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  1. Article: Knochenmetastasen - Pathophysiologie und zellbiologische Grundlagen. Bone metastases - Pathophysiology and cell-biological aspects. .... L. C. Hofbauer für das SkelMet Konsortium

    Jakob, F. / Ebert, R. / Rauner, M. / Rachner, T. / Schütze, N. / Glüer, C.-C. / Hofbauer, L. C.

    Osteologie

    2014  Volume 23, Issue 4, Page(s) 239

    Language German
    Document type Article
    ZDB-ID 1116704-x
    ISSN 1019-1291
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: From Bone Cell Biology to Novel Therapies of Osteoporosis.

    Hofbauer, L C

    Drug research

    2015  Volume 65 Suppl 1, Page(s) S14–5

    MeSH term(s) Biphenyl Compounds/therapeutic use ; Bone Density Conservation Agents/therapeutic use ; Bone Morphogenetic Proteins/immunology ; Bone and Bones/cytology ; Bone and Bones/metabolism ; Denosumab/therapeutic use ; Genetic Markers/immunology ; Humans ; Osteoporosis/drug therapy ; Osteoporosis/pathology
    Chemical Substances Biphenyl Compounds ; Bone Density Conservation Agents ; Bone Morphogenetic Proteins ; Genetic Markers ; SOST protein, human ; Denosumab (4EQZ6YO2HI) ; odanacatib (N673F6W2VH)
    Language English
    Publishing date 2015-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2703847-6
    ISSN 2194-9387 ; 2194-9379
    ISSN (online) 2194-9387
    ISSN 2194-9379
    DOI 10.1055/s-0035-1558064
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Metabolic and inflammatory parameters in relation to baseline characterization and treatment outcome in patients with prolactinoma: insights from a retrospective cohort study at a single tertiary center.

    Hofbauer, Susanna / Horka, Laura / Seidenberg, Samuel / Da Mutten, Raffaele / Regli, Luca / Serra, Carlo / Beuschlein, Felix / Erlic, Zoran

    Frontiers in endocrinology

    2024  Volume 15, Page(s) 1363939

    Abstract: Background: Prolactinomas (PRLs) are prevalent pituitary adenomas associated with metabolic changes and increased cardiovascular morbidity. This study examined clinical, endocrine, metabolic, and inflammatory profiles in PRL patients, aiming to identify ...

    Abstract Background: Prolactinomas (PRLs) are prevalent pituitary adenomas associated with metabolic changes and increased cardiovascular morbidity. This study examined clinical, endocrine, metabolic, and inflammatory profiles in PRL patients, aiming to identify potential prognostic markers.
    Methods: The study comprised data from 59 PRL patients gathered in a registry at the University Hospital of Zurich. Diagnostic criteria included MRI findings and elevated serum prolactin levels. We assessed baseline and follow-up clinical demographics, metabolic markers, serum inflammation-based scores, and endocrine parameters. Treatment outcomes were evaluated based on prolactin normalization, tumor shrinkage, and cabergoline dosage.
    Results: The PRL cohort exhibited a higher prevalence of overweight/obesity, prediabetes/diabetes mellitus, and dyslipidemia compared to the general population. Significant correlations were found between PRL characteristics and BMI, HbA1c, and fT4 levels. Follow-up data indicated decreases in tumor size, tumor volume, prolactin levels, and LDL-cholesterol, alongside increases in fT4 and sex hormones levels. No significant associations were observed between baseline parameters and tumor shrinkage at follow-up. A positive association was noted between PRL size/volume and the time to achieve prolactin normalization, and a negative association with baseline fT4 levels.
    Conclusion: This study underscores the metabolic significance of PRL, with notable correlations between PRL parameters and metabolic indices. However, inflammatory markers were not significantly correlated with patient stratification or outcome prediction. These findings highlight the necessity for standardized follow-up protocols and further research into the metabolic pathogenesis in PRL patients.
    MeSH term(s) Humans ; Prolactinoma/blood ; Prolactinoma/drug therapy ; Prolactinoma/pathology ; Female ; Male ; Adult ; Retrospective Studies ; Middle Aged ; Pituitary Neoplasms/blood ; Pituitary Neoplasms/metabolism ; Pituitary Neoplasms/pathology ; Treatment Outcome ; Inflammation/blood ; Tertiary Care Centers ; Cabergoline/therapeutic use ; Prolactin/blood ; Prognosis ; Follow-Up Studies ; Cohort Studies ; Young Adult
    Chemical Substances Cabergoline (LL60K9J05T) ; Prolactin (9002-62-4)
    Language English
    Publishing date 2024-04-05
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2024.1363939
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Transferrin receptor 2 mitigates periodontitis-driven alveolar bone loss.

    Lösser, Lennart / Ledesma-Colunga, Maria G / Andrés Sastre, Enrique / Scholtysek, Carina / Hofbauer, Lorenz C / Noack, Barbara / Baschant, Ulrike / Rauner, Martina

    Journal of cellular physiology

    2024  Volume 239, Issue 2, Page(s) e31172

    Abstract: Periodontitis is associated with significant alveolar bone loss. Patients with iron overload suffer more frequently from periodontitis, however, the underlying mechanisms remain largely elusive. Here, we investigated the role of transferrin receptor 2 ( ... ...

    Abstract Periodontitis is associated with significant alveolar bone loss. Patients with iron overload suffer more frequently from periodontitis, however, the underlying mechanisms remain largely elusive. Here, we investigated the role of transferrin receptor 2 (Tfr2), one of the main regulators of iron homeostasis, in the pathogenesis of periodontitis and the dental phenotype under basal conditions in mice. As Tfr2 suppresses osteoclastogenesis, we hypothesized that deficiency of Tfr2 may exacerbate periodontitis-induced bone loss. Mice lacking Tfr2 (Tfr2
    MeSH term(s) Animals ; Humans ; Mice ; Alveolar Bone Loss/genetics ; Alveolar Bone Loss/metabolism ; Iron ; Osteoclasts ; Periodontitis/genetics ; Periodontitis/metabolism ; Receptors, Transferrin/genetics ; X-Ray Microtomography ; Mice, Inbred C57BL ; Cells, Cultured
    Chemical Substances Iron (E1UOL152H7) ; Receptors, Transferrin ; TRF2 protein, mouse
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3116-1
    ISSN 1097-4652 ; 0021-9541
    ISSN (online) 1097-4652
    ISSN 0021-9541
    DOI 10.1002/jcp.31172
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Patellar Size Variation at the Quadriceps Tendon-Bone Block Harvest Site: A Magnetic Resonance Imaging Study to Evaluate the Safe Zone for Harvesting a Sufficient Bone Block.

    Negrin, Lukas L / Zeitler, Cornelia / Hofbauer, Marcus

    The American journal of sports medicine

    2021  Volume 49, Issue 14, Page(s) 3850–3858

    Abstract: Background: Quadriceps tendon (QT) autografts with and without a bone block are the least studied and least used options for anterior cruciate ligament reconstruction surgery. In particular, there is a lack of literature describing patellar anatomy. ... ...

    Abstract Background: Quadriceps tendon (QT) autografts with and without a bone block are the least studied and least used options for anterior cruciate ligament reconstruction surgery. In particular, there is a lack of literature describing patellar anatomy. Until now, guidelines for patellar bone block harvesting have been based solely on personal experience. In this study, we intended to derive recommendations from physical regularities and objective criteria.
    Purpose: To determine the maximal, individual-related length and depth of the bone block that can be safely harvested and to provide guidelines to help surgeons make decisions on graft choice.
    Study design: Descriptive laboratory study.
    Methods: The study group consisted of 50 male participants and 50 female participants (mean age, 29.4 ± 7.9 years) who underwent 3.0-T magnetic resonance imaging of their knee. Patellar height was determined at the center of the middle third of the QT insertion on the patella and the medial and lateral endpoints; the depth was measured at the midpoints of the respective heights.
    Results: The mean width of the QT and the mean thickness were 49.0 ± 7.6 and 7.3 ± 1.0 mm, respectively. The mean patellar thickness in reference to the medial endpoint, the center, and the lateral endpoint was 18.3 ± 2.4, 17.9 ± 2.3, and 15.1 ± 2.3 mm, respectively, whereas the mean patellar height was 35.1 ± 4.1, 36.7 ± 4.2, and 35.1 ± 3.9 mm. In general, the tendon and patellar dimensions were significantly larger in male participants than in female participants (
    Conclusion: Bone block harvesting, with its depth not exceeding 50% of the patellar thickness and its length accounting for <50% of the patellar height, poses the least risk for a patellar fracture when located medial to midline. If the bone block is excised from the medial half of the central area (the latter is defined by the middle third of the QT insertion), with the outer edge of the saw positioned at the medial border of the central area, a graft of 15 mm length, 10 mm width, and 8 mm depth can be safely harvested in all White male participants and almost all female participants taller than 165 cm, according to our findings.
    Clinical relevance: This is the first study presenting recommendations for patellar bone block harvesting at the quadriceps tendon insertionbased on physical regularities and objective criteria and not on personal experience.
    MeSH term(s) Adult ; Anterior Cruciate Ligament Injuries/surgery ; Anterior Cruciate Ligament Reconstruction ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Patella/diagnostic imaging ; Patella/surgery ; Patellar Ligament ; Quadriceps Muscle/surgery ; Tendons ; Young Adult
    Language English
    Publishing date 2021-10-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197482-8
    ISSN 1552-3365 ; 0363-5465
    ISSN (online) 1552-3365
    ISSN 0363-5465
    DOI 10.1177/03635465211049226
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: MicroRNA and Diabetic Bone Disease.

    Daamouch, Souad / Emini, Lejla / Rauner, Martina / Hofbauer, Lorenz C

    Current osteoporosis reports

    2022  Volume 20, Issue 3, Page(s) 194–201

    Abstract: Purpose of review: The incidence of diabetes is increasing worldwide. Diabetes mellitus is characterized by hyperglycemia, which in the long-term damages the function of many organs including the eyes, the vasculature, the nervous system, and the ... ...

    Abstract Purpose of review: The incidence of diabetes is increasing worldwide. Diabetes mellitus is characterized by hyperglycemia, which in the long-term damages the function of many organs including the eyes, the vasculature, the nervous system, and the kidneys, thereby imposing an important cause of morbidity for affected individuals. More recently, increased bone fragility was also noted in patients with diabetes. While patients with type 1 diabetes mellitus (T1DM) have low bone mass and a 6-fold risk for hip fractures, patients with type 2 diabetes mellitus (T2DM) have an increased bone mass, yet still display a 2-fold elevated risk for hip fractures. Although the underlying mechanisms are just beginning to be unraveled, it is clear that diagnostic tools are lacking to identify patients at risk for fracture, especially in the case of T2DM, in which classical tools to diagnose osteoporosis such as dual X-ray absorptiometry have limitations. Thus, new biomarkers are urgently needed to help identify patients with diabetes who are at risk to fracture.
    Recent findings: Previously, microRNAs have received great attention not only for being involved in the pathogenesis of various chronic diseases, including osteoporosis, but also for their value as biomarkers. Here, we summarize the current knowledge on microRNAs and their role in diabetic bone disease and highlight recent studies on miRNAs as biomarkers to predict bone fragility in T1DM and T2DM. Finally, we discuss future directions and challenges for their use as prognostic markers.
    MeSH term(s) Biomarkers ; Bone Density ; Bone Diseases/complications ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/epidemiology ; Diabetes Mellitus, Type 1/genetics ; Diabetes Mellitus, Type 2/epidemiology ; Hip Fractures/epidemiology ; Humans ; MicroRNAs ; Osteoporosis/epidemiology
    Chemical Substances Biomarkers ; MicroRNAs
    Language English
    Publishing date 2022-06-08
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2186581-4
    ISSN 1544-2241 ; 1544-1873
    ISSN (online) 1544-2241
    ISSN 1544-1873
    DOI 10.1007/s11914-022-00731-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Knochengesundheit bei Krebserkrankungen

    Rachner, T. D. / Riffel, R. M. / Hofbauer, L. C.

    Krebs im Focus

    2021  Volume 14, Issue -, Page(s) 16

    Language German
    Document type Article
    ZDB-ID 2761631-9
    Database Current Contents Medicine

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  8. Article ; Online: Effect of Anti-Osteoporotic Treatments on Circulating and Bone MicroRNA Patterns in Osteopenic ZDF Rats.

    Carro Vázquez, David / Emini, Lejla / Rauner, Martina / Hofbauer, Christine / Grillari, Johannes / Diendorfer, Andreas B / Eastell, Richard / Hofbauer, Lorenz C / Hackl, Matthias

    International journal of molecular sciences

    2022  Volume 23, Issue 12

    Abstract: Bone fragility is an adverse outcome of type 2 diabetes mellitus (T2DM). The underlying molecular mechanisms have, however, remained largely unknown. MicroRNAs (miRNAs) are short non-coding RNAs that control gene expression in health and disease states. ... ...

    Abstract Bone fragility is an adverse outcome of type 2 diabetes mellitus (T2DM). The underlying molecular mechanisms have, however, remained largely unknown. MicroRNAs (miRNAs) are short non-coding RNAs that control gene expression in health and disease states. The aim of this study was to investigate the genome-wide regulation of miRNAs in T2DM bone disease by analyzing serum and bone tissue samples from a well-established rat model of T2DM, the Zucker Diabetic Fatty (ZDF) model. We performed small RNA-sequencing analysis to detect dysregulated miRNAs in the serum and ulna bone of the ZDF model under placebo and also under anti-sclerostin, PTH, and insulin treatments. The dysregulated circulating miRNAs were investigated for their cell-type enrichment to identify putative donor cells and were used to construct gene target networks. Our results show that unique sets of miRNAs are dysregulated in the serum (n = 12, FDR < 0.2) and bone tissue (n = 34, FDR < 0.2) of ZDF rats. Insulin treatment was found to induce a strong dysregulation of circulating miRNAs which are mainly involved in metabolism, thereby restoring seven circulating miRNAs in the ZDF model to normal levels. The effects of anti-sclerostin treatment on serum miRNA levels were weaker, but affected miRNAs were shown to be enriched in bone tissue. PTH treatment did not produce any effect on circulating or bone miRNAs in the ZDF rats. Altogether, this study provides the first comprehensive insights into the dysregulation of bone and serum miRNAs in the context of T2DM and the effect of insulin, PTH, and anti-sclerostin treatments on circulating miRNAs.
    MeSH term(s) Animals ; Bone and Bones/metabolism ; Diabetes Mellitus, Type 2/metabolism ; Insulin ; MicroRNAs ; Rats ; Rats, Zucker
    Chemical Substances Insulin ; MicroRNAs
    Language English
    Publishing date 2022-06-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23126534
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  9. Article: From Bone Cell Biology to Novel Therapies of Osteoporosis

    Hofbauer, L. C.

    Drug Research

    2015  Volume 65, Issue S 01, Page(s) S14–S15

    Language English
    Publishing date 2015-11-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2703847-6
    ISSN 2194-9387 ; 2194-9379
    ISSN (online) 2194-9387
    ISSN 2194-9379
    DOI 10.1055/s-0035-1558064
    Database Thieme publisher's database

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  10. Article: Editorial. Osteoporose und Diabetes mellitus

    Hofbauer, L. C.

    Osteologie

    2014  Volume 23, Issue 2, Page(s) 75

    Language German
    Document type Article
    ZDB-ID 1116704-x
    ISSN 1019-1291
    Database Current Contents Medicine

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