LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 131

Search options

  1. Article ; Online: Changes in Opioid Prescription Rates at Discharge After Targeted Provider Education in the Emergency Department.

    Booth, Deborah / Amalfitano, Christopher / Forestine, Anthony

    Journal of pharmacy practice

    2022  Volume 37, Issue 2, Page(s) 415–421

    Abstract: Introduction: ...

    Abstract Introduction:
    MeSH term(s) Humans ; United States ; Adolescent ; Analgesics, Opioid/therapeutic use ; Patient Discharge ; Retrospective Studies ; Practice Patterns, Physicians' ; Prescriptions ; Emergency Service, Hospital ; Endrin/analogs & derivatives
    Chemical Substances Analgesics, Opioid ; MME (78185-58-7) ; Endrin (OB9NVE7YCL)
    Language English
    Publishing date 2022-11-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1027474-1
    ISSN 1531-1937 ; 0897-1900
    ISSN (online) 1531-1937
    ISSN 0897-1900
    DOI 10.1177/08971900221131911
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article: What is the content of virtually delivered pain management programmes for people with persistent musculoskeletal pain? A systematic review.

    Booth, Gregory / Williams, Deborah / Patel, Hasina / Gilbert, Anthony W

    British journal of pain

    2021  Volume 16, Issue 1, Page(s) 84–95

    Abstract: Introduction: Virtual consultations (VC) have been embraced by healthcare organisations during the COVID-19 pandemic. VC allows continuation of patient care while adhering to government advised restrictions and social distancing measures. ... ...

    Abstract Introduction: Virtual consultations (VC) have been embraced by healthcare organisations during the COVID-19 pandemic. VC allows continuation of patient care while adhering to government advised restrictions and social distancing measures. Multidisciplinary pain management programmes (PMPs) are a core element of many pain services and utilising virtual methods to deliver PMPs has allowed them to continue to provide care. This systematic review aimed to explore the content of existing virtually delivered PMPs and discuss if and how these findings can be used to guide clinical delivery.
    Methods: Eligible studies included adults (aged ⩾18 years) with persistent musculoskeletal pain and any virtually delivered intervention that was described as a PMP or that had components of PMPs. Databases were searched from inception until July 2020. We performed a content analysis comparing existing interventions with established evidence-based clinical guidelines published by the British Pain Society (BPS). Intervention reporting quality was assessed using the Template for Intervention Description and Replication (TIDieR) checklist: an established checklist developed to improve the completeness of the reporting of interventions.
    Results: Eight studies were included. One intervention included six of the seven components recommended by the BPS; none included all seven. 'Skills training and activity management' was present in all eight interventions; 'education' and 'cognitive therapy methods' were present in six interventions; 'graded activation' and 'methods to enhance acceptance, mindfulness and psychological flexibility' were present in four interventions; 'physical exercise' was present in two interventions and 'graded exposure' was present in one intervention. None of the studies described all 12 items of the TIDieR checklist adequately enough for replication.
    Conclusion: Published virtual PMPs partially meet established clinical guidelines. Future virtual PMPs should be based on evidence-based clinical guidelines, and more research is needed to explore the effectiveness of virtually delivered PMPs and each recommended component.
    Language English
    Publishing date 2021-06-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2670872-3
    ISSN 2049-4645 ; 2049-4637
    ISSN (online) 2049-4645
    ISSN 2049-4637
    DOI 10.1177/20494637211023074
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: RNAi and CRISPR-Cas silencing E3-RING ubiquitin ligase AIP2 enhances soybean seed protein content.

    Shen, Bo / Schmidt, Monica A / Collet, Kristin Haug / Liu, Zhan-Bin / Coy, Monique / Abbitt, Shane / Molloy, Lynda / Frank, Mary / Everard, John D / Booth, Russ / Samadar, Partha P / He, Yonghua / Kinney, Anthony / Herman, Eliot M

    Journal of experimental botany

    2022  Volume 73, Issue 22, Page(s) 7285–7297

    Abstract: The majority of plant protein in the world's food supply is derived from soybean (Glycine max). Soybean is a key protein source for global animal feed and is incorporated into plant-based foods for people, including meat alternatives. Soybean protein ... ...

    Abstract The majority of plant protein in the world's food supply is derived from soybean (Glycine max). Soybean is a key protein source for global animal feed and is incorporated into plant-based foods for people, including meat alternatives. Soybean protein content is genetically variable and is usually inversely related to seed oil content. ABI3-interacting protein 2 (AIP2) is an E3-RING ubiquitin ligase that targets the seed-specific transcription factor ABI3. Silencing both soybean AIP2 genes (AIP2a and AIP2b) by RNAi enhanced seed protein content by up to seven percentage points, with no significant decrease in seed oil content. The protein content enhancement did not alter the composition of the seed storage proteins. Inactivation of either AIP2a or AIP2b by a CRISPR-Cas9-mediated mutation increased seed protein content, and this effect was greater when both genes were inactivated. Transactivation assays in transfected soybean hypocotyl protoplasts indicated that ABI3 changes the expression of glycinin, conglycinin, 2S albumin, and oleosin genes, indicating that AIP2 depletion increased seed protein content by regulating activity of the ABI3 transcription factor protein. These results provide an example of a gene-editing prototype directed to improve global food security and protein availability in soybean that may also be applicable to other protein-source crops.
    MeSH term(s) Soybean Proteins/genetics ; CRISPR-Cas Systems ; Seeds/genetics ; Transcription Factors ; Plant Oils ; Ubiquitin ; Ligases
    Chemical Substances Soybean Proteins ; Transcription Factors ; Plant Oils ; Ubiquitin ; Ligases (EC 6.-)
    Language English
    Publishing date 2022-09-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2976-2
    ISSN 1460-2431 ; 0022-0957
    ISSN (online) 1460-2431
    ISSN 0022-0957
    DOI 10.1093/jxb/erac376
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article: The relationship between boundary layer stability and cloud cover in the post-cold frontal region.

    Naud, Catherine M / Booth, James F / Del Genio, Anthony D

    Journal of climate

    2016  Volume 29, Issue 22, Page(s) 8129–8149

    Abstract: Using NASA-Aqua MODIS and AIRS data, the relationship between low-level cloud cover (cloud top below the 700 hPa level) and boundary layer stability is explored in post-cold frontal conditions. A linear relationship is found between seasonal cloud cover ... ...

    Abstract Using NASA-Aqua MODIS and AIRS data, the relationship between low-level cloud cover (cloud top below the 700 hPa level) and boundary layer stability is explored in post-cold frontal conditions. A linear relationship is found between seasonal cloud cover and two separate measures of inversion strength, the lower tropospheric stability (LTS) and the estimated inversion strength (EIS), for two specific regions in the north Atlantic and Pacific in quiescent and weakly subsiding conditions. The relationship barely changes when considering dynamically active and subsiding post-cold frontal conditions for the same regions. To explore the generality of this result and increase sample size, cold front centered composites of cloud cover and stability are constructed. The northern and southern hemisphere seasonal cloud cover and stability distributions in the post-cold frontal regions are then compared. A fairly good correlation between cloud cover and EIS is found in both hemispheres across all seasons, suggesting that a linear relationship between cloud cover and inversion strength proposed for quiescent conditions exists also in more dynamically active subsiding post-cold frontal conditions. However, for a given season and hemisphere, the correlation between cloud cover and EIS degrades in post-cold frontal regions, especially in the northern hemisphere. At these scales, other large scale factors tend to correlate better with cloud cover.
    Language English
    Publishing date 2016-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2021723-7
    ISSN 1520-0442 ; 0894-8755
    ISSN (online) 1520-0442
    ISSN 0894-8755
    DOI 10.1175/JCLI-D-15-0700.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Regenerative medicine: postnatal approaches.

    Tam, Paul Kwong Hang / Wong, Kenneth Kak Yuen / Atala, Anthony / Giobbe, Giovanni Giuseppe / Booth, Claire / Gruber, Peter J / Monone, Mimmi / Rafii, Shahin / Rando, Thomas A / Vacanti, Joseph / Comer, Carly D / Elvassore, Nicola / Grikscheit, Tracy / de Coppi, Paolo

    The Lancet. Child & adolescent health

    2022  Volume 6, Issue 9, Page(s) 654–666

    Abstract: Paper 2 of the paediatric regenerative medicine Series focuses on recent advances in postnatal approaches. New gene, cell, and niche-based technologies and their combinations allow structural and functional reconstitution and simulation of complex ... ...

    Abstract Paper 2 of the paediatric regenerative medicine Series focuses on recent advances in postnatal approaches. New gene, cell, and niche-based technologies and their combinations allow structural and functional reconstitution and simulation of complex postnatal cell, tissue, and organ hierarchies. Organoid and tissue engineering advances provide human disease models and novel treatments for both rare paediatric diseases and common diseases affecting all ages, such as COVID-19. Preclinical studies for gastrointestinal disorders are directed towards oesophageal replacement, short bowel syndrome, enteric neuropathy, biliary atresia, and chronic end-stage liver failure. For respiratory diseases, beside the first human tracheal replacement, more complex tissue engineering represents a promising solution to generate transplantable lungs. Genitourinary tissue replacement and expansion usually involve application of biocompatible scaffolds seeded with patient-derived cells. Gene and cell therapy approaches seem appropriate for rare paediatric diseases of the musculoskeletal system such as spinal muscular dystrophy, whereas congenital diseases of complex organs, such as the heart, continue to challenge new frontiers of regenerative medicine.
    MeSH term(s) COVID-19 ; Child ; Humans ; Regenerative Medicine ; Tissue Engineering
    Language English
    Publishing date 2022-08-11
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ISSN 2352-4650
    ISSN (online) 2352-4650
    DOI 10.1016/S2352-4642(22)00193-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Mast cell infiltration of the choroid and protease release are early events in age-related macular degeneration associated with genetic risk at both chromosomes 1q32 and 10q26.

    Mcharg, Selina / Booth, Laura / Perveen, Rahat / Riba Garcia, Isabel / Brace, Nicole / Bayatti, Nadhim / Sergouniotis, Panagiotis I / Phillips, Alexander M / Day, Anthony J / Black, Graeme C M / Clark, Simon J / Dowsey, Andrew W / Unwin, Richard D / Bishop, Paul N

    Proceedings of the National Academy of Sciences of the United States of America

    2022  Volume 119, Issue 20, Page(s) e2118510119

    Abstract: Age-related macular degeneration (AMD) is a leading cause of visual loss. It has a strong genetic basis, and common haplotypes on chromosome (Chr) 1 (CFH Y402H variant) and on Chr10 (near HTRA1/ARMS2) contribute the most risk. Little is known about the ... ...

    Abstract Age-related macular degeneration (AMD) is a leading cause of visual loss. It has a strong genetic basis, and common haplotypes on chromosome (Chr) 1 (CFH Y402H variant) and on Chr10 (near HTRA1/ARMS2) contribute the most risk. Little is known about the early molecular and cellular processes in AMD, and we hypothesized that analyzing submacular tissue from older donors with genetic risk but without clinical features of AMD would provide biological insights. Therefore, we used mass spectrometry–based quantitative proteomics to compare the proteins in human submacular stromal tissue punches from donors who were homozygous for high-risk alleles at either Chr1 or Chr10 with those from donors who had protective haplotypes at these loci, all without clinical features of AMD. Additional comparisons were made with tissue from donors who were homozygous for high-risk Chr1 alleles and had early AMD. The Chr1 and Chr10 risk groups shared common changes compared with the low-risk group, particularly increased levels of mast cell–specific proteases, including tryptase, chymase, and carboxypeptidase A3. Histological analyses of submacular tissue from donors with genetic risk of AMD but without clinical features of AMD and from donors with Chr1 risk and AMD demonstrated increased mast cells, particularly the tryptase-positive/chymase-negative cells variety, along with increased levels of denatured collagen compared with tissue from low–genetic risk donors. We conclude that increased mast cell infiltration of the inner choroid, degranulation, and subsequent extracellular matrix remodeling are early events in AMD pathogenesis and represent a unifying mechanistic link between Chr1- and Chr10-mediated AMD.
    MeSH term(s) Alleles ; Choroid/enzymology ; Choroid/pathology ; Chromosomes, Human, Pair 1/genetics ; Chromosomes, Human, Pair 10/genetics ; Humans ; Macular Degeneration/genetics ; Macular Degeneration/pathology ; Mast Cells/pathology ; Peptide Hydrolases/genetics ; Proteomics ; Risk ; Tryptases/metabolism
    Chemical Substances Peptide Hydrolases (EC 3.4.-) ; Tryptases (EC 3.4.21.59)
    Language English
    Publishing date 2022-05-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2118510119
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Validation and application of a novel method of measuring non-response bias in school-based surveys of paediatric overweight and obesity.

    Booth, Michael L / Okely, Anthony D / Denney-Wilson, Elizabeth

    International journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity

    2011  Volume 6, Issue 2-2, Page(s) e87–93

    Abstract: Objective: To validate a method of estimating non-response bias to a school-based survey based on body mass index (BMI).: Methods: A population survey of Australian students in Kindergarten and Grades 2, 4, 6, 8 and 10 (N=5 407) was conducted in 2004, ...

    Abstract Objective: To validate a method of estimating non-response bias to a school-based survey based on body mass index (BMI).
    Methods: A population survey of Australian students in Kindergarten and Grades 2, 4, 6, 8 and 10 (N=5 407) was conducted in 2004, and height and weight measured. Teachers matched the height and weight of all students who were selected to participate, but who were not measured (non-participating students) and of half of the students whose height and weight had been measured based on comparisons with the remaining half of measured students. Among those students whose height and weight had been both measured and estimated based on matching with the most similar student, percent agreement between the BMI categories based on measured and estimated values was calculated to determine the validity of the estimated BMI value. The prevalence of overweight and obesity among participating and non-participating students was compared to determine the magnitude of non-response bias.
    Results: For more than 88% of classes, percent agreement between BMI categories based on estimated and measured height and weight was >60%. The differences in the prevalence of overweight and obesity between participating and non-participating students were all less than one percentage point.
    Conclusions: Most teachers were able to validly match students based on their height and weight, allowing estimation of and adjustment for non-response bias among non-participating students.
    MeSH term(s) Adolescent ; Bias ; Body Height ; Body Mass Index ; Body Weight ; Child ; Child, Preschool ; Epidemiologic Research Design ; Female ; Health Surveys ; Humans ; Male ; New South Wales/epidemiology ; Obesity/diagnosis ; Obesity/epidemiology ; Obesity/physiopathology ; Overweight/diagnosis ; Overweight/epidemiology ; Overweight/physiopathology ; Prevalence ; Reproducibility of Results ; Schools/statistics & numerical data
    Language English
    Publishing date 2011-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Validation Studies
    ZDB-ID 2296128-8
    ISSN 1747-7174 ; 1747-7166
    ISSN (online) 1747-7174
    ISSN 1747-7166
    DOI 10.3109/17477166.2010.498917
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: The first common cold sore susceptibility gene.

    Cunningham, Anthony L / Booth, David

    The Journal of infectious diseases

    2011  Volume 204, Issue 11, Page(s) 1645–1647

    MeSH term(s) Chromosomes, Human, Pair 21 ; Female ; Genetic Predisposition to Disease ; Herpes Genitalis/genetics ; Herpes Genitalis/virology ; Herpes Labialis/genetics ; Herpesvirus 2, Human/isolation & purification ; Humans ; Male ; Polymorphism, Single Nucleotide ; Toll-Like Receptor 2/genetics
    Chemical Substances Toll-Like Receptor 2
    Language English
    Publishing date 2011-12-01
    Publishing country United States
    Document type Comment ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jir635
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article: A Primer on Usability Assessment Approaches for Health-Related Applications of Virtual Reality.

    Zhang, Timothy / Booth, Richard / Jean-Louis, Royce / Chan, Ryan / Yeung, Anthony / Gratzer, David / Strudwick, Gillian

    JMIR serious games

    2020  Volume 8, Issue 4, Page(s) e18153

    Abstract: Health-related virtual reality (VR) applications for patient treatment, rehabilitation, and medical professional training are on the rise. However, there is little guidance on how to select and perform usability evaluations for VR health interventions ... ...

    Abstract Health-related virtual reality (VR) applications for patient treatment, rehabilitation, and medical professional training are on the rise. However, there is little guidance on how to select and perform usability evaluations for VR health interventions compared to the supports that exist for other digital health technologies. The purpose of this viewpoint paper is to present an introductory summary of various usability testing approaches or methods that can be used for VR applications. Along with an overview of each, a list of resources is provided for readers to obtain additionally relevant information. Six categories of VR usability evaluations are described using a previously developed classification taxonomy specific to VR environments: (1) cognitive or task walkthrough, (2) graphical evaluation, (3) post hoc questionnaires or interviews, (4) physical performance evaluation, (5) user interface evaluation, and (6) heuristic evaluation. Given the growth of VR in health care, rigorous evaluation and usability testing is crucial in the development and implementation of novel VR interventions. The approaches outlined in this paper provide a starting point for conducting usability assessments for health-related VR applications; however, there is a need to also move beyond these to adopt those from the gaming industry, where assessments for both usability and user experience are routinely conducted.
    Language English
    Publishing date 2020-10-28
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2798265-8
    ISSN 2291-9279
    ISSN 2291-9279
    DOI 10.2196/18153
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Associations of Blood Pressure Dipping Patterns With Left Ventricular Mass and Left Ventricular Hypertrophy in Blacks: The Jackson Heart Study.

    Abdalla, Marwah / Caughey, Melissa C / Tanner, Rikki M / Booth, John N / Diaz, Keith M / Anstey, D Edmund / Sims, Mario / Ravenell, Joseph / Muntner, Paul / Viera, Anthony J / Shimbo, Daichi

    Journal of the American Heart Association

    2017  Volume 6, Issue 4

    Abstract: Background: Abnormal diurnal blood pressure (BP), including nondipping patterns, assessed using ambulatory BP monitoring, have been associated with increased cardiovascular risk among white and Asian adults. We examined the associations of BP dipping ... ...

    Abstract Background: Abnormal diurnal blood pressure (BP), including nondipping patterns, assessed using ambulatory BP monitoring, have been associated with increased cardiovascular risk among white and Asian adults. We examined the associations of BP dipping patterns (dipping, nondipping, and reverse dipping) with cardiovascular target organ damage (left ventricular mass index and left ventricular hypertrophy), among participants from the Jackson Heart Study, an exclusively black population-based cohort.
    Methods and results: Analyses included 1015 participants who completed ambulatory BP monitoring and had echocardiography data from the baseline visit. Participants were categorized based on the nighttime to daytime systolic BP ratio into 3 patterns: dipping pattern (≤0.90), nondipping pattern (>0.90 to ≤1.00), and reverse dipping pattern (>1.00). The prevalence of dipping, nondipping, and reverse dipping patterns was 33.6%, 48.2%, and 18.2%, respectively. In a fully adjusted model, which included antihypertensive medication use and clinic and daytime systolic BP, the mean differences in left ventricular mass index between reverse dipping pattern versus dipping pattern was 8.3±2.1 g/m
    Conclusions: In this population-based study of blacks, a reverse dipping pattern was associated with increased left ventricular mass index and a higher prevalence of left ventricular hypertrophy. Identification of a reverse dipping pattern on ambulatory BP monitoring may help identify black at increased risk for cardiovascular target organ damage.
    Language English
    Publishing date 2017-04-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.116.004847
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top