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Article: Long-term kidney function of childhood cancer survivors-who needs to be monitored?

Park, Peong Gang / Hong, Kyung Taek / Kang, Hee Gyung

2023 Volume 12, Issue 11, Page(s) 1931–1934

Language	English
Publishing date	2023-11-21
Publishing country	China
Document type	Editorial ; Comment
ZDB-ID	2901309-4
ISSN	2224-4344 ; 2224-4344 ; 2224-4336
ISSN (online)	2224-4344
ISSN	2224-4344 ; 2224-4336
DOI	10.21037/tp-23-406
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Article ; Online: Increasing trend in hypertension prevalence among Korean adolescents from 2007 to 2020.

Park, Peong Gang / Park, Eujin / Kang, Hee Gyung

BMC public health

2024 Volume 24, Issue 1, Page(s) 617

Abstract: Background: The purpose of this study was to examine the prevalence of hypertension in Korean adolescents, its long-term trends, and factors associated with the development of hypertension.: Methods: Data of the Korea National Health and Nutrition ... ...

Abstract	Background: The purpose of this study was to examine the prevalence of hypertension in Korean adolescents, its long-term trends, and factors associated with the development of hypertension. Methods: Data of the Korea National Health and Nutrition Examination Survey (KNHANES) from 2007 to 2020 were combined into three time periods (2007-2011, 2012-2016, and 2017-2020). A total of 11,146 Korean adolescents aged 10-18 were included in the analysis. The definition of hypertension was based on the 2017 American Academy of Pediatrics guidelines for hypertension. Results: The age-adjusted prevalence of hypertension was 5.47%, 7.85%, and 9.92% in 2007-2011, 2012-2016, and 2017-2020, respectively. Long-term trend analysis using Joinpoint analysis over the observation period showed a significantly increasing trend in hypertension prevalence with a mean annual percentage change of 6.4%. Boys, those aged 13-15, those aged 16-18, overweight/obese, and those living in urban areas were more likely to develop hypertension (OR 1.980, 1.492, 3.180, 2.943, and 1.330, respectively). Conclusion: The prevalence of hypertension in Korean adolescents was higher than the global prevalence of hypertension and showed an increase over a 13-year period. Targeted strategies for prevention and early detection of hypertension are needed in this population.
MeSH term(s)	Male ; Humans ; Adolescent ; Child ; Prevalence ; Nutrition Surveys ; Hypertension/epidemiology ; Obesity/epidemiology ; Republic of Korea/epidemiology ; Risk Factors
Language	English
Publishing date	2024-02-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-024-18093-w
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Article: Effects of urinary tract infection during the first years of life in subsequent growth: a nationwide comparative matched cohort study.

Kim, Ye Kyung / Park, Peong Gang

Translational pediatrics

2023 Volume 12, Issue 11, Page(s) 2020–2029

Abstract: Background: Although various childhood illnesses are known to influence growth status, the impact of urinary tract infections (UTI) on subsequent childhood growth remains unclear. This study was conducted to examine the association between UTI during ... ...

Abstract	Background: Although various childhood illnesses are known to influence growth status, the impact of urinary tract infections (UTI) on subsequent childhood growth remains unclear. This study was conducted to examine the association between UTI during infancy and growth status at 30-36 months. Methods: Nationwide population-based matched cohort study was done using data from the Korean National Health Insurance System (NHIS) and the Korean National Health Screening Program for Infants and Children (NHSPIC) between January 2018 and December 2020. Height and weight standard deviation scores (SDSs) at the fourth Korean NHSPIC conducted at 30-36 months were compared between children who experienced UTI during infancy and age- and sex-matched controls. We used weighted multiple linear regression analysis with inverse probability of treatment weighting (IPTW) and identified differences between the two groups using β coefficient with corresponding 95% confidence intervals (CIs). Results: We analyzed 84,519 children diagnosed with UTI during infancy and 84,519 age- and sex-matched controls. The height SDS between children who experienced UTI and the control group was not statistically different (β coefficient for height SDS, -0.0034; 95% CI: -0.0121 to 0.0054). However, the body mass index (BMI) SDS was significantly higher in children who had experienced UTI (β coefficient for BMI SDS, 00426; 95% CI: 0.0304 to 0.0547). Subgroup and sensitivity analysis showed consistent results. Conclusions: Our findings suggest that a history of UTI during infancy is associated with high BMI measured at 30-36 months.
Language	English
Publishing date	2023-11-15
Publishing country	China
Document type	Journal Article
ZDB-ID	2901309-4
ISSN	2224-4344 ; 2224-4344 ; 2224-4336
ISSN (online)	2224-4344
ISSN	2224-4344 ; 2224-4336
DOI	10.21037/tp-23-361
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Article: Genotype and Phenotype Analysis in X-Linked Hypophosphatemia.

Park, Peong Gang / Lim, Seon Hee / Lee, HyunKyung / Ahn, Yo Han / Cheong, Hae Il / Kang, Hee Gyung

Frontiers in pediatrics

2021 Volume 9, Page(s) 699767

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-08-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2021.699767
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Article ; Online: Genotype-phenotype correlations in children with Gitelman syndrome.

Cho, Myung Hyun / Park, Peong Gang / Kim, Ji Hyun / Jang, Kyung Mi / Lee, Jiwon M / Yang, Eun Mi / Park, Se Jin / Suh, Jin-Soon / Cho, Heeyeon / Lee, Jung Won / Lee, Joo Hoon / Koo, Ja Wook / Namgoong, Mee Kyung / Kim, Kee Hyuck / Ahn, Yo Han / Kang, Hee Gyung / Cheong, Hae Il

Clinical and experimental nephrology

2024

Abstract: Background: This study aimed to analyze genotype-phenotype correlations in children with Gitelman syndrome (GS).: Methods: This multicenter retrospective study included 50 Korean children diagnosed with SLC12A3 variants in one or both alleles and the ...

Abstract	Background: This study aimed to analyze genotype-phenotype correlations in children with Gitelman syndrome (GS). Methods: This multicenter retrospective study included 50 Korean children diagnosed with SLC12A3 variants in one or both alleles and the typical laboratory findings of GS. Genetic testing was performed using the Sanger sequencing except for one patient. Results: The median age at the diagnosis was 10.5 years (interquartile range, 6.8;14.1), and 41 patients were followed up for a median duration of 5.4 years (interquartile range, 4.1;9.6). A total of 30 different SLC12A3 variants were identified. Of the patients, 34 (68%) had biallelic variants, and 16 (32%) had monoallelic variants on examination. Among the patients with biallelic variants, those (n = 12) with the truncating variants in one or both alleles had lower serum chloride levels (92.2 ± 3.2 vs. 96.5 ± 3.8 mMol/L, P = 0.002) at onset, as well as lower serum potassium levels (3.0 ± 0.4 vs. 3.4 ± 0.3 mMol/L, P = 0.016), and lower serum chloride levels (96.1 ± 1.9 vs. 98.3 ± 3.0 mMol/L, P = 0.049) during follow-up than those without truncating variants (n = 22). Patients with monoallelic variants on examination showed similar phenotypes and treatment responsiveness to those with biallelic variants. Conclusions: Patients with GS who had truncating variants in one or both alleles had more severe electrolyte abnormalities than those without truncating variants. Patients with GS who had monoallelic SLC12A3 variants on examination had almost the same phenotypes, response to treatment, and long-term prognosis as those with biallelic variants.
Language	English
Publishing date	2024-03-13
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1338768-6
ISSN	1437-7799 ; 1342-1751
ISSN (online)	1437-7799
ISSN	1342-1751
DOI	10.1007/s10157-024-02474-x
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Article ; Online: Clinical Relevance of Fluid Volume Status Assessment by Bioimpedance Spectroscopy in Children Receiving Maintenance Hemodialysis or Peritoneal Dialysis

Peong Gang Park / Jeesu Min / Seon Hee Lim / Ji Hyun Kim / Yo Han Ahn / Il-Soo Ha / Hee Gyung Kang

Journal of Clinical Medicine, Vol 10, Iss 79, p

2021 Volume 79

Abstract: Bioimpedance spectroscopy (BIS) is a noninvasive method used to evaluate body fluid volume status in dialysis patients, but reports on its effectiveness in pediatrics are scarce. We investigated the correlation between BIS and clinical characteristics ... ...

Abstract	Bioimpedance spectroscopy (BIS) is a noninvasive method used to evaluate body fluid volume status in dialysis patients, but reports on its effectiveness in pediatrics are scarce. We investigated the correlation between BIS and clinical characteristics and identified the changes in patients whose dialysis prescription was modified based on BIS. The medical records of children on maintenance dialysis who had undergone BIS between 2017 and 2019 were reviewed. Of the 49 patients, 14 were overhydrated, based on the >15% proportion of overhydration relative to extracellular water (OH/ECW) measured by BIS. Intake of ≥two antihypertensive medications was noted in the majority (85.7%) of children with fluid overload and only in 48.6% of those without fluid overload ( p = 0.017). Elevated blood pressure despite medication use was significantly more common in patients with fluid overload than in those without fluid overload (78.6% vs. 45.7%, p = 0.037). Of the 14 overhydrated children, 13 (92.9%) had significant changes in body weight, OH/ECW, the number of antihypertensive drugs, left ventricular end-diastolic diameter, and cardiothoracic ratio after the change in dialysis prescription. BIS is a useful and noninvasive method to assess fluid status in dialysis children. Long-term follow-up and correlation with a more objective clinical indicator of fluid overload is necessary to verify the clinical effectiveness of BIS.
Keywords	bioimpedance spectroscopy ; kidney failure ; hypertension ; Medicine ; R
Subject code	610
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article: Clinical Relevance of Fluid Volume Status Assessment by Bioimpedance Spectroscopy in Children Receiving Maintenance Hemodialysis or Peritoneal Dialysis.

Park, Peong Gang / Min, Jeesu / Lim, Seon Hee / Kim, Ji Hyun / Ahn, Yo Han / Ha, Il-Soo / Kang, Hee Gyung

Journal of clinical medicine

2020 Volume 10, Issue 1

Abstract	Bioimpedance spectroscopy (BIS) is a noninvasive method used to evaluate body fluid volume status in dialysis patients, but reports on its effectiveness in pediatrics are scarce. We investigated the correlation between BIS and clinical characteristics and identified the changes in patients whose dialysis prescription was modified based on BIS. The medical records of children on maintenance dialysis who had undergone BIS between 2017 and 2019 were reviewed. Of the 49 patients, 14 were overhydrated, based on the >15% proportion of overhydration relative to extracellular water (OH/ECW) measured by BIS. Intake of ≥two antihypertensive medications was noted in the majority (85.7%) of children with fluid overload and only in 48.6% of those without fluid overload (
Language	English
Publishing date	2020-12-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm10010079
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Article ; Online: Out-of-Hospital Cohort Treatment of Coronavirus Disease 2019 Patients with Mild Symptoms in Korea: an Experience from a Single Community Treatment Center.

Park, Peong Gang / Kim, Chang Hyup / Heo, Yoon / Kim, Tae Suk / Park, Chan Woo / Kim, Choong Hyo

Journal of Korean medical science

2020 Volume 35, Issue 13, Page(s) e140

Abstract: The outbreak of Coronavirus Disease 2019 (COVID-19) caused a worldwide pandemic. Less than 6 weeks after the first confirmed cases in Korea, the patient number exceeded 5,000, which overcrowded limited hospital resources and forced confirmed patients to ... ...

Abstract	The outbreak of Coronavirus Disease 2019 (COVID-19) caused a worldwide pandemic. Less than 6 weeks after the first confirmed cases in Korea, the patient number exceeded 5,000, which overcrowded limited hospital resources and forced confirmed patients to stay at home. To allocate medical resources efficiently, Korea implemented a novel institution for the purpose of treating patients with cohort isolation out of hospital, namely the Community Treatment Center (CTC). Herein, we report results of the initial management of patients at one of the largest CTC in Korea. A total of 309 patients were admitted to our CTC. During the first two weeks, 7 patients were transferred to the hospital because of symptom aggravation and 107 patients were discharged without any complication. Although it is a novel concept and may have some limitations, CTC may be a very cost-effective and resource-saving strategy in managing massive cases of COVID-19 or other emerging infectious diseases.
MeSH term(s)	Ambulatory Care Facilities ; Betacoronavirus ; COVID-19 ; Cohort Studies ; Coronavirus Infections/economics ; Coronavirus Infections/therapy ; Cost Savings ; Disease Outbreaks ; Hospitalization ; Humans ; Pandemics/economics ; Patient Isolation ; Patient Transfer ; Pneumonia, Viral/economics ; Pneumonia, Viral/therapy ; Republic of Korea/epidemiology ; Resource Allocation/economics ; SARS-CoV-2 ; Severity of Illness Index
Keywords	covid19
Language	English
Publishing date	2020-04-06
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	639262-3
ISSN	1598-6357 ; 1011-8934
ISSN (online)	1598-6357
ISSN	1011-8934
DOI	10.3346/jkms.2020.35.e140
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Article ; Online: Baseline characteristics of participants enrolled in the KoreaN cohort study for Outcomes in patients With Pediatric Chronic Kidney Disease (KNOW-Ped CKD).

Park, Peong Gang / Kang, Hee Gyung / Park, Eujin / Ahn, Yo Han / Choi, Hyun Jin / Han, Kyoung Hee / Kim, Seong Heon / Cho, Heeyeon / Lee, Keum Hwa / Shin, Jae Il / Cho, Min Hyun / Lee, Joo Hoon / Park, Young Seo / Kim, Jayoun / Ha, Il-Soo

Pediatric nephrology (Berlin, Germany)

2022 Volume 37, Issue 12, Page(s) 3177–3187

Abstract: Background: We developed the KoreaN cohort study for Outcomes in patients With Pediatric Chronic Kidney Disease (KNOW-Ped CKD) as a subcohort of KNOW-CKD to investigate the different characteristics of pediatric CKD between countries and races.: ... ...

Abstract	Background: We developed the KoreaN cohort study for Outcomes in patients With Pediatric Chronic Kidney Disease (KNOW-Ped CKD) as a subcohort of KNOW-CKD to investigate the different characteristics of pediatric CKD between countries and races. Methods: Children aged younger than 18 years with stage 1 ~ 5 CKD were recruited at seven major pediatric nephrology centers in Korea. Blood and urine samples, as well as demographic and clinical data, were collected. From 2011 to 2016, 458 children were enrolled, and the baseline profiles of 437 children were analyzed. Results: The median age of the cohort was 10.9 years old, and 68.0% were males. The median estimated glomerular filtration rate was 53.1 mL/min/1.73 m Conclusion: We report a cross-sectional analysis of the overall baseline characteristics such as age, CKD stage, and underlying kidney disease of the KNOW-Ped CKD. The cohort will be longitudinally followed for ten years. "A higher resolution version of the Graphical abstract is available as Supplementary information."
MeSH term(s)	Male ; Humans ; Child ; Female ; Cohort Studies ; Cross-Sectional Studies ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/etiology ; Glomerular Filtration Rate ; Kidney ; Risk Factors ; Disease Progression
Language	English
Publishing date	2022-03-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	631932-4
ISSN	1432-198X ; 0931-041X
ISSN (online)	1432-198X
ISSN	0931-041X
DOI	10.1007/s00467-021-05278-3
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Zs.A 2196: Show issues

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Article ; Online: Cutaneous Skeletal Hypophosphatemia Syndrome in Association with a Mosaic

Park, Peong Gang / Park, Eujin / Hyun, Hye-Sun / Kang, Hee Gyung / Ha, Il-Soo / Cho, Tae-Joon / Ko, Jung Min / Cheong, Hae Il

Annals of clinical and laboratory science

2018 Volume 48, Issue 5, Page(s) 665–669

Abstract: Recent molecular genetic studies have revealed that Schimmelpenning-Feuerstein-Mims syndrome (SFMS), which presents as sebaceous nevi, is a mosaic RASopathy caused by postzygotic somatic activating mutations ... ...

Abstract	Recent molecular genetic studies have revealed that Schimmelpenning-Feuerstein-Mims syndrome (SFMS), which presents as sebaceous nevi, is a mosaic RASopathy caused by postzygotic somatic activating mutations in
MeSH term(s)	Adolescent ; Female ; Fibroblast Growth Factors/biosynthesis ; Humans ; Mosaicism ; Mutation ; Nevus, Sebaceous of Jadassohn/genetics ; Proto-Oncogene Proteins p21(ras)/genetics ; Rickets, Hypophosphatemic/genetics
Chemical Substances	Fibroblast Growth Factors (62031-54-3) ; fibroblast growth factor 23 (7Q7P4S7RRE) ; HRAS protein, human (EC 3.6.5.2) ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2)
Language	English
Publishing date	2018-10-29
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	193092-8
ISSN	1550-8080 ; 0091-7370 ; 0095-8905
ISSN (online)	1550-8080
ISSN	0091-7370 ; 0095-8905
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