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  1. Article ; Online: Pathway Commons 2019 Update: integration, analysis and exploration of pathway data.

    Rodchenkov, Igor / Babur, Ozgun / Luna, Augustin / Aksoy, Bulent Arman / Wong, Jeffrey V / Fong, Dylan / Franz, Max / Siper, Metin Can / Cheung, Manfred / Wrana, Michael / Mistry, Harsh / Mosier, Logan / Dlin, Jonah / Wen, Qizhi / O'Callaghan, Caitlin / Li, Wanxin / Elder, Geoffrey / Smith, Peter T / Dallago, Christian /
    Cerami, Ethan / Gross, Benjamin / Dogrusoz, Ugur / Demir, Emek / Bader, Gary D / Sander, Chris

    Nucleic acids research

    2019  Volume 48, Issue D1, Page(s) D489–D497

    Abstract: Pathway Commons (https://www.pathwaycommons.org) is an integrated resource of publicly available information about biological pathways including biochemical reactions, assembly of biomolecular complexes, transport and catalysis events and physical ... ...

    Abstract Pathway Commons (https://www.pathwaycommons.org) is an integrated resource of publicly available information about biological pathways including biochemical reactions, assembly of biomolecular complexes, transport and catalysis events and physical interactions involving proteins, DNA, RNA, and small molecules (e.g. metabolites and drug compounds). Data is collected from multiple providers in standard formats, including the Biological Pathway Exchange (BioPAX) language and the Proteomics Standards Initiative Molecular Interactions format, and then integrated. Pathway Commons provides biologists with (i) tools to search this comprehensive resource, (ii) a download site offering integrated bulk sets of pathway data (e.g. tables of interactions and gene sets), (iii) reusable software libraries for working with pathway information in several programming languages (Java, R, Python and Javascript) and (iv) a web service for programmatically querying the entire dataset. Visualization of pathways is supported using the Systems Biological Graphical Notation (SBGN). Pathway Commons currently contains data from 22 databases with 4794 detailed human biochemical processes (i.e. pathways) and ∼2.3 million interactions. To enhance the usability of this large resource for end-users, we develop and maintain interactive web applications and training materials that enable pathway exploration and advanced analysis.
    MeSH term(s) Databases, Factual ; Genome, Human ; Genomics/methods ; Humans ; Metabolic Networks and Pathways ; Metabolomics/methods ; Software
    Language English
    Publishing date 2019-10-23
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 186809-3
    ISSN 1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
    ISSN (online) 1362-4962 ; 1362-4954
    ISSN 0301-5610 ; 0305-1048
    DOI 10.1093/nar/gkz946
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1067: Show issues Location:
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  2. Article: Authoritarianism and attitudes toward AIDS victims.

    Larsen, K S / Elder, R / Bader, M / Dougard, C

    The Journal of social psychology

    1990  Volume 130, Issue 1, Page(s) 77–80

    Abstract: This study investigated the relationship of authoritarianism and attitudes toward AIDS victims in three samples. One hundred fifty-eight students at Oregon State University participated, including 101 students from the United States, 25 from Japan, and ... ...

    Abstract This study investigated the relationship of authoritarianism and attitudes toward AIDS victims in three samples. One hundred fifty-eight students at Oregon State University participated, including 101 students from the United States, 25 from Japan, and 32 from other Asian societies. The survey instrument included the 20-item Attitudes Toward AIDS Victims (ATAV) Scale, the 18-item F Scale, the Form A, and 14-item Formal Content of Dogmatism Scale. Results showed slight but significant correlations between the ATAV and F (r = .17, p less than .044) and Formal Content of Dogmatism (r = .20, p less than .023) Scales for the United States sample. Highly significant differences were found in the predicted direction among the three samples on authoritarianism, F = 43.94, p less than .001.
    MeSH term(s) Acquired Immunodeficiency Syndrome/psychology ; Adult ; Asian Americans/psychology ; Attitude to Health ; Authoritarianism ; Cross-Cultural Comparison ; Female ; Homosexuality/psychology ; Humans ; Indonesia/ethnology ; Japan/ethnology ; Male ; Oregon
    Language English
    Publishing date 1990-02
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 2066653-6
    ISSN 1940-1183 ; 0022-4545
    ISSN (online) 1940-1183
    ISSN 0022-4545
    DOI 10.1080/00224545.1990.9922936
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Efficacy, pharmacokinetics, and in vivo antiviral activity of UC781, a highly potent, orally bioavailable nonnucleoside reverse transcriptase inhibitor of HIV type 1.

    Buckheit, R W / Hollingshead, M / Stinson, S / Fliakas-Boltz, V / Pallansch, L A / Roberson, J / Decker, W / Elder, C / Borgel, S / Bonomi, C / Shores, R / Siford, T / Malspeis, L / Bader, J P

    AIDS research and human retroviruses

    1997  Volume 13, Issue 9, Page(s) 789–796

    Abstract: A series of compounds related to oxathiin carboxanilide has been identified as nonnucleoside reverse transcriptase inhibitors (NNRTIs) of HIV-1, and structure-activity relationships have been described (Buckheit RW, et al.: Antimicrob Agents Chemother ... ...

    Abstract A series of compounds related to oxathiin carboxanilide has been identified as nonnucleoside reverse transcriptase inhibitors (NNRTIs) of HIV-1, and structure-activity relationships have been described (Buckheit RW, et al.: Antimicrob Agents Chemother 1995;39:2718-2727). Three new analogs (UC040, UC82, and UC781) inhibited laboratory and clinical isolates of HIV-1, including isolates representative of the various clades of HIV-1 found worldwide, in both established and fresh human cells. Virus isolates with the amino acid changes L100I, K103N, V106I, and Y181C in the reverse transcriptase were partially resistant to these compounds. However, UC781 inhibited these virus isolates at low nontoxic concentrations, presenting a broad in vitro therapeutic index. As with other NNRTIs, each of the compounds synergistically interacted with AZT to inhibit HIV-1 replication. UC781 possesses a favorable pharmacokinetic profile in mice with a high level of oral bioavailability. Plasma concentrations reached maximum levels within 2 to 4 hr of oral administration and remained in excess of those required for in vitro anti-HIV activity for at least 24 hr after a single oral dose. When evaluated in a murine hollow fiber implant model of HIV infection, UC781 dosed orally or parenterally was able to suppress HIV replication completely in this model system, providing evidence of the in vivo efficacy of the compound.
    MeSH term(s) Administration, Oral ; Anilides/pharmacokinetics ; Anilides/pharmacology ; Animals ; Anti-HIV Agents/pharmacokinetics ; Anti-HIV Agents/pharmacology ; Biological Availability ; Furans/pharmacokinetics ; Furans/pharmacology ; HIV Core Protein p24/analysis ; HIV Reverse Transcriptase/antagonists & inhibitors ; HIV Reverse Transcriptase/genetics ; HIV-1/drug effects ; HIV-1/enzymology ; HIV-1/genetics ; HIV-2/drug effects ; Humans ; Male ; Metabolic Clearance Rate ; Mice ; Mice, Inbred Strains ; Microbial Sensitivity Tests ; Point Mutation ; Reverse Transcriptase Inhibitors/pharmacokinetics ; Reverse Transcriptase Inhibitors/pharmacology
    Chemical Substances Anilides ; Anti-HIV Agents ; Furans ; HIV Core Protein p24 ; Reverse Transcriptase Inhibitors ; HIV Reverse Transcriptase (EC 2.7.7.49) ; UC 781 (L7K247H29H)
    Language English
    Publishing date 1997-06-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 639130-8
    ISSN 1931-8405 ; 0889-2229
    ISSN (online) 1931-8405
    ISSN 0889-2229
    DOI 10.1089/aid.1997.13.789
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1928: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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