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  1. Article ; Online: UV-Light-Tunable p-/n-Type Chemiresistive Gas Sensors Based on Quasi-1D TiS

    Sysoev, Victor V / Lashkov, Andrey V / Lipatov, Alexey / Plugin, Ilya A / Bruns, Michael / Fuchs, Dirk / Varezhnikov, Alexey S / Adib, Mustahsin / Sommer, Martin / Sinitskii, Alexander

    Sensors (Basel, Switzerland)

    2022  Volume 22, Issue 24

    Abstract: The growing demand of society for gas sensors for energy-efficient environmental sensing stimulates studies of new electronic materials. Here, we investigated quasi-one-dimensional titanium trisulfide ( ... ...

    Abstract The growing demand of society for gas sensors for energy-efficient environmental sensing stimulates studies of new electronic materials. Here, we investigated quasi-one-dimensional titanium trisulfide (TiS
    Language English
    Publishing date 2022-12-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s22249815
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  2. Article ; Online: Palladium supported magnetic Fucus Vesiculosus extract as a natural and novel catalyst for the synthesis of N-alkyl-2-(4-methyl-1-oxoisoquinolin-2(1H)-yl)-2-phenylacetamide derivatives.

    Yousefnejad, Faeze / Bahadorikhalili, Saeed / Esmkhani, Maryam / Adib, Mehdi / Javanshir, Shahrzad / Hosseini, Samanehsadat / Larijani, Bagher / Mahdavi, Mohammad

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 1272

    Abstract: ... ICP). The activity of Pd@mFuVe catalyst is studied in the synthesis of N-alkyl-2-(4-methyl-1 ...

    Abstract In this paper, a novel catalyst is introduced based on the immobilization of palladium onto magnetic Fucus Vesiculosus extract (Pd@mFuVe catalyst). For the synthesis of Pd@mFuVe catalyst, Fucus Vesiculosus extract is obtained from the plant source, followed by the synthesis of superparamagnetic iron oxide nanoparticles (SPION) onto the extract. The catalyst is characterized by several methods, including scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), FT-IR spectroscopy, vibrating sample magnetometer (VSM), powder X-ray diffraction analysis (XRD), and inductively coupled plasma (ICP). The activity of Pd@mFuVe catalyst is studied in the synthesis of N-alkyl-2-(4-methyl-1-oxoisoquinolin-2(1H)-yl)-2-phenylacetamides. The products were synthesized in three steps, the synthesis of 2-iodobenzoic acid from 2-aminobenzoic acid, which participated in a multicomponent reaction with allylamine, aldehydes, and isocyanides, followed by a cyclization reaction, catalyzed by Pd@mFuVe catalyst. The product yields are high and the catalyst showed good reusability after 5 sequential runs. The most significant, Pd@mFuVe catalyst is fabricated from a plant extract source as a green support for the catalyst.
    MeSH term(s) Palladium/chemistry ; Fucus ; Spectroscopy, Fourier Transform Infrared ; Catalysis ; Plant Extracts/chemistry ; Magnetic Phenomena
    Chemical Substances Palladium (5TWQ1V240M) ; Plant Extracts
    Language English
    Publishing date 2023-01-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-28121-1
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  3. Article: Copper Supported Imidazolylpyridine Modified SPION as an Efficient Catalyst for Eco-friendly, One-pot and Green Synthesis of Novel (3- Cyanothiophen-2-yl)-N-(arylsulfonyl)acetimidamide Derivatives.

    Askarzadeh, Mohammad / Adib, Mehdi / Mahdavi, Mohammad

    Current organic synthesis

    2022  Volume 20, Issue 4, Page(s) 365–375

    Abstract: Background: In this paper, a novel catalyst is synthesized and characterized by immobilizing copper onto imidazopyridine-modified superparamagnetic iron oxide nanoparticles (SPION).: Methods: The catalyst is characterized by several methods, ... ...

    Abstract Background: In this paper, a novel catalyst is synthesized and characterized by immobilizing copper onto imidazopyridine-modified superparamagnetic iron oxide nanoparticles (SPION).
    Methods: The catalyst is characterized by several methods, including TEM, SEM, ICP, DLS, and VSM. The catalytic activity of the catalyst is evaluated in the synthesis of thiosolfunamide. The synthesized catalyst showed very good activity in the mentioned reaction and performance for synthesizing the desired products in high isolated yields.
    Results: For the synthesis of the products, sequential transformations enable the facile synthesis of complex target molecules from simple building blocks in a single preparative step.
    Conclusion: The reaction can be performed with a high yield using water and ethanol as the reaction green solvent using terminal alkynes and sulfonyl azides as starting materials. The reusability of the catalyst was tested, and the results proved high reusability of the catalyst.
    Language English
    Publishing date 2022-07-04
    Publishing country United Arab Emirates
    Document type Journal Article
    ISSN 1570-1794
    ISSN 1570-1794
    DOI 10.2174/1570179419666220624120250
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Palladium supported magnetic Fucus Vesiculosus extract as a natural and novel catalyst for the synthesis of N-alkyl-2-(4-methyl-1-oxoisoquinolin-2(1H)-yl)-2-phenylacetamide derivatives

    Faeze Yousefnejad / Saeed Bahadorikhalili / Maryam Esmkhani / Mehdi Adib / Shahrzad Javanshir / Samanehsadat Hosseini / Bagher Larijani / Mohammad Mahdavi

    Scientific Reports, Vol 13, Iss 1, Pp 1-

    2023  Volume 10

    Abstract: ... ICP). The activity of Pd@mFuVe catalyst is studied in the synthesis of N-alkyl-2-(4-methyl-1 ...

    Abstract Abstract In this paper, a novel catalyst is introduced based on the immobilization of palladium onto magnetic Fucus Vesiculosus extract (Pd@mFuVe catalyst). For the synthesis of Pd@mFuVe catalyst, Fucus Vesiculosus extract is obtained from the plant source, followed by the synthesis of superparamagnetic iron oxide nanoparticles (SPION) onto the extract. The catalyst is characterized by several methods, including scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), FT-IR spectroscopy, vibrating sample magnetometer (VSM), powder X-ray diffraction analysis (XRD), and inductively coupled plasma (ICP). The activity of Pd@mFuVe catalyst is studied in the synthesis of N-alkyl-2-(4-methyl-1-oxoisoquinolin-2(1H)-yl)-2-phenylacetamides. The products were synthesized in three steps, the synthesis of 2-iodobenzoic acid from 2-aminobenzoic acid, which participated in a multicomponent reaction with allylamine, aldehydes, and isocyanides, followed by a cyclization reaction, catalyzed by Pd@mFuVe catalyst. The product yields are high and the catalyst showed good reusability after 5 sequential runs. The most significant, Pd@mFuVe catalyst is fabricated from a plant extract source as a green support for the catalyst.
    Keywords Medicine ; R ; Science ; Q
    Subject code 540
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
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  5. Article ; Online: In silico molecular investigations of pyridine N-Oxide compounds as potential inhibitors of SARS-CoV-2: 3D QSAR, molecular docking modeling, and ADMET screening.

    Ghaleb, Adib / Aouidate, Adnane / Ayouchia, Hicham Ben El / Aarjane, Mohammed / Anane, Hafid / Stiriba, Salah-Eddine

    Journal of biomolecular structure & dynamics

    2020  Volume 40, Issue 1, Page(s) 143–153

    Abstract: ... the potential inhibitory of a class of human SARS inhibitors, namely pyridine N-oxide derivatives, against CoV-2 ... developed model of 110 pyridine N-oxide based-antiviral compounds, showed Q ...

    Abstract The new coronavirus SARS-CoV-2 virus is causing a severe pneumonia in human, provoking the serious outbreak epidemic CoV-2. Since its appearance in Wuhan, China on December 2019, CoV-2 becomes the biggest challenge the world is facing today, including the discovery of antiviral drug for SARS-CoV-2. In this study, the potential inhibitory of a class of human SARS inhibitors, namely pyridine N-oxide derivatives, against CoV-2 was addressed by quantitative structure-activity relationship 3 D-QSAR. The reliable CoMSIA developed model of 110 pyridine N-oxide based-antiviral compounds, showed Q
    MeSH term(s) Antiviral Agents/pharmacology ; COVID-19 ; Humans ; Molecular Docking Simulation ; Protease Inhibitors ; Pyridines/pharmacology ; Quantitative Structure-Activity Relationship ; SARS-CoV-2
    Chemical Substances Antiviral Agents ; Protease Inhibitors ; Pyridines ; pyridine N-oxide (91F12JJJ4H)
    Keywords covid19
    Language English
    Publishing date 2020-08-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2020.1808530
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  6. Article: A synthesis of pyrazino[1,2-a]indoles via one-pot cascade Ugi condensation and N-annulation under mild conditions

    Peirow, Reihane / Adib, Mehdi / Mahdavi, Mohammad

    Tetrahedron letters. 2021 Dec. 21, v. 87

    2021  

    Abstract: ... followed by N-annulation of the intermediate to afford the titled product under metal and acid-free ...

    Abstract A novel, one-pot, mild and operationally simple synthetic approach for the synthesis of pyrazino[1,2-a]indole derivatives is reported. The reaction proceeds via a 4-component Ugi condensation followed by N-annulation of the intermediate to afford the titled product under metal and acid-free conditions in methanol. The procedure consists of one-step tandem condensation and cyclization of Indole-2-carboxylic acid with isocyanides, phenacylamine hydrochloride and a variety of aromatic aldehydes. This method provides simple access to a wide range of pyrazino[1,2-a]indole derivatives in good to excellent yields under ambient temperature.
    Keywords ambient temperature ; cyanides ; indoles ; methanol
    Language English
    Dates of publication 2021-1221
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 204287-3
    ISSN 1873-3581 ; 0040-4039
    ISSN (online) 1873-3581
    ISSN 0040-4039
    DOI 10.1016/j.tetlet.2021.153547
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: In silico molecular investigations of pyridine N-Oxide compounds as potential inhibitors of SARS-CoV-2

    Ghaleb, Adib / Aouidate, Adnane / Ayouchia, Hicham Ben El / Aarjane, Mohammed / Anane, Hafid / Stiriba, Salah-Eddine

    Journal of Biomolecular Structure and Dynamics

    3D QSAR, molecular docking modeling, and ADMET screening

    2020  , Page(s) 1–11

    Keywords Molecular Biology ; Structural Biology ; General Medicine ; covid19
    Language English
    Publisher Informa UK Limited
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2020.1808530
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  8. Article: In silico molecular investigations of pyridine N-Oxide compounds as potential inhibitors of SARS-CoV-2: 3D QSAR, molecular docking modeling, and ADMET screening

    Ghaleb, Adib / Aouidate, Adnane / Ayouchia, Hicham Ben El / Aarjane, Mohammed / Anane, Hafid / Stiriba, Salah-Eddine

    J Biomol Struct Dyn

    Abstract: ... the potential inhibitory of a class of human SARS inhibitors, namely pyridine N-oxide derivatives, against CoV-2 ... developed model of 110 pyridine N-oxide based-antiviral compounds, showed Q2= 0.54 and[Formula: see text ... COVID-19. The inhibition activity of pyridine N-oxyde compounds against CoV-2 was compared ...

    Abstract The new coronavirus SARS-CoV-2 virus is causing a severe pneumonia in human, provoking the serious outbreak epidemic CoV-2. Since its appearance in Wuhan, China on December 2019, CoV-2 becomes the biggest challenge the world is facing today, including the discovery of antiviral drug for SARS-CoV-2. In this study, the potential inhibitory of a class of human SARS inhibitors, namely pyridine N-oxide derivatives, against CoV-2 was addressed by quantitative structure-activity relationship 3 D-QSAR. The reliable CoMSIA developed model of 110 pyridine N-oxide based-antiviral compounds, showed Q2= 0.54 and[Formula: see text] The molecular surflex-docking was applied to identify the crystal structure of CoV-2 main protease 3CLpro (PDB: 6LU7) and two potentially and largely used antiviral molecules, namely chloroquine, hydroxychloroquine. The obtained free energy affinity and ADMET properties indicate that among the series of model antiviral compounds examined, the new antiviral compound A5 could be an excellent antiviral drug inhibitor against COVID-19. The inhibition activity of pyridine N-oxyde compounds against CoV-2 was compared with the activity of two common antiviral drug, namely chloroquine (CQ) and hydroxychloroquine (HCQ). DFT method was also used to define the sites of reactivity of pyridine N-oxyde derivatives as well as CQ and HCQ. Communicated by Ramaswamy H. Sarma.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #720884
    Database COVID19

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  9. Article: TBHP/n-Bu4PBr-Promoted Oxidative Cross-Dehydrogenative Coupling of Aryl Methanols: A Facile Synthesis of Symmetrical Carboxylic Anhydride Derivatives

    Adib, Mehdi / Pashazadeh, Rahim

    Synlett

    2017  Volume 29, Issue 01, Page(s) 136–140

    Abstract: A transition-metal-free oxidative cross-dehydrogenative coupling reaction has been developed for the preparation of symmetrical carboxylic anhydrides through self-coupling dual C–O bond formations of aryl methanols. In the presence of a catalytic amount ... ...

    Abstract A transition-metal-free oxidative cross-dehydrogenative coupling reaction has been developed for the preparation of symmetrical carboxylic anhydrides through self-coupling dual C–O bond formations of aryl methanols. In the presence of a catalytic amount of tetrabutylphosphonium bromide (TBPB) as transfer agent and aqueous tert -butyl hydroperoxide (TBHP) as oxidant and reactant, methylene groups of aryl methanols were efficiently oxidized to C=O and coupled with the peroxide oxygen from TBHP to form a diverse array of symmetrical carboxylic anhydride derivatives.
    Keywords cross-dehydrogenative coupling ; tetrabutylphosphonium bromide ; -butyl hydroperoxide ; aryl methanols ; symmetrical carboxylic anhydrides
    Language English
    Publishing date 2017-09-15
    Publisher © Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2042012-2
    ISSN 1437-2096 ; 0936-5214
    ISSN (online) 1437-2096
    ISSN 0936-5214
    DOI 10.1055/s-0036-1590905
    Database Thieme publisher's database

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  10. Article ; Online: Synthesis and anticancer activity of N-substituted 2-arylquinazolinones bearing trans-stilbene scaffold.

    Mahdavi, Mohammad / Pedrood, Keyvan / Safavi, Maliheh / Saeedi, Mina / Pordeli, Mahboobeh / Ardestani, Sussan Kabudanian / Emami, Saeed / Adib, Mehdi / Foroumadi, Alireza / Shafiee, Abbas

    European journal of medicinal chemistry

    2015  Volume 95, Page(s) 492–499

    Abstract: A novel series of 2-arylquinazolinones 7a-o bearing trans-stilbene moiety were designed, synthesized, and evaluated against human breast cancer cell lines including human breast adenocarcinoma (MCF-7 and MDA-MB-231) and human ductal breast epithelial ... ...

    Abstract A novel series of 2-arylquinazolinones 7a-o bearing trans-stilbene moiety were designed, synthesized, and evaluated against human breast cancer cell lines including human breast adenocarcinoma (MCF-7 and MDA-MB-231) and human ductal breast epithelial tumor (T-47D). Among the tested compounds, the sec-butyl derivative 7h showed the best profile of activity (IC50 < 5 μM) against all cell lines, being 2-fold more potent than standard drug, etoposide. Our investigation revealed that the cytotoxic activity was significantly affected by N3-alkyl substituents. Furthermore, the morphological analysis by acridine orange/ethidium bromide double staining test and flow cytometry analysis indicated that the prototype compound 7h can induce apoptosis in MCF-7 and MDA-MB-231 cells.
    MeSH term(s) Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Chemistry Techniques, Synthetic ; Drug Screening Assays, Antitumor ; Humans ; MCF-7 Cells ; Quinazolinones/chemical synthesis ; Quinazolinones/chemistry ; Quinazolinones/pharmacology ; Stereoisomerism ; Stilbenes/chemistry ; Structure-Activity Relationship
    Chemical Substances Antineoplastic Agents ; Quinazolinones ; Stilbenes
    Language English
    Publishing date 2015-05-05
    Publishing country France
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2015.03.057
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