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  1. Article: A novel electrochemical IL-6 sensor based on Au nanoparticles-modified platinum carbon electrode.

    Wang, Cai / Xin, Dongyuan / Yue, Qianwen / Wan, Huiyu / Li, Qian / Wang, Ying / Wu, Jingguo

    Frontiers in bioengineering and biotechnology

    2023  Volume 11, Page(s) 1128934

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-02-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2023.1128934
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Association between cardiovascular risk factors and atrial fibrillation.

    Wu, Guohao / Wu, Jingguo / Lu, Qin / Cheng, Yunjiu / Mei, Weiyi

    Frontiers in cardiovascular medicine

    2023  Volume 10, Page(s) 1110424

    Abstract: Background: The most prevalent sustained arrhythmia in medical practice, atrial fibrillation (AF) is closely associated with a high risk of cardiovascular disease. Nevertheless, the risk of AF associated with cardiovascular risk factors has not been ... ...

    Abstract Background: The most prevalent sustained arrhythmia in medical practice, atrial fibrillation (AF) is closely associated with a high risk of cardiovascular disease. Nevertheless, the risk of AF associated with cardiovascular risk factors has not been well elucidated. We pooled all published studies to provide a better depiction of the relationship among cardiovascular risk factors with AF.
    Methods: Studies were searched in the MEDLINE, Web of Science, and EMBASE databases since initiation until January 15, 2022. Prospective cohort studies assessing the relationship a minimum of single cardiovascular risk factors to AF incidence were included if they contained adequate data for obtaining relative risks (RR) and 95% confidence intervals (CI). Random-effects models were utilized to perform independent meta-analyses on each cardiovascular risk factor. PROSPERO registry number: CRD42022310882.
    Results: A total of 17,098,955 individuals and 738,843 incident cases were reported for data from 101 studies included in the analysis. In all, the risk of AF was 1.39 (95% CI, 1.30-1.49) for obesity, 1.27 (95% CI, 1.22-1.32) per 5 kg/m
    Interpretation: Adverse cardiovascular risk factors correlate with an increased risk of AF, yet dyslipidemia does not increase the risk of AF in the general population, potentially providing new insights for AF screening strategies among patients with these risk factors.
    Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/, PROSPERO identifier (CRD42022310882).
    Language English
    Publishing date 2023-09-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1110424
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Novel SERS Signal Amplification Strategy for Ultrasensitive and Specific Detection of Spinal Cord Injury-Related miRNA.

    Wang, Cai / Wang, Chengcheng / Lu, Weizhao / Wang, Yanjiao / Yue, Qianwen / Xin, Dongyuan / Sun, Baoliang / Wu, Jingguo / Sun, Jingyi / Wang, Ying

    ACS sensors

    2024  Volume 9, Issue 2, Page(s) 736–744

    Abstract: The expression of microRNA (miRNA) changes in many diseases plays an important role in the diagnosis, treatment, and prognosis of diseases. Spinal cord injury (SCI) is a serious disease of the central nervous system, accompanied by inflammation, cell ... ...

    Abstract The expression of microRNA (miRNA) changes in many diseases plays an important role in the diagnosis, treatment, and prognosis of diseases. Spinal cord injury (SCI) is a serious disease of the central nervous system, accompanied by inflammation, cell apoptosis, neuronal necrosis, axonal rupture, demyelination, and other pathological processes, resulting in impaired sensory and motor functions of patients. Studies have shown that miRNA expression has changed after SCI, and miRNAs participate in the pathophysiological process and treatment of SCI. Therefore, quantitative analysis and monitoring of the expression of miRNA were of great significance for the diagnosis and treatment of SCI. Through the SCI-related miRNA chord plot, we screened out miRNA-21-5p and miRNA-let-7a with a higher correlation. However, for traditional detection strategies, it is still a great challenge to achieve a fast, accurate, and sensitive detection of miRNA in complex biological environments. The most frequently used method for detecting miRNAs is polymerase chain reaction (PCR), but it has disadvantages such as being time-consuming and cumbersome. In this paper, a novel SERS sensor for the quantitative detection of miRNA-21-5p and miRNA-let-7a in serum and cerebrospinal fluid (CSF) was developed. The SERS probe eventually formed a sandwich-like structure of Fe
    MeSH term(s) Humans ; MicroRNAs ; Polymerase Chain Reaction ; Limit of Detection ; Prognosis ; Spinal Cord Injuries/diagnosis ; Spinal Cord Injuries/genetics
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2024-02-12
    Publishing country United States
    Document type Journal Article
    ISSN 2379-3694
    ISSN (online) 2379-3694
    DOI 10.1021/acssensors.3c02024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Improvement of persistent hydrophilicity and pore uniformity of polyvinyl chloride ultrafiltration membranes by in-situ crosslinking reaction assisted phase separation

    She, Jingguo / Gao, Haifu / Song, Ziping / Shi, Le / Li, Jiahui / Lu, Xiaolong / Wu, Chunrui

    Journal of Membrane Science. 2023 Oct., v. 684 p.121884-

    2023  

    Abstract: A novel in-situ crosslinking reaction assisted phase separation strategy was proposed for persistent hydrophilization and pore size regulation of polyvinyl chloride (PVC) membranes. In-situ cross-linking between PVC molecular chains was achieved through ... ...

    Abstract A novel in-situ crosslinking reaction assisted phase separation strategy was proposed for persistent hydrophilization and pore size regulation of polyvinyl chloride (PVC) membranes. In-situ cross-linking between PVC molecular chains was achieved through grafting of 3-aminopropyltrimethoxysilane (APTMS) during the dissolution process and cross-linking reactions between siloxanes in APTMS molecules initiated by the coagulation bath (water). The effect of in-situ crosslinking reaction on the structure, separation and anti-fouling performance of the PVC membranes was studied. Through in-situ crosslinking reaction induced phase separation, the migration and curing of polymer molecular chains in the phase separation process were regulated, which endowed the modified membrane with improved hydrophilicity, higher porosity and narrow pore size distribution. The pure water flux of the obtained membrane increased 3.5 times as much as that of the pure PVC membrane. In addition, the flux recovery rate (FRR) of the obtained membrane was increased by 15.9% and the strength was also increased slightly at the same time. The stability of the membranes was also improved, without chemical agents leaching during filtration, avoiding secondary pollution to our environment.
    Keywords antifouling activities ; coagulation ; crosslinking ; hydrophilicity ; pollution ; poly(vinyl chloride) ; porosity ; separation ; siloxanes ; ultrafiltration ; Polyvinyl chloride ; Ultrafiltration membrane ; Crosslinking assisted phase inversion ; Pore size uniformity
    Language English
    Dates of publication 2023-10
    Publishing place Elsevier B.V.
    Document type Article ; Online
    ZDB-ID 194516-6
    ISSN 0376-7388
    ISSN 0376-7388
    DOI 10.1016/j.memsci.2023.121884
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 78/706: Show issues

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  5. Article: Bone Mesenchymal Stem Cells Promote Extracellular Matrix Remodeling of Degenerated Nucleus Pulposus Cells

    Wang, Zeng / Ding, Xiaolin / Cao, Feifei / Zhang, Xishan / Wu, Jingguo

    Frontiers in bioengineering and biotechnology

    2021  Volume 9, Page(s) 642502

    Abstract: The etiology of lumbocrural pain is tightly concerned with intervertebral disk degeneration (IDD). Bone mesenchymal stem cell (BMSC)-based therapy bears potentials for IDD treatment. The properties of microRNA (miRNA)-modified BMSCs may be altered. This ... ...

    Abstract The etiology of lumbocrural pain is tightly concerned with intervertebral disk degeneration (IDD). Bone mesenchymal stem cell (BMSC)-based therapy bears potentials for IDD treatment. The properties of microRNA (miRNA)-modified BMSCs may be altered. This study investigated the role and mechanism of BMSCs promoting extracellular matrix (ECM) remodeling of degenerated nucleus pulposus cells (NPCs)
    Language English
    Publishing date 2021-08-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2021.642502
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A comprehensive literature mining and analysis of nitrous oxide emissions from different innovative mainstream anammox-based biological nitrogen removal processes.

    Liu, Shuang / Wu, Fan / Guo, Mingzhu / Zeng, Ming / Liu, Wei / Wang, Zhiqiang / Wu, Nan / Cao, Jingguo

    The Science of the total environment

    2023  Volume 904, Page(s) 166295

    Abstract: The biological nitrogen removal (BNR) process in wastewater treatment plants generates a substantial volume of nitrous oxide ( ... ...

    Abstract The biological nitrogen removal (BNR) process in wastewater treatment plants generates a substantial volume of nitrous oxide (N
    MeSH term(s) Nitrous Oxide/analysis ; Nitrogen/metabolism ; Denitrification ; Anaerobic Ammonia Oxidation ; Data Mining ; Bioreactors ; Sewage ; Oxidation-Reduction
    Chemical Substances Nitrous Oxide (K50XQU1029) ; Nitrogen (N762921K75) ; Sewage
    Language English
    Publishing date 2023-08-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.166295
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: pH-sensitive tumor-tropism hybrid membrane-coated nanoparticles for reprogramming the tumor microenvironment and boosting the antitumor immunity.

    Zhang, Jie / Wei, Liwen / Ma, Xiaocao / Wang, Jingguo / Liang, Siping / Chen, Kang / Wu, Minhao / Niu, Li / Zhang, Yuanqing

    Acta biomaterialia

    2023  Volume 166, Page(s) 470–484

    Abstract: Metabolic dysregulation contributes not only to cancer development but also to a tumor immune microenvironment (TIME), which poses great challenges to chemo- and immunotherapy. Targeting metabolic reprogramming has recently emerged as a promising ... ...

    Abstract Metabolic dysregulation contributes not only to cancer development but also to a tumor immune microenvironment (TIME), which poses great challenges to chemo- and immunotherapy. Targeting metabolic reprogramming has recently emerged as a promising strategy for cancer treatment, but the lethality against solid tumors appears to be fairly restricted, partially due to the poor solubility of small molecule drugs. Herein, we construct a versatile biomimetic nanoplatform (referred to as HM-BPT) employing pH-sensitive tumor-tropism hybrid membrane-coated Manganese oxide (MnO
    MeSH term(s) Humans ; Animals ; Manganese Compounds/pharmacology ; Tumor Microenvironment ; Oxides ; Nanoparticles ; Lysosomes ; Neoplasms ; Immunotherapy ; Disease Models, Animal ; Hydrogen-Ion Concentration ; Cell Line, Tumor
    Chemical Substances Manganese Compounds ; Oxides
    Language English
    Publishing date 2023-05-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2173841-5
    ISSN 1878-7568 ; 1742-7061
    ISSN (online) 1878-7568
    ISSN 1742-7061
    DOI 10.1016/j.actbio.2023.05.040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Online: Knowledge-powered Explainable Artificial Intelligence (XAI) for Network Automation Towards 6G

    Wu, Yulei / Lin, Guozhi / Ge, Jingguo

    2022  

    Abstract: Communication networks are becoming increasingly complex towards 6G. Manual management is no longer an option for network operators. Network automation has been widely discussed in the networking community, and it is a sensible means to manage the ... ...

    Abstract Communication networks are becoming increasingly complex towards 6G. Manual management is no longer an option for network operators. Network automation has been widely discussed in the networking community, and it is a sensible means to manage the complex communication network. Deep learning models developed to enable network automation for given operation practices have the limitations of 1) lack of explainability and 2) inapplicable across different networks and/or network settings. To tackle the above issues, in this article we propose a new knowledge-powered framework that provides a human-understandable explainable artificial intelligence (XAI) agent for network automation. A case study of path selection is developed to demonstrate the feasibility of the proposed framework. Research on network automation is still in its infancy. Therefore, at the end of this article, we provide a list of challenges and open issues that can guide further research in this important area.
    Keywords Computer Science - Networking and Internet Architecture
    Subject code 006
    Publishing date 2022-05-11
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Whole-Transcriptome Profiling and Functional Prediction of Long Non-Coding RNAs Associated with Cold Tolerance in Japonica Rice Varieties.

    Wang, Hao / Jia, Yan / Bai, Xu / Gong, Weibin / Liu, Ge / Wang, Haixing / Xin, Junying / Wu, Yulong / Zheng, Hongliang / Liu, Hualong / Wang, Jingguo / Zou, Detang / Zhao, Hongwei

    International journal of molecular sciences

    2024  Volume 25, Issue 4

    Abstract: Low-temperature chilling is a major abiotic stress leading to reduced rice yield and is a significant environmental threat to food security. Low-temperature chilling studies have focused on physiological changes or coding genes. However, the competitive ... ...

    Abstract Low-temperature chilling is a major abiotic stress leading to reduced rice yield and is a significant environmental threat to food security. Low-temperature chilling studies have focused on physiological changes or coding genes. However, the competitive endogenous RNA mechanism in rice at low temperatures has not been reported. Therefore, in this study, antioxidant physiological indices were combined with whole-transcriptome data through weighted correlation network analysis, which found that the gene modules had the highest correlation with the key antioxidant enzymes superoxide dismutase and peroxidase. The hub genes of the superoxide dismutase-related module included the UDP-glucosyltransferase family protein, sesquiterpene synthase and indole-3-glycerophosphatase gene. The hub genes of the peroxidase-related module included the WRKY transcription factor, abscisic acid signal transduction pathway-related gene plasma membrane hydrogen-ATPase and receptor-like kinase. Therefore, we selected the modular hub genes and significantly enriched the metabolic pathway genes to construct the key competitive endogenous RNA networks, resulting in three competitive endogenous RNA networks of seven long non-coding RNAs regulating three co-expressed messenger RNAs via four microRNAs. Finally, the negative regulatory function of the WRKY transcription factor
    MeSH term(s) Oryza/metabolism ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Antioxidants ; Gene Expression Profiling ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Gene Regulatory Networks ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Peroxidases/genetics ; Superoxide Dismutase/genetics
    Chemical Substances RNA, Long Noncoding ; Antioxidants ; MicroRNAs ; Transcription Factors ; Peroxidases (EC 1.11.1.-) ; Superoxide Dismutase (EC 1.15.1.1)
    Language English
    Publishing date 2024-02-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25042310
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Renal Clearable Mo-Based Polyoxometalate Nanoclusters: A Promising Radioprotectant against Ionizing Irradiation

    Tao, Zhenchao / Wang, Jingguo / Wu, Haitao / Hu, Jiaru / Li, Lu / Zhou, Yuhang / Zheng, Qi / Zha, Lisha / Zha, Zhengbao

    ACS Applied Materials & Interfaces. 2023 Jan. 26, v. 15, no. 9 p.11474-11484

    2023  

    Abstract: In response to diffused ionizing radiation damage throughout the body caused by nuclear leaks and inaccurate radiotherapy, radioprotectants with considerable free radical scavenging capacities, along with negligible adverse effects, are highly regarded. ... ...

    Abstract In response to diffused ionizing radiation damage throughout the body caused by nuclear leaks and inaccurate radiotherapy, radioprotectants with considerable free radical scavenging capacities, along with negligible adverse effects, are highly regarded. Herein, unlike being performed as toxic chemotherapeutic drug candidates, molybdenum-based polyoxometalate nanoclusters (Mo-POM NCs) were developed as a non-toxic potent radioprotectant with impressive free radical scavenging capacities for ionizing radiation protection. In comparison to the clinically used radioprotectant drug amifostine (AM), the as-prepared Mo-POM NCs exhibited effective shielding capacity by virtue of their antioxidant properties resulting from a valence shift of molybdenum ions, alleviating not only ionizing radiation-induced DNA damage but also disruption of the radiation-sensitive hematopoietic system. More encouragingly, without trouble with long-term retention in the body, ultra-small sized Mo-POM NCs prepared by the mimetic Folin-Ciocalteu assay can be removed from the body through the renal-urinary pathway and the hepato-enteral excretory system after completing the mission of radiation protection. This work broadened the biological applications of metal-based POM chemotherapeutic drugs to act as a neozoic radioprotectant.
    Keywords DNA damage ; antioxidants ; drug therapy ; drugs ; excretory system ; free radicals ; irradiation ; molybdenum ; nanoparticles ; radiotherapy ; toxicity ; ionizing radiation ; Mo-POM NCs ; antioxidation ; renal-clearable ; radioprotectant
    Language English
    Dates of publication 2023-0126
    Size p. 11474-11484.
    Publishing place American Chemical Society
    Document type Article ; Online
    ISSN 1944-8252
    DOI 10.1021/acsami.2c19282
    Database NAL-Catalogue (AGRICOLA)

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