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  1. Article: Magnetic resonance imaging of micronized dermal graft in the larynx.

    Moonis, Gul / Dyce, Orville / Loevner, Laurie A / Mirza, Natasha

    The Annals of otology, rhinology, and laryngology

    2005  Volume 114, Issue 8, Page(s) 593–598

    Abstract: Objectives: This study was conducted to evaluate magnetic resonance imaging (MRI) as an objective measure of survival of micronized acellular human dermal graft (Cymetra, LifeCell Corporation) injected into the thyroarytenoid muscle for augmentation of ... ...

    Abstract Objectives: This study was conducted to evaluate magnetic resonance imaging (MRI) as an objective measure of survival of micronized acellular human dermal graft (Cymetra, LifeCell Corporation) injected into the thyroarytenoid muscle for augmentation of unilateral vocal fold paralysis.
    Methods: We performed a retrospective review of MRI scans obtained in 6 patients in whom Cymetra was injected into the thyroarytenoid muscle. Gadolinium-enhanced MRI of the larynx was performed 3 days, 1 month, 8 months, 11 months, 15 months, and 21 months after injection. The survival of injected Cymetra was assessed according to information obtained from the MRI scan. Images were also obtained for 1 cm3 of reconstituted Cymetra paste.
    Results: The identification of Cymetra in the larynx is based on its proteinaceous content. T1-weighted images of the injected material in the true vocal fold showed hyperintense foci corresponding to injected Cymetra. Hyperintense signal was also present on the T2-weighted images. Persistence of the injected Cymetra was readily detectable by MRI for as long as 11 months.
    Conclusions: Cymetra is a viable treatment option for vocal fold augmentation. The duration of survival of Cymetra (as long as 11 months) makes it a good option in cases in which longer survival of the injectable material is needed.
    MeSH term(s) Adult ; Collagen/administration & dosage ; Collagen/therapeutic use ; Female ; Gadolinium ; Humans ; Injections, Intramuscular ; Laryngeal Muscles ; Larynx/pathology ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Retrospective Studies ; Time Factors ; Treatment Outcome ; Vocal Cord Paralysis/diagnosis ; Vocal Cord Paralysis/drug therapy
    Chemical Substances Cymetra ; Collagen (9007-34-5) ; Gadolinium (AU0V1LM3JT)
    Language English
    Publishing date 2005-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120642-4
    ISSN 1943-572X ; 0003-4894
    ISSN (online) 1943-572X
    ISSN 0003-4894
    DOI 10.1177/000348940511400803
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: A parathyroid cyst with mediastinal extension: report of a case.

    Hockstein, Neil / Dyce, Orville / Ross, Adam / Friedburg, Joseph / Mirza, Natasha

    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

    2002  Volume 126, Issue 5, Page(s) 578–580

    MeSH term(s) Adenoma/diagnosis ; Adenoma/surgery ; Adult ; Choristoma/diagnosis ; Choristoma/surgery ; Cysts/diagnosis ; Cysts/surgery ; Humans ; Male ; Mediastinal Diseases/diagnosis ; Mediastinal Diseases/surgery ; Parathyroid Diseases/diagnosis ; Parathyroid Diseases/surgery
    Language English
    Publishing date 2002-05
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 392085-9
    ISSN 1097-6817 ; 0194-5998 ; 0161-6439
    ISSN (online) 1097-6817
    ISSN 0194-5998 ; 0161-6439
    DOI 10.1067/mhn.2002.124475
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Otolaryngologic manifestations of the 22q11.2 deletion syndrome.

    Dyce, Orville / McDonald-McGinn, Donna / Kirschner, Richard E / Zackai, Elaine / Young, Kathleen / Jacobs, Ian N

    Archives of otolaryngology--head & neck surgery

    2002  Volume 128, Issue 12, Page(s) 1408–1412

    Abstract: Background: The 22q11.2 chromosome deletion syndrome occurs at a frequency of 1 in 4000 live births. Fluorescent in situ hybridization is a reliable means of testing for this genetic abnormality.: Objective: To describe the otolaryngologic ... ...

    Abstract Background: The 22q11.2 chromosome deletion syndrome occurs at a frequency of 1 in 4000 live births. Fluorescent in situ hybridization is a reliable means of testing for this genetic abnormality.
    Objective: To describe the otolaryngologic manifestations of the 22q11.2 deletion syndrome to improve recognition and management of these disorders.
    Patients and design: A retrospective medical record review of 102 patients with chromosome 22q 11.2 deletions confirmed by fluorescent in situ hybridization.
    Setting: A multidisciplinary 22q11.2 deletion clinic at an academic children's hospital.
    Outcome measure: All otolaryngologic problems were recorded, including facial dysmorphic features, velopharyngeal insufficiency, speech and airway abnormalities, feeding difficulties, gastroesophageal reflux, hearing loss, otitis media, sinus problems, and vascular anomalies. Additionally, available objective test results were recorded, including those from audiograms, imaging studies, endoscopies, speech evaluations, and vascular studies.
    Results: Dysmorphic facial features were found in most patients. Velopharyngeal incompetence was noted in 76 patients, while overt submucosal clefts were found in 11 patients. Most patients had speech and language delays. In addition, 53 patients had chronic or recurrent otitis media, and 28 had recurrent sinorhinitis. Furthermore, feeding problems were found in 48 patients, while vascular anomalies of the head and neck were found in 16 patients.
    Conclusion: Otolaryngologic abnormalities are relatively common and important to recognize with the 22q11.2 deletion syndrome.
    MeSH term(s) Child ; Chromosome Deletion ; Chromosomes, Human, Pair 22 ; Ear, External/abnormalities ; Humans ; Language Development Disorders/etiology ; Larynx/abnormalities ; Otitis Media/etiology ; Otorhinolaryngologic Diseases/genetics ; Retrospective Studies ; Rhinitis/etiology ; Sinusitis/etiology ; Trachea/abnormalities ; Velopharyngeal Insufficiency/etiology
    Language English
    Publishing date 2002-11-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632721-7
    ISSN 1538-361X ; 0886-4470 ; 2168-6181
    ISSN (online) 1538-361X
    ISSN 0886-4470 ; 2168-6181
    DOI 10.1001/archotol.128.12.1408
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Integrins in head and neck squamous cell carcinoma invasion.

    Dyce, Orville H / Ziober, Amy F / Weber, Randal S / Miyazaki, Kaoru / Khariwala, Samir S / Feldman, Michael / Ziober, Barry L

    The Laryngoscope

    2002  Volume 112, Issue 11, Page(s) 2025–2032

    Abstract: Objective: To relate the invasive properties of different squamous cell cancer cell lines to the function and expression of the integrins.: Study design: A series of in vitro and in vivo experiments were designed to assess and compare integrin ... ...

    Abstract Objective: To relate the invasive properties of different squamous cell cancer cell lines to the function and expression of the integrins.
    Study design: A series of in vitro and in vivo experiments were designed to assess and compare integrin expression and function in two different head and neck squamous cell carcinoma cell lines.
    Methods: Invasive properties of two squamous cell carcinoma cell lines (UM-SCC-1 and JHU-022-SCC) were assessed using an in vitro artificial matrix assay as well as an in vivo system with orthotopically implanted tumor cells in mice. Whole cell and surface expression levels of integrin subunits (alpha2, alpha3, alpha5, alpha6, beta1, and beta4) were determined for each cell line using Western blot analysis and flow cytometry. We compared the ability of JHU-022-SCC and UM-SCC-1 cells to bind the extracellular matrix elements collagen IV, fibronectin, laminin 5, and laminin10 using an in vitro adhesion assay. Contributions of the different integrins to the adhesive properties were determined by selective antibody blocking of different subunits.
    Results: The UM-SCC-1 cell line is 50% more invasive in vitro and displays a greater propensity for perineural and lymphatic invasion in vivo. The UM-SCC-1 cells exhibited greater adherence to fibronectin than JHU-022-SCC cells. Alpha6 and beta4 expression is approximately twofold greater in the JHU-022-SCC cells. Alpha2, alpha3, and beta1 expression appears to be upregulated in UM-SCC-1 cells.
    Conclusion: The UM-SCC-1 carcinoma cells are more invasive than JHU-022-SCC cells and may be related to differential expression of the integrins alpha6beta4, alpha3beta1, and alpha2beta1.
    MeSH term(s) Animals ; Blotting, Western ; Carcinoma, Squamous Cell/metabolism ; Female ; Flow Cytometry ; Head and Neck Neoplasms/metabolism ; Humans ; Integrins/metabolism ; Luminescent Measurements ; Mice ; Mice, Nude ; Neoplasm Invasiveness ; Tumor Cells, Cultured
    Chemical Substances Integrins
    Language English
    Publishing date 2002-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1097/00005537-200211000-00021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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