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Article ; Online: The tumor microenvironment drives NK cell metabolic dysfunction leading to impaired antitumor activity.

Tumino, Nicola / Nava Lauson, Carina B / Tiberti, Silvia / Besi, Francesca / Martini, Stefania / Fiore, Piera Filomena / Scodamaglia, Francesca / Mingari, Maria Cristina / Moretta, Lorenzo / Manzo, Teresa / Vacca, Paola

International journal of cancer

2022 Volume 152, Issue 8, Page(s) 1698–1706

Abstract: NK cells represent key players capable of driving antitumor immune responses. However, the potent immunosuppressive activity of the tumor microenvironment (TME) may impair their effector function. Here, we strengthen the importance of metabolic ... ...

Abstract	NK cells represent key players capable of driving antitumor immune responses. However, the potent immunosuppressive activity of the tumor microenvironment (TME) may impair their effector function. Here, we strengthen the importance of metabolic interactions between NK cells and TME and propose metabolic dysfunction as one of the major mechanisms behind NK failure in cancer treatment. In particular, we described that TME has a direct negative impact on NK cell function by disrupting their mitochondrial integrity and function in pediatric and adult patients with primary and metastatic cancer. Our results will help to design new strategies aimed at increasing the NK cell antitumor efficacy by their metabolic reprogramming. In this regard, we reveal an unprecedented role of IL15 in the metabolic reprogramming of NK cells enhancing their antitumor functions. IL15 prevents the inhibitory effect of soluble factors present in TME and restores both the metabolic characteristics and the effector function of NK cells inhibited by exposure to malignant pleural fluid. Thus, we propose here that IL15 may be exploited as a new strategy to metabolically reprogram NK cells with the aim of increasing the efficacy of NK-based immunotherapy in a wide range of currently refractory adult and pediatric solid tumors.
MeSH term(s)	Adult ; Humans ; Child ; Tumor Microenvironment ; Interleukin-15/metabolism ; Killer Cells, Natural ; Neoplasms/metabolism ; Immunotherapy/methods
Chemical Substances	Interleukin-15
Language	English
Publishing date	2022-12-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218257-9
ISSN	1097-0215 ; 0020-7136
ISSN (online)	1097-0215
ISSN	0020-7136
DOI	10.1002/ijc.34389
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Zs.A 478: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 576: Show issues

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Article ; Online: Thermal Comfort in School Classes in the Era of Global Warming: A Prospective Multicenter Study.

Golshan, Taylor / Lande, Sarah / Nickfardjam, Kaitlyn / Cohensedgh, Sabrina / Roitblat, Yulia / Nehuliaieva, Liliia / Khabie, David / Stillman, Ruby / Volynsky-Lauson, Anna / Mametov, Kadri / Shterenshis, Michael

The Journal of school health

2021 Volume 91, Issue 2, Page(s) 146–154

Abstract: Background: We investigated adolescents' feelings of thermal comfort during the educational process in various geographical locations far apart and present recommendations for the adjustment of the thermal environment in schools.: Methods: The ... ...

Abstract	Background: We investigated adolescents' feelings of thermal comfort during the educational process in various geographical locations far apart and present recommendations for the adjustment of the thermal environment in schools. Methods: The prospective international multicenter study took place in 8 locations on different continents. The survey in the form of a questionnaire was carried out among 2800 healthy high school students. The study was divided into "cold season survey," "warm-season survey," and heat wave survey. Results: The statistically significant difference between the "cold season survey" score of 4.04 (discomfort) and "warm-season survey" score of 3.47 (slight discomfort) (p = .04) indicates that students feel more thermal discomfort during winter months in all 8 locations. The heat wave survey score was 4.53 (discomfort). During the cold season, 29.24% of high school students felt themselves in full thermal comfort and 76.48% of the students felt themselves relatively comfortable (slightly cool-comfortable-slightly warm). Conclusions: Even during the ongoing process of climate change, the cold season discomfort remains the main problem for students in classes. This tendency is present in different continents as a universal problem. We recommend keeping an entrance hall and classroom temperatures at different levels and to advise students about proper clothing.
MeSH term(s)	Adolescent ; Global Warming ; Humans ; Prospective Studies ; Schools ; Seasons ; Temperature
Language	English
Publishing date	2021-01-06
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	952835-0
ISSN	1746-1561 ; 0022-4391
ISSN (online)	1746-1561
ISSN	0022-4391
DOI	10.1111/josh.12986
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Article ; Online: Cardiac arrest in a mother and daughter and the identification of a novel RYR2 variant, predisposing to low penetrant catecholaminergic polymorphic ventricular tachycardia in a four-generation Canadian family.

Tung, Matthew / Van Petegem, Filip / Lauson, Samantha / Collier, Ashley / Hodgkinson, Kathy / Fernandez, Bridget / Connors, Sean / Leather, Rick / Sanatani, Shubhayan / Arbour, Laura

Molecular genetics & genomic medicine

2020 Volume 8, Issue 4, Page(s) e1151

Abstract: Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare inherited arrhythmia syndrome characterized by adrenergically driven ventricular arrhythmia predominantly caused by pathogenic variants in the cardiac ryanodine receptor ( ...

Abstract	Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare inherited arrhythmia syndrome characterized by adrenergically driven ventricular arrhythmia predominantly caused by pathogenic variants in the cardiac ryanodine receptor (RyR2). We describe a novel variant associated with cardiac arrest in a mother and daughter. Methods: Initial sequencing of the RYR2 gene identified a novel variant (c.527G > T, p.R176L) in the index case (the mother), and her daughter. Structural analysis demonstrated the variant was located within the N-terminal domain of RyR2, likely leading to a gain-of-function effect facilitating enhanced calcium ion release. Four generation cascade genetic and clinical screening was carried out. Results: Thirty-eight p.R176L variant carriers were identified of 94 family members with genetic testing, and 108 family members had clinical evaluations. Twelve carriers were symptomatic with previous syncope and 2 additional survivors of cardiac arrest were identified. Thirty-two had clinical features suggestive of CPVT. Of 52 noncarriers, 11 had experienced previous syncope with none exhibiting any clinical features of CPVT. A documented arrhythmic event rate of 2.89/1000 person-years across all carriers was calculated. Conclusion: The substantial variability in phenotype and the lower than previously reported penetrance is illustrative of the importance of exploring family variants beyond first-degree relatives.
MeSH term(s)	Adult ; Female ; Gain of Function Mutation ; Heart Arrest/diagnosis ; Heart Arrest/genetics ; Humans ; Male ; Pedigree ; Penetrance ; Protein Domains ; Ryanodine Receptor Calcium Release Channel/chemistry ; Ryanodine Receptor Calcium Release Channel/genetics ; Tachycardia, Ventricular/diagnosis ; Tachycardia, Ventricular/genetics
Chemical Substances	RyR2 protein, human ; Ryanodine Receptor Calcium Release Channel
Language	English
Publishing date	2020-01-28
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2734884-2
ISSN	2324-9269 ; 2324-9269
ISSN (online)	2324-9269
ISSN	2324-9269
DOI	10.1002/mgg3.1151
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Article ; Online: Linoleic acid potentiates CD8

Nava Lauson, Carina B / Tiberti, Silvia / Corsetto, Paola A / Conte, Federica / Tyagi, Punit / Machwirth, Markus / Ebert, Stefan / Loffreda, Alessia / Scheller, Lukas / Sheta, Dalia / Mokhtari, Zeinab / Peters, Timo / Raman, Ayush T / Greco, Francesco / Rizzo, Angela M / Beilhack, Andreas / Signore, Giovanni / Tumino, Nicola / Vacca, Paola /

McDonnell, Liam A / Raimondi, Andrea / Greenberg, Philip D / Huppa, Johannes B / Cardaci, Simone / Caruana, Ignazio / Rodighiero, Simona / Nezi, Luigi / Manzo, Teresa

Cell metabolism

2023 Volume 35, Issue 4, Page(s) 633–650.e9

Abstract: The metabolic state represents a major hurdle for an effective adoptive T cell therapy (ACT). Indeed, specific lipids can harm ... ...

Abstract	The metabolic state represents a major hurdle for an effective adoptive T cell therapy (ACT). Indeed, specific lipids can harm CD8
MeSH term(s)	Linoleic Acid/metabolism ; CD8-Positive T-Lymphocytes ; Signal Transduction
Chemical Substances	Linoleic Acid (9KJL21T0QJ)
Language	English
Publishing date	2023-03-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2176834-1
ISSN	1932-7420 ; 1550-4131
ISSN (online)	1932-7420
ISSN	1550-4131
DOI	10.1016/j.cmet.2023.02.013
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Article ; Online: Outcome of prenatally diagnosed isolated clubfoot.

Lauson, S / Alvarez, C / Patel, M S / Langlois, S

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology

2010 Volume 35, Issue 6, Page(s) 708–714

Abstract: Objectives: To analyze the aneuploidy risk and treatment outcome of prenatally diagnosed isolated clubfoot, to determine the false-positive rate (FPR) of ultrasound diagnosis and to calculate the risk of diagnostic revision to complex clubfoot.: ... ...

Abstract	Objectives: To analyze the aneuploidy risk and treatment outcome of prenatally diagnosed isolated clubfoot, to determine the false-positive rate (FPR) of ultrasound diagnosis and to calculate the risk of diagnostic revision to complex clubfoot. Methods: By chart review, 65 patients were retrospectively ascertained to have unilateral or bilateral clubfeet diagnosed prenatally. We calculated the rates of false positives, aneuploidy and diagnostic revision to complex clubfoot, and used an ad hoc scoring system to determine orthopedic outcome. Published rates of aneuploidy were pooled and evaluated. Results: Prenatally diagnosed isolated clubfoot FPR (defined as 1 - positive predictive value) was 10.5% (95% CI, 5.8-18%) (calculated per foot). After a minimum of 1-year postnatal follow-up, 13% (95% CI, 6-26%) of patients had revised diagnoses of complex clubfoot. No patients had aneuploidy identified by cytogenetic analysis or clinical assessment. Of the 34 patients with 2-year postnatal follow-up, 76.5% were treated with serial casting with or without Botox. All children with isolated clubfoot were walking and had an average outcome score of 'very good' to 'excellent'. Conclusions: When counseling women regarding prenatally diagnosed isolated clubfoot, it is important to tell them that approximately 10% of individuals will have a normal foot or positional foot deformity requiring minimal treatment. Conversely, 10-13% of prenatally diagnosed cases of isolated clubfoot will have complex clubfoot postnatally, based on the finding of additional structural or neurodevelopmental abnormalities. Although this study did not identify an increased risk of fetal aneuploidy associated with isolated clubfoot, a review of the literature indicates a risk of 1.7-3.6% with predominance of sex chromosome aneuploidy.
MeSH term(s)	Adolescent ; Aneuploidy ; Child ; Clubfoot/diagnostic imaging ; Clubfoot/genetics ; Clubfoot/psychology ; Counseling/methods ; False Positive Reactions ; Female ; Humans ; Infant, Newborn ; Male ; Parents/psychology ; Pregnancy ; Retrospective Studies ; Ultrasonography, Prenatal ; Young Adult
Language	English
Publishing date	2010-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1073183-0
ISSN	1469-0705 ; 0960-7692
ISSN (online)	1469-0705
ISSN	0960-7692
DOI	10.1002/uog.7558
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Zs.A 3214: Show issues

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Article ; Online: GZMK

Tiberti, Silvia / Catozzi, Carlotta / Croci, Ottavio / Ballerini, Mattia / Cagnina, Danilo / Soriani, Chiara / Scirgolea, Caterina / Gong, Zheng / He, Jiatai / Macandog, Angeli D / Nabinejad, Amir / Nava Lauson, Carina B / Quinte', Arianna / Bertalot, Giovanni / Petz, Wanda L / Ravenda, Simona P / Licursi, Valerio / Paci, Paola / Rasponi, Marco /

Rotta, Luca / Fazio, Nicola / Ren, Guangwen / Fumagalli-Romario, Uberto / Schaefer, Martin H / Campaner, Stefano / Lugli, Enrico / Nezi, Luigi / Manzo, Teresa

Nature communications

2022 Volume 13, Issue 1, Page(s) 6752

Abstract: ... ...

Abstract	CD8
MeSH term(s)	Humans ; CD8-Positive T-Lymphocytes ; Neutrophils ; Colorectal Neoplasms/pathology ; Lymphocytes, Tumor-Infiltrating
Language	English
Publishing date	2022-11-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-022-34467-3
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Article ; Online: Author Correction: GZMK

Rotta, Luca / Fazio, Nicola / Ren, Guangwen / Fumagalli-Romario, Uberto / Schaefer, Martin H / Campaner, Stefano / Lugli, Enrico / Nezi, Luigi / Manzo, Teresa

Nature communications

2022 Volume 13, Issue 1, Page(s) 7380

Language	English
Publishing date	2022-11-30
Publishing country	England
Document type	Published Erratum
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-022-35251-z
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Article ; Online: Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8+ T cells.

Manzo, Teresa / Prentice, Boone M / Anderson, Kristin G / Raman, Ayush / Schalck, Aislyn / Codreanu, Gabriela S / Nava Lauson, Carina B / Tiberti, Silvia / Raimondi, Andrea / Jones, Marissa A / Reyzer, Michelle / Bates, Breanna M / Spraggins, Jeffrey M / Patterson, Nathan H / McLean, John A / Rai, Kunal / Tacchetti, Carlo / Tucci, Sara / Wargo, Jennifer A /

Rodighiero, Simona / Clise-Dwyer, Karen / Sherrod, Stacy D / Kim, Michael / Navin, Nicholas E / Caprioli, Richard M / Greenberg, Philip D / Draetta, Giulio / Nezi, Luigi

The Journal of experimental medicine

2020 Volume 217, Issue 8

Abstract: CD8+ T cells are master effectors of antitumor immunity, and their presence at tumor sites correlates with favorable outcomes. However, metabolic constraints imposed by the tumor microenvironment (TME) can dampen their ability to control tumor ... ...

Abstract	CD8+ T cells are master effectors of antitumor immunity, and their presence at tumor sites correlates with favorable outcomes. However, metabolic constraints imposed by the tumor microenvironment (TME) can dampen their ability to control tumor progression. We describe lipid accumulation in the TME areas of pancreatic ductal adenocarcinoma (PDA) populated by CD8+ T cells infiltrating both murine and human tumors. In this lipid-rich but otherwise nutrient-poor TME, access to using lipid metabolism becomes particularly valuable for sustaining cell functions. Here, we found that intrapancreatic CD8+ T cells progressively accumulate specific long-chain fatty acids (LCFAs), which, rather than provide a fuel source, impair their mitochondrial function and trigger major transcriptional reprogramming of pathways involved in lipid metabolism, with the subsequent reduction of fatty acid catabolism. In particular, intrapancreatic CD8+ T cells specifically exhibit down-regulation of the very-long-chain acyl-CoA dehydrogenase (VLCAD) enzyme, which exacerbates accumulation of LCFAs and very-long-chain fatty acids (VLCFAs) that mediate lipotoxicity. Metabolic reprogramming of tumor-specific T cells through enforced expression of ACADVL enabled enhanced intratumoral T cell survival and persistence in an engineered mouse model of PDA, overcoming one of the major hurdles to immunotherapy for PDA.
MeSH term(s)	Acyl-CoA Dehydrogenase, Long-Chain/biosynthesis ; Acyl-CoA Dehydrogenase, Long-Chain/genetics ; Animals ; CD8-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/pathology ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/metabolism ; Carcinoma, Pancreatic Ductal/pathology ; Down-Regulation ; Fatty Acids/genetics ; Fatty Acids/metabolism ; Gene Expression Regulation, Enzymologic ; Gene Expression Regulation, Neoplastic ; Lymphocytes, Tumor-Infiltrating/metabolism ; Lymphocytes, Tumor-Infiltrating/pathology ; Mice ; Mice, Mutant Strains ; Neoplasm Proteins/biosynthesis ; Neoplasm Proteins/genetics ; Pancreas/metabolism ; Pancreas/pathology ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/pathology ; Tumor Microenvironment
Chemical Substances	Fatty Acids ; Neoplasm Proteins ; Acyl-CoA Dehydrogenase, Long-Chain (EC 1.3.8.8)
Language	English
Publishing date	2020-06-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	218343-2
ISSN	1540-9538 ; 0022-1007
ISSN (online)	1540-9538
ISSN	0022-1007
DOI	10.1084/jem.20191920
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Ua VI Zs.107: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: The development of a comprehensive maternal-child health information system for Nunavut-Nutaqqavut (Our Children).

Lauson, Samantha / McIntosh, Sarah / Obed, Natan / Healey, Gwen / Asuri, Sirisha / Osborne, Geraldine / Arbour, Laura

International journal of circumpolar health

2011 Volume 70, Issue 4, Page(s) 363–372

Abstract: Objectives: Nunavut is the most northerly jurisdiction in Canada of which 85% of inhabitants are Inuit. Although most infants are born healthy, Nunavut leads the country for adverse early child health outcomes such as infant mortality, rates of birth ... ...

Abstract	Objectives: Nunavut is the most northerly jurisdiction in Canada of which 85% of inhabitants are Inuit. Although most infants are born healthy, Nunavut leads the country for adverse early child health outcomes such as infant mortality, rates of birth defects, prematurity and low birth weight. Public health and community efforts are needed to understand and improve outcomes. Methods: To inform these issues, a combined University of British Columbia/Nunavut Public Health Strategy effort has initiated a comprehensive maternal-child health surveillance system (from 16 weeks gestation to age 5). A diverse group of professional and lay stakeholders were brought together initially to determine local interest. Following this, a series of small working groups were held to decide on potential prenatal, perinatal and early child health variables, to be documented. Results: Over 100 Nunavut participants have now had some role in the development of the system which has been initiated. Pre-existing standard prenatal forms and well-child assessment forms have been modified to include "Nunavut specific" variables of nutrition, food and domestic security, exposures in pregnancy, birth defects, development, chronic diseases of childhood and paternal information. Conclusion: This comprehensive maternal-child health information system has been developed with the extensive input of health care providers and stakeholders, utilizing community and public health systems already in place. Careful assessment of local needs has contributed to database development, privacy protection, potential data utilization for health promotion and plans for dissemination of findings. It is hoped that this will be a user-friendly surveillance system, adaptable to other community and public health systems that will improve the understanding of Aboriginal maternal-child health determinants.
MeSH term(s)	Child ; Child Welfare ; Consumer Health Information/methods ; Female ; Humans ; Information Services/organization & administration ; Maternal Welfare ; Nunavut ; Population Surveillance ; Pregnancy ; Pregnancy Complications/prevention & control ; Preventive Health Services/organization & administration
Language	English
Publishing date	2011-09-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1386707-6
ISSN	2242-3982 ; 1239-9736
ISSN (online)	2242-3982
ISSN	1239-9736
DOI	10.3402/ijch.v70i4.17840
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Article: Ectopic expression of a conifer Abscisic Acid Insensitive3 transcription factor induces high-level synthesis of recombinant human alpha-L-iduronidase in transgenic tobacco leaves.

Kermode, Allison R / Zeng, Ying / Hu, Xiaoke / Lauson, Samantha / Abrams, Suzanne R / He, Xu

Plant molecular biology

2007 Volume 63, Issue 6, Page(s) 763–776

Abstract: ... particularly in the presence of 150-200 microM S-(+)-ABA. Synthesis of human IDUA containing a carboxy-terminal ... gene. As compared to the natural S-(+)-ABA, two persistent ABA analogues, (+)-8' acetylene ABA and ...

Abstract	We are examining various plant-based systems to produce enzymes for the treatment of human lysosomal storage disorders. Constitutive expression of the gene encoding the human lysosomal enzyme, alpha-L-iduronidase (IDUA; EC 3.2.1.76) in leaves of transgenic tobacco plants resulted in low-enzyme activity, and the protein appeared to be subject to proteolysis. Toward enhancing production of this recombinant enzyme in vegetative tissues, transgenic tobacco plants were generated to co-express a CaMV35S:Chamaecyparis nootkatensis Abscisic Acid Insensitive3 (CnABI3) gene construct, along with the human gene construct. The latter contained regulatory sequences of the Phaseolus vulgaris arcelin 5-I gene (5'-flanking, signal-peptide-encoding, and 3'-flanking regions). Ectopic synthesis of the CnABI3 protein led to the transactivation of the arcelin promoter and accordingly high activity (e.g., 25,000 pmol/min/mg total soluble protein) and levels of recombinant IDUA mRNA and protein were induced in leaves of transgenic tobacco, particularly in the presence of 150-200 microM S-(+)-ABA. Synthesis of human IDUA containing a carboxy-terminal ER retention (SEKDEL) sequence was also inducible by ABA in leaves co-transformed with the CnABI3 gene. As compared to the natural S-(+)-ABA, two persistent ABA analogues, (+)-8' acetylene ABA and (+)-8'methylene ABA, led to greater levels of beta-glucuronidase (GUS) reporter activities in leaves co-expressing the CnABI3 gene and a vicilin:GUS chimeric gene. In contrast, (+)-8' acetylene ABA and natural ABA appeared to be equally effective in stimulating the CnABI3-induced expression of an arcelin:GUS gene, and of the human IDUA gene, the latter also driven by arcelin-gene-regulatory sequences. Various stress-related treatments, particularly high concentrations of NaCl, had an even greater effect than ABA in promoting accumulation of human IDUA in co-transformed tobacco leaves. This strategy provides the means of enhancing the yields of recombinant proteins in transgenic plant vegetative tissues and potentially in cultured plant cells. The human recombinant protein can be readily induced in the presence of chemicals such as NaCl that can be added to cell cultures or even whole plants without a significant increase in production costs.
MeSH term(s)	Abscisic Acid/pharmacology ; Blotting, Northern ; Blotting, Western ; Chamaecyparis/genetics ; Gene Expression Regulation, Plant/drug effects ; Humans ; Iduronidase/genetics ; Iduronidase/metabolism ; Plant Growth Regulators/pharmacology ; Plant Leaves/genetics ; Plant Leaves/metabolism ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Plants, Genetically Modified ; Promoter Regions, Genetic/genetics ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Sodium Chloride/pharmacology ; Nicotiana/genetics ; Nicotiana/metabolism
Chemical Substances	Plant Growth Regulators ; Plant Proteins ; Recombinant Fusion Proteins ; Sodium Chloride (451W47IQ8X) ; Abscisic Acid (72S9A8J5GW) ; Iduronidase (EC 3.2.1.76)
Language	English
Publishing date	2007-01-04
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	778032-1
ISSN	1573-5028 ; 0167-4412
ISSN (online)	1573-5028
ISSN	0167-4412
DOI	10.1007/s11103-006-9122-y
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