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  1. Article ; Online: Sex difference in the association between BMI and cognitive impairment in Chinese older adults.

    Zhu, Lin / Lei, Mei / Tan, Li / Zou, Mingjun

    Journal of affective disorders

    2024  Volume 349, Page(s) 39–47

    Abstract: Background: The association between body mass index (BMI) and cognitive impairment (CI) has been the subject of extensive research, yet the precise dose-response effects remain undefined.: Methods: Older adults were selected from the 2011/2012 survey ...

    Abstract Background: The association between body mass index (BMI) and cognitive impairment (CI) has been the subject of extensive research, yet the precise dose-response effects remain undefined.
    Methods: Older adults were selected from the 2011/2012 survey at baseline and the new recruits from the 2014 and 2018 waves of the Chinese Longitudinal Healthy Longevity Survey (CLHLS). Multiple logistic regression models were used to evaluate the association between BMI categories and CI, and Restricted Cubic Spline (RCS) was used to explore the nonlinear relationship between BMI and CI.
    Results: The study included 29,380 older adults aged from 65 to 117 years, with an average age of 82 years. Of these, 13,465 were men, and 5359 exhibited cognitive impairment. The logistic model indicated that in female participants, being underweight was positively correlated with CI (OR:1.32; 95%CI 1.20-1.46), whereas being overweight was inversely correlated with CI (OR:0.86; 95%CI 0.75-0.99), and we didn't find any association between BMI category and CI in male participants. RCS modeling revealed a U-shaped relationship between BMI and CI. When stratified by sex, men exhibited a similar trend, with the lowest risk at a BMI of 22.774 kg/ m
    Limitation: This was a cross-sectional study, it cannot provide information on causal relationships.
    Conclusion: A U-shaped relationship was observed between BMI and CI in older adults, more pronounced in the male population, suggesting that male older adults may need to manage their BMI more rigorously.
    MeSH term(s) Humans ; Female ; Male ; Aged ; Aged, 80 and over ; Body Mass Index ; Cross-Sectional Studies ; Sex Characteristics ; Cognitive Dysfunction/epidemiology ; Logistic Models ; China/epidemiology
    Language English
    Publishing date 2024-01-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 135449-8
    ISSN 1573-2517 ; 0165-0327
    ISSN (online) 1573-2517
    ISSN 0165-0327
    DOI 10.1016/j.jad.2024.01.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Interlayer bond polarizability model for interlayer phonons in van der Waals heterostructures.

    Mei, Rui / Lin, Miao-Ling / Wu, Heng / Chen, Lin-Shang / Shi, Yan-Meng / Wei, Zhongming / Tan, Ping-Heng

    Nanoscale

    2024  Volume 16, Issue 8, Page(s) 4004–4013

    Abstract: Raman scattering provides essential insights into phonons, electronic structures and electron-phonon coupling within solids through the intensity of Raman peaks, which cannot be easily quantified using the classical bond polarizability model. The ... ...

    Abstract Raman scattering provides essential insights into phonons, electronic structures and electron-phonon coupling within solids through the intensity of Raman peaks, which cannot be easily quantified using the classical bond polarizability model. The interlayer bond polarizability model (IBPM) had been developed to understand the Raman intensity of layer-breathing modes (LBMs) in two-dimensional materials. However, the quantitative understanding of the LBM intensity of a van der Waals heterostructure (vdWH) remains challenging. Here, in polynary vdWHs comprising twisted multilayer graphene (tMLG), MoS
    Language English
    Publishing date 2024-02-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d3nr06437a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Nocardia farcinica

    Tan, Yuying / Yang, Mei / Wan, Chun / Tang, Shijie / Liu, Lin / Chen, Lei

    Frontiers in medicine

    2024  Volume 10, Page(s) 1337303

    Abstract: Nocardia species are gram-positive, acid-fast, saprophytic, aerobic bacilli, predominantly resulting in opportunistic infections in immunocompromised individuals. Here, we reported a case of Nocardia infection in a 27-year-old woman with normal ... ...

    Abstract Nocardia species are gram-positive, acid-fast, saprophytic, aerobic bacilli, predominantly resulting in opportunistic infections in immunocompromised individuals. Here, we reported a case of Nocardia infection in a 27-year-old woman with normal immunocompetence, who presented as a solitary neoplasm in the left principal bronchus with a chief complaint of postural dyspnea. By electrotomy via bronchoscopy, the neoplasm was successfully removed, and it was further identified as
    Language English
    Publishing date 2024-01-10
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1337303
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: An exploratory study of acute analgesia in tibial shaft fractures: a comparison between Māori and Non-Māori.

    Tan, Ruth / Coia, Martin / Tay, Mei Lin / Baker, Joseph F

    ANZ journal of surgery

    2024  Volume 94, Issue 1-2, Page(s) 241–245

    Abstract: Background: Published research suggests Indigenous peoples are less likely to receive analgesia in acute pain settings however there is limited data on the indigenous New Zealand Māori population. The aim of this exploratory pilot study was to compare ... ...

    Abstract Background: Published research suggests Indigenous peoples are less likely to receive analgesia in acute pain settings however there is limited data on the indigenous New Zealand Māori population. The aim of this exploratory pilot study was to compare management between Māori and non-Māori for acute fracture pain in a regional trauma centre.
    Methods: A retrospective review was undertaken for 120 patients with isolated tibial shaft fractures presenting at a tertiary level trauma center between 2015 and 2020. Outcome measures reflected the patient journey including type of analgesia charted pre-hospital, in the ED and on the ward.
    Results: Out of 104 matched patients, 48 (46%) were Māori and 65% were male. Fewer Māori received pre-hospital analgesia compared with non-Māori (odds ratio 0.29, p = 0.006). Pain scores were similar on arrival to ED (6.1 ± 3.5 versus 5.4 ± 2.7, p = 0.2). Once at hospital, there were similar rates of prescribed analgesia (paracetamol, NSAIDs, synthetics, or opioids) both in ED and the ward. Time to analgesia were also similar for both groups (72 ± 71 min versus 65 ± 63 min, P > 0.9).
    Discussion: We found differences in pre-hospital administration of analgesia between Māori and non-Māori patients with tibial shaft fractures. However once in hospital although there was a trend towards lower prescribing for Māori, there were no significant differences. Exploring the reasons underpinning this difference and the development of robust analgesic guidelines for tibial shaft fractures may help in reducing this inequity in care, particularly in the pre-hospital setting.
    MeSH term(s) Female ; Humans ; Male ; Acute Pain/etiology ; Analgesia ; Maori People ; Pain Management ; Pilot Projects ; Retrospective Studies ; Tibial Fractures/complications ; Tibial Fractures/surgery
    Language English
    Publishing date 2024-01-04
    Publishing country Australia
    Document type Comparative Study ; Journal Article
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/ans.18848
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Silencing of METTL3 prevents the proliferation, migration, epithelial-mesenchymal transition, and renal fibrosis of high glucose-induced HK2 cells by mediating WISP1 in m6A-dependent manner.

    Chen, Yuanzhen / Li, Ping / Lin, Mei / Jiang, Ying / Tan, Guiping / Huang, Lianfang / Song, Dan

    Aging

    2024  Volume 16, Issue 2, Page(s) 1237–1248

    Abstract: Diabetic nephropathy (DN) is one of the most serious complications in diabetic patients. And m6A modifications mediated by METTL3 are involved multiple biological processes. However, the specific function and mechanism of METTL3 in DN remains unclear. DN ...

    Abstract Diabetic nephropathy (DN) is one of the most serious complications in diabetic patients. And m6A modifications mediated by METTL3 are involved multiple biological processes. However, the specific function and mechanism of METTL3 in DN remains unclear. DN model mice were first established with streptozotocin, and WISP1 expression was confirmed by qRT-PCR. Then the influences of WISP1 or/and METTL3 on the proliferation, migration, and epithelial-mesenchymal transition (EMT) and fibrosis-related proteins of high glucose (HG)-induced HK2 cells or HK2 cells were tested through CCK-8, wound healing, and western blot. We first revealed that WISP1 was highly expressed in renal tissues of DN model mice and HG-induced HK2 cells. Functionally, WISP1 or METTL3 silencing could weaken the proliferation, migration, EMT, and fibrosis of HG-treated HK2 cells, and WISP1 or METTL3 overexpression could induce the proliferation, migration, EMT, and fibrosis of HK2 cells. Additionally, METTL3 silencing could decrease WISP1 m6A modification, and silencing of METTL3 also could notably suppress the biological functions of HG-induced HK2 cells by downregulating WISP1. Silencing of METTL3 prevents DN development process by decreasing WISP1 with m6A modification pattern. Therefore, we suggest that METTL3/WISP1 axis might be a novel therapeutic target for DN.
    MeSH term(s) Animals ; Humans ; Mice ; Adenine/analogs & derivatives ; Cell Proliferation/genetics ; Diabetic Nephropathies/genetics ; Diabetic Nephropathies/metabolism ; Epithelial-Mesenchymal Transition ; Fibrosis ; Glucose/toxicity ; Methyltransferases/metabolism ; CCN Intercellular Signaling Proteins/genetics ; CCN Intercellular Signaling Proteins/metabolism
    Chemical Substances 6-methyladenine (W7IBY2BGAX) ; Adenine (JAC85A2161) ; Glucose (IY9XDZ35W2) ; Methyltransferases (EC 2.1.1.-) ; METTL3 protein, human (EC 2.1.1.62) ; CCN4 protein, human ; CCN Intercellular Signaling Proteins
    Language English
    Publishing date 2024-01-29
    Publishing country United States
    Document type Journal Article
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.205401
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Review on toxicology and activity of tomato glycoalkaloids in immature tomatoes.

    Wang, Li-Hao / Tan, De-Hong / Zhong, Xue-Song / Jia, Mei-Qi / Ke, Xue / Zhang, Yu-Mei / Cui, Tong / Shi, Lin

    Food chemistry

    2024  Volume 447, Page(s) 138937

    Abstract: Owing to the lack of selection and limited intelligence in mechanical picking, some immature tomatoes that contain alkaloids are thrown away. Tomatine alkaloids are steroidal alkaloids naturally present in Solanaceae plants, which are distributed in ... ...

    Abstract Owing to the lack of selection and limited intelligence in mechanical picking, some immature tomatoes that contain alkaloids are thrown away. Tomatine alkaloids are steroidal alkaloids naturally present in Solanaceae plants, which are distributed in small amounts in immature tomato fruits and decrease as the fruits ripen. Tomato glycoalkaloids are harmful to human health. However, in small quantities, there is some evidence that these compounds might be beneficial, as other non-antioxidant bioactivities. This article considers recent research on the biological effects of tomato glycoalkaloids in immature tomatoes, providing reference value for the potential development of these compounds.
    MeSH term(s) Humans ; Solanum lycopersicum ; Tomatine/toxicity ; Alkaloids/toxicity ; Solanaceae ; Plant Extracts/pharmacology
    Chemical Substances Tomatine (31U6547O08) ; Alkaloids ; Plant Extracts
    Language English
    Publishing date 2024-03-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2024.138937
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Nocardia farcinica infection presenting as a solitary bronchial neoplasm in an immunocompetent adult

    Yuying Tan / Mei Yang / Chun Wan / Shijie Tang / Lin Liu / Lei Chen

    Frontiers in Medicine, Vol

    a case report

    2024  Volume 10

    Abstract: Nocardia species are gram-positive, acid-fast, saprophytic, aerobic bacilli, predominantly resulting in opportunistic infections in immunocompromised individuals. Here, we reported a case of Nocardia infection in a 27-year-old woman with normal ... ...

    Abstract Nocardia species are gram-positive, acid-fast, saprophytic, aerobic bacilli, predominantly resulting in opportunistic infections in immunocompromised individuals. Here, we reported a case of Nocardia infection in a 27-year-old woman with normal immunocompetence, who presented as a solitary neoplasm in the left principal bronchus with a chief complaint of postural dyspnea. By electrotomy via bronchoscopy, the neoplasm was successfully removed, and it was further identified as Nocardia farcinica by metagenomic next-generation sequencing.
    Keywords bronchial neoplasm ; metagenomic next-generation sequencing ; Nocardia farcinica ; postural dyspnea ; immunocompetent adult ; Medicine (General) ; R5-920
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Multiomics integration reveals the effect of Orexin A on glioblastoma.

    Yang, Sha / Huan, Renzheng / Yue, Jianhe / Guo, Jin / Deng, Mei / Wang, Liya / Peng, Shuo / Lin, Xin / Liu, Lin / Wang, Jia / Han, Guoqiang / Zha, Yan / Liu, Jian / Zhang, Jiqin / Tan, Ying

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1096159

    Abstract: Objectives: ...

    Abstract Objectives:
    Language English
    Publishing date 2023-01-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1096159
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Effectiveness of interprofessional education for medical and nursing professionals and students on interprofessional educational outcomes: A systematic review.

    Shuyi, Amelia Tan / Zikki, Lew Yi Ting / Mei Qi, Ang / Koh Siew Lin, Serena

    Nurse education in practice

    2023  Volume 74, Page(s) 103864

    Abstract: Aim and background: Patient safety is a global health priority as unsafe care is a principal cause of death and disability. Ineffective interprofessional communication and collaboration among nursing and medical professionals and students contribute to ... ...

    Abstract Aim and background: Patient safety is a global health priority as unsafe care is a principal cause of death and disability. Ineffective interprofessional communication and collaboration among nursing and medical professionals and students contribute to unsafe practices. Interprofessional education provides opportunities to strengthen nurse-physician collaboration and enhance patient care. However, there is inconclusive evidence regarding interprofessional education effectiveness. This review aims to systematically evaluate interprofessional education effectiveness for nursing and medical professionals and students on interprofessional educational outcomes (interprofessional attitudes, perceptions, skills, knowledge, behaviours, and organisational and patient outcomes).
    Design and methods: PubMed, Cochrane Library, Embase, Scopus, CINAHL, ERIC, PsycInfo, Web of Science were last searched on 13 January 2022. This review included published and unpublished randomised controlled trials, quasi-experimental and mixed-method studies in English examining interprofessional education outcomes among nursing and medical professionals and students. Two reviewers independently appraised studies using the Joanna Briggs Institute Critical Appraisal Tools and extracted data using a modified Joanna Briggs Institute data extraction form. Narrative synthesis was conducted instead of meta-analysis since majority of the included studies had quasi-experimental design, and various interventions and outcomes. Certainty of evidence was appraised using the Grading of Recommendations, Assessment, Development and Evaluations tool.
    Results: This review included 15 studies involving 1185 participants. Improvements were reported in each interprofessional educational outcome after interprofessional education. High-fidelity simulation with multiple scenarios, standardised communication tools, didactic and active learning methods, theoretical frameworks, debriefing sessions and provider training enhanced interprofessional education effectiveness.
    Conclusions: Effectiveness of interprofessional education for nursing and medical professionals and students was demonstrated since improvements were observed for each interprofessional educational outcome. This systematic review addressed literature gaps, demonstrated effectiveness of interprofessional education in clinical practice and academic curricula and provided evidence-based insights that future research can consider to enhance global patient safety standards for optimal patient outcomes and quality of healthcare. Caution is advised in interpreting findings due to 'very low' evidence certainty and limited studies. More high-quality randomised controlled trials with longitudinal designs are needed.
    MeSH term(s) Humans ; Interprofessional Education ; Students ; Delivery of Health Care ; Communication ; Attitude ; Students, Nursing
    Language English
    Publishing date 2023-12-07
    Publishing country Scotland
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2058575-5
    ISSN 1873-5223 ; 1471-5953
    ISSN (online) 1873-5223
    ISSN 1471-5953
    DOI 10.1016/j.nepr.2023.103864
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: An ErbB4-Positive Neuronal Network in the Olfactory Bulb for Olfaction.

    Tan, Zhibing / Liu, Zhipeng / Liu, Yu / Liu, Fang / Robinson, Heath / Lin, Thiri W / Xiong, Wen-Cheng / Mei, Lin

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2022  Volume 42, Issue 34, Page(s) 6518–6535

    Abstract: Olfactory information is relayed and processed in the olfactory bulb (OB). Mitral cells, the principal output excitatory neurons of the OB, are controlled by multiple types of interneurons. However, mechanisms that regulate the activity of OB ... ...

    Abstract Olfactory information is relayed and processed in the olfactory bulb (OB). Mitral cells, the principal output excitatory neurons of the OB, are controlled by multiple types of interneurons. However, mechanisms that regulate the activity of OB interneurons are not well understood. We provide evidence that the transmembrane tyrosine kinase ErbB4 is selectively expressed in subsets of OB inhibitory neurons in both male and female mice. ErbB4-positive (ErbB4
    Language English
    Publishing date 2022-08-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.0131-22.2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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