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  1. Article ; Online: A review of the pharmacokinetics of M

    Matera, Maria Gabriella / Rinaldi, Barbara / Berardo, Carmela / Rinaldi, Michele / Cazzola, Mario

    Expert opinion on drug metabolism & toxicology

    2020  Volume 16, Issue 2, Page(s) 143–148

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Administration, Inhalation ; Anti-Asthmatic Agents/administration & dosage ; Anti-Asthmatic Agents/pharmacokinetics ; Anti-Asthmatic Agents/pharmacology ; Asthma/drug therapy ; Asthma/physiopathology ; Bronchodilator Agents/administration & dosage ; Bronchodilator Agents/pharmacokinetics ; Bronchodilator Agents/pharmacology ; Humans ; Muscarinic Antagonists/administration & dosage ; Muscarinic Antagonists/pharmacokinetics ; Muscarinic Antagonists/pharmacology ; Receptor, Muscarinic M3/antagonists & inhibitors ; Receptor, Muscarinic M3/metabolism ; Severity of Illness Index
    Chemical Substances Anti-Asthmatic Agents ; Bronchodilator Agents ; Muscarinic Antagonists ; Receptor, Muscarinic M3
    Language English
    Publishing date 2020-01-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2214462-6
    ISSN 1744-7607 ; 1742-5255
    ISSN (online) 1744-7607
    ISSN 1742-5255
    DOI 10.1080/17425255.2020.1716730
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Bone marrow assessment in asymptomatic immunoglobulin M monoclonal gammopathies.

    Varettoni, Marzia / Arcaini, Luca / Rattotti, Sara / Ferretti, Virginia / Cazzola, Mario

    British journal of haematology

    2015  Volume 168, Issue 2, Page(s) 301–302

    MeSH term(s) Humans ; Waldenstrom Macroglobulinemia/diagnosis ; Waldenstrom Macroglobulinemia/therapy
    Language English
    Publishing date 2015-01
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.13091
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  3. Book: Roflumilast for asthma

    Cazzola, Mario

    (Pulmonary pharmacology & therapeutics ; volume 35, supplement, December 2015)

    2015  

    Author's details guest editors: Mario Cazzola and Eric Bateman
    Series title Pulmonary pharmacology & therapeutics ; volume 35, supplement, December 2015
    Collection
    Language English
    Size S34 Seiten, Illustrationen
    Publisher Elsevier
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT018922940
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Zs A 2389 -35,Suppl.- not available for loan Zeitschriften-Lesesaal

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  4. Article ; Online: Introduction to a review series on classic myeloproliferative neoplasms.

    Cazzola, Mario

    Blood

    2023  Volume 141, Issue 16, Page(s) 1897–1899

    MeSH term(s) Humans ; Myeloproliferative Disorders/diagnosis ; Myeloproliferative Disorders/genetics ; Janus Kinase 2/genetics ; Neoplasms
    Chemical Substances Janus Kinase 2 (EC 2.7.10.2)
    Language English
    Publishing date 2023-02-28
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2023019876
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  5. Article ; Online: Introduction to a review series on myelodysplastic syndromes in the age of genomic medicine.

    Cazzola, Mario

    Blood

    2023  Volume 142, Issue 26, Page(s) 2223

    MeSH term(s) Humans ; Genomic Medicine ; Myelodysplastic Syndromes/genetics ; Myelodysplastic Syndromes/therapy ; Patients ; Risk Assessment
    Language English
    Publishing date 2023-12-27
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2023022912
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  6. Article ; Online: Introduction to a review series on germ line predisposition to hematologic malignancies: time to consider germ line testing.

    Cazzola, Mario

    Blood

    2023  Volume 141, Issue 13, Page(s) 1509–1512

    MeSH term(s) Humans ; GATA2 Deficiency ; Hematologic Neoplasms ; Genotype ; Disease Susceptibility ; Germ Cells ; GATA2 Transcription Factor
    Chemical Substances GATA2 protein, human ; GATA2 Transcription Factor
    Language English
    Publishing date 2023-02-10
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2023019846
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  7. Article ; Online: Risk stratifying MDS in the time of precision medicine.

    Cazzola, Mario

    Hematology. American Society of Hematology. Education Program

    2022  Volume 2022, Issue 1, Page(s) 375–381

    Abstract: ... for Prognosis in MDS has just developed the International Prognostic Scoring System-Molecular (IPSS-M) for MDS ... which considers hematologic parameters, cytogenetic abnormalities, and somatic gene mutations. The IPSS-M score is ... an efficient risk stratification of patients with MDS, the IPSS-M represents a valuable tool for individual ...

    Abstract Myelodysplastic syndromes (MDS) are myeloid neoplasms characterized by morphologic dysplasia, persistent cytopenia, and a variable risk of evolution to acute myeloid leukemia (AML). Risk stratification is crucial in a patient-centered approach to the treatment of MDS. Based on hematologic parameters and cytogenetic abnormalities, the Revised International Prognostic Scoring System is currently used for this purpose. In the past years, the use of massively parallel DNA sequencing has clarified the genetic basis of MDS and has enabled development of novel diagnostic and prognostic approaches. When conventional cytogenetics is combined with gene sequencing, more than 90% of patients are found to carry a somatic genetic lesion. In addition, a portion of patients has germline variants that predispose them to myeloid neoplasms. The recently developed International Consensus Classification of MDS includes new entities that are molecularly defined-namely, SF3B1-mutant and TP53-mutant MDS. The International Working Group for Prognosis in MDS has just developed the International Prognostic Scoring System-Molecular (IPSS-M) for MDS, which considers hematologic parameters, cytogenetic abnormalities, and somatic gene mutations. The IPSS-M score is personalized and can be obtained using a web-based calculator that returns not only the individual score but also the expected leukemia-free survival, overall survival, and risk of AML transformation. Providing an efficient risk stratification of patients with MDS, the IPSS-M represents a valuable tool for individual risk assessment and treatment decisions.
    Language English
    Publishing date 2022-12-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2084287-9
    ISSN 1520-4383 ; 1520-4391
    ISSN (online) 1520-4383
    ISSN 1520-4391
    DOI 10.1182/hematology.2022000349
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: RNA missplicing and ring sideroblasts in MDS.

    Cazzola, Mario

    Blood

    2022  Volume 139, Issue 13, Page(s) 1933–1935

    MeSH term(s) Anemia, Sideroblastic/genetics ; Erythroid Precursor Cells ; Humans ; RNA
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2022-06-06
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2021014923
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  9. Article ; Online: Introduction to a review series on normal and pathologic erythropoiesis.

    Cazzola, Mario

    Blood

    2022  Volume 139, Issue 16, Page(s) 2413–2414

    MeSH term(s) Erythropoiesis
    Language English
    Publishing date 2022-01-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2022015497
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  10. Article: Immunoglobulin M memory B cell decrease in inflammatory bowel disease.

    Di Sabatino, A / Carsetti, R / Rosado, M M / Ciccocioppo, R / Cazzola, P / Morera, R / Tinozzi, F P / Tinozzi, S / Corazza, G R

    European review for medical and pharmacological sciences

    2004  Volume 8, Issue 5, Page(s) 199–203

    Abstract: Background & objectives: Memory B cells represent 30-60% of the B cell pool and can be subdivided in IgM memory and switched memory. IgM memory B cells differ from switched because they express IgM and their frequency may vary from 20-50% of the total ... ...

    Abstract Background & objectives: Memory B cells represent 30-60% of the B cell pool and can be subdivided in IgM memory and switched memory. IgM memory B cells differ from switched because they express IgM and their frequency may vary from 20-50% of the total memory pool. Switched memory express IgG, IgA or IgE and lack surface expression of IgM and IgD. Switched memory B cells derive from the germinal centres, whereas IgM memory B cells, which require the spleen for their survival and/or generation, are involved in the immune response to encapsulated bacteria. Since infections are one of the most frequent comorbid conditions in inflammatory bowel disease, we aimed to verify whether IgM memory B cell pool was decreased in Crohn's disease and ulcerative colitis patients.
    Patients & methods: Peripheral blood samples were obtained from 22 Crohn's disease patients, 20 ulcerative colitis patients, 22 healthy controls and 18 splenectomized patients. To analyse peripheral blood lymphocytes, flow cytometry was performed using anti-CD19, anti-CD22, anti-CD27, anti-IgM, anti-IgD and anti-CD38 monoclonal antibodies.
    Results: Circulating IgM memory B cells were significantly lower in Crohn's disease (median 7.1%, range 1.8-20.7) and ulcerative colitis patients (median 8.1%, range 2.1-18.8) in comparison to control subjects (median 14.0%, range 6.8-31.1). As expected, there was a highly significant difference in the proportion of IgM memory B cells between splenectomized patients (median 2.4%, range 0.9-6.9) and healthy controls. Crohn's disease patients with abscesses showed the lowest frequency of IgM memory B cells.
    Discussion: Our findings show that peripheral IgM memory B cells are reduced in inflammatory bowel disease patients. Further studies are necessary to answer the question of whether high risk of infection (abscess development) is promoted by the reduction/depletion of IgM memory B-cell pool in inflammatory bowel disease.
    MeSH term(s) Adult ; Aged ; B-Lymphocytes/immunology ; Biomarkers ; Colitis, Ulcerative/immunology ; Crohn Disease/immunology ; Female ; Flow Cytometry ; Humans ; Immunoglobulin M/immunology ; Immunologic Memory/immunology ; Inflammatory Bowel Diseases/immunology ; Lymphocyte Count ; Male ; Middle Aged
    Chemical Substances Biomarkers ; Immunoglobulin M
    Language English
    Publishing date 2004-09
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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