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  1. Article: Probing long-lived radioactive isotopes on the double-logarithmic Segrè chart.

    Shang, Haitao

    Frontiers in chemistry

    2024  Volume 12, Page(s) 1057928

    Abstract: Isotopes have been widely applied in a variety of scientific subjects; many aspects of isotopes, however, remain not well understood. In this study, I investigate the relation between the number of neutrons ( ...

    Abstract Isotopes have been widely applied in a variety of scientific subjects; many aspects of isotopes, however, remain not well understood. In this study, I investigate the relation between the number of neutrons (
    Language English
    Publishing date 2024-02-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711776-5
    ISSN 2296-2646
    ISSN 2296-2646
    DOI 10.3389/fchem.2024.1057928
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Scaling laws in the evolutionary processes of marine animals over the last 540 million years

    Haitao Shang

    Geosystems and Geoenvironment, Vol 3, Iss 1, Pp 100242- (2024)

    1481  

    Abstract: Scaling laws are ubiquitous in modern biological systems. However, whether such patterns existed in deep-time biological systems is less investigated; the best-known example is the scaling law between the frequency and size of extinction events. Here, I ... ...

    Abstract Scaling laws are ubiquitous in modern biological systems. However, whether such patterns existed in deep-time biological systems is less investigated; the best-known example is the scaling law between the frequency and size of extinction events. Here, I show that the variation rates of biodiversity, origination intensity, extinction intensity, and body size of marine animals during the last 540 million years exhibited scaling laws. I then derive a general form of these scaling laws from a conceptual model with some principles of thermodynamics and assumptions about the global biological system. The results in this study suggest that the scaling laws systematically appearing in the biological metrics characterizing different aspects of the evolutionary processes of marine animals likely belong to the same universality class and probably derived from a set of common factors.
    Keywords Scaling law ; Variation rate ; Marine animals ; Phanerozoic Eon ; Evolutionary processes ; Biodiversity ; Physical geography ; GB3-5030
    Subject code 612
    Language English
    Publishing date 2024-02-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: A generic hierarchical model of organic matter degradation and preservation in aquatic systems

    Haitao Shang

    Communications Earth & Environment, Vol 4, Iss 1, Pp 1-

    2023  Volume 10

    Abstract: Organic matter in aquatic systems is broken down in a hierarchical ensemble, involving a decrease in effective kinetic barriers, according to a mechanistic model using decay kinetics that predicts degradation and preservation characteristics consistent ... ...

    Abstract Organic matter in aquatic systems is broken down in a hierarchical ensemble, involving a decrease in effective kinetic barriers, according to a mechanistic model using decay kinetics that predicts degradation and preservation characteristics consistent with observations.
    Keywords Geology ; QE1-996.5 ; Environmental sciences ; GE1-350
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Dichotomous effects of oxidative metabolisms: A theoretical perspective on the dolomite problem

    Shang, Haitao

    Global and Planetary Change. 2023 Mar., v. 222 p.104041-

    2023  

    Abstract: The dolomite problem, which refers to the high abundance of dolomite in ancient geologic records in contrast to its scarcity in modern sediments, has been a century-long enigma in Earth science. Here I propose an explanation: the formation of carboxyl- ... ...

    Abstract The dolomite problem, which refers to the high abundance of dolomite in ancient geologic records in contrast to its scarcity in modern sediments, has been a century-long enigma in Earth science. Here I propose an explanation: the formation of carboxyl-rich oxidative metabolites (CROMs), which play a crucial role in dolomite precipitation, was favored by Earth’s ancient oxygen-limiting environments but is inhibited under the modern oxygen-rich conditions. I first suggest the CROM hypothesis via a conceptual model, which predicts the dichotomous effects of oxidative metabolisms on dolomite production. I then reconstruct the evolutionary history of one representative CROM-producing enzyme family to test the hypothesis and show the temporal correlation between the variation in dolomite abundance on Earth’s surface and the diversification of this enzyme family over geologic time. These results together suggest that the dolomite problem is a consequence of the intertwined environmental changes and biological evolution.
    Keywords dolomite ; enzymes ; evolution ; metabolites ; models ; Dolomite problem ; Oxidative metabolisms ; Carboxyl-rich oxidative metabolites ; Molecular evolution ; Gene diversification
    Language English
    Dates of publication 2023-03
    Publishing place Elsevier B.V.
    Document type Article ; Online
    ZDB-ID 2016967-X
    ISSN 0921-8181
    ISSN 0921-8181
    DOI 10.1016/j.gloplacha.2023.104041
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Identification of key autophagy-related genes and pathways in spinal cord injury.

    Shang, Zhen / Shi, Weipeng / Fu, Haitao / Zhang, Yingze / Yu, Tengbo

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 6553

    Abstract: Spinal cord injury (SCI) can cause a range of functional impairments, and patients with SCI have limited potential for functional recovery. Previous studies have demonstrated that autophagy plays a role in the pathological process of SCI, but the ... ...

    Abstract Spinal cord injury (SCI) can cause a range of functional impairments, and patients with SCI have limited potential for functional recovery. Previous studies have demonstrated that autophagy plays a role in the pathological process of SCI, but the specific mechanism of autophagy in this context remains unclear. Therefore, we explored the role of autophagy in SCI by identifying key autophagy-related genes and pathways. This study utilized the GSE132242 expression profile dataset, which consists of four control samples and four SCI samples; autophagy-related genes were sourced from GeneCards. R software was used to screen differentially expressed genes (DEGs) in the GSE132242 dataset, which were then intersected with autophagy-related genes to identify autophagy-related DEGs in SCI. Subsequently, the expression levels of these genes were confirmed and analyzed with gene ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG). A protein-protein interaction (PPI) analysis was conducted to identify interaction genes, and the resulting network was visualized with Cytoscape. The MCODE plug-in was used to build gene cluster modules, and the cytoHubba plug-in was applied to screen for hub genes. Finally, the GSE5296 dataset was used to verify the reliability of the hub genes. We screened 129 autophagy-related DEGs, including 126 up-regulated and 3 down-regulated genes. GO and KEGG pathway enrichment analysis showed that these 129 genes were mainly involved in the process of cell apoptosis, angiogenesis, IL-1 production, and inflammatory reactions, the TNF signaling pathway and the p53 signaling pathway. PPI identified 10 hub genes, including CCL2, TGFB1, PTGS2, FN1, HGF, MYC, IGF1, CD44, CXCR4, and SERPINEL1. The GSE5296 dataset revealed that the control group exhibited lower expression levels than the SCI group, although only CD44 and TGFB1 showed significant differences. This study identified 129 autophagy-related genes that might play a role in SCI. CD44 and TGFB1 were identified as potentially important genes in the autophagy process after SCI. These findings provide new targets for future research and offer new perspectives on the pathogenesis of SCI.
    MeSH term(s) Humans ; Gene Expression Profiling/methods ; Protein Interaction Maps/genetics ; Reproducibility of Results ; Spinal Cord Injuries/genetics ; Spinal Cord Injuries/metabolism ; Autophagy/genetics ; Computational Biology/methods
    Language English
    Publishing date 2024-03-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-56683-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Oxidative metabolisms catalyzed Earth’s oxygenation

    Haitao Shang / Daniel H. Rothman / Gregory P. Fournier

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 9

    Abstract: How Earth’s atmosphere became oxygenated remains enigmatic. Here the authors use mathematical and phylogenetic analyses to find that Earth’s oxygenation is induced by the interactions of microbial oxidative metabolites with sediment minerals. ...

    Abstract How Earth’s atmosphere became oxygenated remains enigmatic. Here the authors use mathematical and phylogenetic analyses to find that Earth’s oxygenation is induced by the interactions of microbial oxidative metabolites with sediment minerals.
    Keywords Science ; Q
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Oxidative metabolisms catalyzed Earth's oxygenation.

    Shang, Haitao / Rothman, Daniel H / Fournier, Gregory P

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 1328

    Abstract: The burial of organic carbon, which prevents its remineralization via oxygen-consuming processes, is considered one of the causes of Earth's oxygenation. Yet, higher levels of oxygen are thought to inhibit burial. Here we propose a resolution of this ... ...

    Abstract The burial of organic carbon, which prevents its remineralization via oxygen-consuming processes, is considered one of the causes of Earth's oxygenation. Yet, higher levels of oxygen are thought to inhibit burial. Here we propose a resolution of this conundrum, wherein Earth's initial oxygenation is favored by oxidative metabolisms generating partially oxidized organic matter (POOM), increasing burial via interaction with minerals in sediments. First, we introduce the POOM hypothesis via a mathematical argument. Second, we reconstruct the evolutionary history of one key enzyme family, flavin-dependent Baeyer-Villiger monooxygenases, that generates POOM, and show the temporal consistency of its diversification with the Proterozoic and Phanerozoic atmospheric oxygenation. Finally, we propose that the expansion of oxidative metabolisms instigated a positive feedback, which was amplified by the chemical changes to minerals on Earth's surface. Collectively, these results suggest that Earth's oxygenation is an autocatalytic transition induced by a combination of biological innovations and geological changes.
    MeSH term(s) Atmosphere ; Biological Evolution ; Catalysis ; Oxidative Stress ; Oxygen/metabolism
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2022-03-14
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-28996-0
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  8. Article ; Online: Construction of a Humanized PBMC-PDX Model to Study the Efficacy of a Bacterial Marker in Lung Cancer Immunotherapy.

    Wu, Chengwei / Wang, Xinning / Shang, Haitao / Wei, Hong

    Disease markers

    2022  Volume 2022, Page(s) 1479246

    Abstract: Commensal microbiome is a key factor of lung cancer immunotherapy efficacy. Elucidating the role of specific strains as bacterial markers in immunotherapy has drawn great attention from the academia. At present, most preclinical studies about the ... ...

    Abstract Commensal microbiome is a key factor of lung cancer immunotherapy efficacy. Elucidating the role of specific strains as bacterial markers in immunotherapy has drawn great attention from the academia. At present, most preclinical studies about the relationship between bacterial markers and immunotherapy rely on the syngeneic mouse models. However, mice differ greatly from humans in immune system and tumor characteristics. In this study, humanized mouse models based on peripheral blood mononuclear cells (PBMCs) immune reconstitution and lung cancer cell line-derived xenograft (CDX) or patient-derived xenograft (PDX) were constructed. The PBMC-PDX model was shown to be superior to the PBMC-CDX model in preserving tumor heterogeneity and construction time-saving. Through optimizing the experimental process, the time it took for humanized models to evaluate the effect of cancer treatment was reduced to 42 days. Next, by utilizing PBMC-PDX mice treated with antibiotics (ATB), the role of
    MeSH term(s) Animals ; Bacteria ; Biomarkers ; Disease Models, Animal ; Humans ; Immunologic Factors ; Immunotherapy ; Leukocytes, Mononuclear ; Lung Neoplasms/therapy ; Mice ; Xenograft Model Antitumor Assays
    Chemical Substances Biomarkers ; Immunologic Factors
    Language English
    Publishing date 2022-08-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604951-5
    ISSN 1875-8630 ; 0278-0240
    ISSN (online) 1875-8630
    ISSN 0278-0240
    DOI 10.1155/2022/1479246
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  9. Article: Fabrication and characterization of Pickering emulsion gels stabilized by gliadin/starch complex for the delivery of astaxanthin

    Song, Jia / Li, Hongliang / Shang, Wenbo / Wang, Haitao / Tan, Mingqian

    Food hydrocolloids

    2023  Volume 137, Issue -, Page(s) 108388

    Language English
    Document type Article
    ZDB-ID 742742-6
    ISSN 0268-005X
    Database Current Contents Nutrition, Environment, Agriculture

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  10. Article: Fabrication and characterization of Pickering emulsion gels stabilized by gliadin/starch complex for the delivery of astaxanthin

    Song, Jia / Li, Hongliang / Shang, Wenbo / Wang, Haitao / Tan, Mingqian

    Food hydrocolloids

    2023  Volume 137, Issue -, Page(s) 108388

    Language English
    Document type Article
    ZDB-ID 742742-6
    ISSN 0268-005X
    Database Current Contents Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Z 4414: Show issues

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