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Article ; Online: Music Therapy Intervention to Reduce Caregiver Distress at End of Life: A Feasibility Study.

Whitford, Kevin J / Ulrich, Angela M / Larsen, Brianna E / Phelps, Christina M / Siska, Martha J / Bigelow, Maureen L / Dockter, Travis J / Wood, Christina / Walton, Monica P / Stelpflug, Amy J / Lapid, Maria I

Journal of pain and symptom management

2023 Volume 65, Issue 5, Page(s) e417–e423

Abstract: Background: Music therapy (MT) can relieve distressing end-of-life symptoms, but little is known regarding its effect on caregivers who are at risk for emotional distress as their loved ones approach death.: Measures: Quality of life (Linear Analogue ...

Abstract	Background: Music therapy (MT) can relieve distressing end-of-life symptoms, but little is known regarding its effect on caregivers who are at risk for emotional distress as their loved ones approach death. Measures: Quality of life (Linear Analogue Self-Assessment), depressive and anxiety symptoms (Patient Health Questionnaire for Depression and Anxiety), and stress (Role Overload Measure) pre-MT, post-MT and at 6-month follow-up, as well as a satisfaction survey post-MT. Intervention: Single MT session for 20-45 minutes OUTCOMES: 15/20 completed MT intervention, 14 also completed pre-MT and post-MT assessments, and 9 completed assessments at all 3 timepoints. Post-MT satisfaction survey (n=14) showed 100% of caregivers were very satisfied with MT and would recommend to others, and found MT very effective for emotional support (85.7%), stress relief (78.6%), spiritual support (71.4%), general feeling of wellness (71.4%), relaxation (69.2%), and pain relief (33.3%). Conclusions: Research on MT is feasible for caregivers of inpatient hospice patients. Trial registration: ClinicalTrials.gov Identifier: NCT03322228.
MeSH term(s)	Humans ; Caregivers/psychology ; Quality of Life/psychology ; Music Therapy ; Feasibility Studies ; Death
Language	English
Publishing date	2023-01-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639142-4
ISSN	1873-6513 ; 0885-3924
ISSN (online)	1873-6513
ISSN	0885-3924
DOI	10.1016/j.jpainsymman.2023.01.009
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Article ; Online: Impact of Pharmacy School Characteristics on NAPLEX First-time Pass Rates.

Williams, Jennifer S / Spivey, Christina A / Hagemann, Tracy M / Phelps, Stephanie J / Chisholm-Burns, Marie

American journal of pharmaceutical education

2019 Volume 83, Issue 6, Page(s) 6875

Abstract: Objective. ...

Abstract	Objective.
MeSH term(s)	Education, Pharmacy/statistics & numerical data ; Educational Measurement/statistics & numerical data ; Humans ; Internship and Residency/statistics & numerical data ; Licensure, Pharmacy/statistics & numerical data ; Linear Models ; Pharmaceutical Services ; Pharmacists/statistics & numerical data ; Pharmacy/statistics & numerical data ; Retrospective Studies ; Schools, Pharmacy/statistics & numerical data ; Students, Pharmacy/statistics & numerical data
Language	English
Publishing date	2019-08-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	603807-4
ISSN	1553-6467 ; 0002-9459
ISSN (online)	1553-6467
ISSN	0002-9459
DOI	10.5688/ajpe6875
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Article ; Online: Worsening racial disparity in waitlist mortality for pediatric heart transplant candidates since the 2016 Pediatric Heart Allocation Policy revision.

Wright, Lydia K / Gajarski, Robert J / Phelps, Christina / Hoffman, Timothy M / Lytrivi, Irene D / Magnetta, Defne A / Shaw, Fawwaz R / Thompson, Consuela / Weisert, Molly / Nandi, Deipanjan

Pediatric transplantation

2022 Volume 27, Issue 3, Page(s) e14412

Abstract: Background: The US Pediatric Heart Allocation Policy (PHAP) was revised in March 2016, with the goal of reducing waitlist mortality. We evaluated the hypothesis that these changes, which increased status exceptions, have worsened racial disparities in ... ...

Abstract	Background: The US Pediatric Heart Allocation Policy (PHAP) was revised in March 2016, with the goal of reducing waitlist mortality. We evaluated the hypothesis that these changes, which increased status exceptions, have worsened racial disparities in waitlist outcomes. Methods: Children in the Pediatric Heart Transplant Study database listed for first heart transplant from January 2012 - June 2020 were included and stratified by listing before (Era 1) or after (Era 2) the PHAP revision. Results: A total of 4,089 children were listed during the study period. Compared with white children (n = 2648), non-white children (n = 1441) were more likely to have an underlying diagnosis of cardiomyopathy in both eras. Waitlist mortality was similar in white and non-white children in Era 1, but comparatively worse for non-white children in Era 2. In multivariable analysis controlling for diagnosis, age, and severity markers, non-white children had a significantly higher waitlist mortality only in Era 2 (Era 1: sHR 1.22 [95%CI 0.90 - 1.66] vs. Era 2: sHR 1.57 [95%CI 1.17 - 2.10]). Conclusions: Widening racial disparities in waitlist mortality may be an unintended consequence of the 2016 PHAP revision. Additional analyses may inform the degree to which this policy vs. unrelated changes in care differentially contribute to these disparities.
MeSH term(s)	Humans ; Child ; Heart Transplantation ; Cardiomyopathies ; Waiting Lists ; Policy ; Retrospective Studies
Language	English
Publishing date	2022-11-03
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	1390284-2
ISSN	1399-3046 ; 1397-3142
ISSN (online)	1399-3046
ISSN	1397-3142
DOI	10.1111/petr.14412
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Article ; Online: Tricuspid Valve and Right Ventricular Function Throughout the Hybrid Palliation Strategy for Hypoplastic Left Heart Syndrome and Variants.

Carrillo, Sergio A / Texter, Karen M / Phelps, Christina / Tan, Yubo / McConnell, Patrick I / Galantowicz, Mark

World journal for pediatric & congenital heart surgery

2020 Volume 12, Issue 1, Page(s) 9–16

Abstract: Background: Tricuspid valve (TV) and right ventricular (RV) function are major determinants of morbidity and mortality in patients with hypoplastic left heart syndrome (HLHS). We sought to retrospectively evaluate these parameters throughout the hybrid ... ...

Abstract	Background: Tricuspid valve (TV) and right ventricular (RV) function are major determinants of morbidity and mortality in patients with hypoplastic left heart syndrome (HLHS). We sought to retrospectively evaluate these parameters throughout the hybrid palliation strategy. Methods: From 2002 to 2018, 203 patients with HLHS and variants presented for hybrid stage I (HS1). Echocardiographic evaluation of tricuspid regurgitation (TR) and RV function was assessed at multiple time points. Clinical outcomes including tricuspid valvuloplasty, transplantation, and death were reviewed. Results: The most prevalent HLHS subtype was aortic atresia/mitral atresia. The presence of significant TR and/or RV dysfunction was 14.78% and 9.36%, respectively, at the time of initial HS1. There were 185 survivors following HS1 (91.13%, n = 185/203), while 147 patients underwent comprehensive stage II or bidirectional Glenn shunt (72.41%, n = 147/203). Tricuspid valvuloplasty was undertaken in nine patients (4.86%, n = 9/185). Ultimately, 100 patients underwent the Fontan procedure. The odds of development of significant TR and/or RV dysfunction were not statistically different throughout the stages of palliation (TR: odds ratio [OR] = 0.14-0.25, Conclusion: Following hybrid palliation for HLHS, the majority of survivors have normal RV and TV functions. Tricuspid valvuloplasty was required in few patients. Once significant TR and/or RV dysfunction ensues, there is a two- to three-fold risk of death and/or transplant.
MeSH term(s)	Echocardiography/methods ; Female ; Fontan Procedure/methods ; Humans ; Hypoplastic Left Heart Syndrome/complications ; Hypoplastic Left Heart Syndrome/diagnosis ; Hypoplastic Left Heart Syndrome/surgery ; Infant, Newborn ; Male ; Palliative Care/methods ; Retrospective Studies ; Risk Factors ; Time Factors ; Tricuspid Valve/diagnostic imaging ; Tricuspid Valve/physiopathology ; Tricuspid Valve Insufficiency/diagnosis ; Tricuspid Valve Insufficiency/etiology ; Tricuspid Valve Insufficiency/physiopathology ; Ventricular Function, Right/physiology
Language	English
Publishing date	2020-08-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2550261-X
ISSN	2150-136X ; 2150-1351
ISSN (online)	2150-136X
ISSN	2150-1351
DOI	10.1177/2150135120947692
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Article: Real World Tracking of Modified Ride-On Car Usage in Young Children With Disabilities.

Logan, Samuel W / Hospodar, Christina M / Bogart, Kathleen R / Catena, Michele A / Feldner, Heather A / Fitzgerald, Jenna / Schaffer, Sarah / Sloane, Bethany / Phelps, Benjamin / Phelps, Joshua / Smart, William D

Journal of motor learning and development

2019 Volume 7, Issue 3, Page(s) 336–353

Abstract: Background: Go Baby Go is a community program that provides modified ride-on cars to young children with disabilities.: Aims: (1) To describe the real world modified ride-on car usage of young children with disabilities; (2) To compare subjectively ... ...

Abstract	Background: Go Baby Go is a community program that provides modified ride-on cars to young children with disabilities. Aims: (1) To describe the real world modified ride-on car usage of young children with disabilities; (2) To compare subjectively reported modified ride-on car usage recorded by parents with objectively reported usage based on electronic tracking data. Methods: 14 young children (1-3 years old) with disabilities used a modified ride-on car for three months. Results: On average, parent-reported activity log data indicated that children used the modified ride-on car for 17.8 minutes per session ( Conclusions: This study may inform future research studies and local chapters of the Go Baby Go community program.
Language	English
Publishing date	2019-02-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2711488-0
ISSN	2325-3215 ; 2325-3193
ISSN (online)	2325-3215
ISSN	2325-3193
DOI	10.1123/jmld.2019-0015
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Article ; Online: Pediatric marginal donor hearts: Trends in US national use, 2005-2014.

Morrison, Adam K / Gowda, Charitha / Tumin, Dmitry / Phelps, Christina M / Hayes, Don / Tobias, Joseph / Gajarski, Robert J / Nandi, Deipanjan

Pediatric transplantation

2018 Volume 22, Issue 5, Page(s) e13216

Abstract: ... and eGFR < 30 mL/min/1.73 m ...

Abstract	Pediatric patients awaiting heart transplant face high mortality rates due to donor organ shortages, including non-use of marginal donor hearts. We examined national trends in pediatric marginal donor heart use over time. UNOS data were queried for heart donors <18 years from 2005 to 2014. The proportion of donor hearts considered marginal was determined using previously cited marginal characteristics: left ventricular ejection fraction (LVEF) <50%, use of ≥2 inotropes, cerebrovascular death, CDC high-risk status, and eGFR < 30 mL/min/1.73 m
MeSH term(s)	Adolescent ; Child ; Child, Preschool ; Donor Selection/standards ; Donor Selection/statistics & numerical data ; Donor Selection/trends ; Female ; Heart Transplantation ; Humans ; Infant ; Infant, Newborn ; Male ; Registries ; Retrospective Studies ; Tissue Donors/supply & distribution ; United States
Language	English
Publishing date	2018-05-17
Publishing country	Denmark
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	1390284-2
ISSN	1399-3046 ; 1397-3142
ISSN (online)	1399-3046
ISSN	1397-3142
DOI	10.1111/petr.13216
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Article: Data-driven computational models of ventricular-arterial hemodynamics in pediatric pulmonary arterial hypertension.

Tossas-Betancourt, Christopher / Li, Nathan Y / Shavik, Sheikh M / Afton, Katherine / Beckman, Brian / Whiteside, Wendy / Olive, Mary K / Lim, Heang M / Lu, Jimmy C / Phelps, Christina M / Gajarski, Robert J / Lee, Simon / Nordsletten, David A / Grifka, Ronald G / Dorfman, Adam L / Baek, Seungik / Lee, Lik Chuan / Figueroa, C Alberto

Frontiers in physiology

2022 Volume 13, Page(s) 958734

Abstract: Pulmonary arterial hypertension (PAH) is a complex disease involving increased resistance in the pulmonary arteries and subsequent right ventricular (RV) remodeling. Ventricular-arterial interactions are fundamental to PAH pathophysiology but are rarely ... ...

Abstract	Pulmonary arterial hypertension (PAH) is a complex disease involving increased resistance in the pulmonary arteries and subsequent right ventricular (RV) remodeling. Ventricular-arterial interactions are fundamental to PAH pathophysiology but are rarely captured in computational models. It is important to identify metrics that capture and quantify these interactions to inform our understanding of this disease as well as potentially facilitate patient stratification. Towards this end, we developed and calibrated two multi-scale high-resolution closed-loop computational models using open-source software: a high-resolution arterial model implemented using CRIMSON, and a high-resolution ventricular model implemented using FEniCS. Models were constructed with clinical data including non-invasive imaging and invasive hemodynamic measurements from a cohort of pediatric PAH patients. A contribution of this work is the discussion of inconsistencies in anatomical and hemodynamic data routinely acquired in PAH patients. We proposed and implemented strategies to mitigate these inconsistencies, and subsequently use this data to inform and calibrate computational models of the ventricles and large arteries. Computational models based on adjusted clinical data were calibrated until the simulated results for the high-resolution arterial models matched within 10% of adjusted data consisting of pressure and flow, whereas the high-resolution ventricular models were calibrated until simulation results matched adjusted data of volume and pressure waveforms within 10%. A statistical analysis was performed to correlate numerous data-derived and model-derived metrics with clinically assessed disease severity. Several model-derived metrics were strongly correlated with clinically assessed disease severity, suggesting that computational models may aid in assessing PAH severity.
Language	English
Publishing date	2022-09-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2022.958734
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Article: The Impact of Nutritional Supplementation on Sweat Metabolomic Content: A Proof-of-Concept Study.

Harshman, Sean W / Browder, Andrew B / Davidson, Christina N / Pitsch, Rhonda L / Strayer, Kraig E / Schaeublin, Nicole M / Phelps, Mandy S / O'Connor, Maegan L / Mackowski, Nicholas S / Barrett, Kristyn N / Eckerle, Jason J / Strang, Adam J / Martin, Jennifer A

Frontiers in chemistry

2021 Volume 9, Page(s) 659583

Abstract: Sweat is emerging as a prominent biosource for real-time human performance monitoring applications. Although promising, sources of variability must be identified to truly utilize sweat for biomarker applications. In this proof-of-concept study, a ... ...

Abstract	Sweat is emerging as a prominent biosource for real-time human performance monitoring applications. Although promising, sources of variability must be identified to truly utilize sweat for biomarker applications. In this proof-of-concept study, a targeted metabolomics method was applied to sweat collected from the forearms of participants in a 12-week exercise program who ingested either low or high nutritional supplementation twice daily. The data establish the use of dried powder mass as a method for metabolomic data normalization from sweat samples. Additionally, the results support the hypothesis that ingestion of regular nutritional supplementation semi-quantitatively impact the sweat metabolome. For example, a receiver operating characteristic (ROC) curve of relative normalized metabolite quantities show an area under the curve of 0.82 suggesting the sweat metabolome can moderately predict if an individual is taking nutritional supplementation. Finally, a significant correlation between physical performance and the sweat metabolome are established. For instance, the data illustrate that by utilizing multiple linear regression modeling approaches, sweat metabolite quantities can predict VO
Language	English
Publishing date	2021-05-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711776-5
ISSN	2296-2646
ISSN	2296-2646
DOI	10.3389/fchem.2021.659583
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Article ; Online: Interstage outcomes in single ventricle patients undergoing hybrid stage 1 palliation.

Simsic, Janet M / Phelps, Christina / Kirchner, Kristin / Carpenito, Kirby-Rose / Allen, Robin / Miller-Tate, Holly / Texter, Karen / Galantowicz, Mark

Congenital heart disease

2018 Volume 13, Issue 5, Page(s) 757–763

Abstract: Objective: Interstage readmissions are common in infants with single ventricle congenital heart disease undergoing staged surgical palliation. We retrospectively examined readmissions during the interstage period.: Design: Retrospective analysis.: ... ...

Abstract	Objective: Interstage readmissions are common in infants with single ventricle congenital heart disease undergoing staged surgical palliation. We retrospectively examined readmissions during the interstage period. Design: Retrospective analysis. Setting: The Heart Center at Nationwide Children's Hospital, Columbus, Ohio. Patients: Newborns undergoing hybrid stage 1 palliation from January 2012 to December 2016 who survived to hospital discharge and were followed at our institution. Interventions: All patients underwent hybrid stage 1 palliation. Outcome measures: Outcomes included (1) reason for interstage readmission; (2) feeding modality during interstage period; (3) major interstage adverse events; and (4) interstage mortality. Results: Study group comprised 57 patients. Five patients only admitted once during the interstage period for scheduled cardiac catheterization were included in the no readmission group. Therefore, 43 patients (75%) had a total of 87 interstage readmissions. Fourteen patients had 15 major interstage adverse events accounting for 17% of total readmissions. Stroke (n = 1); sepsis (n = 1); pericardial effusion requiring drainage (n = 1); mesenteric ischemia (n = 1); shock (n = 1); and cardiac catheterization requiring intervention (n = 11)-ductal stent balloon angioplasty (n = 3), enlargement of atrial septal defect/stent placement (n = 3), retrograde aortic arch stenosis (n = 4). Thirty-three readmissions were secondary to gastrointestinal/feeding issues; 15 cyanosis; 15 work of breathing; and 9 asymptomatic patients. Four patients suffered interstage deaths (7%). Five patients (9%) spent >30 days in the hospital during the interstage period. Of the 47 newborns (82%) discharged exclusively orally feeding, 74% remained all orally feeding throughout interstage period. No patient discharged with tube feedings learned to eat during the interstage period. Conclusion: Interstage readmissions are common in the hybrid patient population. Seventeen percent were secondary to major adverse events. Interstage mortality was 7%. Future studies to identify interventions aimed at decreasing feeding issues and viral bronchiolitis in this tenuous patient population will hopefully improve quality outcomes, reduce readmissions, and lessen health care costs.
MeSH term(s)	Female ; Heart Defects, Congenital/diagnosis ; Heart Defects, Congenital/surgery ; Heart Ventricles/abnormalities ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/surgery ; Humans ; Incidence ; Infant ; Infant, Newborn ; Male ; Norwood Procedures/methods ; Ohio/epidemiology ; Palliative Care/methods ; Patient Readmission/trends ; Postoperative Complications/epidemiology ; Quality Improvement ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2018-07-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2274321-2
ISSN	1747-0803 ; 1747-079X
ISSN (online)	1747-0803
ISSN	1747-079X
DOI	10.1111/chd.12649
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Article ; Online: Rate normalization for sweat metabolomics biomarker discovery.

Harshman, Sean W / Strayer, Kraig E / Davidson, Christina N / Pitsch, Rhonda L / Narayanan, Latha / Scott, Alexander M / Schaeublin, Nicole M / Wiens, Taylor L / Phelps, Mandy S / O'Connor, Maegan L / Mackowski, Nicholas S / Barrett, Kristyn N / Leyh, Samantha M / Eckerle, Jason J / Strang, Adam J / Martin, Jennifer A

Talanta

2020 Volume 223, Issue Pt 1, Page(s) 121797

Abstract: As the demand for real-time exercise performance feedback increases, excreted sweat has become a biosource of interest for continuous human performance assessment. For sweat to truly fulfill this requirement, analyte concentrations must be normalized to ... ...

Abstract	As the demand for real-time exercise performance feedback increases, excreted sweat has become a biosource of interest for continuous human performance assessment. For sweat to truly fulfill this requirement, analyte concentrations must be normalized to adequately assess day-to-day differences within and among individuals. In this manuscript, data are presented highlighting the use of accurate localized sweat rate as a means for ion and global metabolomic data normalization. The results illustrate large sweat rate variability among individuals over the course of two distinct exercises protocols. Furthermore, the data show sweat rate is not symmetrical at similar locations among right and left forearms of individuals (p = 0.0007). Sweat ion conductivity analysis suggest overall sweat rate normalization reduces variability collectively among ion values and participants with principal component analysis showing 77.8% of variation in the data set attributable to sweat rate normalization. Global metabolomic analysis of sweat illustrated overall rate normalization increases the variability among test subjects with 72.7% of the variation explained by sweat rate normalization. Finally, overall rate normalized metabolomic features of sweat significantly correlated (ρ ≥ 0.7, ρ ≤ -0.7) with measured performance metrics of the individual, establishing the potential for sweat to be used as a biosource for performance monitoring. Collectively, these data illustrate the importance of accurate localized sweat rate determination, for analyte data normalization, in support for the use of sweat in biomarker discovery efforts to predict human performance.
MeSH term(s)	Biomarkers ; Exercise ; Humans ; Metabolomics ; Principal Component Analysis ; Sweat
Chemical Substances	Biomarkers
Language	English
Publishing date	2020-10-27
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500969-5
ISSN	1873-3573 ; 0039-9140
ISSN (online)	1873-3573
ISSN	0039-9140
DOI	10.1016/j.talanta.2020.121797
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