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Article: Helicobacter pylori induces direct activation of the lymphotoxin beta receptor and non-canonical nuclear factor-kappa B signaling.

Feige, Michael Hartmut / Vieth, Michael / Sokolova, Olga / Täger, Christian / Naumann, Michael

Biochimica et biophysica acta. Molecular cell research

2018 Volume 1865, Issue 4, Page(s) 545–550

Abstract: ... for a type IV secretion system (T4SS). The T4SS induces fast canonical nuclear factor-kappa B (NF-κB ...

Abstract	The pathogen Helicobacter pylori, which infects half of the world's population, is a major risk factor for the development of gastric diseases including chronic gastritis and gastric cancer. Among H. pylori's virulence factors is the cytotoxin-associated gene pathogenicity island (cagPAI), which encodes for a type IV secretion system (T4SS). The T4SS induces fast canonical nuclear factor-kappa B (NF-κB) signaling, a major factor increasing inflammation, supressing apoptotic cell death and thereby promoting the development of neoplasia. However, H. pylori's capability to mediate fast non-canonical NF-κB signaling is unresolved, despite a contribution of non-canonical NF-κB signaling to gastric cancer has been suggested. We analyzed signaling elements within non-canonical NF-κB in response to H. pylori in epithelial cell lines by immunoprecipitation, immunoblot, electrophoretic mobility shift assay and RNA interference knockdown. In addition, tissue samples of H. pylori-infected patients were investigated by immunohistochemistry. Here, we provide evidence for a T4SS-dependent direct activation of non-canonical NF-κB signaling. We identified the lymphotoxin beta receptor (LTβR) to elicit the fast release of NF-κB inducing kinase (NIK) from the receptor complex leading to non-canonical NF-κB signaling. Further, NIK expression was increased in human biopsies of H. pylori-associated gastritis. Thus, NIK could represent a novel target to reduce Helicobacter pylori-induced gastric inflammation and pathology.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Antigens, Bacterial/metabolism ; Bacterial Proteins/metabolism ; Bacterial Secretion Systems ; HeLa Cells ; Helicobacter pylori/metabolism ; Humans ; Lymphotoxin beta Receptor/metabolism ; Middle Aged ; Models, Biological ; Mucous Membrane/metabolism ; NF-kappa B/metabolism ; Protein Serine-Threonine Kinases/metabolism ; Signal Transduction ; Stomach/pathology ; Young Adult ; NF-kappaB-Inducing Kinase
Chemical Substances	Antigens, Bacterial ; Bacterial Proteins ; Bacterial Secretion Systems ; Lymphotoxin beta Receptor ; NF-kappa B ; cagA protein, Helicobacter pylori ; Protein Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2018-01-09
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	60-7
ISSN	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0167-4889 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0167-4889 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbamcr.2018.01.006
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Article ; Online: Hemodynamic Determinants of the Biologic Variation of N-Terminal Pro-B-Type Natriuretic Peptide in Patients With Stable Systolic Chronic Heart Failure.

Täger, Tobias / Wiedergruen, Ann-Kathrin / Fröhlich, Hanna / Cebola, Rita / Corletto, Anna / Horsch, Andrea / Hess, Georg / Slottje, Karen / Zdunek, Dietmar / Katus, Hugo A / Wians, Frank H / Frankenstein, Lutz

Journal of cardiac failure

2017 Volume 23, Issue 12, Page(s) 835–842

Abstract: Background context: Biologic variation of N-terminal pro-B-type natriuretic peptide (NT-proBNP ...

Abstract	Background context: Biologic variation of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in chronic heart failure (CHF) may affect blood levels and risk stratification. The sources of NT-proBNP variation are unknown. Methods and results: We performed NT-proBNP measurements and clinical and hemodynamic assessments in 50 patients with heart failure with reduced ejection fraction (HFrEF) who met criteria for clinical stability over 2 time intervals. Hemodynamic variables were measured with the use of inert gas rebreathing and impedance cardiography. Heart rhythm was monitored with the use of external electrocardiographic event recorders throughout the study. Determinants of NT-proBNP-levels and both absolute (ΔNT-proBNP Conclusions: In patients with stable HFrEF, changes in clinical and hemodynamic variables only marginally contribute to the variation of NT-proBNP.
MeSH term(s)	Aged ; Chronic Disease ; Electrocardiography/methods ; Female ; Heart Failure/blood ; Heart Failure/diagnosis ; Heart Failure/physiopathology ; Hemodynamics/physiology ; Humans ; Male ; Middle Aged ; Natriuretic Peptide, Brain/blood ; Peptide Fragments/blood ; Prospective Studies
Chemical Substances	Peptide Fragments ; pro-brain natriuretic peptide (1-76) ; Natriuretic Peptide, Brain (114471-18-0)
Language	English
Publishing date	2017-12
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	1281194-4
ISSN	1532-8414 ; 1071-9164
ISSN (online)	1532-8414
ISSN	1071-9164
DOI	10.1016/j.cardfail.2017.07.404
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Article: BLT1 and BLT2: the leukotriene B(4) receptors.

Tager, Andrew M / Luster, Andrew D

Prostaglandins, leukotrienes, and essential fatty acids

2003 Volume 69, Issue 2-3, Page(s) 123–134

Abstract: Two receptors for leukotriene B(4) (LTB(4)) have been molecularly identified: BLT1 and BLT2 ...

Abstract	Two receptors for leukotriene B(4) (LTB(4)) have been molecularly identified: BLT1 and BLT2. Both receptors are G protein-coupled seven transmembrane domain receptors, whose genes are located in very close proximity to each other in the human and mouse genomes. The two receptors differ in their affinity and specificity for LTB(4): BLT1 is a high-affinity receptor specific for LTB(4), whereas BLT2 is a low-affinity receptor that also binds other eicosanoids. The two receptors also differ in their pattern of expression with BLT1 being expressed primarily in leukocytes, whereas BLT2 is expressed more ubiquitously. By mediating the activities of LTB(4), these receptors participate both in host immune responses and in the pathogenesis of inflammatory diseases. Reduced disease severity in animal inflammatory models seen with LTB(4) receptor antagonists and in mice with targeted deletion of BLT1 have revealed important roles for LTB(4) and its receptors in regulating pathologic inflammation.
MeSH term(s)	Amino Acid Sequence ; Animals ; Cell Line ; Cloning, Molecular ; GTP-Binding Proteins/metabolism ; Gene Expression Regulation ; Humans ; Inflammation/etiology ; Inflammation/prevention & control ; Leukotriene B4/metabolism ; Ligands ; Mice ; Molecular Sequence Data ; Neutrophils/metabolism ; Purinergic P2 Receptor Antagonists ; Receptors, Leukotriene B4/antagonists & inhibitors ; Receptors, Leukotriene B4/genetics ; Receptors, Leukotriene B4/metabolism ; Receptors, Purinergic P2/genetics ; Receptors, Purinergic P2/metabolism ; Sequence Alignment
Chemical Substances	LTB4R protein, human ; LTB4R2 protein, human ; Ligands ; Ltb4r1 protein, mouse ; Ltb4r2 protein, mouse ; Purinergic P2 Receptor Antagonists ; Receptors, Leukotriene B4 ; Receptors, Purinergic P2 ; Leukotriene B4 (1HGW4DR56D) ; GTP-Binding Proteins (EC 3.6.1.-)
Language	English
Publishing date	2003-07-22
Publishing country	Scotland
Document type	Comparative Study ; Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Review
ZDB-ID	286714-x
ISSN	1532-2823 ; 0952-3278
ISSN (online)	1532-2823
ISSN	0952-3278
DOI	10.1016/s0952-3278(03)00073-5
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Zs.B 2123: Show issues

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Article ; Online: CEACAMs interaction with Helicobacter pylori HopQ supports the type 4 secretion system-dependent activation of non-canonical NF-κB.

Maubach, Gunter / Sokolova, Olga / Täger, Christian / Naumann, Michael

International journal of medical microbiology : IJMM

2020 Volume 310, Issue 6, Page(s) 151444

Abstract: ... of activated B cells (NF-κB) in a T4SS-dependent manner but CagA-independent manner. Here we investigated ...

Abstract	Helicobacter pylori infection represents a major risk factor for the development of gastric diseases and gastric cancer. The capability of H. pylori to inject the virulence factor cytotoxin-associated gene A (CagA) depends on a type IV secretion system (T4SS) encoded by the cag pathogenicity island (cagPAI). Further, infection by H. pylori activates the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) in a T4SS-dependent manner but CagA-independent manner. Here we investigated the role of host cell receptors carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) and the bacterial adhesin HopQ in the activation of non-canonical NF-κB and CagA translocation into gastric epithelial cells. AGS cells express six of twelve CEACAMs found in humans. In HeLa cells, only CEACAM19 is expressed. We showed that deletion of hopQ attenuates the activation of non-canonical NF-κB only in AGS but not in HeLa cells. CagA translocation was in both cell lines affected by HopQ depletion, although to a much lesser extent in HeLa cells. Moreover, we observed a possible redundancy between the three HopQ-binding CEACAMs 1, 5 and 6 and their capacity to support non-canonical NF-κB activation. Our results illustrate that the interaction between HopQ and CEACAMs could promote the efficiency of the T4SS.
MeSH term(s)	Antigens, Bacterial/genetics ; Antigens, Bacterial/metabolism ; Antigens, Neoplasm/genetics ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Cell Adhesion Molecules/genetics ; Epithelial Cells ; HeLa Cells ; Helicobacter Infections/metabolism ; Helicobacter pylori/genetics ; Humans ; NF-kappa B/metabolism ; Type IV Secretion Systems/genetics
Chemical Substances	Antigens, Bacterial ; Antigens, Neoplasm ; Bacterial Proteins ; CEACAM19 protein, human ; Cell Adhesion Molecules ; NF-kappa B ; Type IV Secretion Systems ; cagA protein, Helicobacter pylori
Language	English
Publishing date	2020-08-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2006518-8
ISSN	1618-0607 ; 1438-4221
ISSN (online)	1618-0607
ISSN	1438-4221
DOI	10.1016/j.ijmm.2020.151444
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Article ; Online: Synthesis and structure-activity relationships of USP48 deubiquitinylase inhibitors.

Böhm, Kevin / Schulze-Niemand, Eric / Kähne, Thilo / Siddiqui, Elisa / Täger, Christian / Ramsbeck, Daniel / Buchholz, Mirko / Naumann, Michael

Archiv der Pharmazie

2023 Volume 356, Issue 7, Page(s) e2200661

Abstract: ... to inflammatory signaling via regulation of the transcription factor nuclear factor kappa B. Nonetheless ...

Abstract	Ubiquitin-specific proteases represent a family of enzymes that catalyze the cleavage of ubiquitin from specific substrate proteins to regulate their activity. USP48 is a rarely studied USP, which has recently been linked to inflammatory signaling via regulation of the transcription factor nuclear factor kappa B. Nonetheless, a crystal structure of USP48 has not yet been resolved and potent inhibitors are not known. We screened a set of 14 commercially available USP inhibitors for their activity against USP48 and identified the USP2 inhibitor "ML364" as a candidate for further optimization. Using a ligand-based approach, we derived and synthesized a series of ML364 analogs. The IC
MeSH term(s)	Structure-Activity Relationship ; Ubiquitin-Specific Proteases/chemistry ; Ubiquitin-Specific Proteases/metabolism ; Signal Transduction ; Transcription Factors ; Ubiquitins
Chemical Substances	Ubiquitin-Specific Proteases (EC 3.4.19.12) ; Transcription Factors ; Ubiquitins
Language	English
Publishing date	2023-05-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	6381-2
ISSN	1521-4184 ; 0365-6233 ; 1437-1014
ISSN (online)	1521-4184
ISSN	0365-6233 ; 1437-1014
DOI	10.1002/ardp.202200661
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Article ; Online: Associations between attentional biases to fearful faces and social-emotional development in infants with and without an older sibling with autism.

Wagner, Jennifer B / Keehn, Brandon / Tager-Flusberg, Helen / Nelson, Charles A

Infant behavior & development

2023 Volume 71, Page(s) 101811

Abstract: During the first year of life, infants become increasingly attuned to facial emotion, with heightened sensitivity to faces conveying threat observed by age seven months as illustrated through attentional biases (e.g., slower shifting away from fearful ... ...

Abstract	During the first year of life, infants become increasingly attuned to facial emotion, with heightened sensitivity to faces conveying threat observed by age seven months as illustrated through attentional biases (e.g., slower shifting away from fearful faces). Individual differences in these cognitive attentional biases have been discussed in relation to broader social-emotional functioning, and the current study examines these associations in infants with an older sibling with autism spectrum disorder (ASD), a group with an elevated likelihood of a subsequent ASD diagnosis (ELA; n = 33), and a group of infants with no family history of ASD who are at low likelihood of ASD (LLA; n = 24). All infants completed a task measuring disengagement of attention from faces at 12 months (fearful, happy, neutral), and caregivers completed the Infant-Toddler Social and Emotional Assessment at 12, 18, and/or 24 months. For the full sample, greater fear bias in attention disengagement at 12 months related to more internalizing behaviors at 18 months, and this was driven by the LLA infants. When examining groups separately, findings revealed that LLA with a greater fear bias had more difficult behaviors at 12, 18, and 24 months; in contrast, ELA showed the opposite pattern, and this was most pronounced for ELA who later received an ASD diagnosis. These preliminary group-level findings suggest that heightened sensitivity to fearful faces might serve an adaptive function in children who later receive an ASD diagnosis, but in infants with no family history of ASD, increased biases might reflect a marker of social-emotional difficulties.
MeSH term(s)	Infant ; Humans ; Autism Spectrum Disorder/psychology ; Autistic Disorder ; Attentional Bias ; Siblings ; Facial Expression ; Emotions ; Fear/psychology
Language	English
Publishing date	2023-03-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	224510-3
ISSN	1934-8800 ; 1879-0453 ; 0163-6383
ISSN (online)	1934-8800 ; 1879-0453
ISSN	0163-6383
DOI	10.1016/j.infbeh.2023.101811
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Article ; Online: Parental Perspectives: How Sensory Sensitivities Impact the Transition to Adulthood in Adolescents and Young Adults with Autism Spectrum Disorder.

Hantman, Rachel M / Johnston, Emily B / Tager-Flusberg, Helen

Journal of autism and developmental disorders

2022 Volume 54, Issue 2, Page(s) 544–562

Abstract: Sensory sensitivities are common in autism spectrum disorder (ASD) and impact daily life, but research has largely focused on children, neglecting older individuals. Likewise, while there is research regarding parental concerns for their autistic ... ...

Abstract	Sensory sensitivities are common in autism spectrum disorder (ASD) and impact daily life, but research has largely focused on children, neglecting older individuals. Likewise, while there is research regarding parental concerns for their autistic children's transition to adulthood, little is known about the role of sensory sensitivities. To address this gap, 66 parents of autistic adolescents and young adults were interviewed and their responses were qualitatively analyzed. All parents believed their children's sensory sensitivities impacted their transition to adulthood, primary developmentally/psychologically, interpersonally/socially, and managerially. These beliefs did not significantly differ by child characteristics, such as age and ASD severity. Parent perceptions were modality and context specific. Given these findings, transition planning should consider individual's specific sensory sensitivities to optimize independence.
MeSH term(s)	Child ; Humans ; Adolescent ; Young Adult ; Autism Spectrum Disorder ; Autistic Disorder ; Parents
Language	English
Publishing date	2022-11-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	391999-7
ISSN	1573-3432 ; 0162-3257
ISSN (online)	1573-3432
ISSN	0162-3257
DOI	10.1007/s10803-022-05815-5
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Zs.A 765: Show issues

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Article: An Evaluation of the Use of Aggressive Fluid Resuscitation in the Early Treatment of Sepsis Patients.

Payne, William N / Tager, Alfred / Broce, Mike / Tager, Dany / Hoy, Marion / Abad, Hythem

Cureus

2021 Volume 13, Issue 2, Page(s) e13518

Abstract: ... outcome data. Evidence of fluid overload (chest X-ray [CXR] evidence, rising B-type natriuretic peptide ...

Abstract	Introduction Fluid resuscitation is a critical aspect of the sepsis protocol with the usual initial dose being 30 mL per kilogram. Although this dose is well accepted in patients with normal cardiac function, there is some significant variation in clinical practice concerning the optimal fluid resuscitation in septic patients with underlying congestive heart failure (CHF). Many different approaches have been tried to best treat these patients by using lesser volumes of fluid. The purpose of this retrospective study is to attempt to better define optimal fluid resuscitation in congestive heart failure patients and whether standard fluid resuscitation exacerbates CHF in these cases. Methods This was a retrospective study involving patients admitted to the Emergency Department (ED) during the time period of September of 2016 through March of 2019 with a primary diagnosis of sepsis and pre-existing CHF. Data collected from the data warehouse and patient charts included demographics, total amount of fluid received in the ED and outcome data. Evidence of fluid overload (chest X-ray [CXR] evidence, rising B-type natriuretic peptide [BNP], or use of diuretics), was evaluated with respect to in-hospital mortality, white blood cell (WBC) count and comorbidities (chronic obstructive pulmonary disease [COPD], hypertension and coronary artery disease). Results There were 422 patients included in the cohort. Of the 422, 113 (26.8%) patients showed evidence of fluid overload on CXR during hospital stay and received diuretics and therefore considered in the CHF exacerbation group. The patients that experienced CHF exacerbation were significantly older (mean ± SD, 70.9 ± 11.8 years versus 67.4 ± 15.1 years, p=0.014). Patients with exacerbation also received more fluid (median and interquartile range, 3.0, 2:5.5 L versus 2.0, 1:4.3 L, p=0.017). The receiver operating characteristic curve analysis for fluid to predict exacerbation resulted in an area under the curve of 0.59 with a 95% confidence interval (CI) of 0.52 to 0.65, p=0.012. The Youden Index was used to determine an optimal cutoff value of 2.6 L. The percentage of patients in the exacerbation group above the threshold was significantly higher (57.3%) than those without exacerbation (43.3%), p=0.019. Following multivariate analysis, age greater than 60 (odds ratio [OR]: 2.5; CI: 1.4-4.6, p=0.003) and fluid cutoff of 2.6 L (OR: 1.9; CI: 1.2-3.1, p=0.007) were both found to be independent predictors of CHF exacerbation. There was no significant difference in mortality based on the total fluid received in the ED. Conclusion The findings of this study showed that septic patients with pre-existing CHF who received more than 2.6 L of fluid in the ED were 90% more likely to develop symptoms of CHF exacerbation with no evidence of lowering mortality compared to the group that received less than 2.6 L. Our data supports the practice of limiting total fluid resuscitation in CHF to 2.6 L and reconfirms the idea that fluid resuscitation for patients with CHF needs to be individualized.
Language	English
Publishing date	2021-02-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.13518
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Article ; Online: Human gastric fibroblasts ameliorate A20-dependent cell survival in co-cultured gastric epithelial cells infected by Helicobacter pylori.

Jantaree, Phatcharida / Yu, Yanfei / Chaithongyot, Supattra / Täger, Christian / Sarabi, Mohsen Abdi / Meyer, Thomas F / Boccellato, Francesco / Maubach, Gunter / Naumann, Michael

Biochimica et biophysica acta. Molecular cell research

2022 Volume 1869, Issue 12, Page(s) 119364

Abstract: ... the activation of the transcription factor nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), which is involved ...

Abstract	Crosstalk within the gastric epithelium, which is closely in contact with stromal fibroblasts in the gastric mucosa, has a pivotal impact in proliferation, differentiation and transformation of the gastric epithelium. The human pathogen Helicobacter pylori colonises the gastric epithelium and represents a risk factor for gastric pathophysiology. Infection of H. pylori induces the activation of the transcription factor nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), which is involved in the pro-inflammatory response but also in cell survival. In co-cultures with human gastric fibroblasts (HGF), we found that apoptotic cell death is reduced in the polarised human gastric cancer cell line NCI-N87 or in gastric mucosoids during H. pylori infection. Interestingly, suppression of apoptotic cell death in NCI-N87 cells involved an enhanced A20 expression regulated by NF-κB activity in response to H. pylori infection. Moreover, A20 acts as an important negative regulator of caspase-8 activity, which was suppressed in NCI-N87 cells during co-culture with gastric fibroblasts. Our results provide evidence for NF-κB-dependent regulation of apoptotic cell death in cellular crosstalk and highlight the protective role of gastric fibroblasts in gastric epithelial cell death during H. pylori infection.
MeSH term(s)	Caspase 8/metabolism ; Cell Survival ; Coculture Techniques ; Epithelial Cells/metabolism ; Fibroblasts/metabolism ; Helicobacter Infections/metabolism ; Helicobacter pylori/metabolism ; Humans ; NF-kappa B/metabolism ; Transcription Factors/metabolism
Chemical Substances	NF-kappa B ; Transcription Factors ; Caspase 8 (EC 3.4.22.-)
Language	English
Publishing date	2022-09-23
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	60-7
ISSN	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbamcr.2022.119364
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Article ; Online: Distressing Discussions in Pediatric Interpreted Medical Encounters: A Qualitative Study of Medical Interpreter Perspectives on Clinician Communication Practices.

Olen, Amy / Lim, Paulina S / Escandell, Sthephany / Balistreri, Kathryn A / Tager, Julia B / Davies, W Hobart / Scanlon, Matthew C / Rothschild, Charles B

Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners

2024 Volume 38, Issue 2, Page(s) 127–139

Abstract: Introduction: This study explores pediatric medical interpreters' perspectives on clinician communication practices in medical encounters characterized by distressing content and difficult discussions.: Method: In this interpretative phenomenological ...

Abstract	Introduction: This study explores pediatric medical interpreters' perspectives on clinician communication practices in medical encounters characterized by distressing content and difficult discussions. Method: In this interpretative phenomenological analysis, 13 Spanish-English interpreters at a midwestern pediatric hospital were purposively recruited and, in 2021-2022, completed a demographic survey and semistructured interview on communication in distressing interpreted medical encounters. Results: Participants described clinician practices for effective cross-cultural interpreted communication. Practices align with recommendations on prebriefing, debriefing, jargon, stakeholder positioning, and teamwork. Novel findings relate to encounters with multiple parties, multilingual patients with monolingual parents, and coordination among clinicians. Discussion: Findings corroborate recommendations for interpreted communication best practices, extend them to distressing pediatric encounters, and offer recommendations for clinicians using interpreting services in distressing encounters. Participants' insights are distilled into a series of clinician best practices for high-quality interpreted communication during difficult discussions and for strengthening language access services in pediatric medical settings.
MeSH term(s)	Humans ; Child ; Communication Barriers ; Communication ; Language ; Qualitative Research ; Allied Health Personnel
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1036356-7
ISSN	1532-656X ; 0891-5245
ISSN (online)	1532-656X
ISSN	0891-5245
DOI	10.1016/j.pedhc.2023.11.017
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In stock of ZB MED Cologne/Königswinter

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Order via subito

Full text online

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In stock of ZB MED Cologne/Königswinter

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More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito