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  1. Article: Outlook of IL-6 signaling blockade for COVID-19 pneumonia.

    Hashizume, Misato

    Inflammation and regeneration

    2020  Volume 40, Page(s) 24

    Abstract: In this review article, it is highlighted the implications of pleiotropic functions of interleukin-6 (IL-6) for one of the therapeutic options targeting for COVID-19. Moreover, it is discussed how real-world data and trials with IL-6 signaling blockade ... ...

    Abstract In this review article, it is highlighted the implications of pleiotropic functions of interleukin-6 (IL-6) for one of the therapeutic options targeting for COVID-19. Moreover, it is discussed how real-world data and trials with IL-6 signaling blockade will be crucial in informing the development of new treatment for COVID-19 pneumonia. Given physiological roles of IL-6 in inflammatory conditions and the data from real world, IL-6 signal inhibitors, along with standard of care (SOC) treatment, might provide efficacy, offering the potential to treat COVID-19 in hospitalized populations more effectively than current SOC alone. Therefore, on-going and planned randomized placebo-controlled studies in combination with SOC and other therapeutics to assess safety and efficacy of IL-6 signal inhibitors in hospitalized patients with severe COVID-19 pneumonia will be warranted to address the high unmet need and burden of disease in this severely ill population.
    Keywords covid19
    Language English
    Publishing date 2020-10-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2051471-2
    ISSN 1880-9693 ; 0389-4290
    ISSN 1880-9693 ; 0389-4290
    DOI 10.1186/s41232-020-00134-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Outlook of IL-6 signaling blockade for COVID-19 pneumonia

    Misato Hashizume

    Inflammation and Regeneration, Vol 40, Iss 1, Pp 1-

    2020  Volume 8

    Abstract: Abstract In this review article, it is highlighted the implications of pleiotropic functions of interleukin-6 (IL-6) for one of the therapeutic options targeting for COVID-19. Moreover, it is discussed how real-world data and trials with IL-6 signaling ... ...

    Abstract Abstract In this review article, it is highlighted the implications of pleiotropic functions of interleukin-6 (IL-6) for one of the therapeutic options targeting for COVID-19. Moreover, it is discussed how real-world data and trials with IL-6 signaling blockade will be crucial in informing the development of new treatment for COVID-19 pneumonia. Given physiological roles of IL-6 in inflammatory conditions and the data from real world, IL-6 signal inhibitors, along with standard of care (SOC) treatment, might provide efficacy, offering the potential to treat COVID-19 in hospitalized populations more effectively than current SOC alone. Therefore, on-going and planned randomized placebo-controlled studies in combination with SOC and other therapeutics to assess safety and efficacy of IL-6 signal inhibitors in hospitalized patients with severe COVID-19 pneumonia will be warranted to address the high unmet need and burden of disease in this severely ill population.
    Keywords Interleukin-6 ; COVID-19 pneumonia ; Cytokine release syndrome ; Tocilizumab ; Sarilumab ; Siltuximab ; Pathology ; RB1-214 ; covid19
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Outlook of IL-6 signaling blockade for COVID-19 pneumonia

    Hashizume, Misato

    Inflammation and Regeneration

    Abstract: In this review article, it is highlighted the implications of pleiotropic functions of interleukin-6 (IL-6) for one of the therapeutic options targeting for COVID-19 Moreover, it is discussed how real-world data and trials with IL-6 signaling blockade ... ...

    Abstract In this review article, it is highlighted the implications of pleiotropic functions of interleukin-6 (IL-6) for one of the therapeutic options targeting for COVID-19 Moreover, it is discussed how real-world data and trials with IL-6 signaling blockade will be crucial in informing the development of new treatment for COVID-19 pneumonia
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #814634
    Database COVID19

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  4. Article ; Online: IL-6 as a target in inflammation.

    Hashizume, Misato / Ohsugi, Yoshiyuki

    Endocrine, metabolic & immune disorders drug targets

    2015  

    Abstract: Interleukin-6 (IL-6) has a unique feature of its own signaling pathway. IL-6 can act on various types of cells because there are abundant amounts of soluble IL-6 receptor in peripheral blood and can mediate signaling into cells. IL-6 participates in a ... ...

    Abstract Interleukin-6 (IL-6) has a unique feature of its own signaling pathway. IL-6 can act on various types of cells because there are abundant amounts of soluble IL-6 receptor in peripheral blood and can mediate signaling into cells. IL-6 participates in a broad spectrum of biological events, such as immune responses, hematopoiesis, and acute-phase reactions. In contrast, overproduction of IL-6 has been implicated in the pathogenesis of a variety of diseases, including several chronic inflammatory diseases. Future studies to clarify the molecular mechanisms of IL-6 functions as well as studies in which inhibitors of IL-6 signaling are used should provide information critical to a better understanding of the molecular mechanisms of diseases and the development of new therapeutic methods.
    Language English
    Publishing date 2015-03-16
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2228325-0
    ISSN 2212-3873 ; 1871-5303
    ISSN (online) 2212-3873
    ISSN 1871-5303
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  5. Article: IL-6 as a target in autoimmune disease and inflammation.

    Hashizume, Misato / Ohsugi, Yoshiyuki

    Nihon yakurigaku zasshi. Folia pharmacologica Japonica

    2014  Volume 144, Issue 4, Page(s) 172–177

    MeSH term(s) Autoimmune Diseases/drug therapy ; Autoimmune Diseases/immunology ; Humans ; Inflammation/drug therapy ; Inflammation/immunology ; Interleukin-6/antagonists & inhibitors ; Interleukin-6/immunology ; Neovascularization, Pathologic ; Receptors, Interleukin-6/immunology ; Signal Transduction/drug effects
    Chemical Substances Interleukin-6 ; Receptors, Interleukin-6
    Language Japanese
    Publishing date 2014
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1097532-9
    ISSN 1347-8397 ; 0015-5691
    ISSN (online) 1347-8397
    ISSN 0015-5691
    DOI 10.1254/fpj.144.172
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Translating IL-6 biology into effective treatments.

    Choy, Ernest H / De Benedetti, Fabrizio / Takeuchi, Tsutomu / Hashizume, Misato / John, Markus R / Kishimoto, Tadamitsu

    Nature reviews. Rheumatology

    2020  Volume 16, Issue 6, Page(s) 335–345

    Abstract: In 1973, IL-6 was identified as a soluble factor that is secreted by T cells and is important for antibody production by B cells. Since its discovery more than 40 years ago, the IL-6 pathway has emerged as a pivotal pathway involved in immune regulation ... ...

    Abstract In 1973, IL-6 was identified as a soluble factor that is secreted by T cells and is important for antibody production by B cells. Since its discovery more than 40 years ago, the IL-6 pathway has emerged as a pivotal pathway involved in immune regulation in health and dysregulation in many diseases. Targeting of the IL-6 pathway has led to innovative therapeutic approaches for various rheumatic diseases, such as rheumatoid arthritis, juvenile idiopathic arthritis, adult-onset Still's disease, giant cell arteritis and Takayasu arteritis, as well as other conditions such as Castleman disease and cytokine release syndrome. Targeting this pathway has also identified avenues for potential expansion into several other indications, such as uveitis, neuromyelitis optica and, most recently, COVID-19 pneumonia. To mark the tenth anniversary of anti-IL-6 receptor therapy worldwide, we discuss the history of research into IL-6 biology and the development of therapies that target IL-6 signalling, including the successes and challenges and with an emphasis on rheumatic diseases.
    MeSH term(s) Betacoronavirus ; Biological Factors/therapeutic use ; COVID-19 ; Comorbidity ; Coronavirus Infections/epidemiology ; Global Health ; Humans ; Interleukin-6/antagonists & inhibitors ; Interleukin-6/immunology ; Pandemics/statistics & numerical data ; Pneumonia, Viral/epidemiology ; Rheumatic Diseases/drug therapy ; Rheumatic Diseases/epidemiology ; SARS-CoV-2
    Chemical Substances Biological Factors ; Interleukin-6
    Keywords covid19
    Language English
    Publishing date 2020-04-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2491532-4
    ISSN 1759-4804 ; 1759-4790
    ISSN (online) 1759-4804
    ISSN 1759-4790
    DOI 10.1038/s41584-020-0419-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6338: Show issues Location:
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  7. Article ; Online: Correction: Baseline Serum Osteopontin Levels Predict the Clinical Effectiveness of Tocilizumab but Not Infliximab in Biologic-Naïve Patients with Rheumatoid Arthritis: A Single-Center Prospective Study at 1 Year (the Keio First-Bio Cohort Study).

    Izumi, Keisuke / Kaneko, Yuko / Hashizume, Misato / Yoshimoto, Keiko / Takeuchi, Tsutomu

    PloS one

    2016  Volume 11, Issue 3, Page(s) e0152341

    Language English
    Publishing date 2016
    Publishing country United States
    Document type Published Erratum
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0152341
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  8. Article ; Online: The Roles of Interleukin-6 in the Pathogenesis of Rheumatoid Arthritis

    Masahiko Mihara / Misato Hashizume

    Arthritis, Vol

    2011  Volume 2011

    Keywords Diseases of the musculoskeletal system ; RC925-935 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Internal medicine ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2011-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Correction

    Keisuke Izumi / Yuko Kaneko / Misato Hashizume / Keiko Yoshimoto / Tsutomu Takeuchi

    PLoS ONE, Vol 11, Iss 3, p e

    Baseline Serum Osteopontin Levels Predict the Clinical Effectiveness of Tocilizumab but Not Infliximab in Biologic-Naïve Patients with Rheumatoid Arthritis: A Single-Center Prospective Study at 1 Year (the Keio First-Bio Cohort Study).

    2016  Volume 0152341

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Atherogenic effects of TNF-α and IL-6 via up-regulation of scavenger receptors.

    Hashizume, Misato / Mihara, Masahiko

    Cytokine

    2012  Volume 58, Issue 3, Page(s) 424–430

    Abstract: Patients with chronic inflammatory disorders such as rheumatoid arthritis (RA) have a high risk of developing cardiovascular disease. We evaluated the effects of TNF-α and IL-6 on foam cell formation, a pivotal process in atherogenesis. Accumulation of ... ...

    Abstract Patients with chronic inflammatory disorders such as rheumatoid arthritis (RA) have a high risk of developing cardiovascular disease. We evaluated the effects of TNF-α and IL-6 on foam cell formation, a pivotal process in atherogenesis. Accumulation of intracellular oxidized LDL (oxLDL) was induced when THP-1/macrophages were stimulated with TNF-α or IL-6. TNF-α induced the expressions of scavenger receptors SR-A and LOX-1, and IL-6 induced SR-A expression. Inhibition of the NF-κB signaling markedly decreased TNF-α-induced foam cell formation and SR-A expression. Serum from RA patients, but not healthy subjects, induced foam cell formation, which was partially reversed by either IL-6 or TNF-α blockade in conjunction with inhibiting the induction of scavenger receptors. The present study clearly showed that in patients with chronic inflammation mediated by TNF-α and IL-6, these cytokines are directly implicated in atherosclerotic plaque formation.
    MeSH term(s) Cell Line ; Flow Cytometry ; Humans ; Interleukin-6/physiology ; Macrophages/metabolism ; Real-Time Polymerase Chain Reaction ; Receptors, Scavenger/physiology ; Signal Transduction ; Tumor Necrosis Factor-alpha/physiology ; Up-Regulation/physiology
    Chemical Substances Interleukin-6 ; Receptors, Scavenger ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2012-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1018055-2
    ISSN 1096-0023 ; 1043-4666
    ISSN (online) 1096-0023
    ISSN 1043-4666
    DOI 10.1016/j.cyto.2012.02.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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