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  1. Article ; Online: Reaction to: Persson et al. Educational achievements in Pierre Robin sequence. J Plast Surg Hand Surg 2013;47(1):36-9.

    van Nunen, Daan P F / Filip, Charles / Feragen, Kristin J B / van den Boogaard, Marie-José H / Breugem, Corstiaan C

    Journal of plastic surgery and hand surgery

    2014  Volume 48, Issue 4, Page(s) 287–288

    MeSH term(s) Early Intervention (Education)/methods ; Education of Intellectually Disabled/methods ; Educational Measurement/methods ; Female ; Humans ; Male ; Pierre Robin Syndrome/diagnosis
    Language English
    Publishing date 2014-08
    Publishing country Sweden
    Document type Comment ; Letter
    ZDB-ID 2551921-9
    ISSN 2000-6764 ; 2000-656X
    ISSN (online) 2000-6764
    ISSN 2000-656X
    DOI 10.3109/2000656X.2014.924956
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online: Mineralogy and isotope chemistry of GISP2 and potential source areas, supplementary data to: Biscaye, Pierre Eginton; Grousset, Francis E; Revel, Marie; van der Gaast, Sjierk; Zielinski, G A; Vaars, A; Kukla, George J (1997): Asian provenance of glacial dust (stage 2) in the Greenland Ice Sheet Project 2 ice core, Summit, Greenland. Journal of Geophysical Research-Oceans, 102(C12), 26765-26782

    Biscaye, Pierre Eginton / Grousset, Francis E / Kukla, George J / Revel, Marie / Vaars, A / Zielinski, G A / van der Gaast, Sjierk

    1997  

    Abstract: Samples of dust from the Greenland Ice Sheet Project 2 (GISP2) ice core, Summit, Greenland, dated within marine isotope stage 2 (between 23,340 and 26,180 calendar years B.P.) around the time of the coldest, local, last glacial temperatures, have been ... ...

    Abstract Samples of dust from the Greenland Ice Sheet Project 2 (GISP2) ice core, Summit, Greenland, dated within marine isotope stage 2 (between 23,340 and 26,180 calendar years B.P.) around the time of the coldest, local, last glacial temperatures, have been analyzed to determine their provenance. To accomplish this, we have compared them with approximately Coeval aeolian sediments (mostly loesses) sampled in possible source areas (PSAs) from around the northern hemisphere. The <5-?m grain-size fraction of these samples was analyzed on the basis that it corresponds to the atmospheric dust component of that time and locale, which was sufficiently fine grained to be transported over long distances. On the basis of comparison of the clay mineralogy and Sr, Nd and Pb isotope composition with ice dust and PSAs and assuming that we have sampled the most important PSAs, we have determined that the probable source area of these GISP2 dusts was in eastern Asia. The dust was not derived from either the midcontinental United States or the Sahara, two more proximal areas that have been suggested as potential sources based on atmospheric circulation modeling. Except for a brief period during an interstadial, when dust transport was exceptionally low (for glacial times) and had a mineralogical composition indicative of a slightly more southern provenance, the source area of the dust did not change significantly during times of variably higher fluxes of dust with larger mean grain size or lower fluxes of dust with smaller mean grain size. This includes the high-dust period that correlates with the Heinrich 2 period of major iceberg discharge into the North Atlantic. Variable wind strengths must therefore be invoked to account for these abrupt and significant changes in dust flux and grain size.

    REFERENCE:
    GRIP/GISP (1997): The Greenland Summit Ice Cores CD-ROM and new data archived since 1998. National Snow and Ice Data Center, University of Colorado at Boulder, and World Data Center for Paleoclimatology, National Geophysical Data Center, Boulder Colorado
    Language English
    Dates of publication 1997-9999
    Size Online-Ressource
    Publisher PANGAEA - Data Publisher for Earth & Environmental Science
    Publishing place Bremen/Bremerhaven
    Document type Book ; Online
    Note This dataset is supplement to doi:10.1029/97JC01249
    DOI 10.1594/PANGAEA.730452
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  3. Book ; Online: Rio, Tokyo Paralympic Games and beyond: How to Prepare Athletes with Motor Disabilities for Peaking

    Janssen, Thomas W. J. / Goosey-Tolfrey, Victoria L. / Lepretre, Pierre-Marie / Perret, Claudio

    2017  

    Abstract: In 1960, the 9th Annual International Stoke Mandeville Games were supported, for the first time, by the Italian Olympic Committee. Taking place six days after the Closing Ceremony of the XVII Olympic Games, the paralympic games for disabled athletes were ...

    Abstract In 1960, the 9th Annual International Stoke Mandeville Games were supported, for the first time, by the Italian Olympic Committee. Taking place six days after the Closing Ceremony of the XVII Olympic Games, the paralympic games for disabled athletes were born. From Roma in 1960 to London in 2012, the Paralympic Games grew in terms of athletes' number from 400 to 4,237, and now brings together more than 164 nations (Perret, 2015). The word "Paralympic" derives from the Greek preposition "para" (beside or alongside) and the word "Olympic". Paralympics want to be the parallel Games to the Olympics and illustrate how the two movements exist side-by-side (Paralympics - History of the Movement, 2016). Now taking place after the Olympics Games, the Paralympic Games are the pinnacle of the career of athletes with physical impairments and have become the second largest sport event in the world (Perret, 2015; Paralympics - History of the Movement, 2016; Gold and Gold, 2011).-

    The first statement of the vision of the International Paralympic Committee (IPC), i.e. "to create the conditions for athlete empowerment through self-determination" (Paralympics - History of the Movement, 2016; International Paralympic Committee, 2016), shows the importance of the place of the athlete with an impairment at the heart of the Paralympic Movement. The ultimate aim of the IPC is « to enable Paralympic athletes to achieve sporting excellence and inspire and excite the world. » (International Paralympic Committee, 2016). The performance level of athletes with an impairment improved to a point that, in the present days, sport news and world sport movements focus on the potential advantage of artificial limbs among athletes with amputations and their integration in able-bodied competitions (Burkett, 2010). However, they do not represent the totality of athletes with an impairment at the Paralympic Games.-

    Athletes with other physical impairments (visual deficit, spinal cord injury, cerebral palsy or else) are eligible to compete. These impairments induce typical functional and physiological (e.g., cardiovascular, thermoregulatory) responses to exercise. For example, spinal cord injury (athletes with tetraplegia or paraplegia) causes thermoregulatory impairment (Goosey-Tolfrey et al., 2008) and individuals with cerebral palsy have also demonstrated higher thermal and metabolic strain than matched controls during treadmill walking in the heat (Maltais et al., 2004). Thus, hyperthermia among these athletes with an impairment alters their performance compared to their Olympic counterparts (Bhambhani, 2002).-
    Keywords Physiology ; Science (General)
    Size 1 electronic resource (87 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020095389
    ISBN 9782889451715 ; 2889451712
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Hypermetabolism and energetic constraints in mitochondrial disorders.

    Sercel, Alexander J / Sturm, Gabriel / Gallagher, Dympna / St-Onge, Marie-Pierre / Kempes, Christopher P / Pontzer, Herman / Hirano, Michio / Picard, Martin

    Nature metabolism

    2024  Volume 6, Issue 2, Page(s) 192–195

    MeSH term(s) Humans ; Mitochondrial Diseases/genetics ; Mitochondria
    Language English
    Publishing date 2024-02-09
    Publishing country Germany
    Document type Journal Article
    ISSN 2522-5812
    ISSN (online) 2522-5812
    DOI 10.1038/s42255-023-00968-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Vaccine promotion strategies in community pharmacy addressing vulnerable populations: a scoping review.

    Chadi, Alexandre / Thirion, Daniel J G / David, Pierre-Marie

    BMC public health

    2023  Volume 23, Issue 1, Page(s) 1855

    Abstract: Context: Social determinants of health are drivers of vaccine inequity and lead to higher risks of complications from infectious diseases in under vaccinated communities. In many countries, pharmacists have gained the rights to prescribe and administer ... ...

    Abstract Context: Social determinants of health are drivers of vaccine inequity and lead to higher risks of complications from infectious diseases in under vaccinated communities. In many countries, pharmacists have gained the rights to prescribe and administer vaccines, which contributes to improving vaccination rates. However, little is known on how they define and target vulnerable communities.
    Objective: The purpose of this study is to describe how vulnerable communities are targeted in community pharmacies.
    Methods: We performed a systematic search of the Embase and MEDLINE database in August 2021 inspired by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocols (PRISMA ScR). Articles in English, French or Spanish addressing any vaccine in a community pharmacy context and that target a population defined as vulnerable were screened for inclusion.
    Results: A total of 1039 articles were identified through the initial search, and 63 articles met the inclusion criteria. Most of the literature originated from North America (n = 54, 86%) and addressed influenza (n = 29, 46%), pneumococcal (n = 14, 22%), herpes zoster (n = 14, 22%) or human papilloma virus vaccination (n = 14, 22%). Lifecycle vulnerabilities (n = 48, 76%) such as age and pregnancy were most often used to target vulnerable patients followed by clinical factors (n = 18, 29%), socio-economical determinants (n = 16, 25%) and geographical vulnerabilities (n = 7, 11%). The most frequently listed strategy was providing a strong recommendation for vaccination, promotional posters in pharmacy, distributing leaflet/bag stuffers and providing staff training. A total of 24 barriers and 25 facilitators were identified. The main barriers associated to each vulnerable category were associated to effective promotional strategies to overcome them.
    Conclusion: Pharmacists prioritize lifecycle and clinical vulnerability at the expense of narrowing down the definition of vulnerability. Some vulnerable groups are also under targeted in pharmacies. A wide variety of promotional strategies are available to pharmacies to overcome the specific barriers experienced by various groups.
    MeSH term(s) Female ; Pregnancy ; Humans ; Pharmacies ; Vaccination ; Pneumococcal Vaccines ; Influenza Vaccines ; Databases, Factual
    Chemical Substances Pneumococcal Vaccines ; Influenza Vaccines
    Language English
    Publishing date 2023-09-23
    Publishing country England
    Document type Systematic Review ; Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041338-5
    ISSN 1471-2458 ; 1471-2458
    ISSN (online) 1471-2458
    ISSN 1471-2458
    DOI 10.1186/s12889-023-16601-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Conference proceedings ; Online: Stable isotope composition of carbonates in the Tyrrhenian Sea, supplementary data to: Pierre, Catherine; Rouchy, Jean Marie (1990): Sedimentary and diagenetic evolution of Messinian evaporites in the Tyrrhenian Sea (ODP Leg 107, Sites 652, 653, and 654): petrographic, mineralogical, and stable isotope records. In: Kastens, KA; Mascle, J; et al. (eds.), Proceedings of the Ocean Drilling Program, Scientific Results, College Station, TX (Ocean Drilling Program), 107, 187-210

    Pierre, Catherine / Rouchy, Jean Marie

    1990  

    Abstract: The Messinian evaporitic succession recovered at ODP Sites 652, 653, and 654 in the Tyrrhenian Sea was generated under various environmental conditions which ranged from brackish to hypersaline, as deduced from the sedimentary facies and stable isotope ... ...

    Abstract The Messinian evaporitic succession recovered at ODP Sites 652, 653, and 654 in the Tyrrhenian Sea was generated under various environmental conditions which ranged from brackish to hypersaline, as deduced from the sedimentary facies and stable isotope compositions of the carbonate and sulfate deposits. Water in the basins had to be shallow to undergo such rapid and large geochemical variations.
    The marine influence was omnipresent in the basin at least during the deposition of sulfate evaporites; seawater or marine brines might have been supplied either by direct input into evaporitic lagoons as at Sites 653 and 654, or by subterraneous infiltration in marginal areas as at Site 652.
    Episodes of severe dilution by continental waters occurred frequently throughout Messinian times in the more basinal areas at Sites 653 and 654, while a fresh water body was standing permanently at Site 652.
    The high heat flow present at Site 652 was responsible for a major late authigenesis of iron-rich dolomites, which was initiated during the subsidence of the basin and ended before Pliocene.
    Language English
    Dates of publication 1990-9999
    Size Online-Ressource
    Publisher PANGAEA - Data Publisher for Earth & Environmental Science
    Publishing place Bremen/Bremerhaven
    Document type Book ; Conference proceedings ; Online
    Note This dataset is supplement to doi:10.2973/odp.proc.sr.107.131.1990
    DOI 10.1594/PANGAEA.745825
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  7. Book ; Online: La Préhistoire du Jura et l'Europe néolithique en 100 mots-clés

    Pétrequin, Pierre / Pétrequin, Anne-Marie

    5300-2100 av J.-C

    (Les Cahiers de la MSHE Ledoux)

    2021  

    Series title Les Cahiers de la MSHE Ledoux
    Keywords Archaeology ; Neolithic ; Jura ; ethnoarchaeology ; Europe ; New Guinea
    Language fra
    Size 1 electronic resource (1944 pages)
    Publisher Presses universitaires de Franche-Comté
    Publishing place Besançon
    Document type Book ; Online
    Note French
    HBZ-ID HT030378163
    ISBN 9782848678467 ; 2848678461
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  8. Article ; Online: Dysfunction of Human Estrogen Signaling as a Novel Molecular Signature of Polycystic Ovary Syndrome.

    Marie, Clémentine / Pierre, Alice / Mayeur, Anne / Giton, Frank / Corre, Raphael / Grynberg, Michaël / Cohen-Tannoudji, Joëlle / Guigon, Céline J / Chauvin, Stéphanie

    International journal of molecular sciences

    2023  Volume 24, Issue 23

    Abstract: Estradiol (E2) is a major hormone-controlling folliculogenesis whose dysfunction may participate in polycystic ovary syndrome (PCOS) infertility. To determine whether both the concentration and action of E2 could be impaired in non-hyperandrogenic ... ...

    Abstract Estradiol (E2) is a major hormone-controlling folliculogenesis whose dysfunction may participate in polycystic ovary syndrome (PCOS) infertility. To determine whether both the concentration and action of E2 could be impaired in non-hyperandrogenic overweight PCOS women, we isolated granulosa cells (GCs) and follicular fluid (FF) from follicles of women undergoing ovarian stimulation (27 with PCOS, and 54 without PCOS). An analysis of the transcript abundance of 16 genes in GCs showed that androgen and progesterone receptor expressions were significantly increased in GCs of PCOS (by 2.7-fold and 1.5-fold, respectively), while those of the steroidogenic enzymes
    MeSH term(s) Humans ; Female ; Polycystic Ovary Syndrome/metabolism ; Estrogens/metabolism ; Granulosa Cells/metabolism ; Estradiol/metabolism ; Follicular Fluid/metabolism
    Chemical Substances Estrogens ; Estradiol (4TI98Z838E)
    Language English
    Publishing date 2023-11-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242316689
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: New late-emphasis and combination tests based on infimum and supremum logrank statistics with application in oncology trials.

    Boher, Jean Marie / Filleron, Thomas / Bunouf, Pierre / Cook, Richard J

    Statistics in medicine

    2023  Volume 42, Issue 12, Page(s) 1981–1994

    Abstract: Immunotherapy cancer clinical trials routinely feature an initial period during which the treatment is given without evident therapeutic benefit, which may be followed by a period during which an effective therapy reduces the hazard for event occurrence. ...

    Abstract Immunotherapy cancer clinical trials routinely feature an initial period during which the treatment is given without evident therapeutic benefit, which may be followed by a period during which an effective therapy reduces the hazard for event occurrence. The nature of this treatment effect is incompatible with the proportional hazards assumption, which has prompted much work on the development of alternative effect measures of frameworks for testing. We consider tests based on individual and combination of early- and late-emphasis infimum and supremum logrank statistics, describe how they can be implemented, and evaluate their performance in simulation studies. Through this work and illustrative applications we conclude that this class of test statistics offers a new and powerful framework for assessing treatment effects in cancer clinical trials involving immunotherapies.
    MeSH term(s) Humans ; Proportional Hazards Models ; Computer Simulation ; Neoplasms/drug therapy ; Medical Oncology ; Survival Analysis
    Language English
    Publishing date 2023-03-31
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 843037-8
    ISSN 1097-0258 ; 0277-6715
    ISSN (online) 1097-0258
    ISSN 0277-6715
    DOI 10.1002/sim.9709
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Vanadium Electronic Configuration Determination From L2,3 Transition in V-oxide Compounds and Roscoelite.

    Zanetta, Pierre-Marie / Drexler, Maxwell S / Barton, Isabel F / Zega, Thomas J

    Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada

    2023  Volume 29, Issue 2, Page(s) 459–469

    Abstract: We report on the electronic structure of vanadium in synthetic V-oxides and in natural roscoelite (V-rich phyllosilicate). This study applied electron energy-loss spectroscopy (EELS) in the scanning transmission electron microscope (STEM), combined with ... ...

    Abstract We report on the electronic structure of vanadium in synthetic V-oxides and in natural roscoelite (V-rich phyllosilicate). This study applied electron energy-loss spectroscopy (EELS) in the scanning transmission electron microscope (STEM), combined with first-principle calculations, to (1) establish relationships between the V oxidation state and EELS L2,3 features and (2) better constrain the oxidation state and crystallographic siting of V in roscoelite, with implications for other V-bearing phyllosilicates. Both EELS measurements and band structure calculations show that the EELS L2/L3 ratio increases as the oxidation state of V increases. We establish a quantitative relationship between the V L2,3 near-edge structure and the V oxidation state by normalizing the L2 maximum peak intensity to the L3 peak intensity. By applying this method to roscoelite, we find that it hosts a mix of trivalent and tetravalent V distributed between the octahedral and tetrahedral sites with a V4+/ΣV = 0.6 ± 0.1. This relationship is applicable to measurements of V oxidation states in oxide and phyllosilicate minerals, which is useful for constraining the conditions of rock and mineral formation and has potential implications for metal extraction from phyllosilicate ores.
    Language English
    Publishing date 2023-09-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1385710-1
    ISSN 1435-8115 ; 1431-9276
    ISSN (online) 1435-8115
    ISSN 1431-9276
    DOI 10.1093/micmic/ozac057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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