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  1. Article ; Online: N

    Zhu, Mengjie / Wu, Nan / Zhong, Jiayi / Chen, Chen / Liu, Wenwen / Ren, Yingdang / Wang, Xifeng / Jin, Huaibing

    Cell reports

    2024  Volume 43, Issue 2, Page(s) 113821

    Abstract: ... shown to be downregulated by increased levels of N ...

    Abstract The titer of viruses that persist and propagate in their insect vector must be high enough for transmission yet not harm the insect, but the mechanism of this dynamic balance is unclear. Here, expression of inosine monophosphate dehydrogenase (LsIMPDH), a rate-limiting enzyme for guanosine triphosphate (GTP) synthesis, is shown to be downregulated by increased levels of N
    MeSH term(s) Animals ; Insect Vectors ; Guanosine Triphosphate ; RNA, Messenger/genetics ; Cell Proliferation ; Adenosine/analogs & derivatives
    Chemical Substances N-methyladenosine (CLE6G00625) ; Guanosine Triphosphate (86-01-1) ; RNA, Messenger ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2024-02-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2024.113821
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: N

    Li, Chunyang / Zhu, Maoshu / Gao, Chuane / Lu, Fuhua / Chen, Huoshu / Liu, Jiancheng / Zhong, Weimin

    Frontiers in bioscience (Landmark edition)

    2024  Volume 29, Issue 1, Page(s) 33

    MeSH term(s) Humans ; Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/therapy ; B7-H1 Antigen ; Tumor Microenvironment/genetics ; Kidney Neoplasms/drug therapy ; Kidney Neoplasms/genetics ; Methylation
    Chemical Substances B7-H1 Antigen
    Language English
    Publishing date 2024-02-10
    Publishing country Singapore
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2704569-9
    ISSN 2768-6698 ; 2768-6698
    ISSN (online) 2768-6698
    ISSN 2768-6698
    DOI 10.31083/j.fbl2901033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: N

    Zhang, Ru Zhong / Gao, Yan Fang / Yu, Jian Xin / Xu, Cong / Wang, Mang

    Organic letters

    2024  Volume 26, Issue 13, Page(s) 2641–2645

    Abstract: A wide range ... ...

    Abstract A wide range of
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.4c00708
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: N

    Chen, Wentian / Ma, Tianran / Liu, Sinuo / Zhong, Yaogang / Yu, Hanjie / Shu, Jian / Wang, Xiurong / Li, Zheng

    Viruses

    2024  Volume 16, Issue 2

    Abstract: The cleavage of sialic acids by neuraminidase (NA) facilitates the spread of influenza A virus (IV) descendants. Understanding the enzymatic activity of NA aids research into the transmission of IVs. An effective method for purifying NA was developed ... ...

    Abstract The cleavage of sialic acids by neuraminidase (NA) facilitates the spread of influenza A virus (IV) descendants. Understanding the enzymatic activity of NA aids research into the transmission of IVs. An effective method for purifying NA was developed using
    MeSH term(s) Animals ; Chick Embryo ; Chickens ; Influenza A virus ; Influenza, Human ; Lectins ; Neuraminidase ; Polysaccharides/chemistry
    Chemical Substances Lectins ; Neuraminidase (EC 3.2.1.18) ; Polysaccharides
    Language English
    Publishing date 2024-01-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v16020190
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: N

    Wang, Zhong-Qun / Yao, Hai-Peng / Sun, Zhen

    World journal of diabetes

    2023  Volume 14, Issue 3, Page(s) 222–233

    Abstract: ... that cannot be ignored. N: Aim: Our study aimed to explore the role of RAGE and CD36 in CML-induced mac ... We synthesized a novel N-succinimidyl-4-: Results: The study revealed that CML significantly promoted lipid ...

    Abstract Background: Advanced glycation end products (AGEs) are diabetic metabolic toxic products that cannot be ignored. N
    Aim: Our study aimed to explore the role of RAGE and CD36 in CML-induced mac-rophage lipid uptake.
    Methods: In this study, we examined the effect of CML on lipid uptake by Raw264.7 macrophages. After adding 10 mmol/L CML, the lipid accumulation in macro-phages was confirmed by oil red O staining. Expression changes of CD36 and RAGE were detected with immunoblotting and quantitative real-time polymerase chain reaction. The interaction between CML with CD36 and RAGE was verified by immunoprecipitation. We synthesized a novel N-succinimidyl-4-
    Results: The study revealed that CML significantly promoted lipid uptake by macro-phages. Immunoprecipitation and radioactive receptor-ligand binding assays indicated that CML could specifically bind to both CD36 and RAGE. CML had a higher affinity for CD36 than RAGE. ARG82, ASN71, and THR70 were the potential interacting amino acids that CD36 binds to CML Anti-CD36 and anti-RAGE could block the uptake of CML by macrophages. The lipid uptake promotion effect of CML was significantly attenuated after blocking CD36 or RAGE.
    Conclusion: Our results suggest that the binding of CML with CD36 and RAGE promotes macrophage lipid uptake.
    Language English
    Publishing date 2023-03-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2583471-X
    ISSN 1948-9358
    ISSN 1948-9358
    DOI 10.4239/wjd.v14.i3.222
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: N

    Liang, Junqing / Fu, Wen / Dong, Lefeng / Zhou, Cong / Yuan, Qinglong / Chang, Wenning / Yang, Wu-Lin / Xu, Xiaoyong / Shao, Xusheng / Li, Zhong

    Organic letters

    2023  Volume 25, Issue 26, Page(s) 4797–4802

    Abstract: The compounds featuring α-difluorothiomethylated ketone skeleton derivatives are of particular interest in pharmaceuticals and agrochemicals. Herein, we designed novel ... ...

    Abstract The compounds featuring α-difluorothiomethylated ketone skeleton derivatives are of particular interest in pharmaceuticals and agrochemicals. Herein, we designed novel electrophilic
    MeSH term(s) Ketones/chemistry ; Catalysis ; Phthalimides ; Radiopharmaceuticals
    Chemical Substances N-difluoromethylthiophthalimide ; Ketones ; Phthalimides ; Radiopharmaceuticals
    Language English
    Publishing date 2023-06-22
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.3c01468
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  7. Article: N

    Shi, Ling-Zhu / Chen, Xi / Cao, Hui-Hui / Tian, Chun-Yang / Zou, Li-Fang / Yu, Jian-Hai / Lu, Zi-Bin / Zhao, Wei / Liu, Jun-Shan / Yu, Lin-Zhong

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 2

    Abstract: Background: At present, about half of the world's population is at risk of being infected with dengue virus (DENV). However, there are no specific drugs to prevent or treat DENV infection. Glycyrrhizae Radix et Rhizome, a well-known traditional Chinese ... ...

    Abstract Background: At present, about half of the world's population is at risk of being infected with dengue virus (DENV). However, there are no specific drugs to prevent or treat DENV infection. Glycyrrhizae Radix et Rhizome, a well-known traditional Chinese medicine, performs multiple pharmacological activities, including exerting antiviral effects. The aim of this study was to investigate the anti-DENV effects of
    Methods: Compounds analysis of GRE was conducted via ultra-performance liquid chromatography/tandem mass spectrometry (UHPLC-MS/MS). The antiviral activities of GRE were determined by the CCK-8 assay, plaque assay, qRT-PCR, Western blotting, and the immunofluorescence assay. The DENV-infected suckling mice model was constructed to explore the antiviral effects of GRE in vivo.
    Results: Four components in GRE were analyzed by UHPLC-MS/MS, including glycyrrhizic acid, glycyrrhetnic acid, liquiritigenin, and isoliquiritigenin. GRE inhibited the attachment process of the virus replication cycle and reduced the expression of the E protein in cell models. In the in vivo study, GRE significantly relieved clinical symptoms and prolong survival duration. GRE also significantly decreased viremia, reduced the viral load in multiple organs, and inhibited the release of pro-inflammatory cytokines in DENV-infected suckling mice.
    Conclusions: GRE exhibited significant inhibitory activities in the adsorption stage of the DENV-2 replication cycle by targeting the envelope protein. Thus, GRE might be a promising candidate for the treatment of DENV infection.
    Language English
    Publishing date 2023-02-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16020263
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  8. Article ; Online: N

    Liu, Deyin / Li, Zhong / Zhang, Kun / Lu, Daigang / Zhou, Dawei / Meng, Yibin

    Journal of cancer research and clinical oncology

    2022  Volume 149, Issue 8, Page(s) 4601–4610

    Abstract: Purpose: N: Methods: The aerobic glycolysis of osteosarcoma cells were calculated by glucose ...

    Abstract Purpose: N
    Methods: The aerobic glycolysis of osteosarcoma cells were calculated by glucose uptake, lactate production analysis, ATP analysis and metabolic flux analysis for extracellular acidification rate (ECAR). Molecular binding was identified by RIP-qPCR, RNA decay analysis.
    Results: Results indicated that YTHDF3 is upregulated in the osteosarcoma tissue samples and cells, and closely correlated to the poor prognosis of osteosarcoma patients. Functionally, gain and loss-of-functional assays illustrated that YTHDF3 promoted the proliferation and aerobic glycolysis of osteosarcoma cells in vitro, and accelerated the tumor growth in vivo. Mechanistically, a m
    Conclusions: In conclusion, these findings indicated that YTHDF3 functioned as an oncogene in osteosarcoma tumorigenesis through m
    MeSH term(s) Humans ; Citric Acid Cycle ; Carcinogenesis/metabolism ; Cell Transformation, Neoplastic ; Osteosarcoma/genetics ; Glycolysis ; Cell Line, Tumor ; Cell Proliferation ; Phosphoglycerate Kinase/genetics ; Phosphoglycerate Kinase/metabolism
    Chemical Substances N-methyladenosine (CLE6G00625) ; PGK1 protein, human (EC 2.7.2.3) ; Phosphoglycerate Kinase (EC 2.7.2.3)
    Language English
    Publishing date 2022-09-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 134792-5
    ISSN 1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
    ISSN (online) 1432-1335
    ISSN 0171-5216 ; 0084-5353 ; 0943-9382
    DOI 10.1007/s00432-022-04337-y
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    Uh III Zs.10: Show issues Location:
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  9. Article ; Online: N

    Szczuka, Aleksandra / Huang, Nan / MacDonald, Jessica A / Nayak, Adam / Zhang, Zhong / Mitch, William A

    Environmental science & technology

    2020  Volume 54, Issue 23, Page(s) 15465–15475

    Abstract: Chloramines applied to control microfiltration and reverse osmosis (RO) membrane biofouling in potable reuse trains form the potent carcinogen, ...

    Abstract Chloramines applied to control microfiltration and reverse osmosis (RO) membrane biofouling in potable reuse trains form the potent carcinogen,
    MeSH term(s) Chlorine ; Dimethylnitrosamine ; Hydrogen Peroxide ; Osmosis ; Ultraviolet Rays ; Water Pollutants, Chemical ; Water Purification
    Chemical Substances Water Pollutants, Chemical ; Chlorine (4R7X1O2820) ; Hydrogen Peroxide (BBX060AN9V) ; Dimethylnitrosamine (M43H21IO8R)
    Language English
    Publishing date 2020-11-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 1520-5851
    ISSN (online) 1520-5851
    DOI 10.1021/acs.est.0c05704
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: N-

    Ma, Bin / Li, Jing / Yang, Wen-Ke / Zhang, Mei-Gui / Xie, Xiao-Dong / Bai, Zhong-Tian

    Analytical cellular pathology (Amsterdam)

    2021  Volume 2021, Page(s) 1560307

    Abstract: N- ...

    Abstract N-
    MeSH term(s) Apoptosis/drug effects ; Apoptosis/genetics ; Apoptosis Regulatory Proteins/genetics ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Coumaric Acids/chemistry ; Coumaric Acids/pharmacology ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Molecular Structure ; Octopamine/analogs & derivatives ; Octopamine/chemistry ; Octopamine/pharmacology ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Proto-Oncogene Proteins c-bcl-2/genetics ; RNA-Seq/methods ; Signal Transduction/drug effects ; Signal Transduction/genetics ; Transcription Factor CHOP/genetics
    Chemical Substances Apoptosis Regulatory Proteins ; BBC3 protein, human ; CDKN1A protein, human ; Coumaric Acids ; Cyclin-Dependent Kinase Inhibitor p21 ; DDIT3 protein, human ; N-feruloyloctopamine ; PMAIP1 protein, human ; Proto-Oncogene Proteins ; Proto-Oncogene Proteins c-bcl-2 ; Transcription Factor CHOP (147336-12-7) ; Octopamine (14O50WS8JD) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2021-05-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2583629-8
    ISSN 2210-7185 ; 2210-7177
    ISSN (online) 2210-7185
    ISSN 2210-7177
    DOI 10.1155/2021/1560307
    Database MEDical Literature Analysis and Retrieval System OnLINE

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