) 1872-8111
    ISSN 0168-0102 ; 0921-8696
    DOI 10.1016/j.neures.2021.09.006
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