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Article ; Online: Unraveling the crosstalk: circRNAs and the wnt signaling pathway in cancers of the digestive system.

Zhang, Yu / Zhang, Cheng / Peng, Chuanhui / Jia, Junjun

Non-coding RNA research

2024 Volume 9, Issue 3, Page(s) 853–864

Abstract: Circular RNA (circRNA) is a unique type of noncoding RNA molecule characterized by its closed-loop structure. Functionally versatile, circRNAs play pivotal roles in gene expression regulation, protein activity modulation, and participation in cell ... ...

Abstract	Circular RNA (circRNA) is a unique type of noncoding RNA molecule characterized by its closed-loop structure. Functionally versatile, circRNAs play pivotal roles in gene expression regulation, protein activity modulation, and participation in cell signaling processes. In the context of cancers of the digestive system, the Wnt signaling pathway holds particular significance. Anomalous activation of the Wnt pathway serves as a primary catalyst for the development of colorectal cancer. Extensive research underscores the notable participation of circRNAs associated with the Wnt pathway in the progression of digestive system tumors. These circRNAs exhibit pronounced dysregulation across esophageal cancer, gastric cancer, liver cancer, colorectal cancer, pancreatic cancer, and cholangiocarcinoma. Furthermore, the altered expression of circRNAs linked to the Wnt pathway correlates with prognostic factors in digestive system tumors. Additionally, circRNAs related to the Wnt pathway showcase potential as diagnostic, therapeutic, and prognostic markers within the realm of digestive system tumors. This comprehensive review outlines the interplay between circRNAs and the Wnt signaling pathway in cancers of the digestive system. It seeks to provide a comprehensive perspective on their association while delving into ongoing research that explores the clinical applications of circRNAs associated with the Wnt pathway.
Language	English
Publishing date	2024-04-03
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	2468-0540
ISSN (online)	2468-0540
DOI	10.1016/j.ncrna.2024.03.004
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Article: The Emerging, Multifaceted Role of WTAP in Cancer and Cancer Therapeutics.

Ju, Guomin / Lei, Jiangchu / Cai, Shuqi / Liu, Siyuan / Yin, Xinjia / Peng, Chuanhui

Cancers

2023 Volume 15, Issue 11

Abstract: Cancer is a grave and persistent illness, with the rates of both its occurrence and death toll increasing at an alarming pace. N6-methyladenosine ( ... ...

Abstract	Cancer is a grave and persistent illness, with the rates of both its occurrence and death toll increasing at an alarming pace. N6-methyladenosine (m
Language	English
Publishing date	2023-06-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15113053
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Article: GPR37-centered ceRNA network contributes to metastatic potential in lung adenocarcinoma: Evidence from high-throughput sequencing.

Chen, Chuanhui / Wan, Mengzhi / Peng, Xiong / Zhang, Qing / Liu, Yu

Translational oncology

2023 Volume 39, Page(s) 101819

Abstract: The competing endogenous RNA (ceRNA)-based profiling has been extensively studied in carcinogenesis of lung adenocarcinoma (LUAD), while it has seldomly been applied to investigate the metastatic potential of LUAD. This study aims to examine the function ...

Abstract	The competing endogenous RNA (ceRNA)-based profiling has been extensively studied in carcinogenesis of lung adenocarcinoma (LUAD), while it has seldomly been applied to investigate the metastatic potential of LUAD. This study aims to examine the function and in-depth mechanism of GPR37-centered ceRNA network in LUAD. Cancer tissues and adjacent normal tissues from three LUAD patients were collected for high-throughput sequencing to screen for differentially expressed genes. A PPI network was constructed to screen the key gene GPR37, followed by analysis for the functions and pathways. Clinical data from LUAD patients were integrated with gene expression data in TCGA-LUAD dataset for survival analysis. Based on the miRNAs targeting_GPR37 and lncRNAs targeting_miRNAs, a lncRNA-miRNA-mRNA ceRNA network was established. GPR37 was up-regulated in LUAD tissue samples, and it may be a key gene involved in LUAD progression. GPR37 in LUAD was mainly enriched in the mitosis-related pathways. High GPR37 expression corresponded to poor prognosis in LUAD patients. Meanwhile, GPR37 could be used as an independent factor to predict the prognosis in LUAD patients. LncRNA DLEU1, up-regulated in LUAD tissue samples, may competitively bind to miR-4458 to up-regulate the expression of the miR-4458 downstream target GPR37. DLEU1 was associated with poor prognosis and tumor metastasis in LUAD patients. Altogether, our findings reveal a novel ceRNA network of DLEU1/miR-4458/GPR37 in LUAD growth and metastasis.
Language	English
Publishing date	2023-11-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2443840-6
ISSN	1936-5233
ISSN	1936-5233
DOI	10.1016/j.tranon.2023.101819
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Article ; Online: HOXB9 promotes laryngeal squamous cell carcinoma progression by upregulating MMP12.

Sun, Chuanhui / Deng, Hua / Li, Qiuying / Wang, Peng / Chen, Yujiang / Sun, Yanan / Han, Changsong

Functional & integrative genomics

2024 Volume 24, Issue 3, Page(s) 78

Abstract: Transcriptional factor HOXB9, a part of the HOX gene family, plays a crucial role in the development of diverse cancer types. This study aimed to elucidate the regulatory mechanism of HOXB9 on the proliferation and invasion of laryngeal squamous cell ... ...

Abstract	Transcriptional factor HOXB9, a part of the HOX gene family, plays a crucial role in the development of diverse cancer types. This study aimed to elucidate the regulatory mechanism of HOXB9 on the proliferation and invasion of laryngeal squamous cell carcinoma (LSCC) cells to provide guidance for the development and prognosis of LSCC. The CRISPR/Cas9 method was employed in LSCC cell lines to knock out the HOXB9 gene and validate its effects on the proliferation, migration, invasion, and regulation of LSCC cells. CCK-8 and flow cytometry were used to detect cell viability and proliferation; Tunnel was used to detect cell apoptosis, and transwell was used to detect cell migration and invasion. The effect of HOXB9 on tumor growth was tested in nude mice. The downstream target genes regulated by HOXB9 were screened by microarray analysis and verified by Western blotting, immunohistochemistry, chromatin immunoprecipitation, and double-luciferase reporter assays. The current research investigated molecular pathways governed by HOXB9 in the development of LSCC. Additionally, both laboratory- and living-organism-based investigations revealed that disrupting the HOXB9 gene through the CRISPR/CAS9 mechanism restrained cellular growth, movement, and infiltration, while enhancing cellular apoptosis. Detailed analyses of LSCC cell strains and human LSCC samples revealed that HOXB9 promoted LSCC progression by directly elevating the transcriptional activity of MMP12. HOXB9 could influence changes in LSCC cell functions, and the mechanism of action might be exerted through its downstream target gene, MMP12.
MeSH term(s)	Animals ; Humans ; Mice ; Carcinoma, Squamous Cell/genetics ; Cell Line, Tumor ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Genes, Homeobox ; Head and Neck Neoplasms/genetics ; Homeodomain Proteins/genetics ; Laryngeal Neoplasms/genetics ; Laryngeal Neoplasms/metabolism ; Laryngeal Neoplasms/pathology ; Matrix Metalloproteinase 12/genetics ; Matrix Metalloproteinase 12/metabolism ; Mice, Nude ; Squamous Cell Carcinoma of Head and Neck/genetics
Chemical Substances	Homeodomain Proteins ; HOXB9 protein, human ; Matrix Metalloproteinase 12 (EC 3.4.24.65) ; MMP12 protein, human (EC 3.4.24.65)
Language	English
Publishing date	2024-04-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2014670-X
ISSN	1438-7948 ; 1438-793X
ISSN (online)	1438-7948
ISSN	1438-793X
DOI	10.1007/s10142-024-01357-4
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Article: An extremely rare phenomenon of mucinous cystic neoplasm of the liver: spontaneous rupture.

Xu, Xiaofeng / Peng, Chuanhui / Tong, Rongliang / Dong, Miaoxia / Deng, Junfang

Hepatobiliary surgery and nutrition

2021 Volume 10, Issue 3, Page(s) 424–427

Language	English
Publishing date	2021-04-27
Publishing country	China (Republic : 1949- )
Document type	Journal Article
ZDB-ID	2812398-0
ISSN	2304-389X ; 2304-3881
ISSN (online)	2304-389X
ISSN	2304-3881
DOI	10.21037/hbsn-21-102
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Article ; Online: Sleep quality, circadian preferences, and mood among patients with acne vulgaris: a case-control study.

Zhu, Jiangting / Peng, Ke / Zhang, Yunjie / Bai, Xiaohong / Zhong, Chuanhui / Ye, Junru / Lu, Mao

Sleep & breathing = Schlaf & Atmung

2023 Volume 27, Issue 5, Page(s) 1997–2003

Abstract: Purpose: Poor sleep and mood may be predisposing factors for acne. We aimed to investigate the associations between acne and sleep quality, circadian preferences, and mood.: Methods: This case-control study recruited patients with acne and age- and ... ...

Abstract	Purpose: Poor sleep and mood may be predisposing factors for acne. We aimed to investigate the associations between acne and sleep quality, circadian preferences, and mood. Methods: This case-control study recruited patients with acne and age- and sex-matched healthy controls. We used the Investigator's Global Assessment to evaluate acne severity and various validated questionnaires to measure sleep quality, daytime sleepiness, sleep apnea, circadian preference, and mood symptoms. Results: A total of 81 patients with acne (age: 21.6 ± 5.0 years, 52% female) and 76 controls were recruited. Compared to controls, patients had a higher score on the Pittsburgh Sleep Quality Index (5.2 ± 2.6 vs. 4.1 ± 2.3, p = 0.008) and State-Trait Anxiety Inventory (State: 44.6 ± 9.7 vs. 40.6 ± 6.6, p = 0.003; Trait: 47.9 ± 8.2 vs. 45.3 ± 6.2, p = 0.03), and a lower score on a reduced version of the Morningness and Eveningness Questionnaire (13.9 ± 2.6 vs. 14.7 ± 2.3, p = 0.05) and Epworth Sleepiness Scale (7.4 ± 3.4 vs. 8.6 ± 3.6, p = 0.04). Acne severity was associated with sleep quality (β = 0.33), eveningness (β = 0.34), depression (β = 0.66), and anxiety (State: β = 1.73; Trait: β = 1.21), even when adjusted for education level and family history of acne. Conclusion: Acne is highly associated with poor sleep and mood. Dermatologists are advised to attend closely to the psychological impact of acne. Improvements in sleep and mood may benefit the treatment of acne.
MeSH term(s)	Humans ; Female ; Adolescent ; Young Adult ; Adult ; Male ; Sleep Quality ; Case-Control Studies ; Affect ; Sleep ; Sleep Initiation and Maintenance Disorders ; Surveys and Questionnaires ; Acne Vulgaris ; Circadian Rhythm
Language	English
Publishing date	2023-01-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1500381-4
ISSN	1522-1709 ; 1520-9512
ISSN (online)	1522-1709
ISSN	1520-9512
DOI	10.1007/s11325-023-02777-5
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Article: Comprehensive analysis about prognostic and immunological role of WTAP in pan-cancer.

Lei, Jiangchu / Fan, Yuzhi / Yan, Chaobiao / Jiamaliding, Yeernaer / Tang, Yang / Zhou, Jiawei / Huang, Mengna / Ju, Guomin / Wu, Jian / Peng, Chuanhui

Frontiers in genetics

2022 Volume 13, Page(s) 1007696

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2022-09-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2022.1007696
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Article: Inclusion of Soluble Fiber During Gestation Regulates Gut Microbiota, Improves Bile Acid Homeostasis, and Enhances the Reproductive Performance of Sows.

Wu, Xiaoyu / Yin, Shengnan / Cheng, Chuanshang / Xu, Chuanhui / Peng, Jian

Frontiers in veterinary science

2021 Volume 8, Page(s) 756910

Abstract: Interaction between the dietary fiber and the gut microbes can regulate host bile acid metabolism. This study sought to explore the effects of guar gum combined with pregelatinized waxy maize starch (GCW) in a gestation diet on reproductive performance, ... ...

Abstract	Interaction between the dietary fiber and the gut microbes can regulate host bile acid metabolism. This study sought to explore the effects of guar gum combined with pregelatinized waxy maize starch (GCW) in a gestation diet on reproductive performance, gut microbiota composition, and bile acid homeostasis of sows. A total of 61 large white sows were randomly grouped into the control (
Language	English
Publishing date	2021-11-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2834243-4
ISSN	2297-1769
ISSN	2297-1769
DOI	10.3389/fvets.2021.756910
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Article ; Online: m

Liu, Hua / Jiang, Yifan / Lu, Jiahua / Peng, Chuanhui / Ling, Zhenan / Chen, Yunhao / Chen, Diyu / Tong, Rongliang / Zheng, Shusen / Wu, Jian

Epigenetics

2023 Volume 18, Issue 1, Page(s) 2204772

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/pathology ; Cell Line, Tumor ; Cell Proliferation/genetics ; Chaperonin Containing TCP-1/genetics ; Chaperonin Containing TCP-1/metabolism ; DNA Methylation ; Gene Expression Regulation, Neoplastic ; In Situ Hybridization, Fluorescence ; Liver Neoplasms/metabolism ; Methyltransferases/genetics ; Methyltransferases/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; RNA, Circular/genetics
Chemical Substances	CCT3 protein, human ; Chaperonin Containing TCP-1 (EC 3.6.1.-) ; Methyltransferases (EC 2.1.1.-) ; METTL3 protein, human (EC 2.1.1.62) ; MicroRNAs ; RNA, Circular ; MIRN378 microRNA, human
Language	English
Publishing date	2023-04-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1559-2308
ISSN (online)	1559-2308
DOI	10.1080/15592294.2023.2204772
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Article ; Online: Inclusion of Soluble Fiber in the Gestation Diet Changes the Gut Microbiota, Affects Plasma Propionate and Odd-Chain Fatty Acids Levels, and Improves Insulin Sensitivity in Sows

Chuanhui Xu / Chuanshang Cheng / Xiu Zhang / Jian Peng

International Journal of Molecular Sciences, Vol 21, Iss 2, p

2020 Volume 635

Abstract: The transition from pregnancy to lactation is characterized by a progressive decrease in insulin sensitivity. Propionate increases with dietary fiber consumption and has been shown to improve insulin sensitivity. Recent studies suggest that plasma odd- ... ...

Abstract	The transition from pregnancy to lactation is characterized by a progressive decrease in insulin sensitivity. Propionate increases with dietary fiber consumption and has been shown to improve insulin sensitivity. Recent studies suggest that plasma odd-chain fatty acids [OCFAs; pentadecanoic acid (C15:0) and heptadecanoic acid (C17:0)] that inversely correlated with insulin resistance are synthesized endogenously from gut-derived propionate. The present study investigated the effects of soluble fiber during gestation on gut microbiota, plasma non-esterified fatty acids and insulin sensitivity in sows. Sows were allocated to either control or 2.0% guar gum plus pregelatinized waxy maize starch (SF) dietary treatment during gestation. The SF addition changes the structure and composition of gut microbiota in sows. Genus Eubacterium increased by SF addition may promote intestinal propionate production. Moreover, the dietary SF increased circulating levels of plasma OCFAs, especially C17:0. The SF-fed sows had a higher insulin sensitivity and a lower systemic inflammation level during perinatal period. Furthermore, the plasma C15:0 and C17:0 was negatively correlated with the area under curve of plasma glucose after meal and plasma interleukin-6. In conclusion, dietary SF improves insulin sensitivity and alleviates systemic inflammation in perinatal sows, potentially related to its stimulating effect on propionate and OCFAs production.
Keywords	soluble fiber ; propionate ; odd-chain fatty acids ; insulin sensitivity ; sow ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	571
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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