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Article ; Online: The relationship between caffeine and its metabolites and bone mineral density in postmenopausal women: a cross-sectional analysis from the NHANES database.

Liao, Sheng / Zhou, Jianhong / Chen, Hui / Wei, Wei / Ye, Feng / Zhang, Yidong / Zhang, Zhongrong

2024 Volume 12, Page(s) e131

Abstract: We aim to explore the association between caffeine and its metabolites and bone mineral density (BMD) in postmenopausal women. Data of 4286 postmenopausal women were extracted from the National Health and Nutrition Examination Survey (NHANES) database in ...

Abstract	We aim to explore the association between caffeine and its metabolites and bone mineral density (BMD) in postmenopausal women. Data of 4286 postmenopausal women were extracted from the National Health and Nutrition Examination Survey (NHANES) database in 2009-14 in this cross-sectional study. Weighted linear regression and stepwise regression analyses were used to screen the covariates. Weighted univariate and multivariate linear regression analyses were used to explore the associations between caffeine and its metabolites and BMD. The evaluation index was estimated value (
MeSH term(s)	Humans ; Female ; Aged ; Bone Density ; Cross-Sectional Studies ; Nutrition Surveys ; Caffeine/pharmacology ; Postmenopause ; Calcium
Chemical Substances	Caffeine (3G6A5W338E) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2024-01-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2656288-1
ISSN	2048-6790 ; 2048-6790
ISSN (online)	2048-6790
ISSN	2048-6790
DOI	10.1017/jns.2023.98
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Co-infection of hepatitis E virus,

Zhang, Lu / Wang, Xiaohao / Zhang, Jing / Wang, Zhongrong / Cai, Dachuan

Frontiers in cellular and infection microbiology

2023 Volume 13, Page(s) 1078870

Abstract: Hepatitis E virus (HEV) is a common cause of acute hepatitis that threatens human health worldwide. With the popularization of detection technology, the reports of hepatitis E have gradually increased. Here, we present a rare case of co-infection with ... ...

Abstract	Hepatitis E virus (HEV) is a common cause of acute hepatitis that threatens human health worldwide. With the popularization of detection technology, the reports of hepatitis E have gradually increased. Here, we present a rare case of co-infection with hepatitis E viruses,
MeSH term(s)	Male ; Animals ; Humans ; Middle Aged ; Hepatitis E virus/genetics ; Hepatitis E/complications ; Hepatitis E/diagnosis ; Hepatitis E/drug therapy ; Clonorchis sinensis/genetics ; Coinfection/diagnosis ; Escherichia coli/genetics ; Bilirubin ; RNA, Viral
Chemical Substances	Bilirubin (RFM9X3LJ49) ; RNA, Viral
Language	English
Publishing date	2023-03-07
Publishing country	Switzerland
Document type	Case Reports ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2023.1078870
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Article ; Online: The relationship between antiplatelet therapies and the outcome of endovascular treatment for acute ischemic stroke.

Zhang, Xuelei / Jia, Baixue / Wang, Anxin / Miao, Zhongrong

Clinical neurology and neurosurgery

2023 Volume 229, Page(s) 107716

Abstract: Purpose: We conducted this study to investigate the safety and efficacy of antiplatelet therapies (APT) for acute ischemic patients received endovascular treatment (EVT).: Methods: The population of our study was derived from a nationwide ... ...

Abstract	Purpose: We conducted this study to investigate the safety and efficacy of antiplatelet therapies (APT) for acute ischemic patients received endovascular treatment (EVT). Methods: The population of our study was derived from a nationwide multicentered registry conducted by 111 centers in China. Patients were divided to groups of no APT, single APT (SAPT) or dual APT (DAPT) according to the APT received at 24 h after EVT. The primary outcome was 90-day functional independence, and the safety outcomes included the symptomatic intracranial hemorrhage (sICH), any type of intracranial hemorrhage, and all-caused death within 90 days. Patient characteristics, procedural data, and outcomes were analyzed. Results: A total of 1679 patients were included in this study, 71.42% of whom received oral APT at 24 h after EVT, and the initial time was 20.53(13.94-27.17) hours after recanalization or the end of procedure. 90-day functional independence was significantly more observed in patients with DAPT (54.02% vs. 33.64%; adjusted odds ratio [OR] 1.940, 95% CI 1.444-2.606), but not in SAPT (40.75% vs. 33.64%; adjusted OR 1.280, 95% CI 0.907-1.804) compared with patients without APT. APT increased the risk of sICH (1.14% vs. 0, p = 0.036). Both the application of DAPT (adjusted OR 0.264, 95% CI 0.178-0.392, p < 0.001) and SAPT (adjusted OR 0.341, 95% CI 0.213-0.545, p < 0.001) could reduce the 90-day mortality. Conclusions: In this uncontrolled series of patients APT at 24 h after EVT showed improvement of the patients' functional independence and reduction of mortality, even though the rate of sICH was increased, especially in the DAPT-group.
MeSH term(s)	Humans ; Stroke/drug therapy ; Stroke/surgery ; Stroke/etiology ; Ischemic Stroke/drug therapy ; Ischemic Stroke/surgery ; Brain Ischemia/drug therapy ; Brain Ischemia/surgery ; Platelet Aggregation Inhibitors ; Treatment Outcome ; Risk Factors ; Intracranial Hemorrhages/etiology ; Endovascular Procedures/adverse effects ; Thrombectomy/adverse effects
Chemical Substances	Platelet Aggregation Inhibitors
Language	English
Publishing date	2023-04-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	193107-6
ISSN	1872-6968 ; 0303-8467
ISSN (online)	1872-6968
ISSN	0303-8467
DOI	10.1016/j.clineuro.2023.107716
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Article: A CNN-LSTM Model Based on a Meta-Learning Algorithm to Predict Groundwater Level in the Middle and Lower Reaches of the Heihe River, China

Yang, Xingyu / Zhang, Zhongrong

Water. 2022 July 31, v. 14, no. 15

2022

Abstract: In this study, a deep learning model is proposed to predict groundwater levels. The model is able to accurately complete the prediction task even when the data utilized are insufficient. The hybrid model that we have developed, CNN-LSTM-ML, uses a ... ...

Abstract	In this study, a deep learning model is proposed to predict groundwater levels. The model is able to accurately complete the prediction task even when the data utilized are insufficient. The hybrid model that we have developed, CNN-LSTM-ML, uses a combined network structure of convolutional neural networks (CNN) and long short-term memory (LSTM) network to extract the time dependence of groundwater level on meteorological factors, and uses a meta-learning algorithm framework to ensure the network’s performance under sample conditions. The study predicts groundwater levels from 66 observation wells in the middle and lower reaches of the Heihe River in arid regions and compares them with other data-driven models. Experiments show that the CNN-LSTM-ML model outperforms other models in terms of prediction accuracy in both the short term (1 month) and long term (12 months). Under the condition that the training data are reduced by 50%, the MAE of the proposed model is 33.6% lower than that of LSTM. The results of ablation experiments show that CNN-LSTM-ML is 26.5% better than the RMSE of the original CNN-LSTM structure. The model provides an effective method for groundwater level prediction and contributes to the sustainable management of water resources in arid regions.
Keywords	algorithms ; groundwater ; neural networks ; prediction ; rivers ; water table ; China
Language	English
Dates of publication	2022-0731
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2521238-2
ISSN	2073-4441
ISSN	2073-4441
DOI	10.3390/w14152377
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: [Cloning and expression analysis of

Yuan, Xing / Liu, Jinming / Guo, Caihua / Kang, Chao / Zhang, Zhongrong / Quan, Shaowen / Niu, Jianxin

Sheng wu gong cheng xue bao = Chinese journal of biotechnology

2023 Volume 39, Issue 2, Page(s) 640–652

Abstract: ... ...

Abstract	GI
MeSH term(s)	Juglans/genetics ; Phylogeny ; Plant Leaves ; Cloning, Molecular ; Gene Expression Regulation, Plant ; Plant Proteins/genetics ; Plant Proteins/metabolism
Chemical Substances	Plant Proteins
Language	Chinese
Publishing date	2023-02-28
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	1042206-7
ISSN	1872-2075 ; 1042-749X
ISSN (online)	1872-2075
ISSN	1042-749X
DOI	10.13345/j.cjb.220551
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Article ; Online: Associations between estimation of salt intake and salt-restriction spoons and hypertension status in patients with poorly controlled hypertension: a community-based study from Huzhou City, Eastern China.

Zhang, Qi / Shen, Yimei / Yu, Meihua / Yang, Zhongrong / Huang, Zheng / Ding, Jingying / Zhu, Xinfeng

Nutrition journal

2024 Volume 23, Issue 1, Page(s) 9

Abstract: Background: As the prevalence of hypertension increases in China, it is advised to use salt-restriction spoons (SRS) as a lifestyle modification. This study aimed to examine the associations between estimated salt consumption, SRS usage, and the ... ...

Abstract	Background: As the prevalence of hypertension increases in China, it is advised to use salt-restriction spoons (SRS) as a lifestyle modification. This study aimed to examine the associations between estimated salt consumption, SRS usage, and the hypertension status in individuals with poorly controlled hypertension. Methods: Data was collected in Huzhou City, Zhejiang Province, in 2021 using convenience sampling. The analysis involved ordinal logistic regression and restricted cubic splines to assess the relevant factors. Results: The study found that 73.34% of the 1215 patients had uncontrolled blood pressure (BP). Urinary excretion was assessed through the utilization of the Kawasaki, INTERSALT, and Tanaka formulas. The outcomes of these three methodologies revealed average daily sodium excretion values of 208.70 (65.65), 154.78 (33.91), and 162.61 (40.87) mmol, respectively. The prevalence of utilizing SRS was found to be 37.78% in this study. Despite the acknowledgment among SRS users of the potential hazards associated with excessive salt consumption, there exists a contradictory pattern of attitudes and behaviors concerning salt reduction. Among individuals with different levels of salt intake (quartiles 1-4, Q1 vs Q4), there was a positive association between limiting salt and hypertension status when controlling for other variables (Kawasaki adjusted OR = 0.58, 95% CI = 0.43-0.79; INTERSALT adjusted OR = 0.62, 95% CI = 0.41-0.92; Tanaka adjusted OR = 0.61, 95% CI = 0.45-0.92, p < 0.05). Our research also revealed that using or used SRS was a protective factor for blood BP control (adjusted OR = 0.79, 95% CI = 0.64-0.99, P < 0.05). The restricted cubic spline plots illustrated a monotonic upward relationship between estimated 24-h urinary Na and BP (P-overall association < 0.05; P-non-linear association > 0.05). Conclusions: The use of dietary SRS could result in decrease in daily salt intake for BP control in patients with poorly controlled hypertension. To reduce the impact of high BP in China, additional studies are required to create interventions that can enhance the results for patients.
MeSH term(s)	Humans ; Sodium Chloride, Dietary/urine ; Hypertension/epidemiology ; Sodium/urine ; Sodium, Dietary ; China/epidemiology
Chemical Substances	Sodium Chloride, Dietary ; Sodium (9NEZ333N27) ; Sodium, Dietary
Language	English
Publishing date	2024-01-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2091602-4
ISSN	1475-2891 ; 1475-2891
ISSN (online)	1475-2891
ISSN	1475-2891
DOI	10.1186/s12937-024-00912-w
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Article ; Online: The relationship between caffeine and its metabolites and bone mineral density in postmenopausal women

Sheng Liao / Jianhong Zhou / Hui Chen / Wei Wei / Feng Ye / Yidong Zhang / Zhongrong Zhang

Journal of Nutritional Science, Vol

a cross-sectional analysis from the NHANES database

2023 Volume 12

Abstract	We aim to explore the association between caffeine and its metabolites and bone mineral density (BMD) in postmenopausal women. Data of 4286 postmenopausal women were extracted from the National Health and Nutrition Examination Survey (NHANES) database in 2009–14 in this cross-sectional study. Weighted linear regression and stepwise regression analyses were used to screen the covariates. Weighted univariate and multivariate linear regression analyses were used to explore the associations between caffeine and its metabolites and BMD. The evaluation index was estimated value (β) with 95 % confidence intervals (CIs). We also explored these relationships in age subgroups. The median BMD level among the eligible women was 0⋅7 gm/cm2. After adjusting for covariates including age, body mass index (BMI), fat intake, Calcium (Ca) supplements, diabetes mellitus (DM), angina pectoris, parental history of osteoporosis (OP), anti-osteoporosis therapy, poverty income ratio (PIR), vitamin D (VD) supplements, coronary heart disease (CHD), and previous fracture, we found that caffeine intake was not significantly related to the BMD reduction (β = 0, P = 0⋅135). However, caffeine metabolites, including MethyluricAcid3, MethyluricAcid7, MethyluricAcid37, Methylxanthine3, and Methylxanthine37, were negatively associated with the BMD (all P < 0⋅05). In addition, MethyluricAcid37 and Methylxanthine37 were negatively associated with BMD in females aged <65 years old, while MethyluricAcid3 and Methylxanthine3 were noteworthy in those who aged ≥65 years old. The roles of caffeine and its metabolites in BMD reduction and OP in postmenopausal women needed further exploration.
Keywords	Bone mineral density ; Caffeine ; Metabolites ; NHANES ; Postmenopausal ; Nutrition. Foods and food supply ; TX341-641 ; Medicine ; R
Subject code	610
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Cambridge University Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Static magnetic field assisted thawing improves cryopreservation of mouse whole ovaries.

Zhang, Liyuan / Chi, Mengqiao / Cheng, Yue / Chen, Zhongrong / Cao, Yunxia / Zhao, Gang

Bioengineering & translational medicine

2023 Volume 9, Issue 1, Page(s) e10613

Abstract: Ovarian tissue cryopreservation is considered to be the only means to preserve fertility for prepubertal girls and women whose cancer treatment cannot be postponed. However, ovarian tissues are inevitably damaged by oxidative stress during ... ...

Abstract	Ovarian tissue cryopreservation is considered to be the only means to preserve fertility for prepubertal girls and women whose cancer treatment cannot be postponed. However, ovarian tissues are inevitably damaged by oxidative stress during cryopreservation, which threatens follicle survival and development, and thus affects female fertility. Therefore, reducing tissue oxidative stress injury is one of the major challenges to achieving efficient cryopreservation of ovarian tissues, especially for whole ovaries. Here, we proposed a new method to improve the antioxidant capacity of whole ovaries during cryopreservation, static magnetic field assisted thawing. The results demonstrated that the antioxidant capacity of the ovarian tissue was significantly improved by static magnetic field treatment. In addition, ovarian tissue allograft transplantation was carried out, which successfully achieved vascular regeneration and maintained follicular development. The findings of this study not only provide a new reference for the preservation of female fertility, but also is a major step forward in the cryopreservation of tissues and organs. It will have good application prospects in the field of assisted reproduction and cryo-biomedicine.
Language	English
Publishing date	2023-10-18
Publishing country	United States
Document type	Journal Article
ISSN	2380-6761
ISSN	2380-6761
DOI	10.1002/btm2.10613
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Article ; Online: Systemic Immune-Inflammation Response is Associated with Futile Recanalization After Endovascular Treatment.

Chen, Guojuan / Wang, Anxin / Zhang, Xiaoli / Li, Yuhao / Xia, Xue / Tian, Xue / Li, Jing / Miao, Zhongrong / Yue, Wei

Neurocritical care

2024

Abstract: Background: Frequent incidence of futile recanalization decreases the benefit of endovascular treatment (EVT) in acute ischemic stroke. We hypothesized that the inflammation and immune response after ischemic are associated with futile recanalization. ... ...

Abstract	Background: Frequent incidence of futile recanalization decreases the benefit of endovascular treatment (EVT) in acute ischemic stroke. We hypothesized that the inflammation and immune response after ischemic are associated with futile recanalization. We aimed to investigate the correlation of admission systemic immune-inflammation index (SII) with futile recanalization post EVT. Methods: Patients with successful recanalization (modified Thrombolysis in Cerebral Ischemia angiographic score 2b-3) and maintained artery recanalized after 24 h of EVT were chosen from a prospective nationwide registry study. Futile recanalization was defined as a poor functional outcome (modified Rankin Scale score 3-6) at 90 days, irrespective of a successful recanalization. At admission, SII was calculated as (platelet count × neutrophil count)/lymphocyte count/100. Logistic regression analysis helped to test the relationship of SII with futile recanalization. Results: Among the 1,002 patients included, futile recanalization occurred in 508 (50.70%). No matter whether tested as quartiles or continuous variables, SII was significantly associated with futile recanalization (P < 0.05), and for every one standard deviation increase of SII, the risk of futile recanalization elevated by 22.3% (odds ratio 1.223, 95% confidence interval 1.053-1.444, P = 0.0093). Moreover, no significant interactions could be observed between SII or SII quartiles and age, baseline National Institutes of Health Stroke Scale scores, onset-to-recanalization time, and modified Thrombolysis in Cerebral Ischemia angiographic scores (all P for interaction > 0.05). Conclusions: Early SII elevation was associated with an increased risk of futile recanalization among patients with EVT. Our results indicated that therapeutic drug targeting hyperreactive immune-inflammation response might be helpful for reducing the incidence of futile recanalization.
Language	English
Publishing date	2024-02-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2381896-7
ISSN	1556-0961 ; 1541-6933
ISSN (online)	1556-0961
ISSN	1541-6933
DOI	10.1007/s12028-023-01930-y
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Article ; Online: Anesthesia on Clinical Outcomes in an Extended Time Window During Endovascular Stroke Therapy: Exploratory Analysis of the ANGEL-ACT Registry.

Wang, Xinyan / Liang, Fa / Wu, Youxuan / Jia, Baixue / Zhang, Xiaoli / Jian, Minyu / Liu, Haiyang / Wang, Anxin / Miao, Zhongrong / Han, Ruquan

Journal of neurosurgical anesthesiology

2024

Abstract: Objective: Data on the impact of different anesthesia methods on clinical outcomes in patients with acute ischemic stroke undergoing endovascular therapy (EVT) in extended windows are limited. This study compared clinical outcomes in patients with ... ...

Abstract	Objective: Data on the impact of different anesthesia methods on clinical outcomes in patients with acute ischemic stroke undergoing endovascular therapy (EVT) in extended windows are limited. This study compared clinical outcomes in patients with stroke having general anesthesia (GA), conscious sedation (CS), or local anesthesia (LA) during EVT in extended (>6 h) time windows. Methods: We conducted an exploratory analysis of data from the ANGEL-ACT registry. The primary outcome was the modified Rankin Scale (mRS) score at 90 days. Secondary outcomes included the proportions of patients with mRS scores of 0 to 1, 0 to 2, and 0 to 3, and safety outcomes were any intracranial hemorrhage (ICH), symptomatic ICH, or mortality within 90 days. Multivariate analyses, inverse probability of treatment weighting, and coarsened exact matching were used to adjust for indication bias. Results: A total of 646 patients were included in the analysis (GA,280; CS, 103; LA, 263). Patients having LA during EVT were more likely to have a favorable mRS score (adjusted odds ratio [aOR]: 1.75; 95% CI: 1.28 to 2.40) and a lower incidence of symptomatic ICH (aOR: 0.33; 95% CI: 0.14 to 0.76) than those having GA group. Similarly, CS was associated with greater odds of favorable 90-day mRS scores compared with GA (aOR: 1.69; 95% CI: 1.11 to 2.56). Posterior circulation stroke was overrepresented in the GA group (29.6%) and may be a reason for the worse outcomes in the GA group. Conclusions: Patients who received LA or CS had better neurological outcomes than those who received GA within extended time windows in a real-world setting.
Language	English
Publishing date	2024-03-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1018119-2
ISSN	1537-1921 ; 0898-4921
ISSN (online)	1537-1921
ISSN	0898-4921
DOI	10.1097/ANA.0000000000000959
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