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Article ; Online: Lebanon facing an exodus of psychiatrists when they are most needed.

Cherro, Michele / El-Khoury, Joseph

2022 Volume 71, Page(s) 103081

MeSH term(s)	Emigration and Immigration ; Humans ; Lebanon ; Psychiatry
Language	English
Publishing date	2022-03-11
Publishing country	Netherlands
Document type	Letter
ZDB-ID	2456678-0
ISSN	1876-2026 ; 1876-2018
ISSN (online)	1876-2026
ISSN	1876-2018
DOI	10.1016/j.ajp.2022.103081
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Article ; Online: Biomarkers vs Machines: The Race to Predict Acute Kidney Injury.

Ghazi, Lama / Farhat, Kassem / Hoenig, Melanie P / Durant, Thomas J S / El-Khoury, Joe M

Clinical chemistry

2024

Abstract: Background: Acute kidney injury (AKI) is a serious complication affecting up to 15% of hospitalized patients. Early diagnosis is critical to prevent irreversible kidney damage that could otherwise lead to significant morbidity and mortality. However, ... ...

Abstract	Background: Acute kidney injury (AKI) is a serious complication affecting up to 15% of hospitalized patients. Early diagnosis is critical to prevent irreversible kidney damage that could otherwise lead to significant morbidity and mortality. However, AKI is a clinically silent syndrome, and current detection primarily relies on measuring a rise in serum creatinine, an imperfect marker that can be slow to react to developing AKI. Over the past decade, new innovations have emerged in the form of biomarkers and artificial intelligence tools to aid in the early diagnosis and prediction of imminent AKI. Content: This review summarizes and critically evaluates the latest developments in AKI detection and prediction by emerging biomarkers and artificial intelligence. Main guidelines and studies discussed herein include those evaluating clinical utilitiy of alternate filtration markers such as cystatin C and structural injury markers such as neutrophil gelatinase-associated lipocalin and tissue inhibitor of metalloprotease 2 with insulin-like growth factor binding protein 7 and machine learning algorithms for the detection and prediction of AKI in adult and pediatric populations. Recommendations for clinical practices considering the adoption of these new tools are also provided. Summary: The race to detect AKI is heating up. Regulatory approval of select biomarkers for clinical use and the emergence of machine learning algorithms that can predict imminent AKI with high accuracy are all promising developments. But the race is far from being won. Future research focusing on clinical outcome studies that demonstrate the utility and validity of implementing these new tools into clinical practice is needed.
Language	English
Publishing date	2024-02-01
Publishing country	England
Document type	Journal Article
ZDB-ID	80102-1
ISSN	1530-8561 ; 0009-9147
ISSN (online)	1530-8561
ISSN	0009-9147
DOI	10.1093/clinchem/hvad217
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Article ; Online: Glycerol Kinase Deficiency with Increased Triglycerides and Weight Gain: Pseudo or Real?

Jiao, Jingjing / Bernard, Paul E / Meeusen, Jeffrey / Militello, Leah / El-Khoury, Joe M

Clinical chemistry

2024 Volume 70, Issue 5, Page(s) 703–706

MeSH term(s)	Humans ; Weight Gain ; Triglycerides/blood ; Glycerol Kinase/deficiency ; Glycerol Kinase/genetics ; Male ; Hypertriglyceridemia/blood ; Female ; Glucose Metabolism Disorders
Chemical Substances	Triglycerides ; Glycerol Kinase (EC 2.7.1.30)
Language	English
Publishing date	2024-05-01
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	80102-1
ISSN	1530-8561 ; 0009-9147
ISSN (online)	1530-8561
ISSN	0009-9147
DOI	10.1093/clinchem/hvae032
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Article ; Online: Glaucoma after penetrating keratoplasty and keratoprosthesis.

Khair, D / El-Khoury, J / Thompson, P / Racine, L / Harissi-Dagher, M

Journal francais d'ophtalmologie

2023 Volume 47, Issue 3, Page(s) 104023

Abstract: Purpose: To compare visual and glaucoma outcomes in patients with known glaucoma after a penetrating keratoplasty (PKP) or a Boston Keratoprosthesis Type 1 (KPro) as a second corneal replacement procedure.: Design: Retrospective interventional case ... ...

Abstract	Purpose: To compare visual and glaucoma outcomes in patients with known glaucoma after a penetrating keratoplasty (PKP) or a Boston Keratoprosthesis Type 1 (KPro) as a second corneal replacement procedure. Design: Retrospective interventional case series. Participants: Charts of 141 eyes that underwent either a PKP or KPro at the Centre hospitalier de l'Université de Montréal after one failed PKP from 2008 to 2020 were reviewed. Forty-six eyes with preoperative glaucoma were included. Methods: Data collected included demographics, indication for the initial surgery, best corrected visual acuity (BCVA), concurrent ocular disorders, number of glaucoma medications, need for glaucoma surgery, cup-to-disc ratios (CDRs), mean RNFL thickness, and visual field (VF) characteristics. Primary outcomes were glaucoma progression trends. Secondary outcomes were visual outcomes and need for additional procedures. Results: Mean follow-up was 4.7 years for the PKP and 7.3 for the KPro group (P<0.007). 30.6% of PKP compared to 70.5% of KPro patients were diagnosed with glaucoma preoperatively. Glaucoma worsened similarly in both groups; this is based on an analysis of the number of glaucoma medications, CDR, need for glaucoma surgery, and characteristic VF changes. Patients in the PKP group required significantly more regrafts than patients in the KPro group (31.8 vs. 8.3%; P=0.045). Conclusions: A preoperative diagnosis of glaucoma does not preclude KPro implantation. In glaucomatous eyes, the disease progressed similarly in both groups. Since both procedures increase the risk of worsening glaucoma, close follow-up is recommended. KPro may decrease the need for further corneal transplantation surgery.
MeSH term(s)	Humans ; Cornea/surgery ; Keratoplasty, Penetrating/adverse effects ; Retrospective Studies ; Prostheses and Implants/adverse effects ; Corneal Diseases/diagnosis ; Corneal Diseases/epidemiology ; Corneal Diseases/etiology ; Glaucoma/diagnosis ; Glaucoma/epidemiology ; Glaucoma/etiology
Language	English
Publishing date	2023-11-14
Publishing country	France
Document type	Journal Article
ZDB-ID	426662-6
ISSN	1773-0597 ; 0181-5512
ISSN (online)	1773-0597
ISSN	0181-5512
DOI	10.1016/j.jfo.2023.07.023
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Zs.A 1417: Show issues

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Article ; Online: An Unusual Case of High 6-Monoacetylmorphine and Low Morphine in Urine: Heroin Abuse or Analytical Error?

Choucair, Ibrahim / Cassella-Mclane, Gina / Rogers, Katherine / Durant, Thomas J S / El-Khoury, Joe M

Clinical chemistry

2023 Volume 68, Issue 10, Page(s) 1344–1345

MeSH term(s)	Humans ; Morphine ; Heroin Dependence/diagnosis ; Morphine Derivatives ; Body Fluids
Chemical Substances	6-O-monoacetylmorphine (M5E47P1ZCH) ; Morphine (76I7G6D29C) ; Morphine Derivatives
Language	English
Publishing date	2023-08-22
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	80102-1
ISSN	1530-8561 ; 0009-9147
ISSN (online)	1530-8561
ISSN	0009-9147
DOI	10.1093/clinchem/hvac110
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Article: Gastroentérologie et hépatologie: ce qui a changé en 2023.

Fraga, Montserrat / Wakim El-Khoury, Jeanine / Oumrani, Sarra / Godat, Sébastien / Vionnet, Julien / Schoepfer, Alain / Vieira Barbosa, Joana

Revue medicale suisse

2024 Volume 20, Issue 856-7, Page(s) 42–46

Abstract: 2023 has been marked by numerous advancements in the fields of hepatology, liver transplantation, gastroenterology, and interventional endoscopy. These developments hold the promise of changing our daily practice while enhancing the diagnosis and ... ...

Title translation	Gastroenterology and hepatology: what's new in 2023.
Abstract	2023 has been marked by numerous advancements in the fields of hepatology, liver transplantation, gastroenterology, and interventional endoscopy. These developments hold the promise of changing our daily practice while enhancing the diagnosis and treatment of various hepatic and gastroenterological conditions. Additionally, the European Association for the Study of the Liver (EASL) has issued recommendations for the management of hepatitis delta, acute-on-chronic liver failure, liver diseases of pregnancy, and intrahepatic cholangiocarcinoma. Risankizumab was approved by Swiss Authorities for patients with Crohn's disease and dupilumab was approved for patients with eosinophilic esophagitis. The European Society of Gastrointestinal Endoscopy (ESGE) has revised its recommendations regarding Barrett's esophagus.
MeSH term(s)	Female ; Pregnancy ; Humans ; Gastroenterology ; Acute-On-Chronic Liver Failure ; Bile Duct Neoplasms ; Bile Ducts, Intrahepatic
Language	French
Publishing date	2024-01-17
Publishing country	Switzerland
Document type	English Abstract ; Journal Article
ZDB-ID	2177010-4
ISSN	1660-9379
ISSN	1660-9379
DOI	10.53738/REVMED.2024.20.856-7.42
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Zs.A 5998: Show issues

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Article: Longitudinal Assessment of SARS-CoV-2 Antinucleocapsid and Antispike-1-RBD Antibody Testing Following PCR-Detected SARS-CoV-2 Infection.

El-Khoury, Joe M / Schulz, Wade L / Durant, Thomas J S

The journal of applied laboratory medicine

2021 Volume 6, Issue 4, Page(s) 1005–1011

Abstract: Background: SARS-CoV-2 serologic assays are becoming increasingly available and may serve as a diagnostic aid in a multitude of settings relating to past infection status. However, there is limited literature detailing the longitudinal performance of ... ...

Abstract	Background: SARS-CoV-2 serologic assays are becoming increasingly available and may serve as a diagnostic aid in a multitude of settings relating to past infection status. However, there is limited literature detailing the longitudinal performance of EUA-cleared serologic assays in US populations, particularly in cohorts with a remote history of PCR-confirmed SARS-CoV-2 infection (e.g., >2 months). Methods: We evaluated the diagnostic sensitivities and specificities of the Elecsys® Anti-SARS-CoV-2 (anti-N) and Elecsys Anti-SARS-CoV-2 S (anti-S1-RBD) assays, using 174 residual clinical samples up to 267 days post-PCR diagnosis of SARS-CoV-2 infection (n = 154) and a subset of samples obtained prior to the COVID-19 pandemic as negative controls (n = 20). Results: The calculated diagnostic sensitivities for the anti-N and anti-S1-RBD assays were 89% and 93%, respectively. Of the 154 samples in the SARS-CoV-2-positive cohort, there were 6 discrepant results between the anti-N and anti-S1-RBD assays, 5 of which were specimens collected ≥200 days post-PCR positivity and only had detectable levels of anti-S1-RBD antibodies. When only considering specimens collected ≥100 days post-PCR positivity (n = 41), the sensitivities for the anti-N and anti-S1-RBD assays were 85% and 98%, respectively. Conclusions: The anti-S1-RBD assay demonstrated superior sensitivity at time points more remote to the PCR detection date, with 6 more specimens from the SARS-CoV-2-positive cohort detected, 5 of which were collected more than 200 days post-PCR positivity. While analytical differences and reagent lot-to-lot variability are possible, this may indicate that, in some instances, anti-S1-RBD antibodies may persist longer in vivo and may be a better target for detecting remote SARS-CoV-2 infection.
MeSH term(s)	Antibodies, Viral/blood ; Antibodies, Viral/immunology ; COVID-19/blood ; COVID-19/diagnosis ; COVID-19/genetics ; COVID-19/virology ; COVID-19 Testing/methods ; Europe ; Humans ; Longitudinal Studies ; Nucleocapsid/immunology ; Polymerase Chain Reaction/methods ; Predictive Value of Tests ; Reagent Kits, Diagnostic ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; SARS-CoV-2/isolation & purification ; Spike Glycoprotein, Coronavirus/immunology ; United States
Chemical Substances	Antibodies, Viral ; Reagent Kits, Diagnostic ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
Language	English
Publishing date	2021-04-06
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2576-9456
ISSN	2576-9456
DOI	10.1093/jalm/jfab030
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Article: Impact of a Standardized, Pharmacist-Initiated "Test-Claim" Workflow for Anticipating Barriers to Accessing Discharge Antimicrobials.

Mulugeta, Surafel G / MacDonald, Nancy C / El-Khoury, Caren J / Davis, Susan L / Kenney, Rachel M

The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians

2023 Volume 39, Issue 5, Page(s) 218–223

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-09-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	54478-4
ISSN	8755-1225
ISSN	8755-1225
DOI	10.1177/87551225231196047
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Zs.A 3673: Show issues

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Article ; Online: Telomeric i-motifs and C-strands inhibit parallel G-quadruplex extension by telomerase.

El-Khoury, Roberto / Roman, Morgane / Assi, Hala Abou / Moye, Aaron L / Bryan, Tracy M / Damha, Masad J

Nucleic acids research

2023 Volume 51, Issue 19, Page(s) 10395–10410

Abstract: Telomeric C-rich repeated DNA sequences fold into tetrahelical i-motif structures in vitro at acidic pH. While studies have suggested that i-motifs may form in cells, little is known about their potential role in human telomere biology. In this study, we ...

Abstract	Telomeric C-rich repeated DNA sequences fold into tetrahelical i-motif structures in vitro at acidic pH. While studies have suggested that i-motifs may form in cells, little is known about their potential role in human telomere biology. In this study, we explore the effect of telomeric C-strands and i-motifs on the ability of human telomerase to extend G-rich substrates. To promote i-motif formation at neutral pH, we use telomeric sequences where the cytidines have been substituted with 2'-fluoroarabinocytidine. Using FRET-based studies, we show that the stabilized i-motifs resist hybridization to concomitant parallel G-quadruplexes, implying that both structures could exist simultaneously at telomeric termini. Moreover, through telomerase activity assays, we show that both unstructured telomeric C-strands and telomeric i-motifs can inhibit the activity and processivity of telomerase extension of parallel G-quadruplexes and linear telomeric DNA. The data suggest at least three modes of inhibition by C-strands and i-motifs: direct hybridization to the substrate DNA, hybridization to nascent product DNA resulting in early telomerase dissociation, and interference with the unique mechanism of telomerase unwinding and extension of a G-quadruplex. Overall, this study highlights a potential inhibitory role for the telomeric C-strand in telomere maintenance.
MeSH term(s)	Humans ; G-Quadruplexes ; Telomerase/metabolism ; DNA/chemistry ; Nucleic Acid Hybridization ; Telomere/metabolism
Chemical Substances	Telomerase (EC 2.7.7.49) ; DNA (9007-49-2)
Language	English
Publishing date	2023-09-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gkad764
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Article ; Online: Time to achieve best postoperative visual acuity following Boston keratoprosthesis surgery.

El-Khoury, Jonathan / Mustafa, Majd / Daoud, Roy / Harissi-Dagher, Mona

The British journal of ophthalmology

2021 Volume 106, Issue 7, Page(s) 929–934

Abstract: Background/aims: To evaluate the time needed for patients with Boston type 1 keratoprosthesis (KPro) to reach their best-corrected visual acuity (BCVA) and all contributing factors.: Methods: We retrospectively reviewed 137 consecutive eyes from 118 ... ...

Abstract	Background/aims: To evaluate the time needed for patients with Boston type 1 keratoprosthesis (KPro) to reach their best-corrected visual acuity (BCVA) and all contributing factors. Methods: We retrospectively reviewed 137 consecutive eyes from 118 patients, measured how long they needed to reach their BCVA and looked at factors that might affect this time duration including patient demographics, ocular comorbidities and postoperative complications. Results: The mean follow-up was 5.49 years. The median time to BCVA postoperatively was 6 months, with 47% of patients achieving their BCVA by 3 months. The mean best achieved logMAR visual acuity was 0.71, representing a gain of 6 lines on the Snellen visual acuity chart. Postoperative glaucoma, retroprosthetic membrane (RPM) and endophthalmitis prolonged this duration. We found no correlation between the following factors and time to BCVA: gender, age, indication for KPro surgery, primary versus secondary KPro, number of previous penetrating keratoplasties, previous retinal surgery, intraoperative anterior vitrectomy and preoperative glaucoma. Conclusion: In our retrospective cohort, the majority of subjects reached their BCVA between 3 and 6 months after KPro implantation. This duration was significantly prolonged by the development of postoperative glaucoma, RPM and endophthalmitis.
MeSH term(s)	Artificial Organs ; Cornea/surgery ; Corneal Diseases/surgery ; Endophthalmitis ; Follow-Up Studies ; Glaucoma/surgery ; Humans ; Postoperative Complications/surgery ; Prostheses and Implants ; Prosthesis Implantation ; Retrospective Studies ; Visual Acuity
Language	English
Publishing date	2021-03-03
Publishing country	England
Document type	Journal Article
ZDB-ID	80078-8
ISSN	1468-2079 ; 0007-1161
ISSN (online)	1468-2079
ISSN	0007-1161
DOI	10.1136/bjophthalmol-2020-317483
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