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Book: Formelsammlung Physiologie

Averbeck, Beate / Küper, Christoph

2021

Author's details	fachliche Beratung: Dr. Beate Averbeck und Prof. Dr. Christoph Küper
Keywords	Physiologie
Subject	Humanphysiologie ; Mensch ; Körperfunktion
Subject code	610
Language	German
Size	54 Seiten, Illustrationen
Edition	1. Auflage
Publisher	Elsevier
Publishing place	München
Publishing country	Germany
Document type	Book
HBZ-ID	HT020578791
ISBN	978-3-437-41207-3 ; 3-437-41207-8 ; 9783437099632 ; 3437099639
Database	Catalogue ZB MED Medicine, Health

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2021 A 26	available for loan (reading room)	Lesesaal EG

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Article ; Online: Social preferences and psychopathy in a sample of male prisoners-a pilot study.

Kuper-Smith, Benjamin J / Voulgaris, Alexander / Briken, Peer / Fuss, Johannes / Korn, Christoph W

Scientific reports

2024 Volume 14, Issue 1, Page(s) 8344

Abstract: Social decisions are influenced by a person's social preferences. High psychopathy is defined by antisocial behaviour, but the relationship between psychopathy and social preferences remains unclear. In this study, we used a battery of economic games to ... ...

Abstract	Social decisions are influenced by a person's social preferences. High psychopathy is defined by antisocial behaviour, but the relationship between psychopathy and social preferences remains unclear. In this study, we used a battery of economic games to study social decision-making and social preferences in relation to psychopathy in a sample of 35 male prison inmates, who were arrested for sexual and severe violent offenses (mean age = 39 years). We found no evidence for a relationship between social preferences (measured with the Dictator and Ultimatum Games, Social Value Orientation, and one-shot 2 × 2 games) and psychopathy (measured by the overall Hare Psychopathy Checklist-Revised score and both factors). These results are surprising but also difficult to interpret due to the small sample size. Our results contribute to the ongoing debate about psychopathy and social decision-making by providing crucial data that can be combined with future datasets to reach large sample sizes that can provide a more nuanced understanding about the relationship between psychopathy and social preferences.
MeSH term(s)	Humans ; Male ; Adult ; Antisocial Personality Disorder/diagnosis ; Pilot Projects ; Prisoners ; Aggression ; Social Behavior Disorders
Language	English
Publishing date	2024-04-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-59066-8
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Article ; Online: Optical properties of NIR photoluminescent PbS nanocrystal-based three-dimensional networks.

Pluta, Denis / Kuper, Henning / Graf, Rebecca T / Wesemann, Christoph / Rusch, Pascal / Becker, Joerg August / Bigall, Nadja C

Nanoscale advances

2023 Volume 5, Issue 18, Page(s) 5005–5014

Abstract: The assembly of nanocrystals (NCs) into three-dimensional network structures is a recently established strategy to produce macroscopic materials with nanoscopic properties. These networks can be formed by the controlled destabilization of NC colloids and ...

Abstract	The assembly of nanocrystals (NCs) into three-dimensional network structures is a recently established strategy to produce macroscopic materials with nanoscopic properties. These networks can be formed by the controlled destabilization of NC colloids and subsequent supercritical drying to obtain NC-based aerogels. Even though this strategy has been used for many different semiconductor NCs, the emission of NC-based aerogels is limited to the ultraviolet and visible and no near-infrared (NIR) emitting NC-based aerogels have been investigated in literature until now. In the present work we have optimized a gelation route of NIR emitting PbS and PbS/CdS quantum dots (QDs) by means of a recently established gel formation method using trivalent ions to induce the network formation. Thereby, depending on the surface ligands and QDs used the resulting network structure is different. We propose, that the ligand affinity to the nanocrystal surface plays an essential role during network formation, which is supported by theoretical calculations. The optical properties were investigated with a focus on their steady-state and time resolved photoluminescence (PL). Unlike in PbS/CdS aerogels, the absorption of PbS aerogels and their PL shift strongly. For all aerogels the PL lifetimes are reduced in comparison to those of the building blocks with this reduction being especially pronounced in the PbS aerogels.
Language	English
Publishing date	2023-08-14
Publishing country	England
Document type	Journal Article
ISSN	2516-0230
ISSN (online)	2516-0230
DOI	10.1039/d3na00404j
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Article: Risk perception and optimism during the early stages of the COVID-19 pandemic.

Kuper-Smith, Benjamin J / Doppelhofer, Lisa M / Oganian, Yulia / Rosenblau, Gabriela / Korn, Christoph W

Royal Society open science

2021 Volume 8, Issue 11, Page(s) 210904

Abstract: Slowing the spread of COVID-19 requires people to actively change their lives by following protective practices, such as physical distancing and disinfecting their hands. Perceptions about the personal risk of COVID-19 may affect compliance with these ... ...

Abstract	Slowing the spread of COVID-19 requires people to actively change their lives by following protective practices, such as physical distancing and disinfecting their hands. Perceptions about the personal risk of COVID-19 may affect compliance with these practices. In this study, we assessed risk perception and optimism about COVID-19 in a multinational (UK, USA and Germany), longitudinal design during the early stages of the pandemic (16 March 2020; 1 April 2020; 20 May 2020). Our main findings are that (i) people showed a comparative optimism bias about getting infected and infecting others, but not for getting severe symptoms, (ii) this optimism bias did not change over time, (iii) optimism bias seemed to relate to perceived level of control over the action, (iv) risk perception was linked to publicly available information about the disorder, (v) people reported adhering closely to protective measures but these measures did not seem to be related to risk perception, and (vi) risk perception was related to questions about stress and anxiety. In additional cross-sectional samples, we replicated our most important findings. Our open and partly preregistered results provide detailed descriptions of risk perceptions and optimistic beliefs during the early stages of the COVID-19 pandemic in three Western countries.
Language	English
Publishing date	2021-11-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2787755-3
ISSN	2054-5703
ISSN	2054-5703
DOI	10.1098/rsos.210904
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Article ; Online: The novel KIT exon 11 germline mutation K558N is associated with gastrointestinal stromal tumor, mastocytosis, and seminoma development.

Meir, Michael / Maurus, Katja / Kuper, Jochen / Hankir, Mohammed / Wardelmann, Eva / Rosenwald, Andreas / Germer, Christoph-Thomas / Wiegering, Armin

Genes, chromosomes & cancer

2021 Volume 60, Issue 12, Page(s) 827–832

Abstract: Familial gastrointestinal stromal tumors (GIST) are dominant genetic disorders that are caused by germline mutations of the type III receptor tyrosine kinase KIT. While sporadic mutations are frequently found in mastocytosis and GISTs, germline mutations ...

Abstract	Familial gastrointestinal stromal tumors (GIST) are dominant genetic disorders that are caused by germline mutations of the type III receptor tyrosine kinase KIT. While sporadic mutations are frequently found in mastocytosis and GISTs, germline mutations of KIT have only been described in 39 families until now. We detected a novel germline mutation of KIT in exon 11 (p.Lys-558-Asn; K558N) in a patient from a kindred with several GISTs harboring different secondary somatic KIT mutations. Structural analysis suggests that the primary germline mutation alone is not sufficient to release the autoinhibitory region of KIT located in the transmembrane domain. Instead, the KIT kinase module becomes constitutively activated when K558N combines with different secondary somatic mutations. The identical germline mutation in combination with an additional somatic KIT mutation was detected in a second patient of the kindred with seminoma while a third patient within the family had a cutaneous mastocytosis. These findings suggest that the K558N mutation interferes with the juxtamembranous part of KIT, since seminoma and mastocystosis are usually not associated with exon 11 mutations.
MeSH term(s)	Adolescent ; Adult ; Child ; Child, Preschool ; Exons/genetics ; Female ; Gastrointestinal Stromal Tumors/genetics ; Gastrointestinal Stromal Tumors/pathology ; Genetic Predisposition to Disease ; Germ-Line Mutation/genetics ; Humans ; Male ; Mastocytosis/genetics ; Mastocytosis/pathology ; Pedigree ; Proto-Oncogene Proteins c-kit/genetics ; Seminoma/genetics ; Seminoma/pathology ; Young Adult
Chemical Substances	KIT protein, human (EC 2.7.10.1) ; Proto-Oncogene Proteins c-kit (EC 2.7.10.1)
Language	English
Publishing date	2021-08-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1018988-9
ISSN	1098-2264 ; 1045-2257
ISSN (online)	1098-2264
ISSN	1045-2257
DOI	10.1002/gcc.22988
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Article ; Online: Risk perception and optimism during the early stages of the COVID-19 pandemic

Benjamin J. Kuper-Smith / Lisa M. Doppelhofer / Yulia Oganian / Gabriela Rosenblau / Christoph W. Korn

Royal Society Open Science, Vol 8, Iss

2021 Volume 11

Abstract	Slowing the spread of COVID-19 requires people to actively change their lives by following protective practices, such as physical distancing and disinfecting their hands. Perceptions about the personal risk of COVID-19 may affect compliance with these practices. In this study, we assessed risk perception and optimism about COVID-19 in a multinational (UK, USA and Germany), longitudinal design during the early stages of the pandemic (16 March 2020; 1 April 2020; 20 May 2020). Our main findings are that (i) people showed a comparative optimism bias about getting infected and infecting others, but not for getting severe symptoms, (ii) this optimism bias did not change over time, (iii) optimism bias seemed to relate to perceived level of control over the action, (iv) risk perception was linked to publicly available information about the disorder, (v) people reported adhering closely to protective measures but these measures did not seem to be related to risk perception, and (vi) risk perception was related to questions about stress and anxiety. In additional cross-sectional samples, we replicated our most important findings. Our open and partly preregistered results provide detailed descriptions of risk perceptions and optimistic beliefs during the early stages of the COVID-19 pandemic in three Western countries.
Keywords	coronavirus ; COVID-19 ; optimism bias ; pandemic ; risk perception ; Science ; Q
Subject code	300
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	The Royal Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online ; Thesis: Charakterisierung der transkriptionellen Aktivierung des cadBA-Operons durch den Transmembranregulator CadC aus Escherichia coli

Küper, Christoph [Verfasser]

2005

Author's details	von Christoph Küper
Keywords	Biowissenschaften, Biologie ; Life Science, Biology
Subject code	sg570
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Book ; Online: Optimistic beliefs about the personal impact of COVID-19

Kuper-Smith, Benjamin James / Doppelhofer, Lisa Marie / Oganian, Yulia / Rosenblau, Gabriela / Korn, Christoph

2020

Abstract: Slowing the spread of COVID-19 requires people to actively change their lives and follow best practices for social distancing and hygiene. On 16.03.2020, we tested individuals’ beliefs about infection probabilities and abilities to practice social ... ...

Abstract	Slowing the spread of COVID-19 requires people to actively change their lives and follow best practices for social distancing and hygiene. On 16.03.2020, we tested individuals’ beliefs about infection probabilities and abilities to practice social distancing in UK, USA and Germany. Given the rapidly evolving situation, we report here initial analyses in a preliminary brief manuscript. We found that individuals show an optimism bias: they estimate the probability of getting infected with the virus, and of infecting others if infected themselves as lower for themselves than for someone similar to them. We link this optimism to the estimated frequency of direct social contacts as well as to the necessity and ease of reducing these. Our ongoing studies will assess how these biases change over the course of the COVID-19 outbreak, and how adaptive it is.
Keywords	covid19
Publisher	Center for Open Science
Publishing country	us
Document type	Book ; Online
DOI	10.31234/osf.io/epcyb
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: EASY (endoscopic approach to the symphysis): a new minimally invasive approach for the plate osteosynthesis of the symphysis and the anterior pelvic ring-a cadaver study and first clinical results.

Küper, Markus Alexander / Trulson, Alexander / Trulson, Inga Maria / Minarski, Christian / Grünwald, Leonard / Gonser, Christoph / Bahrs, Christian / Hirt, Bernhard / Stöckle, Ulrich / Stuby, Fabian Maria

European journal of trauma and emergency surgery : official publication of the European Trauma Society

2018 Volume 45, Issue 4, Page(s) 745–755

Abstract: Background: Minimally invasive surgical approaches to reduce approach-associated morbidity are an interdisciplinary goal in surgery. In principle, the endoscopic approach for the extraperitoneal repair of groin hernias is the minimally invasive variant ... ...

Abstract	Background: Minimally invasive surgical approaches to reduce approach-associated morbidity are an interdisciplinary goal in surgery. In principle, the endoscopic approach for the extraperitoneal repair of groin hernias is the minimally invasive variant of the modified Stoppa-approach, which is used for the treatment of pelvic ring injuries in traumatology. Method: Anatomical feasibility study regarding the plate osteosynthesis of the anterior pelvic ring via a minimally invasive variant of the modified Stoppa-approach. Results: We present the minimally invasive variant of the modified Stoppa-approach in a human cadaver step by step, both photographically and radiologically. Feasibility of the plate osteosynthesis of the symphysis is presented in a patient with open book injury via the minimally invasive approach using standard laparoscopic instruments. Conclusion: The plate osteosynthesis of the anterior pelvic ring via the minimally invasive variant of the modified Stoppa-approach is feasible with existing standard laparoscopic instruments.
MeSH term(s)	Accidents, Traffic ; Acetabulum/injuries ; Acetabulum/surgery ; Bone Plates ; Bone Screws ; Cadaver ; Endoscopy/methods ; Feasibility Studies ; Fracture Fixation, Internal/instrumentation ; Fracture Fixation, Internal/methods ; Fractures, Bone/surgery ; Humans ; Male ; Motorcycles ; Pelvic Bones/injuries ; Pelvic Bones/surgery ; Pubic Symphysis/injuries ; Pubic Symphysis/surgery ; Supine Position ; Young Adult
Language	English
Publishing date	2018-03-13
Publishing country	Germany
Document type	Case Reports ; Evaluation Study ; Journal Article
ZDB-ID	2275480-5
ISSN	1863-9941 ; 1863-9933
ISSN (online)	1863-9941
ISSN	1863-9933
DOI	10.1007/s00068-018-0928-5
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Zs.A 1221: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: The role of the osmosensitive transcription factor NFAT5 in corneal edema resorption after injury.

Hadrian, Karina / Musial, Gwen / Schönberg, Alfrun / Georgiev, Tihomir / Küper, Christoph / Bock, Felix / Jantsch, Jonathan / Cursiefen, Claus / Eming, Sabine A / Hos, Deniz

Experimental & molecular medicine

2023 Volume 55, Issue 3, Page(s) 565–573

Abstract: The osmosensitive transcription factor nuclear factor of activated T cells 5 (NFAT5; or tonicity-responsive enhancer binding protein; TonEBP) plays a key role in macrophage-driven regulation of cutaneous salt and water balance. In the immune-privileged ... ...

Abstract	The osmosensitive transcription factor nuclear factor of activated T cells 5 (NFAT5; or tonicity-responsive enhancer binding protein; TonEBP) plays a key role in macrophage-driven regulation of cutaneous salt and water balance. In the immune-privileged and transparent cornea, disturbances in fluid balance and pathological edema result in corneal transparency loss, which is one of the main causes of blindness worldwide. The role of NFAT5 in the cornea has not yet been investigated. We analyzed the expression and function of NFAT5 in naive corneas and in an established mouse model of perforating corneal injury (PCI), which causes acute corneal edema and transparency loss. In uninjured corneas, NFAT5 was mainly expressed in corneal fibroblasts. In contrast, after PCI, NFAT5 expression was highly upregulated in recruited corneal macrophages. NFAT5 deficiency did not alter corneal thickness in steady state; however, loss of NFAT5 led to accelerated resorption of corneal edema after PCI. Mechanistically, we found that myeloid cell-derived NFAT5 is crucial for controlling corneal edema, as edema resorption after PCI was significantly enhanced in mice with conditional loss of NFAT5 in the myeloid cell lineage, presumably due to increased pinocytosis of corneal macrophages. Collectively, we uncovered a suppressive role for NFAT5 in corneal edema resorption, thereby identifying a novel therapeutic target to combat edema-induced corneal blindness.
MeSH term(s)	Mice ; Animals ; Corneal Edema/etiology ; Gene Expression Regulation ; NFATC Transcription Factors/genetics ; Transcription Factors
Chemical Substances	NFATC Transcription Factors ; Nfat5 protein, mouse ; Transcription Factors
Language	English
Publishing date	2023-03-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1328915-9
ISSN	2092-6413 ; 1226-3613 ; 0378-8512
ISSN (online)	2092-6413
ISSN	1226-3613 ; 0378-8512
DOI	10.1038/s12276-023-00954-w
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