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Article ; Online: Devenir maternel après un diabète gestationnel. Dépistage et prévention du diabète de type 2. Revue de la littérature.

Vérier-Mine, O

Journal de gynecologie, obstetrique et biologie de la reproduction

2010 Volume 39, Issue 8 Suppl 2, Page(s) S299–321

Abstract: Women with a history of gestational diabetes mellitus (GDM) are characterized by a high risk of type 2 diabetes mellitus (T2DM) (X 7), metabolic syndrome (X 2 to 5) and cardiovascular diseases (X 1,7). Women with lesser degrees of glucose intolerance ... ...

Title translation	Outcomes in women with history of gestational diabetes mellitus. Screening and prevention of type 2 diabetes mellitus. Literature review.
Abstract	Women with a history of gestational diabetes mellitus (GDM) are characterized by a high risk of type 2 diabetes mellitus (T2DM) (X 7), metabolic syndrome (X 2 to 5) and cardiovascular diseases (X 1,7). Women with lesser degrees of glucose intolerance share the same risks. T2DM may occur from postpartum (5 to 14%) to several years later, up to 25 years. Some factors associated with T2DM are identified: obesity, early diagnostic before 24 weeks, high pregnancy OGTT blood glucose or insulinotherapy. Screening for T2DM only with fasting glucose provides less sensibility than with OGTT; HbA1c may supplant these dosages. The recurrence rate of GDM is between 30 and 84%, non-white ethnicity and insulinotherapy during GDM being the best proven predictors. High risk women need repeated life-long screenings for glycemic abnomalies, or when another pregnancy is planned. Among overweight or obese women with history of GDM who show minor glycoregulation disturbances, it is proved that modifications of lifestyle in intensive programs or metformin halve the risk of DT2. However, studies analysing practices show low adhesion to screening; without an intensive program, few women implement lifestyle modifications. These intensive programs should be implemented and proposed to high-risk women. Their therapeutic education should also include prevention of cardiovascular risk factors.
MeSH term(s)	Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/etiology ; Diabetes Mellitus, Type 2/prevention & control ; Diabetes, Gestational ; Female ; Humans ; Incidence ; Pregnancy ; Pregnancy Outcome ; Risk Factors
Language	French
Publishing date	2010-12
Publishing country	France
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	121670-3
ISSN	1773-0430 ; 0368-2315 ; 0150-9918
ISSN (online)	1773-0430
ISSN	0368-2315 ; 0150-9918
DOI	10.1016/S0368-2315(10)70056-9
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Zs.A 855: Show issues

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Article ; Online: Outcomes in women with a history of gestational diabetes. Screening and prevention of type 2 diabetes. Literature review.

Verier-Mine, O

Diabetes & metabolism

2010 Volume 36, Issue 6 Pt 2, Page(s) 595–616

Abstract: Women with a history of gestational diabetes mellitus (GDM) are characterized by a high risk of type 2 diabetes mellitus (T2DM) (x 7), metabolic syndrome (x 2 to 5) and cardiovascular diseases (x 1,7). Women with lesser degrees of glucose intolerance ... ...

Abstract	Women with a history of gestational diabetes mellitus (GDM) are characterized by a high risk of type 2 diabetes mellitus (T2DM) (x 7), metabolic syndrome (x 2 to 5) and cardiovascular diseases (x 1,7). Women with lesser degrees of glucose intolerance share the same risks. T2DM may occur from post-partum (5 to 14%) to several years later, up to 25 years. Some factors associated with T2DM are identified: obesity, early diagnosis of GDM before 24 weeks gestation, high pregnancy OGTT blood glucose or insulin-therapy during GDM. Screening for T2DM only with fasting glucose provides less sensibility than with OGTT; HbA1c may supplant these dosages. The recurrence rate of GDM is between 30 and 84%, non-white ethnicity and insulinotherapy during GDM being the best proven predictors. High risk women need repeated life-long screenings for glycaemic abnormalities, or when another pregnancy is planned. Among obese women with history of GDM who show minor glycoregulation disturbances, modifications of lifestyle in intensive programs or metformin halve the risk of DT2. However, studies analysing practices show low adhesion to screening; without an intensive program, few women implement lifestyle modifications. These intensive programs should be implemented and proposed to high-risk women. Their therapeutic education should also include prevention of cardiovascular risk factors.
MeSH term(s)	Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/prevention & control ; Diabetes, Gestational ; Female ; Humans ; Pregnancy ; Pregnancy Outcome ; Risk Factors ; Risk Reduction Behavior
Language	English
Publishing date	2010-12
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	1315751-6
ISSN	1878-1780 ; 1262-3636 ; 0338-1684
ISSN (online)	1878-1780
ISSN	1262-3636 ; 0338-1684
DOI	10.1016/j.diabet.2010.11.011
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Zs.A 1267: Show issues

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Article ; Online: Which oral antidiabetic drug to combine with metformin to minimize the risk of hypoglycemia when initiating basal insulin?: A randomized controlled trial of a DPP4 inhibitor versus insulin secretagogues.

Gautier, J F / Monguillon, P / Verier-Mine, O / Valensi, P / Fiquet, B / Dejager, S / Charbonnel, B

Diabetes research and clinical practice

2016 Volume 116, Page(s) 26–28

Abstract: We conducted a pilot study to evaluate two therapeutic strategies at the time of insulin initiation in type 2 diabetic patients insufficiently controlled with metformin+insulin-secretagogues (IS, sulfonylureas or glinides). Patients were randomized to ... ...

Abstract	We conducted a pilot study to evaluate two therapeutic strategies at the time of insulin initiation in type 2 diabetic patients insufficiently controlled with metformin+insulin-secretagogues (IS, sulfonylureas or glinides). Patients were randomized to remain under the same dual therapy or to receive metformin+DPP4 inhibitors while starting insulin. Similar glycemic control was achieved in both groups. However less hypoglycemia was observed with DPP4 inhibitors despite higher doses of insulin.
MeSH term(s)	Adamantane/analogs & derivatives ; Adamantane/therapeutic use ; Aged ; Blood Glucose ; Diabetes Mellitus, Type 2/drug therapy ; Dipeptidyl-Peptidase IV Inhibitors/therapeutic use ; Drug Therapy, Combination ; Female ; Glycated Hemoglobin A ; Humans ; Hypoglycemia/chemically induced ; Hypoglycemic Agents/therapeutic use ; Insulin/therapeutic use ; Male ; Metformin/therapeutic use ; Middle Aged ; Nitriles/therapeutic use ; Pilot Projects ; Pyrrolidines/therapeutic use ; Sulfonylurea Compounds/therapeutic use
Chemical Substances	Blood Glucose ; Dipeptidyl-Peptidase IV Inhibitors ; Glycated Hemoglobin A ; Hypoglycemic Agents ; Insulin ; Nitriles ; Pyrrolidines ; Sulfonylurea Compounds ; Metformin (9100L32L2N) ; vildagliptin (I6B4B2U96P) ; Adamantane (PJY633525U)
Language	English
Publishing date	2016-06
Publishing country	Ireland
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	632523-3
ISSN	1872-8227 ; 0168-8227
ISSN (online)	1872-8227
ISSN	0168-8227
DOI	10.1016/j.diabres.2016.04.008
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Zs.A 2047: Show issues

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Article: Is pregnancy a risk factor for microvascular complications? The EURODIAB Prospective Complications Study.

Vérier-Mine, O / Chaturvedi, N / Webb, D / Fuller, J H

Diabetic medicine : a journal of the British Diabetic Association

2005 Volume 22, Issue 11, Page(s) 1503–1509

Abstract: Aims: To examine the long-term influence of pregnancy on the development and progression of microvascular complications in Type 1 diabetes.: Methods: In the EURODIAB Prospective Complications Study (PCS), 793 women potentially child bearing at ... ...

Abstract	Aims: To examine the long-term influence of pregnancy on the development and progression of microvascular complications in Type 1 diabetes. Methods: In the EURODIAB Prospective Complications Study (PCS), 793 women potentially child bearing at baseline completed the follow-up (7.3 years) and 163 (21%) gave birth during the follow-up period. We compared risk factors [mean levels of age, duration of diabetes, HbA(1c), systolic blood pressure (SBP) and proportion giving birth] between those that did or did not develop microvascular complications during the follow-up period. Results: For the 425 childless women at baseline, 102 gave birth during follow-up. HbA(1c) was a significant risk factor for progression to microalbuminuria but age, duration of diabetes, systolic blood pressure or giving birth were not. Duration of diabetes and high HbA(1c) were significant risk factors for progression to proliferative retinopathy, whereas giving birth was not. Similar results were obtained for progression to any form of retinopathy. Giving birth was not significantly related to the incidence of neuropathy. Similar results were obtained for women with children at baseline giving birth during follow-up (n = 61/368). Conclusions: In this European study, having a first or another pregnancy did not seem to be a risk factor for long-term progression of any microvascular complication. This is in accordance with the findings of the Diabetes Control and Complications Trial (DCCT).
MeSH term(s)	Adult ; Age Factors ; Blood Pressure/physiology ; Diabetes Mellitus, Type 1/physiopathology ; Diabetic Angiopathies/physiopathology ; Female ; Glycated Hemoglobin A/analysis ; Humans ; Microcirculation/physiology ; Pregnancy ; Pregnancy Complications, Cardiovascular/physiopathology ; Pregnancy in Diabetics/physiopathology ; Prospective Studies ; Risk Factors
Chemical Substances	Glycated Hemoglobin A
Language	English
Publishing date	2005-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605769-x
ISSN	1464-5491 ; 0742-3071 ; 1466-5468
ISSN (online)	1464-5491
ISSN	0742-3071 ; 1466-5468
DOI	10.1111/j.1464-5491.2005.01682.x
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Zs.A 1954: Show issues

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Article ; Online: Effect of adding vildagliptin to insulin in haemodialysed patients with type 2 diabetes: The VILDDIAL study, a randomized, multicentre, prospective study.

Diabetes, obesity & metabolism

2020 Volume 22, Issue 6, Page(s) 978–987

Abstract: Aim: To evaluate the effect of adding the dipeptidyl-peptidase-4 inhibitor vildagliptin to insulin on the glycaemic control of patients with type 2 diabetes undergoing haemodialysis.: Methods: Overall, 65 insulin-treated patients with type 2 diabetes ...

Abstract	Aim: To evaluate the effect of adding the dipeptidyl-peptidase-4 inhibitor vildagliptin to insulin on the glycaemic control of patients with type 2 diabetes undergoing haemodialysis. Methods: Overall, 65 insulin-treated patients with type 2 diabetes undergoing haemodialysis (HbA1c: 7.3% ± 1.1%; age: 70.5 ± 8.5 years) were randomized (1:1) either to receive vildagliptin 50 mg/day in addition to insulin (vildagliptin-insulin group) or to pursue their usual insulin regimen (insulin-only group). Continuous glucose monitoring (CGM) was performed for 48 ± 6 hours at baseline and at week 12. The primary study endpoint was change from baseline in mean interstitial glucose using CGM. The secondary endpoints included other CGM variables and glucose control markers. Results: After 12 weeks, a greater reduction in mean CGM glucose from baseline was observed in the vildagliptin-insulin group compared with the insulin-only group, although the between-treatment difference was not statistically significant (mean difference [CI 95%]: -0.96 mmol/L [-2.09; 0.18] vs. -0.29 mmol/L [-1.29; 0.76], P = 0.32). However, a significant decrease from baseline in HbA1c, glycated albumin and insulin daily doses was observed in the vildagliptin-insulin group versus the insulin-only group (-0.6% [-1.19; -0.1], P < 0.01), in the vildagliptin-insulin group versus no change in the insulin-only group (-130.6 μmol/L [-271; 10.7] vs. +36.2 μmol/L [-164.4; 236.9], P = 0.04 and - 5.9 IU/day [-1.8; 7.1] vs. +1.1 IU/day [-14.5; 16.6], P = 0.01, respectively). There was no significant difference in the percentage of time spent in hypoglycaemia using CGM, occurrence of severe hypoglycaemia or number of adverse events. Conclusion: In this study, vildagliptin added to insulin improved glycaemic control with an associated insulin-sparing effect in patients with type 2 diabetes undergoing haemodialysis and was well tolerated.
MeSH term(s)	Adamantane/adverse effects ; Aged ; Blood Glucose ; Blood Glucose Self-Monitoring ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Glycated Hemoglobin A/analysis ; Humans ; Hypoglycemic Agents/therapeutic use ; Insulin/therapeutic use ; Middle Aged ; Nitriles/adverse effects ; Prospective Studies ; Pyrrolidines ; Renal Dialysis ; Vildagliptin/therapeutic use
Chemical Substances	Blood Glucose ; Glycated Hemoglobin A ; Hypoglycemic Agents ; Insulin ; Nitriles ; Pyrrolidines ; Vildagliptin (I6B4B2U96P) ; Adamantane (PJY633525U)
Language	English
Publishing date	2020-02-25
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	1454944-x
ISSN	1463-1326 ; 1462-8902
ISSN (online)	1463-1326
ISSN	1462-8902
DOI	10.1111/dom.13988
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Zs.A 5442: Show issues

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Article: Quelle(s) définition(s) du diabète gestationnel doit-on choisir?

Verier-Mine, O / Timsit, J

Diabetes & metabolism

1997 Volume 23 Suppl 5, Page(s) 15–16

Title translation	Which definition(s) of gestational diabetes should one choose?.
MeSH term(s)	Diabetes, Gestational/classification ; Diabetes, Gestational/diagnosis ; Diabetes, Gestational/therapy ; Diagnosis, Differential ; Female ; Humans ; Hyperglycemia ; Infant, Newborn ; Pregnancy
Language	French
Publishing date	1997-12
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	1315751-6
ISSN	1262-3636 ; 0338-1684
ISSN	1262-3636 ; 0338-1684
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Article: Quelles sont les différentes modalités de prise en charge thérapeutique du diabéte gestationnel?

Verier-Mine, O / Timsit, J

Diabetes & metabolism

1997 Volume 23 Suppl 5, Page(s) 30–33

Title translation	What are the different modalities for the therapeutic management of gestational diabetes?.
MeSH term(s)	Blood Glucose/metabolism ; Diabetes, Gestational/blood ; Diabetes, Gestational/therapy ; Diet, Diabetic ; Exercise ; Female ; Humans ; Hypoglycemic Agents/therapeutic use ; Insulin/therapeutic use ; Pregnancy
Chemical Substances	Blood Glucose ; Hypoglycemic Agents ; Insulin
Language	French
Publishing date	1997-12
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	1315751-6
ISSN	1262-3636 ; 0338-1684
ISSN	1262-3636 ; 0338-1684
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Article ; Online: Loss-of-function mutations in SOX10 cause Kallmann syndrome with deafness.

American journal of human genetics

2013 Volume 92, Issue 5, Page(s) 707–724

Abstract: Transcription factor SOX10 plays a role in the maintenance of progenitor cell multipotency, lineage specification, and cell differentiation and is a major actor in the development of the neural crest. It has been implicated in Waardenburg syndrome (WS), ... ...

Abstract	Transcription factor SOX10 plays a role in the maintenance of progenitor cell multipotency, lineage specification, and cell differentiation and is a major actor in the development of the neural crest. It has been implicated in Waardenburg syndrome (WS), a rare disorder characterized by the association between pigmentation abnormalities and deafness, but SOX10 mutations cause a variable phenotype that spreads over the initial limits of the syndrome definition. On the basis of recent findings of olfactory-bulb agenesis in WS individuals, we suspected SOX10 was also involved in Kallmann syndrome (KS). KS is defined by the association between anosmia and hypogonadotropic hypogonadism due to incomplete migration of neuroendocrine gonadotropin-releasing hormone (GnRH) cells along the olfactory, vomeronasal, and terminal nerves. Mutations in any of the nine genes identified to date account for only 30% of the KS cases. KS can be either isolated or associated with a variety of other symptoms, including deafness. This study reports SOX10 loss-of-function mutations in approximately one-third of KS individuals with deafness, indicating a substantial involvement in this clinical condition. Study of SOX10-null mutant mice revealed a developmental role of SOX10 in a subpopulation of glial cells called olfactory ensheathing cells. These mice indeed showed an almost complete absence of these cells along the olfactory nerve pathway, as well as defasciculation and misrouting of the nerve fibers, impaired migration of GnRH cells, and disorganization of the olfactory nerve layer of the olfactory bulbs.
MeSH term(s)	Animals ; DNA Mutational Analysis ; Deafness/genetics ; Deafness/pathology ; Female ; France ; Galactosides ; Genetic Predisposition to Disease/genetics ; HeLa Cells ; Humans ; Indoles ; Kallmann Syndrome/genetics ; Kallmann Syndrome/pathology ; Male ; Mice ; Mutation/genetics ; Neuroglia/pathology ; Olfactory Pathways/pathology ; Plasmids/genetics ; SOXE Transcription Factors/genetics
Chemical Substances	Galactosides ; Indoles ; SOX10 protein, human ; SOXE Transcription Factors ; 5-bromo-4-chloro-3-indolyl beta-galactoside (V595OG374W)
Language	English
Publishing date	2013-05-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	219384-x
ISSN	1537-6605 ; 0002-9297
ISSN (online)	1537-6605
ISSN	0002-9297
DOI	10.1016/j.ajhg.2013.03.024
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Zs.A 107: Show issues

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Article: Higher carbohydrate intake is associated with decreased incidence of newborn macrosomia in women with gestational diabetes.

Romon, M / Nuttens, M C / Vambergue, A / Vérier-Mine, O / Biausque, S / Lemaire, C / Fontaine, P / Salomez, J L / Beuscart, R

Journal of the American Dietetic Association

2001 Volume 101, Issue 8, Page(s) 897–902

Abstract: Objective: To study the influence of energy and macronutrient intake on infant birthweight in women with gestational diabetes mellitus undergoing intensive management.: Design: This prospective study evaluated the impact of intensive management of ... ...

Abstract	Objective: To study the influence of energy and macronutrient intake on infant birthweight in women with gestational diabetes mellitus undergoing intensive management. Design: This prospective study evaluated the impact of intensive management of gestational diabetes on maternal and fetal morbidity, and addressed the relationship between food intake and infant birthweight. Setting: Fifteen maternity hospitals in northern France. Subjects: Ninety-nine women with gestational diabetes or gestational mild hyperglycemia diagnosed between 24 and 34 weeks of gestation were surveyed. After 1 was excluded because of a premature birth and 18 were excluded as underreporters, 80 women were included in the final analysis. Diet intake was assessed by a dietary history at the first interview, and by two 3-day diet records at the 3rd and 7th week after diagnosis. Results: In a forward-stepwise regression analysis (controlling for maternal age; smoking; parity; prepregnancy BMI; pregnancy weight gain; gestational duration; infant sex; fasting and 2-hour postprandial serum glucose; insulin therapy; and energy, fat, protein and carbohydrate intake during treatment) infant birthweight was positively associated with gestational duration (beta = +0.34, P<.002), and negatively with smoking (beta = -0.27, P<.02) and carbohydrate intake (beta = -0.24, P<.03). There were no large-for-gestational-age infants among women whose carbohydrate intake exceeded 210 g/day. Conclusion: For women with gestational diabetes undergoing intensive management, higher carbohydrate intake is associated with decreased incidence of macrosomia. Application: These findings suggest that nutrition counseling in gestational diabetes must be directed to maintain a sufficient carbohydrate intake (at least 250 g per day), which implies a low-fat diet to limit energy intake. A careful distribution of carbohydrate throughout the day and the use of low-glycemic index foods may help limit postprandial hyperglycemia.
MeSH term(s)	Adult ; Birth Weight ; Blood Glucose/analysis ; Diabetes, Gestational/blood ; Diabetes, Gestational/complications ; Diabetes, Gestational/diet therapy ; Diabetes, Gestational/mortality ; Diet Records ; Diet Surveys ; Diet, Diabetic ; Dietary Carbohydrates/administration & dosage ; Energy Intake ; Female ; Fetal Macrosomia/etiology ; Fetal Macrosomia/mortality ; Fetal Macrosomia/prevention & control ; Gestational Age ; Humans ; Hyperglycemia/diet therapy ; Hyperglycemia/prevention & control ; Incidence ; Infant, Newborn ; Nutritional Physiological Phenomena ; Nutritional Requirements ; Pregnancy ; Pregnancy Complications/blood ; Pregnancy Complications/diet therapy ; Pregnancy Complications/mortality ; Pregnancy Outcome ; Pregnancy Trimester, Second ; Prospective Studies ; Regression Analysis
Chemical Substances	Blood Glucose ; Dietary Carbohydrates
Language	English
Publishing date	2001-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	390806-9
ISSN	1878-3570 ; 0002-8223
ISSN (online)	1878-3570
ISSN	0002-8223
DOI	10.1016/S0002-8223(01)00220-6
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Article ; Online: Practical implementation, education and interpretation guidelines for continuous glucose monitoring: A French position statement.

Borot, S / Benhamou, P Y / Atlan, C / Bismuth, E / Bonnemaison, E / Catargi, B / Charpentier, G / Farret, A / Filhol, N / Franc, S / Gouet, D / Guerci, B / Guilhem, I / Guillot, C / Jeandidier, N / Joubert, M / Melki, V / Merlen, E / Penfornis, A /

Picard, S / Renard, E / Reznik, Y / Riveline, J P / Rudoni, S / Schaepelynck, P / Sola-Gazagnes, A / Tubiana-Rufi, N / Verier-Mine, O / Hanaire, H

Diabetes & metabolism

2017 Volume 44, Issue 1, Page(s) 61–72

Abstract: The use by diabetes patients of real-time continuous interstitial glucose monitoring (CGM) or the FreeStyle ... ...

Abstract	The use by diabetes patients of real-time continuous interstitial glucose monitoring (CGM) or the FreeStyle Libre
MeSH term(s)	Blood Glucose Self-Monitoring ; Diabetes Mellitus, Type 1/blood ; Diabetes Mellitus, Type 1/therapy ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/therapy ; France ; Humans ; Patient Education as Topic ; Practice Guidelines as Topic ; Retrospective Studies
Language	English
Publishing date	2017-11-11
Publishing country	France
Document type	Journal Article
ZDB-ID	1315751-6
ISSN	1878-1780 ; 1262-3636 ; 0338-1684
ISSN (online)	1878-1780
ISSN	1262-3636 ; 0338-1684
DOI	10.1016/j.diabet.2017.10.009
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