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  1. Article ; Online: DNA Damage Response, Runx2 (Runt-Related Transcription Factor 2), and Vascular Calcification.

    Boström, Kristina I

    Arteriosclerosis, thrombosis, and vascular biology

    2021  Volume 41, Issue 4, Page(s) 1358–1359

    MeSH term(s) Apoptosis ; Core Binding Factor Alpha 1 Subunit/genetics ; DNA Damage ; Humans ; Muscle, Smooth, Vascular ; Myocytes, Smooth Muscle ; Vascular Calcification/genetics
    Chemical Substances Core Binding Factor Alpha 1 Subunit ; RUNX2 protein, human
    Language English
    Publishing date 2021-03-24
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.121.315836
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1705: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: The Shifting Nature of Endothelial Progenitor Cells in Aortic Stenosis.

    Boström, Kristina I

    Mayo Clinic proceedings

    2019  Volume 94, Issue 4, Page(s) 567–569

    MeSH term(s) Aortic Valve Stenosis ; Endothelial Progenitor Cells ; Humans ; Stem Cells
    Language English
    Publishing date 2019-04-04
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2019.02.013
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  3. Article ; Online: Reply: Transitioning endothelial cells contribute to pulmonary fibrosis.

    Wu, Xiuju / Boström, Kristina I / Yao, Yucheng

    The European respiratory journal

    2023  Volume 62, Issue 3

    MeSH term(s) Humans ; Bleomycin ; Endothelial Cells/pathology ; Lung/pathology ; Myofibroblasts ; Pulmonary Fibrosis/pathology ; Animals ; Mice
    Chemical Substances Bleomycin (11056-06-7)
    Language English
    Publishing date 2023-09-28
    Publishing country England
    Document type Letter ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01329-2023
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    Zs.MO 292: Show issues

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  4. Article ; Online: Options for COVID-19 Entry into Pulmonary Cells.

    Boström, Kristina I / Yao, Yucheng

    Biomedical journal of scientific & technical research

    2020  Volume 29, Issue 2, Page(s) 22337–22338

    Language English
    Publishing date 2020-08-05
    Publishing country United States
    Document type Journal Article
    ISSN 2574-1241
    ISSN (online) 2574-1241
    DOI 10.26717/bjstr.2020.29.004781
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  5. Article ; Online: COVID-19 Infection May Drive EC-like Myofibroblasts towards Myofibroblasts to Contribute to Pulmonary Fibrosis.

    Wu, Xiuju / Zhang, Daoqin / Boström, Kristina I / Yao, Yucheng

    International journal of molecular sciences

    2023  Volume 24, Issue 14

    Abstract: COVID-19 has an extensive impact on Homo sapiens globally. Patients with COVID-19 are at an increased risk of developing pulmonary fibrosis. A previous study identified that myofibroblasts could be derived from pulmonary endothelial lineage cells as an ... ...

    Abstract COVID-19 has an extensive impact on Homo sapiens globally. Patients with COVID-19 are at an increased risk of developing pulmonary fibrosis. A previous study identified that myofibroblasts could be derived from pulmonary endothelial lineage cells as an important cell source that contributes to pulmonary fibrosis. Here, we analyzed publicly available data and showed that COVID-19 infection drove endothelial lineage cells towards myofibroblasts in pulmonary fibrosis of patients with COVID-19. We also discovered a similar differentiation trajectory in mouse lungs after viral infection. The results suggest that COVID-19 infection leads to the development of pulmonary fibrosis partly through the activation of endothelial cell (EC)-like myofibroblasts.
    MeSH term(s) Mice ; Animals ; Pulmonary Fibrosis/etiology ; Pulmonary Fibrosis/pathology ; Myofibroblasts/pathology ; COVID-19/pathology ; Lung ; Cell Differentiation ; Endothelial Cells/pathology ; Fibrosis
    Language English
    Publishing date 2023-07-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241411500
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  6. Article ; Online: Hypertension treatment in the oldest-old: focus group interviews with Swedish general practitioners.

    Berkhout, Marjo / Bengtsson Boström, Kristina / Östberg, Anna-Lena

    Scandinavian journal of primary health care

    2022  Volume 40, Issue 3, Page(s) 395–404

    Abstract: Objective: This study explored the considerations and experiences of Swedish General Practitioners (GPs) of hypertension treatment in patients 80 years and above.: Design: Qualitative design with focus group interviews. Data were analysed by ... ...

    Abstract Objective: This study explored the considerations and experiences of Swedish General Practitioners (GPs) of hypertension treatment in patients 80 years and above.
    Design: Qualitative design with focus group interviews. Data were analysed by qualitative content analysis.
    Setting: Primary health care centres (PHCCs), both rural and urban, in the Region of Västra Götaland, Sweden.
    Subjects: GPs and GP trainees working at PHCCs in 2019 and 2020. Five focus group interviews with 24 physicians were performed.
    Main outcome measures: Considerations and experiences of hypertension treatment in the oldest-old.
    Results: Eighteen GPs and six GP trainees participated in the study. The latent content was formulated in a theme: 'The physician's decision-making in the treatment of hypertension in the oldest-old implies the inclusion of both medical and humanistic considerations.' The manifest content constituted three main categories: 'The patient characteristics' included medical condition, behavioural factors and daily life. 'The physician's role' described the GP as a professional and her/his experienced support. 'The treatment decision' considered these categories and involved risk-benefit balancing and communication. For the future, the participants proposed better guidelines for the oldest-old multimorbid patients, increased teamwork, continuous cooperation with nurses and better cooperation with hospital physicians.
    Conclusion: Hypertension care for the oldest-old was experienced as complicated by GPs, due to the need of balancing medical and humanistic considerations. The GP's clinical experience and the received support were of importance when making the treatment decision based on risk-benefit balancing and communication with the patient.Key pointsGPs experienced the task of caring for the oldest-old patients with hypertension as complicated.Patient factors like multimorbidity, polypharmacy, behavioural factors and the patient's condition of daily life were identified.Clinical experience and the experienced support at the PHCC were discussed as important for the GPs' treatment decision.Treatment decisions for the oldest-old patients with hypertension were based on risk-benefit balancing and communication with the patients.
    MeSH term(s) Aged, 80 and over ; Female ; Humans ; Attitude of Health Personnel ; Focus Groups ; General Practitioners/psychology ; Hypertension/drug therapy ; Qualitative Research ; Sweden ; Male
    Language English
    Publishing date 2022-11-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605763-9
    ISSN 1502-7724 ; 0281-3432 ; 0284-6020
    ISSN (online) 1502-7724
    ISSN 0281-3432 ; 0284-6020
    DOI 10.1080/02813432.2022.2139436
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    Zs.B 2713: Show issues Location:
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  7. Article ; Online: Where do we stand on vascular calcification?

    Boström, Kristina I

    Vascular pharmacology

    2016  Volume 84, Page(s) 8–14

    Abstract: Vascular disease, such as atherosclerosis and diabetic vasculopathy, is frequently complicated by vascular calcification. Previously believed to be an end-stage process of unregulated mineral precipitation, it is now well established to be a multi- ... ...

    Abstract Vascular disease, such as atherosclerosis and diabetic vasculopathy, is frequently complicated by vascular calcification. Previously believed to be an end-stage process of unregulated mineral precipitation, it is now well established to be a multi-faceted disease influenced by the characteristics of its vascular location, the origins of calcifying cells and numerous regulatory pathways. It reflects the fundamental plasticity of the vasculature that is gradually being revealed by progress in vascular and stem cell biology. This review provides a brief overview of where we stand in our understanding of vascular calcification, facing the challenge of translating this knowledge into viable preventive and therapeutic strategies.
    MeSH term(s) Animals ; Atherosclerosis/physiopathology ; Atherosclerosis/therapy ; Diabetic Angiopathies/physiopathology ; Diabetic Angiopathies/therapy ; Humans ; Signal Transduction/physiology ; Vascular Calcification/physiopathology ; Vascular Calcification/therapy ; Vascular Diseases/physiopathology ; Vascular Diseases/therapy
    Language English
    Publishing date 2016-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2082846-9
    ISSN 1879-3649 ; 1537-1891 ; 1879-3649
    ISSN (online) 1879-3649 ; 1537-1891
    ISSN 1879-3649
    DOI 10.1016/j.vph.2016.05.014
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    Zs.A 591: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article ; Online: Progenitor cells from brown adipose tissue undergo neurogenic differentiation.

    Jumabay, Medet / Zhang, Li / Yao, Jiayi / Boström, Kristina I

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 5614

    Abstract: Multipotent cells derived from white adipose tissue have been shown to differentiate into multiple lineages including neurogenic lineages. However, the high innervation of brown adipose tissue by the sympathetic nervous system suggest it might be a ... ...

    Abstract Multipotent cells derived from white adipose tissue have been shown to differentiate into multiple lineages including neurogenic lineages. However, the high innervation of brown adipose tissue by the sympathetic nervous system suggest it might be a better source of neural precursor cells. To investigate potential differences between white and brown progenitors, we cultured white and brown dedifferentiated fat (wDFAT and brDFAT) cells from mouse and human adipose tissue and compared marker expression of neural precursors, and neuronal and glial cells, using fluorescence-activated cell sorting, bright-field imaging, immunofluorescence, and RNA analysis by qPCR. The results showed that both wDFAT and brDFAT cells had the capacity to generate neuronal and glial-like cells under neurogenic conditions. However, the brDFAT cells exhibited enhanced propensity for neurogenic differentiation. The neurogenic cells were at least in part derived from Adiponectin-expressing cells. TdTomato-expressing cells derived from Adiponectin (Adipoq) Cre
    MeSH term(s) Adipose Tissue, Brown ; Adipose Tissue, White ; Animals ; Cell Differentiation/physiology ; Mice ; Neural Stem Cells ; Neurogenesis
    Language English
    Publishing date 2022-04-04
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-09382-8
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  9. Article ; Online: Hypertension treatment in the oldest-old

    Marjo Berkhout / Kristina Bengtsson Boström / Anna-Lena Östberg

    Scandinavian Journal of Primary Health Care, Pp 1-

    focus group interviews with Swedish general practitioners

    2022  Volume 10

    Abstract: Objective This study explored the considerations and experiences of Swedish General Practitioners (GPs) of hypertension treatment in patients 80 years and above.Design Qualitative design with focus group interviews. Data were analysed by qualitative ... ...

    Abstract Objective This study explored the considerations and experiences of Swedish General Practitioners (GPs) of hypertension treatment in patients 80 years and above.Design Qualitative design with focus group interviews. Data were analysed by qualitative content analysis.Setting Primary health care centres (PHCCs), both rural and urban, in the Region of Västra Götaland, Sweden.Subjects GPs and GP trainees working at PHCCs in 2019 and 2020. Five focus group interviews with 24 physicians were performed.Main outcome measures Considerations and experiences of hypertension treatment in the oldest-old.Results Eighteen GPs and six GP trainees participated in the study. The latent content was formulated in a theme: ‘The physician’s decision-making in the treatment of hypertension in the oldest-old implies the inclusion of both medical and humanistic considerations.’ The manifest content constituted three main categories: ‘The patient characteristics’ included medical condition, behavioural factors and daily life. ‘The physician’s role’ described the GP as a professional and her/his experienced support. ‘The treatment decision’ considered these categories and involved risk-benefit balancing and communication. For the future, the participants proposed better guidelines for the oldest-old multimorbid patients, increased teamwork, continuous cooperation with nurses and better cooperation with hospital physicians.Conclusion Hypertension care for the oldest-old was experienced as complicated by GPs, due to the need of balancing medical and humanistic considerations. The GP’s clinical experience and the received support were of importance when making the treatment decision based on risk-benefit balancing and communication with the patient.Key pointsGPs experienced the task of caring for the oldest-old patients with hypertension as complicated.Patient factors like multimorbidity, polypharmacy, behavioural factors and the patient’s condition of daily life were identified.Clinical experience and the experienced support at the PHCC ...
    Keywords Focus group interviews ; general practitioners ; hypertension ; oldest-old ; physicians ; primary health care ; Public aspects of medicine ; RA1-1270
    Subject code 360
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Primary care physicians' concerned voices on sickness certification after a period of reorganization. Focus group interviews in Sweden.

    Bengtsson Boström, Kristina / Starzmann, Karin / Östberg, Anna-Lena

    Scandinavian journal of primary health care

    2020  Volume 38, Issue 2, Page(s) 146–155

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Adult ; Attitude of Health Personnel ; Certification ; Female ; Focus Groups ; Health Care Reform ; Humans ; Male ; Middle Aged ; Physicians, Primary Care ; Practice Patterns, Physicians' ; Primary Health Care ; Qualitative Research ; Sick Leave ; Surveys and Questionnaires ; Sweden ; Work Capacity Evaluation
    Language English
    Publishing date 2020-04-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605763-9
    ISSN 1502-7724 ; 0281-3432 ; 0284-6020
    ISSN (online) 1502-7724
    ISSN 0281-3432 ; 0284-6020
    DOI 10.1080/02813432.2020.1753341
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