LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 44

Search options

  1. Article ; Online: Out-patient physiotherapy service delivery post COVID-19: opportunity for a re-set and a new normal?

    Rawlinson, Gillian / Connell, Louise

    Physiotherapy

    2021  Volume 111, Page(s) 1–3

    MeSH term(s) Ambulatory Care ; COVID-19 ; Humans ; Outpatients ; Physical Therapy Modalities ; SARS-CoV-2
    Language English
    Publishing date 2021-02-19
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 391109-3
    ISSN 1873-1465 ; 0031-9406
    ISSN (online) 1873-1465
    ISSN 0031-9406
    DOI 10.1016/j.physio.2021.02.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 383: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Differential Expression of PDGF Receptor-α in Human Placental Trophoblasts Leads to Different Entry Pathways by Human Cytomegalovirus Strains.

    Naing, Zin / Hamilton, Stuart T / van Zuylen, Wendy J / Scott, Gillian M / Rawlinson, William D

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 1082

    Abstract: Human cytomegalovirus (CMV) is the leading non-genetic cause of fetal malformation in developed countries. CMV placental infection is a pre-requisite for materno-fetal transmission of virus, and fetal infection. We investigated the roles of the viral ... ...

    Abstract Human cytomegalovirus (CMV) is the leading non-genetic cause of fetal malformation in developed countries. CMV placental infection is a pre-requisite for materno-fetal transmission of virus, and fetal infection. We investigated the roles of the viral pentameric complex gH/gL/pUL128-pUL131A, and cellular platelet-derived growth factor receptor-α (PDGFRα) for CMV infection in first trimester extravillous-derived (SGHPL-4) and villous-derived (HTR-8/SVneo) trophoblast cells. Infection with four CMV clinical and laboratory strains (Merlin, TB40E, Towne, AD169), and Merlin deletion mutants of UL128-, UL130-, and UL131A-genes, showed a cell type-dependent requirement of the viral pentameric complex for infection of trophoblast cells. The viral pentameric complex was essential for infection of villous trophoblasts, but non-essential for extravillous trophoblasts. Blocking of PDGFRα in extravillous trophoblasts, which naturally express PDGFRα, inhibited entry of pentameric complex-deficient CMV strains, but not the entry of pentameric positive CMV strains. Transient expression of PDGFRα in villous trophoblasts, which are naturally deficient in PDGFRα, promoted the entry of CMV strains lacking gH/gL/pUL128-pUL131A, but had no effect on entry of pentameric positive CMV strains. These results suggest PDGFRα is an important cell receptor for entry of CMV mutant strains lacking gH/gL/pUL128-pUL131A complexes in some placental cells, suggesting these entry pathways could be potential antiviral targets.
    MeSH term(s) Cell Line ; Cytomegalovirus/genetics ; Cytomegalovirus/physiology ; Cytomegalovirus Infections/genetics ; Cytomegalovirus Infections/metabolism ; Cytomegalovirus Infections/virology ; Female ; Humans ; Placenta/cytology ; Placenta/metabolism ; Placenta/virology ; Pregnancy ; Pregnancy Complications, Infectious/genetics ; Pregnancy Complications, Infectious/metabolism ; Pregnancy Complications, Infectious/virology ; Receptor, Platelet-Derived Growth Factor alpha/genetics ; Receptor, Platelet-Derived Growth Factor alpha/metabolism ; Trophoblasts/metabolism ; Trophoblasts/virology ; Viral Envelope Proteins/genetics ; Viral Envelope Proteins/metabolism ; Virus Internalization
    Chemical Substances Viral Envelope Proteins ; Receptor, Platelet-Derived Growth Factor alpha (EC 2.7.10.1)
    Language English
    Publishing date 2020-01-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-57471-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Improving diagnosis of primary cytomegalovirus infection in pregnant women using immunoblots.

    Rajasekariah, Harshita / Scott, Gillian / Robertson, Peter W / Rawlinson, William D

    Journal of medical virology

    2013  Volume 85, Issue 2, Page(s) 315–319

    Abstract: Human cytomegalovirus (CMV) is the most common infectious cause of mental disability in newborns of developed countries. Transmission of CMV from mother to baby is more frequent in maternal primary infection, although CMV reactivation causes more ... ...

    Abstract Human cytomegalovirus (CMV) is the most common infectious cause of mental disability in newborns of developed countries. Transmission of CMV from mother to baby is more frequent in maternal primary infection, although CMV reactivation causes more congenital infections overall. Current diagnostic tests for distinguishing primary and reactivation CMV have problems with interpretation and immunoblots may assist with diagnosis. Sera from 60 pregnant women were analyzed using conventional serology in parallel with a commercial immunoblot assay (using Recomblot, Mikrogen Diagnostik). Comparison of detection of CMV IgG, IgM, IgG avidity in maternal primary infection showed the immunoblot relative to conventional serology had sensitivity and specificity of 100% for IgG identification. The detection of IgM on immunoblot showed sensitivity of 75%, specificity of 62.5%, positive predictive value (PPV) of 81.8% and negative predictive value (NPV) of 52.6%. The immunoblot IgG avidity assay had sensitivity of 94.1%, with a PPV of 100% when identifying low avidity serum samples, and sensitivity of 100% with a PPV of 97.1% for high avidity serum samples. Overall agreement between conventional serology (IgM, IgG avidity) and immunoblot (IgM, IgG avidity) for detection of primary CMV infection was 65%. Although the immunoblot is effective in detecting IgG and determining IgG avidity, it showed no significant benefits in performance or utility as a first line diagnostic technique for IgM or primary CMV infection in pregnant women.
    MeSH term(s) Adult ; Antibodies, Viral/blood ; Antibody Affinity ; Clinical Laboratory Techniques/methods ; Cytomegalovirus/immunology ; Cytomegalovirus Infections/diagnosis ; Female ; Humans ; Immunoblotting/methods ; Immunoglobulin G/blood ; Immunoglobulin M/blood ; Infant, Newborn ; Middle Aged ; Predictive Value of Tests ; Pregnancy ; Pregnancy Complications, Infectious/diagnosis ; Sensitivity and Specificity ; Virology/methods ; Young Adult
    Chemical Substances Antibodies, Viral ; Immunoglobulin G ; Immunoglobulin M
    Language English
    Publishing date 2013-02
    Publishing country United States
    Document type Evaluation Studies ; Journal Article
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.23471
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Human cytomegalovirus directly modulates expression of chemokine CCL2 (MCP-1) during viral replication.

    Hamilton, Stuart T / Scott, Gillian M / Naing, Zin / Rawlinson, William D

    The Journal of general virology

    2013  Volume 94, Issue Pt 11, Page(s) 2495–2503

    Abstract: Human cytomegalovirus (CMV) infects monocytes and other haematopoietic progenitor cells which then act as reservoirs for latency and virus dissemination. The chemokine CCL2 (monocyte chemotactic protein-1 or MCP-1) exhibits potent chemotactic activity ... ...

    Abstract Human cytomegalovirus (CMV) infects monocytes and other haematopoietic progenitor cells which then act as reservoirs for latency and virus dissemination. The chemokine CCL2 (monocyte chemotactic protein-1 or MCP-1) exhibits potent chemotactic activity for monocytes and is a likely target for CMV-induced immunomodulation. In this study, we demonstrate CMV modulates CCL2 expression in MRC-5 fibroblasts with multiplicity-dependent kinetics, where CCL2 is upregulated during early stage infection, followed by CCL2 inhibition at late stage infection. This CMV-induced CCL2 modulation was dependent upon virus replication, as UV-inactivated virus did not elicit any changes in CCL2 levels. Dual immunofluorescence staining showed CMV strains AD169, purified AD169, Merlin, FIX WT (FLAG-US28/WT) and pUS28-deficient FIX (FIX-ΔUS28) all induced upregulation of CCL2 primarily within infected cells. Focal upregulation of CCL2 within FIX-ΔUS28-infected cells demonstrated intracellular CCL2 accumulation was independent of CCL2 sequestration by the CMV-encoded chemokine receptor US28. Infection with purified virus confirmed CMV-induced CCL2 upregulation was not due to any CCL2-inducing factors contained within non-purified virus stocks. The CMV-induced CCL2 expression kinetics occurred concurrently with modulation of the CCL2 transcriptional activators NF-κB, interferon regulatory factor 3 and cytokine IFN-β, independent of virus strain, and with the establishment of viral replication compartments within infected cell nuclei. This is the first report to our knowledge to demonstrate CMV modulation of CCL2 expression within infected cells during viral replication. This immune modulation may facilitate virus dissemination, establishment of latency and pathogenesis of CMV-induced host disease.
    MeSH term(s) Cell Line ; Chemokine CCL2/genetics ; Chemokine CCL2/metabolism ; Cytomegalovirus/pathogenicity ; Cytomegalovirus/physiology ; Fibroblasts/virology ; Gene Expression Regulation ; Humans ; Immunomodulation ; Kinetics ; Virus Replication/physiology
    Chemical Substances Chemokine CCL2
    Language English
    Publishing date 2013-08-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 219316-4
    ISSN 1465-2099 ; 0022-1317
    ISSN (online) 1465-2099
    ISSN 0022-1317
    DOI 10.1099/vir.0.052878-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 610: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Stimulatory effects of human cytomegalovirus tegument protein pp71 lead to increased expression of CCL2 (monocyte chemotactic protein-1) during infection.

    Naing, Zin / Webel, Rike / Hamilton, Stuart / Schmeiser, Cathrin / Scott, Gillian / Marschall, Manfred / Rawlinson, William

    The Journal of general virology

    2015  Volume 96, Issue Pt 7, Page(s) 1855–1862

    Abstract: Human cytomegalovirus (CMV) is the most common infectious cause of congenital birth defects in developed countries. Studies of infected amniotic fluid and placentae show CMV infection leads to a pro-inflammatory shift in cytokine profiles with ... ...

    Abstract Human cytomegalovirus (CMV) is the most common infectious cause of congenital birth defects in developed countries. Studies of infected amniotic fluid and placentae show CMV infection leads to a pro-inflammatory shift in cytokine profiles with implications for pathogenesis of foetal disease. ELISA, immunofluorescence and real-time-PCR assays were used to investigate CCL2 (monocyte chemotactic protein-1) and TNF-α changes following CMV infection of human fibroblasts, as well as following transient expression of CMV gene products in HeLa cells. Infection of human fibroblasts with CMV AD169 resulted in increased cytoplasmic and extracellular expression of CCL2 during early stages of infection, followed by marked downregulation of the chemokine at late times. Induction of CCL2 was not observed with CMV clinical strain Merlin, consistent with the postulated immune-evasion potential of this genetically intact WT strain. Comparison between live and UV-irradiated virus infections showed that changes in CCL2 levels were a direct response to active CMV replication. There were no significant changes in TNF-α expression during a parallel time-course of CMV infection. In transient transfection assays, overexpression of CMV tegument protein pp71 resulted in intracellular and extracellular upregulation of CCL2 protein. mRNA analysis showed that pp71-induced elevation in CCL2 was mediated through transcriptional upregulation. The data showed that CMV-induced upregulation of CCL2 during early stages of infection was mediated, at least in part, by stimulation of viral pp71, which may contribute to viral pathogenesis through enhanced virus dissemination.
    MeSH term(s) Cells, Cultured ; Chemokine CCL2/biosynthesis ; Cytomegalovirus/immunology ; Enzyme-Linked Immunosorbent Assay ; Epithelial Cells/immunology ; Epithelial Cells/virology ; Fibroblasts/immunology ; Fibroblasts/virology ; Fluorescent Antibody Technique ; Gene Expression Profiling ; Humans ; Real-Time Polymerase Chain Reaction ; Tumor Necrosis Factor-alpha/biosynthesis ; Viral Proteins/immunology
    Chemical Substances Chemokine CCL2 ; Tumor Necrosis Factor-alpha ; Viral Proteins ; cytomegalovirus phosphoprotein 71kDa (107852-97-1)
    Language English
    Publishing date 2015-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 219316-4
    ISSN 1465-2099 ; 0022-1317
    ISSN (online) 1465-2099
    ISSN 0022-1317
    DOI 10.1099/vir.0.000101
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 610: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Maintaining Prehospital Intubation Success with COVID-19 Personal Protective Precautions.

    Avery, Pascale / McAleer, Sam / Rawlinson, David / Gill, Stuart / Lockey, David

    Prehospital and disaster medicine

    2022  Volume 37, Issue 6, Page(s) 783–787

    Abstract: Background: Tracheal intubation is a high-risk intervention for exposure to airborne infective pathogens, including the novel coronavirus disease 2019 (COVID-19). During the recent pandemic, personal protective equipment (PPE) was essential to protect ... ...

    Abstract Background: Tracheal intubation is a high-risk intervention for exposure to airborne infective pathogens, including the novel coronavirus disease 2019 (COVID-19). During the recent pandemic, personal protective equipment (PPE) was essential to protect staff during intubation but is recognized to make the practical conduct of anesthesia and intubation more difficult. In the early phase of the coronavirus pandemic, some simple alterations were made to the emergency anesthesia standard operating procedure (SOP) of a prehospital critical care service to attempt to maintain high intubation success rates despite the challenges posed by wearing PPE. This retrospective observational cohort study aims to compare first-pass intubation success rates before and after the introduction of PPE and an altered SOP.
    Methodology: A retrospective observational cohort study was conducted from January 1, 2019 through August 30, 2021. The retrospective analysis used prospectively collected data using prehospital electronic patient records. Anonymized data were held in Excel (v16.54) and analyzed using IBM SPSS Statistics (v28). Patient inclusion criteria were those of all ages who received a primary tracheal intubation attempt outside the hospital by critical care teams. March 27, 2020 was the date from which the SOP changed to mandatory COVID-19 SOP including Level 3 PPE - this date is used to separate the cohort groups.
    Results: Data were analyzed from 1,266 patients who received primary intubations by the service. The overall first-pass intubation success rate was 89.7% and the overall intubation success rate was 99.9%. There was no statistically significant difference in first-pass success rate between the two groups: 90.3% in the pre-COVID-19 group (n = 546) and 89.3% in the COVID-19 group (n = 720); Pearson chi-square 0.329; P = .566. In addition, there was no statistical difference in overall intubation success rate between groups: 99.8% in the pre-COVID-19 group and 100.0% in the COVID-19 group; Pearson chi-square 1.32; P = .251.Non-drug-assisted intubations were more than twice as likely to require multiple attempts in both the pre-COVID-19 group (n = 546; OR = 2.15; 95% CI, 1.19-3.90; P = .01) and in the COVID-19 group (n = 720; OR = 2.5; 95% CI, 1.5-4.1; P = <.001).
    Conclusion: This study presents simple changes to a prehospital intubation SOP in response to COVID-19 which included mandatory use of PPE, the first intubator always being the most experienced clinician, and routine first use of video laryngoscopy (VL). These changes allowed protection of the clinical team while successfully maintaining the first-pass and overall success rates for prehospital tracheal intubation.
    Language English
    Publishing date 2022-09-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1025975-2
    ISSN 1945-1938 ; 1049-023X
    ISSN (online) 1945-1938
    ISSN 1049-023X
    DOI 10.1017/S1049023X22001273
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2859: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: Cytomegalovirus. A common virus causing serious disease.

    Rawlinson, William / Scott, Gillian

    Australian family physician

    2003  Volume 32, Issue 10, Page(s) 789–793

    Abstract: Background: Human cytomegalovirus (CMV) is a herpes virus that causes severe illness and death in people whose immune systems are compromised, including organ and bone marrow transplant recipients, HIV infected people, those on immunosuppressive drugs ... ...

    Abstract Background: Human cytomegalovirus (CMV) is a herpes virus that causes severe illness and death in people whose immune systems are compromised, including organ and bone marrow transplant recipients, HIV infected people, those on immunosuppressive drugs and newborns infected during pregnancy.
    Objective: This article aims to present a clear guide to diagnosis and treatment of CMV in at risk patients in the community.
    Discussion: Cytomegalovirus is a common infection in the community, but diagnosis is often seen as difficult. The use of careful clinical assessment tests and a clear diagnostic algorithm can provide appropriate diagnosis in most immunocompromised patients, pregnant women and newborns with CMV. Treatment strategies and available antivirals are improving, complementing the advances made with diagnostic techniques and algorithms.
    MeSH term(s) Adult ; Age Distribution ; Antiviral Agents/therapeutic use ; Australia/epidemiology ; Carrier State ; Child, Preschool ; Cytomegalovirus/isolation & purification ; Cytomegalovirus Infections/diagnosis ; Cytomegalovirus Infections/drug therapy ; Cytomegalovirus Infections/epidemiology ; Cytomegalovirus Infections/immunology ; DNA, Viral/analysis ; Female ; Humans ; Immunocompromised Host ; Incidence ; Infant, Newborn ; Infectious Disease Transmission, Vertical ; Male ; Polymerase Chain Reaction/methods ; Pregnancy ; Prognosis ; Risk Assessment ; Severity of Illness Index ; Sex Distribution
    Chemical Substances Antiviral Agents ; DNA, Viral
    Language English
    Publishing date 2003-10
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 423718-3
    ISSN 0300-8495
    ISSN 0300-8495
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 2235: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 27: Show issues
    Zs.MO 642: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: Hematologic, Biochemical, and Endocrine Parameters in Horses With Tooth Resorption and Hypercementosis.

    Earley, Edward T / Rawlinson, Jennifer R / Baratt, Robert M / Galloway, Stephen S / Smedley, Rebecca C / Scarlett, Janet M / Refsal, Kent R / Dotzel, Allison R / Cox, Victor S / Perkins, Gillian A

    Journal of veterinary dentistry

    2017  Volume 34, Issue 3, Page(s) 155–160

    Abstract: Background: Equine odontoclastic tooth resorption and hypercementosis (EOTRH) is a frequently diagnosed condition in adult horses. The underlying etiology is still unknown. Hematologic, biochemical, and endocrine values have not been reported in EOTRH- ... ...

    Abstract Background: Equine odontoclastic tooth resorption and hypercementosis (EOTRH) is a frequently diagnosed condition in adult horses. The underlying etiology is still unknown. Hematologic, biochemical, and endocrine values have not been reported in EOTRH-affected horses.
    Objectives: The main objective of the study was to describe the hematologic, biochemical, and endocrine parameters in horses with EOTRH.
    Study design: Descriptive cross-sectional study of client-owned animals with EOTRH.
    Methods: A complete blood count, biochemistry panel, and endocrine profile were performed in horses diagnosed with EOTRH. Diagnosis was based on oral and radiographic examination findings and confirmed with histopathology.
    Results: Eighteen horses with EOTRH aged 10 to 32 years from various regions of the United States were sampled. The only consistent abnormality on the complete blood cell count and chemistry panel was hypoalbuminemia (88%). Endocrine parameters demonstrated no major abnormalities in the functioning of the thyroid and pituitary pars intermedia. The parathyroid hormone concentration was increased in 7 (47%) of 15 horses with an elevated 25-hydroxy vitamin D in 3 (17%) of 17 horses. Main Limitations: The main limitations of this study are the small sample size and lack of age-matched and management-matched control horses.
    Conclusions: The relevance of elevated parathyroid hormone in this study cannot be determined due to the lack of age-based controls and large population studies. With the small population evaluated in this study, there are no obvious hematological, biochemical, and endocrine changes evident. Further evaluation with signalment-matched controls will be necessary to evaluate some trends noted in the laboratory values.
    MeSH term(s) Animals ; Cross-Sectional Studies ; Female ; Horse Diseases/blood ; Horse Diseases/etiology ; Horse Diseases/physiopathology ; Horses ; Hypercementosis/blood ; Hypercementosis/etiology ; Hypercementosis/physiopathology ; Hypercementosis/veterinary ; Male ; Prospective Studies ; Tooth Resorption/blood ; Tooth Resorption/etiology ; Tooth Resorption/physiopathology ; Tooth Resorption/veterinary
    Language English
    Publishing date 2017-08-14
    Publishing country United States
    Document type Journal Article
    ISSN 0898-7564
    ISSN 0898-7564
    DOI 10.1177/0898756417717039
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article ; Online: Prevention of congenital cytomegalovirus complications by maternal and neonatal treatments: a systematic review.

    Hamilton, Stuart T / van Zuylen, Wendy / Shand, Antonia / Scott, Gillian M / Naing, Zin / Hall, Beverley / Craig, Maria E / Rawlinson, William D

    Reviews in medical virology

    2014  Volume 24, Issue 6, Page(s) 420–433

    Abstract: Human cytomegalovirus is the leading non-genetic cause of congenital malformation in developed countries. Congenital CMV may result in fetal and neonatal death or development of serious clinical sequelae. In this review, we identified evidence-based ... ...

    Abstract Human cytomegalovirus is the leading non-genetic cause of congenital malformation in developed countries. Congenital CMV may result in fetal and neonatal death or development of serious clinical sequelae. In this review, we identified evidence-based interventions for prevention of congenital CMV at the primary level (prevention of maternal infection), secondary level (risk reduction of fetal infection and disease) and tertiary level (risk reduction of infected neonates being affected by CMV). A systematic review of existing literature revealed 24 eligible studies that met the inclusion criteria. Prevention of maternal infection using hygiene and behavioural interventions reduced maternal seroconversion rates during pregnancy. However, evidence suggested maternal adherence to education on preventative behaviours was a limiting factor. Treatment of maternal CMV infection with hyperimmune globulin (HIG) showed some evidence for efficacy in prevention of fetal infection and fetal/neonatal morbidity with a reasonable safety profile. However, more robust clinical evidence is required before HIG therapy can be routinely recommended. Limited evidence also existed for the safety and efficacy of established CMV antivirals (valaciclovir, ganciclovir and valganciclovir) to treat neonatal consequences of CMV infection, but toxicity and lack of randomised clinical trial data remain major issues. In the absence of a licensed CMV vaccine or robust clinical evidence for anti-CMV therapeutics, patient education and behavioural interventions that emphasise adherence remain the best preventative strategies for congenital CMV. There is a strong need for further data on the use of HIG and other antivirals in pregnancy, as well as the development of less toxic, novel, antiviral agents.
    MeSH term(s) Adult ; Antiviral Agents/therapeutic use ; Cytomegalovirus/drug effects ; Cytomegalovirus/physiology ; Cytomegalovirus Infections/congenital ; Cytomegalovirus Infections/drug therapy ; Cytomegalovirus Infections/prevention & control ; Cytomegalovirus Infections/transmission ; Female ; Humans ; Infant, Newborn ; Infectious Disease Transmission, Vertical/prevention & control ; Male ; Pregnancy ; Pregnancy Complications, Infectious/drug therapy ; Pregnancy Complications, Infectious/prevention & control ; Pregnancy Complications, Infectious/virology
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2014-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1086043-5
    ISSN 1099-1654 ; 1052-9276
    ISSN (online) 1099-1654
    ISSN 1052-9276
    DOI 10.1002/rmv.1814
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3308: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Recombinant glycoprotein B vaccine formulation with Toll-like receptor 9 agonist and immune-stimulating complex induces specific immunity against multiple strains of cytomegalovirus.

    Dasari, Vijayendra / Smith, Corey / Zhong, Jie / Scott, Gillian / Rawlinson, William / Khanna, Rajiv

    The Journal of general virology

    2011  Volume 92, Issue Pt 5, Page(s) 1021–1031

    Abstract: Natural human cytomegalovirus (CMV) infection is characterized by a strain-specific neutralizing antibody response. This is particularly relevant in clinical settings such as transplantation and pregnancy where reinfection with heterologous strains ... ...

    Abstract Natural human cytomegalovirus (CMV) infection is characterized by a strain-specific neutralizing antibody response. This is particularly relevant in clinical settings such as transplantation and pregnancy where reinfection with heterologous strains occurs and the immune system does not mount an effective response against the infecting strain due to underlying immunosuppression. There is an emerging argument that a CMV vaccine that induces high titres of cross-neutralizing antibodies will be more effective in protecting individuals from infection with antigenically different CMV strains. In addition, induction of cell-mediated immunity offers the additional advantage of targeting virus-infected cells. This study presents a novel formulation of a CMV vaccine that, by combining recombinant soluble gB protein with a Toll-like receptor 9 agonist (CpG ODN1826) and immune-stimulating complexes (AbISCO 100), was able to elicit strong polyfunctional CMV-specific cellular and cross-neutralizing humoral immune responses. These data demonstrated that prime-boost immunization of human leukocyte antigen (HLA)-A2 mice with gB protein in combination with CpG ODN1826 and AbISCO 100 induced long-lasting CMV-specific CD4(+) and CD8(+) T-cell and humoral responses. Furthermore, these responses neutralized infection with multiple strains of CMV expressing different gB genotypes and afforded protection against challenge with recombinant vaccinia virus encoding the gB protein. These observations argue that this novel vaccine strategy, if applied to humans, should facilitate the generation of a robust, pluripotent immune response, which may be more effective in preventing infection with multiple strains of CMV.
    MeSH term(s) Adjuvants, Immunologic/administration & dosage ; Animals ; Antibodies, Neutralizing/blood ; Antibodies, Viral/blood ; Antigen-Antibody Complex/administration & dosage ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cytomegalovirus Vaccines/administration & dosage ; Cytomegalovirus Vaccines/immunology ; Female ; Humans ; Immunization, Secondary/methods ; Mice ; Mice, Transgenic ; Oligodeoxyribonucleotides/administration & dosage ; Toll-Like Receptor 9/agonists ; Vaccination/methods ; Vaccines, Synthetic/administration & dosage ; Vaccines, Synthetic/immunology ; Viral Envelope Proteins/administration & dosage ; Viral Envelope Proteins/immunology
    Chemical Substances Adjuvants, Immunologic ; Antibodies, Neutralizing ; Antibodies, Viral ; Antigen-Antibody Complex ; CPG-oligonucleotide ; Cytomegalovirus Vaccines ; Oligodeoxyribonucleotides ; Toll-Like Receptor 9 ; Vaccines, Synthetic ; Viral Envelope Proteins ; glycoprotein B, Simplexvirus
    Language English
    Publishing date 2011-02-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 219316-4
    ISSN 1465-2099 ; 0022-1317
    ISSN (online) 1465-2099
    ISSN 0022-1317
    DOI 10.1099/vir.0.029413-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 610: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top