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Article ; Online: Clinical Efficacy and Gut Microbiota Regulating-Related Effect of Si-Jun-Zi Decoction in Postoperative Non-Small Cell Lung Cancer Patients: A Prospective Observational Study.

He, Yiyun / Qi, Ao / Gu, Yifeng / Zhang, Congmeng / Wang, Yichao / Yang, Wenxiao / Bi, Ling / Gong, Yabin / Jiao, Lijing / Xu, Ling

Integrative cancer therapies

2024 Volume 23, Page(s) 15347354241237973

Abstract: ... a deteriorated quality of life (QOL), disturbed immune response, and disordered homeostasis. Si-Jun-Zi Decoction ...

Abstract	Background: Postoperative non-small cell lung cancer (NSCLC) patients frequently encounter a deteriorated quality of life (QOL), disturbed immune response, and disordered homeostasis. Si-Jun-Zi Decoction (SJZD), a well-known traditional Chinese herbal formula, is frequently employed in clinical application for many years. Exploration is underway to investigate the potential therapeutic effect of SJZD for treating postoperative NSCLC. Objective: To assess the efficacy of SJZD on QOLs, hematological parameters, and regulations of gut microbiota in postoperative NSCLC patients. Methods: A prospective observational cohort study was conducted, enrolling 65 postoperative NSCLC patients between May 10, 2020 and March 15, 2021 in Yueyang Hospital, with 33 patients in SJZD group and 32 patients in control (CON) group. The SJZD group comprised of patients who received standard treatments and the SJZD decoction, while the CON group consisted of those only underwent standard treatments. The treatment period was 4 weeks. The primary outcome was QOL. The secondary outcomes involved serum immune cell and inflammation factor levels, safety, and alterations in gut microbiota. Results: SJZD group showed significant enhancements in cognitive functioning ( Conclusions: SJZD appears to be an effective and safe treatment for postoperative NSCLC patients. As a preliminary observational study, this study provides a foundation for further research.
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/surgery ; Lung Neoplasms/drug therapy ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Quality of Life ; Prospective Studies ; Gastrointestinal Microbiome ; Treatment Outcome
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2024-03-19
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	2182320-0
ISSN	1552-695X ; 1534-7354
ISSN (online)	1552-695X
ISSN	1534-7354
DOI	10.1177/15347354241237973
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Article ; Online: Vortex-assisted dispersive liquid-phase microextraction for the analysis of main active compounds from Zi-Cao-Cheng-Qi decoction based on a hydrophobic deep eutectic solvent.

Xue, Jiao / Yang, Li / Chen, Xuan / Bai, Xiao-Hong / Hu, Shuang

Journal of separation science

2021 Volume 44, Issue 24, Page(s) 4376–4383

Abstract: ... liquid-phase microextraction was developed and used for the extraction and preconcentration of six main active compounds in Zi ...

Abstract	In this study, a vortex-assisted hydrophobic deep eutectic solvent dispersive liquid-phase microextraction was developed and used for the extraction and preconcentration of six main active compounds in Zi-Cao-Cheng-Qi decoction. The deep eutectic solvent, prepared by mixing tetrabutylammonium chloride and hexanoic acid at a molar ratio of 1:1, was added to the sample solution containing the analytes. In the absence of disperser, the extractant was rapidly dispersed into fine droplets by the aid of vortex and adequately contacted with the analytes. Some key parameters affecting the approach including extraction solvent type and volume, sample phase pH, extraction time, centrifugation time, and salt concentration were investigated and optimized. Under the optimum conditions, enrichment factors of the target analytes were in the range of 3-330. The calibration graphs were linear with a correlation coefficient (r) ≥ 0.9929. The detection limits were 0.3-0.9 ng/mL, and the satisfactory precisions (relative standard deviations, 0.5-8.9%) and accuracies (relative recoveries, 91.1-102.2%) were also obtained. The developed method was rapid (only 2 min), eco-friendly, effective, and easy to operate. And it has been successfully applied to simultaneous extraction, enrichment, and determination of the main active compounds in a traditional Chinese medicinal formula coupled with high-performance liquid chromatography.
MeSH term(s)	Chromatography, High Pressure Liquid/methods ; Deep Eutectic Solvents/chemistry ; Drugs, Chinese Herbal/chemistry ; Hydrophobic and Hydrophilic Interactions ; Limit of Detection ; Liquid Phase Microextraction/methods
Chemical Substances	Deep Eutectic Solvents ; Drugs, Chinese Herbal
Language	English
Publishing date	2021-11-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2047990-6
ISSN	1615-9314 ; 1615-9306
ISSN (online)	1615-9314
ISSN	1615-9306
DOI	10.1002/jssc.202100270
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Article: Antineuroinflammatory Effects of Modified Wu-Zi-Yan-Zong Prescription in

Yu, Qian / Song, Fang-Jiao / Chen, Jin-Feng / Dong, Xin / Jiang, Yong / Zeng, Ke-Wu / Tu, Peng-Fei / Wang, Xue-Mei

Evidence-based complementary and alternative medicine : eCAM

2017 Volume 2017, Page(s) 8470381

Abstract: Modified Wu-Zi-Yan-Zong prescription (MWP), a traditional Chinese medicinal decoction, has ...

Abstract	Modified Wu-Zi-Yan-Zong prescription (MWP), a traditional Chinese medicinal decoction, has possessed the neuroprotective and anti-inflammatory properties. The mechanisms associated with these properties, however, are not completely understood. We designed the experiments to elucidate the antineuroinflammatory property of MWP in BV2 microglia activated by
Language	English
Publishing date	2017-07-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2017/8470381
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Article: Vortex‐assisted dispersive liquid‐phase microextraction for the analysis of main active compounds from Zi‐Cao‐Cheng‐Qi decoction based on a hydrophobic deep eutectic solvent

Xue, Jiao / Yang, Li / Chen, Xuan / Bai, Xiao‐Hong / Hu, Shuang

Journal of separation science. 2021 Dec., v. 44, no. 24

2021

Abstract: ... microextraction was developed and used for the extraction and preconcentration of six main active compounds in Zi ...

Abstract	In this study, a vortex‐assisted hydrophobic deep eutectic solvent dispersive liquid‐phase microextraction was developed and used for the extraction and preconcentration of six main active compounds in Zi‐Cao‐Cheng‐Qi decoction. The deep eutectic solvent, prepared by mixing tetrabutylammonium chloride and hexanoic acid at a molar ratio of 1:1, was added to the sample solution containing the analytes. In the absence of disperser, the extractant was rapidly dispersed into fine droplets by the aid of vortex and adequately contacted with the analytes. Some key parameters affecting the approach including extraction solvent type and volume, sample phase pH, extraction time, centrifugation time, and salt concentration were investigated and optimized. Under the optimum conditions, enrichment factors of the target analytes were in the range of 3–330. The calibration graphs were linear with a correlation coefficient (r) ≥ 0.9929. The detection limits were 0.3–0.9 ng/mL, and the satisfactory precisions (relative standard deviations, 0.5–8.9%) and accuracies (relative recoveries, 91.1–102.2%) were also obtained. The developed method was rapid (only 2 min), eco‐friendly, effective, and easy to operate. And it has been successfully applied to simultaneous extraction, enrichment, and determination of the main active compounds in a traditional Chinese medicinal formula coupled with high‐performance liquid chromatography.
Keywords	calibration ; centrifugation ; chemical species ; chlorides ; hexanoic acid ; high performance liquid chromatography ; hydrophobicity ; liquid-phase microextraction ; pH ; salt concentration ; separation ; solvents ; tetrabutylammonium compounds
Language	English
Dates of publication	2021-12
Size	p. 4376-4383.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	2047990-6
ISSN	1615-9314 ; 1615-9306
ISSN (online)	1615-9314
ISSN	1615-9306
DOI	10.1002/jssc.202100270
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Article ; Online: Simultaneous determination of eight bioactive constituents of Zhi-Zi-Hou-Po decoction in rat plasma by ultra high performance liquid chromatography with tandem mass spectrometry and its application to a pharmacokinetic study.

Zhu, Heyun / Guan, Jiao / Shi, Jianyi / Pan, Xu / Chang, Sheng / Zhang, Tianyi / Feng, Bo / Gu, Jingkai

Journal of separation science

2019 Volume 43, Issue 2, Page(s) 406–417

Abstract: Zhi-Zi-Hou-Po Decoction, consisting of Gardenia jasminoides Ellis, Magnolia officinalis Rehd. et ... the major bioactive constituents of Zhi-Zi-Hou-Po Decoction, in rat plasma using paeoniflorin as internal ...

Abstract	Zhi-Zi-Hou-Po Decoction, consisting of Gardenia jasminoides Ellis, Magnolia officinalis Rehd. et Wils., and Citrus aurantium L, is a classical Traditional Chinese Medicine formula for the treatment of depression. In order to make good and rational use of this formula in the future, a sensitive, selective, and reliable ultra high performance liquid chromatography with tandem mass spectrometry method was developed for simultaneous determination of two iridoid glycosides (geniposide and genipin gentiobioside), two lignans (honokiol and magnolol), four flavonoid glycosides (isonaringin, naringin, hesperidin, and neohesperidin), the major bioactive constituents of Zhi-Zi-Hou-Po Decoction, in rat plasma using paeoniflorin as internal standard. Plasma samples were pretreated by a simple protein precipitation with acetonitrile. Chromatographic separation was performed on a shim-pack XR-ODS C
MeSH term(s)	Administration, Oral ; Animals ; Chromatography, High Pressure Liquid ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/analysis ; Drugs, Chinese Herbal/pharmacokinetics ; Flavonoids/administration & dosage ; Flavonoids/blood ; Flavonoids/pharmacokinetics ; Iridoid Glycosides/administration & dosage ; Iridoid Glycosides/blood ; Iridoid Glycosides/pharmacokinetics ; Lignans/administration & dosage ; Lignans/blood ; Lignans/pharmacokinetics ; Male ; Medicine, Chinese Traditional ; Molecular Structure ; Rats ; Rats, Sprague-Dawley ; Tandem Mass Spectrometry
Chemical Substances	Drugs, Chinese Herbal ; Flavonoids ; Iridoid Glycosides ; Lignans
Language	English
Publishing date	2019-11-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2047990-6
ISSN	1615-9314 ; 1615-9306
ISSN (online)	1615-9314
ISSN	1615-9306
DOI	10.1002/jssc.201900670
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Article: Simultaneous determination of eight bioactive constituents of Zhi‐Zi‐Hou‐Po decoction in rat plasma by ultra high performance liquid chromatography with tandem mass spectrometry and its application to a pharmacokinetic study

Zhu, Heyun / Guan, Jiao / Shi, Jianyi / Pan, Xu / Chang, Sheng / Zhang, Tianyi / Feng, Bo / Gu, Jingkai

Journal of separation science. 2020 Jan., v. 43, no. 2

2020

Abstract: Zhi‐Zi‐Hou‐Po Decoction, consisting of Gardenia jasminoides Ellis, Magnolia officinalis Rehd. et ... the major bioactive constituents of Zhi‐Zi‐Hou‐Po Decoction, in rat plasma using paeoniflorin as internal ... to a pharmacokinetic study of the eight analytes after oral administration of Zhi‐Zi‐Hou‐Po decoction to rats. ...

Abstract	Zhi‐Zi‐Hou‐Po Decoction, consisting of Gardenia jasminoides Ellis, Magnolia officinalis Rehd. et Wils., and Citrus aurantium L, is a classical Traditional Chinese Medicine formula for the treatment of depression. In order to make good and rational use of this formula in the future, a sensitive, selective, and reliable ultra high performance liquid chromatography with tandem mass spectrometry method was developed for simultaneous determination of two iridoid glycosides (geniposide and genipin gentiobioside), two lignans (honokiol and magnolol), four flavonoid glycosides (isonaringin, naringin, hesperidin, and neohesperidin), the major bioactive constituents of Zhi‐Zi‐Hou‐Po Decoction, in rat plasma using paeoniflorin as internal standard. Plasma samples were pretreated by a simple protein precipitation with acetonitrile. Chromatographic separation was performed on a shim‐pack XR‐ODS C18 column (75 × 3.0 mm, 2.2 μm) using gradient elution with mobile phase consisting of 0.1% formic acid aqueous solution and acetonitrile at a flow rate of 0.5 mL/min. Mass spectrometric detection was conducted on a 3200 QTRAP mass spectrometry equipped with electrospray ionization source in negative ionization mode. Quantification was performed using multiple reactions monitoring mode. Calibration curves exhibited good linearity (r > 0.9947) over a wide concentration range for all analytes, and the lower limits of quantification were 10, 5, 1, 5, 1, 5, 1, and 5 ng/mL for geniposide, genipin gentiobioside, honokiol, magnolol, isonaringin, naringin, hesperidin, and neohesperidin, respectively. The intraday and interday precisions at three quality control levels were less than 12.3% and the accuracies ranged from −11.2 to 10.7%. Extraction recovery, matrix effect, and stability were satisfactory in rat plasma. The validated method was successfully applied to a pharmacokinetic study of the eight analytes after oral administration of Zhi‐Zi‐Hou‐Po decoction to rats.
Keywords	Citrus aurantium ; Gardenia jasminoides ; Magnolia officinalis ; Oriental traditional medicine ; acetonitrile ; aqueous solutions ; electrospray ionization mass spectrometry ; formic acid ; honokiol ; ionization ; iridoid glycosides ; magnolol ; monitoring ; naringin ; neohesperidin ; oral administration ; pharmacokinetics ; quality control ; rats ; tandem mass spectrometry ; ultra-performance liquid chromatography
Language	English
Dates of publication	2020-01
Size	p. 406-417.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	2047990-6
ISSN	1615-9314 ; 1615-9306
ISSN (online)	1615-9314
ISSN	1615-9306
DOI	10.1002/jssc.201900670
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Characterization of chemical constituents in Zhi-Zi-Da-Huang decoction by ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.

Zhu, Heyun / Yin, Ran / Han, Fei / Guan, Jiao / Zhang, Xiaoshu / Mao, Xinjuan / Zhao, Longshan / Li, Qing / Hou, Xiaohong / Bi, Kaishun

Journal of separation science

2014 Volume 37, Issue 23, Page(s) 3489–3496

Abstract: ... Zi-Da-Huang decoction, a classic traditional Chinese medicine formula. The chromatographic separation ... organic acids were major constituents in Zhi-Zi-Da-Huang decoction. It is concluded that the developed ultra ... constituents of Zhi-Zi-Da-Huang decoction, and the analysis provides a helpful chemical basis for further ...

Abstract	A sensitive and reliable ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry method was established to separate and identify the chemical constituents of Zhi-Zi-Da-Huang decoction, a classic traditional Chinese medicine formula. The chromatographic separation was achieved on a Shim-pack XR-ODS C18 column (75 × 3.0 mm, 2.2 μm) using a gradient elution program. The detection was performed on a Waters Xevo G2 Q-TOF mass spectrometer equipped with electrospray ionization source in both positive and negative modes. With the optimized conditions, a total of 82 compounds were identified or tentatively characterized. Of the 82 compounds, 21 compounds were identified by comparing the retention time and MS data with reference standards, the rest were characterized by analyzing MS data and retrieving the reference literature. In addition, 31 compounds were identified from Gardenia jasminoides Ellis, ten compounds were identified from Rheum palmatum L., 33 compounds were identified from Citrus aurantium L., and eight compounds were identified from Sojae Semen Praeparatum. Results indicated that iridoids, anthraquinones, flavonoids, isoflavonoids, coumarins, glycosides of crocetin, monoterpenoids, and organic acids were major constituents in Zhi-Zi-Da-Huang decoction. It is concluded that the developed ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry method with high sensitivity and resolution is suitable for identifying and characterizing the chemical constituents of Zhi-Zi-Da-Huang decoction, and the analysis provides a helpful chemical basis for further research on Zhi-Zi-Da-Huang decoction.
MeSH term(s)	Chromatography, High Pressure Liquid/methods ; Drugs, Chinese Herbal/chemistry ; Mass Spectrometry/methods ; Molecular Structure ; Plants, Medicinal/chemistry
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2014-12
Publishing country	Germany
Document type	Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2047990-6
ISSN	1615-9314 ; 1615-9306
ISSN (online)	1615-9314
ISSN	1615-9306
DOI	10.1002/jssc.201400728
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Article ; Online: Identification of the absorbed components and metabolites of Zhi-Zi-Da-Huang decoction in rat plasma by ultra-high performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry.

Zhu, Heyun / Bi, Kaishun / Han, Fei / Guan, Jiao / Zhang, Xiaoshu / Mao, Xinjuan / Zhao, Longshan / Li, Qing / Hou, Xiaohong / Yin, Ran

Journal of pharmaceutical and biomedical analysis

2015 Volume 111, Page(s) 277–287

Abstract: Zhi-Zi-Da-Huang decoction (ZZDHD), consisting of Gardenia jasminoides Ellis, Rheum palmatum L ...

Abstract	Zhi-Zi-Da-Huang decoction (ZZDHD), consisting of Gardenia jasminoides Ellis, Rheum palmatum L., Citrus aurantium L. and Sojae Semen Praeparatum, is a widely used traditional Chinese medicine preparation for the treatment of acute or chronic hepatic diseases. In the present study, a sensitive and selective ultra-high performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (UHPLC-Q-TOF-MS) method was developed to separate and identify the absorbed components and metabolites in rat plasma after oral administration of ZZDHD. The plasma samples were pretreated by protein precipitation and separated on a Shim-pack XR-ODS C18 column (75 mm × 3.0 mm, 2.2 μm) using a gradient elution program. Mass spectrometric detection was performed on an Agilent 6520 Q-TOF mass spectrometer equipped with electrospray ionization (ESI) source in positive and negative ion modes. By comparing the retention time, high resolution mass data of blank plasma and dosed plasma, a total of 43 constituents, including 21 prototype compounds and 22 metabolites were identified or tentatively characterized. Results indicated that glucuronidation and sulfation were the main metabolic pathways of iridoid glycosides and anthraquinones, glucuronidation was the main metabolic pathways of flavanone-related compounds. It is concluded the developed UHPLC-Q-TOF-MS method with high sensitivity and resolution is suitable for identifying and characterizing the absorbed components and metabolites of ZZDHD, and the results will provide essential data for further studying the relationship between the chemical components and pharmacological activity of ZZDHD.
MeSH term(s)	Administration, Oral ; Animals ; Anthraquinones/chemistry ; Chromatography, High Pressure Liquid/methods ; Drugs, Chinese Herbal/chemistry ; Iridoid Glycosides/chemistry ; Male ; Medicine, Chinese Traditional/methods ; Plasma/chemistry ; Rats ; Rats, Sprague-Dawley ; Rheum/chemistry ; Spectrometry, Mass, Electrospray Ionization/methods ; Tandem Mass Spectrometry/methods
Chemical Substances	Anthraquinones ; Drugs, Chinese Herbal ; Iridoid Glycosides
Language	English
Publishing date	2015
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2015.03.043
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Article ; Online: Antineuroinflammatory Effects of Modified Wu-Zi-Yan-Zong Prescription in β-Amyloid-Stimulated BV2 Microglia via the NF-κB and ERK/p38 MAPK Signaling Pathways

Qian Yu / Fang-Jiao Song / Jin-Feng Chen / Xin Dong / Yong Jiang / Ke-Wu Zeng / Peng-Fei Tu / Xue-Mei Wang

Evidence-Based Complementary and Alternative Medicine, Vol

2017 Volume 2017

Abstract: Modified Wu-Zi-Yan-Zong prescription (MWP), a traditional Chinese medicinal decoction, has ...

Abstract	Modified Wu-Zi-Yan-Zong prescription (MWP), a traditional Chinese medicinal decoction, has possessed the neuroprotective and anti-inflammatory properties. The mechanisms associated with these properties, however, are not completely understood. We designed the experiments to elucidate the antineuroinflammatory property of MWP in BV2 microglia activated by β-amyloid (Aβ), which is a characteristic feature of Alzheimer’s disease (AD). The composition of MWP was studied using HPLC. BV2 microglia cells were then treated with Aβ in the presence or absence of MWP. The effects of MWP treatment on Aβ-activated neuroinflammation were determined using PCR, western blotting, and immunofluorescence staining. MWP significantly inhibited the mRNA expression of inflammatory mediators such as IL-1β, IL-6, TNF-α, and MCP-1, as well as the expression of inducible nitric oxide synthase (iNOS) in Aβ-activated BV2 microglia. MWP also inhibited the nuclear translocation and signaling pathway of nuclear factor kappa B (NF-κB) by suppressing inhibitor of nuclear factor-κB (IκB) degradation and downregulating IκB kinase β (IKKβ) phosphorylation. Moreover, MWP decreased extracellular regulated protein kinase (ERK)/p38 mitogen-activated protein kinase (MAPK) phosphorylation, which is an important signaling pathway for proinflammatory gene expression. We concluded that MWP could suppress neuroinflammatory responses in Aβ-activated BV2 microglia via the NF-κB and ERK/p38 MAPK signaling cascades and could prove an effective therapeutic agent for the prevention and treatment of neuroinflammatory diseases such as AD.
Keywords	Other systems of medicine ; RZ201-999
Language	English
Publishing date	2017-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Characterization of chemical constituents in Zhi–Zi–Da–Huang decoction by ultra high performance liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry

Zhu, Heyun / Yin, Ran / Han, Fei / Guan, Jiao / Zhang, Xiaoshu / Mao, Xinjuan / Zhao, Longshan / Li, Qing / Hou, Xiaohong / Bi, Kaishun

Journal of separation science. 2014 Dec., v. 37, no. 23

2014

Abstract: ... Zi–Da–Huang decoction, a classic traditional Chinese medicine formula. The chromatographic separation ... organic acids were major constituents in Zhi–Zi–Da–Huang decoction. It is concluded that the developed ultra ... constituents of Zhi–Zi–Da–Huang decoction, and the analysis provides a helpful chemical basis for further ...

Abstract	A sensitive and reliable ultra high performance liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry method was established to separate and identify the chemical constituents of Zhi–Zi–Da–Huang decoction, a classic traditional Chinese medicine formula. The chromatographic separation was achieved on a Shim‐pack XR‐ODS C₁₈column (75 × 3.0 mm, 2.2 μm) using a gradient elution program. The detection was performed on a Waters Xevo G2 Q‐TOF mass spectrometer equipped with electrospray ionization source in both positive and negative modes. With the optimized conditions, a total of 82 compounds were identified or tentatively characterized. Of the 82 compounds, 21 compounds were identified by comparing the retention time and MS data with reference standards, the rest were characterized by analyzing MS data and retrieving the reference literature. In addition, 31 compounds were identified from Gardenia jasminoides Ellis, ten compounds were identified from Rheum palmatum L., 33 compounds were identified from Citrus aurantium L., and eight compounds were identified from Sojae Semen Praeparatum. Results indicated that iridoids, anthraquinones, flavonoids, isoflavonoids, coumarins, glycosides of crocetin, monoterpenoids, and organic acids were major constituents in Zhi–Zi–Da–Huang decoction. It is concluded that the developed ultra high performance liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry method with high sensitivity and resolution is suitable for identifying and characterizing the chemical constituents of Zhi–Zi–Da–Huang decoction, and the analysis provides a helpful chemical basis for further research on Zhi–Zi–Da–Huang decoction.
Keywords	Citrus aurantium ; Gardenia jasminoides ; Oriental traditional medicine ; Rheum palmatum ; anthraquinones ; chemical composition ; coumarins ; glycosides ; ionization ; iridoids ; isoflavonoids ; mass spectrometry ; monoterpenoids ; organic acids and salts ; reference standards ; semen ; ultra-performance liquid chromatography
Language	English
Dates of publication	2014-12
Size	p. 3489-3496.
Publishing place	Wiley-VCH
Document type	Article
ZDB-ID	2047990-6
ISSN	1615-9314 ; 1615-9306
ISSN (online)	1615-9314
ISSN	1615-9306
DOI	10.1002/jssc.201400728
Database	NAL-Catalogue (AGRICOLA)

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