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  1. Article ; Online: Trusting a gut feeling: the potential of a newly refined human intestinal enteroid model to evaluate viral-host interactions.

    Coish, Jeremia M / Crozier, Robert W E / Schertzer, Katarina E

    The Journal of physiology

    2020  Volume 598, Issue 22, Page(s) 5013–5015

    MeSH term(s) Host Microbial Interactions ; Humans ; Immunity, Innate ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-20
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP280368
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.65: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Out of the frying pan and into the fire? Due diligence warranted for ADE in COVID-19.

    Coish, Jeremia M / MacNeil, Adam J

    Microbes and infection

    2020  Volume 22, Issue 9, Page(s) 405–406

    Abstract: Antibody-dependent enhancement (ADE) is an atypical immunological paradox commonly associated with dengue virus re-infection. However, various research models have demonstrated this phenomenon with other viral families, including Coronaviridae. Recently, ...

    Abstract Antibody-dependent enhancement (ADE) is an atypical immunological paradox commonly associated with dengue virus re-infection. However, various research models have demonstrated this phenomenon with other viral families, including Coronaviridae. Recently, ADE in SARS-CoV-2 has emerged as one hypothesis to explain severe clinical manifestations. Whether SARS-CoV-2 is augmented by ADE remains undetermined and has therefore garnered criticism for the improper attribution of the phenomenon to the pandemic. Thus, critical evaluation of ADE in SARS-CoV-2 vaccine development will be indispensable to avoid a global setback and the erosion of public trust.
    MeSH term(s) Antibodies, Neutralizing/biosynthesis ; Antibodies, Viral/biosynthesis ; Antibody-Dependent Enhancement ; Betacoronavirus/immunology ; Betacoronavirus/pathogenicity ; COVID-19 ; COVID-19 Vaccines ; Coronavirus Infections/epidemiology ; Coronavirus Infections/immunology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/psychology ; Humans ; Pandemics/prevention & control ; Patient Safety ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/immunology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/psychology ; SARS-CoV-2 ; Severity of Illness Index ; Vaccination/adverse effects ; Vaccination/psychology ; Vaccination Refusal/psychology ; Viral Vaccines/administration & dosage ; Viral Vaccines/adverse effects ; Virus Replication
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines ; Viral Vaccines
    Keywords covid19
    Language English
    Publishing date 2020-06-24
    Publishing country France
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1465093-9
    ISSN 1769-714X ; 1286-4579
    ISSN (online) 1769-714X
    ISSN 1286-4579
    DOI 10.1016/j.micinf.2020.06.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5014: Show issues Location:
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  3. Article ; Online: Carnosic acid inhibits secretion of allergic inflammatory mediators in IgE-activated mast cells via direct regulation of Syk activation.

    Crozier, Robert W E / Yousef, Michael / Coish, Jeremia M / Fajardo, Val A / Tsiani, Evangelia / MacNeil, Adam J

    The Journal of biological chemistry

    2023  Volume 299, Issue 4, Page(s) 102867

    Abstract: Mast cells are essential regulators of inflammation most recognized for their central role in allergic inflammatory disorders. Signaling via the high-affinity immunoglobulin E (IgE) receptor, FcεRI, leads to rapid degranulation of preformed granules and ... ...

    Abstract Mast cells are essential regulators of inflammation most recognized for their central role in allergic inflammatory disorders. Signaling via the high-affinity immunoglobulin E (IgE) receptor, FcεRI, leads to rapid degranulation of preformed granules and the sustained release of newly synthesized proinflammatory mediators. Our group recently established rosemary extract as a potent regulator of mast cell functions, attenuating MAPK and NF-κB signaling. Carnosic acid (CA)-a major polyphenolic constituent of rosemary extract-has been shown to exhibit anti-inflammatory effects in other immune cell models, but its role as a potential modulator of mast cell activation is undefined. Therefore, we sought here to determine the modulatory effects of CA in a mast cell model of allergic inflammation. We sensitized bone marrow-derived mast cells with anti-trinitrophenyl IgE and activated with allergen (TNP-BSA) under stem cell factor potentiation, in addition to treatment with CA. Our results indicate that CA significantly inhibits allergen-induced early phase responses including Ca
    MeSH term(s) Humans ; Allergens ; Cell Degranulation ; Hypersensitivity ; Immunoglobulin E ; Inflammation/metabolism ; Inflammation Mediators/metabolism ; Mast Cells/drug effects ; Mast Cells/metabolism ; NF-kappa B/metabolism ; Receptors, IgE/metabolism ; Syk Kinase/metabolism ; Abietanes/pharmacology
    Chemical Substances Allergens ; Immunoglobulin E (37341-29-0) ; Inflammation Mediators ; NF-kappa B ; Receptors, IgE ; salvin (LI791SXT24) ; Syk Kinase (EC 2.7.10.2) ; SYK protein, human (EC 2.7.10.2) ; Abietanes
    Language English
    Publishing date 2023-01-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2022.102867
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.108: Show issues Location:
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  4. Article: Trusting a gut feeling: the potential of a newly refined human intestinal enteroid model to evaluate viral-host interactions

    Coish, Jeremia M / Crozier, Robert W E / Schertzer, Katarina E

    J. physiol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #695477
    Database COVID19

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  5. Article ; Online: Out of the frying pan and into the fire? Due diligence warranted for ADE in COVID-19

    Coish, Jeremia M. / MacNeil, Adam J.

    Microbes and Infection

    2020  Volume 22, Issue 9, Page(s) 405–406

    Keywords Immunology ; Microbiology ; Infectious Diseases ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1465093-9
    ISSN 1769-714X ; 1286-4579
    ISSN (online) 1769-714X
    ISSN 1286-4579
    DOI 10.1016/j.micinf.2020.06.006
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Zs.A 5014: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Zika Virus Replication in a Mast Cell Model is Augmented by Dengue Virus Antibody-Dependent Enhancement and Features a Selective Immune Mediator Secretory Profile.

    Coish, Jeremia M / Crozier, Robert W E / Schieffelin, John S / Coorssen, Jens R / Hunter, Fiona F / MacNeil, Adam J

    Microbiology spectrum

    2022  Volume 10, Issue 4, Page(s) e0177222

    Abstract: Zika virus and dengue virus are evolutionarily related and structurally similar mosquito- ... ...

    Abstract Zika virus and dengue virus are evolutionarily related and structurally similar mosquito-borne
    MeSH term(s) Animals ; Antibodies, Viral ; Antibody-Dependent Enhancement ; Chemokines ; Cross Reactions ; Dengue Virus/physiology ; Granzymes ; Humans ; Ligands ; Mast Cells ; Virus Replication ; Zika Virus ; Zika Virus Infection
    Chemical Substances Antibodies, Viral ; Chemokines ; Ligands ; Granzymes (EC 3.4.21.-)
    Language English
    Publishing date 2022-07-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.01772-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Out of the frying pan and into the fire? Due diligence warranted for ADE in COVID-19

    Coish, Jeremia M / MacNeil, Adam J

    Microbes Infect

    Abstract: Antibody-dependent enhancement (ADE) is an atypical immunological paradox commonly associated with dengue virus re-infection. However, various research models have demonstrated this phenomenon with other viral families, including Coronaviridae. Recently, ...

    Abstract Antibody-dependent enhancement (ADE) is an atypical immunological paradox commonly associated with dengue virus re-infection. However, various research models have demonstrated this phenomenon with other viral families, including Coronaviridae. Recently, ADE in SARS-CoV-2 has emerged as one hypothesis to explain severe clinical manifestations. Whether SARS-CoV-2 is augmented by ADE remains undetermined and has therefore garnered criticism for the improper attribution of the phenomenon to the pandemic. Thus, critical evaluation of ADE in SARS-CoV-2 vaccine development will be indispensable to avoid a global setback and the erosion of public trust.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #611296
    Database COVID19

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  8. Article ; Online: Decoding communication patterns of the innate immune system by quantitative proteomics.

    Sukumaran, Arjun / Coish, Jeremia M / Yeung, Jason / Muselius, Benjamin / Gadjeva, Mihaela / MacNeil, Adam J / Geddes-McAlister, Jennifer

    Journal of leukocyte biology

    2019  Volume 106, Issue 6, Page(s) 1221–1232

    Abstract: The innate immune system is a collective network of cell types involved in cell recruitment and activation using a robust and refined communication system. Engagement of receptor-mediated intracellular signaling initiates communication cascades by ... ...

    Abstract The innate immune system is a collective network of cell types involved in cell recruitment and activation using a robust and refined communication system. Engagement of receptor-mediated intracellular signaling initiates communication cascades by conveying information about the host cell status to surrounding cells for surveillance and protection. Comprehensive profiling of innate immune cells is challenging due to low cell numbers, high dynamic range of the cellular proteome, low abundance of secreted proteins, and the release of degradative enzymes (e.g., proteases). However, recent advances in mass spectrometry-based proteomics provides the capability to overcome these limitations through profiling the dynamics of cellular processes, signaling cascades, post-translational modifications, and interaction networks. Moreover, integration of technologies and molecular datasets provide a holistic view of a complex and intricate network of communications underscoring host defense and tissue homeostasis mechanisms. In this Review, we explore the diverse applications of mass spectrometry-based proteomics in innate immunity to define communication patterns of the innate immune cells during health and disease. We also provide a technical overview of mass spectrometry-based proteomic workflows, with a focus on bottom-up approaches, and we present the emerging role of proteomics in immune-based drug discovery while providing a perspective on new applications in the future.
    MeSH term(s) Animals ; Cell Communication/immunology ; Computational Biology/methods ; Disease Susceptibility/immunology ; Drug Delivery Systems ; Drug Discovery ; Humans ; Immunity, Innate ; Mass Spectrometry/methods ; Proteome ; Proteomics/methods ; Signal Transduction
    Chemical Substances Proteome
    Language English
    Publishing date 2019-09-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1002/JLB.2RI0919-302R
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 603: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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    ab Jg. 2022: Lesesaal (EG)

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