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Article ; Online: Histopathology and immunohistochemical analysis of 5-fluorouracil and triamcinolone treated keloids in double-blinded randomized controlled trial.

Hietanen, Kriistiina E / Järvinen, Tero A H / Huhtala, Heini / Tolonen, Teemu T / Kaartinen, Ilkka S

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society

2020 Volume 28, Issue 3, Page(s) 385–399

Abstract: Keloids are a major complication related to surgical wound healing and very challenging condition to treat. Many treatment options are available, but the efficacy of the treatment is poor in most of cases and some keloids do not respond to the treatment ... ...

Abstract	Keloids are a major complication related to surgical wound healing and very challenging condition to treat. Many treatment options are available, but the efficacy of the treatment is poor in most of cases and some keloids do not respond to the treatment at all. We compared the efficacy of intralesional 5-fluorouracil (5-FU) and triamcinolone (TAC) injections in a double-blind randomized controlled trial (RCT). Forty-three patients with 50 keloid scars were treated with either intralesional TAC or 5-FU-injections over 6 months. We wanted to find out whether biological features (cell density, cell proliferation rate, vascular density, myofibroblast numbers, steroid hormone receptor expression) in keloids could be used to predict the response to therapy and define the biological changes that take place in patients receiving a response. As there was no statistically significant difference in the remission rate between TAC and 5-FU treatments, all patients were combined and analyzed as responders and nonresponders. Although responders have slightly more myofibroblasts than the nonresponders in their keloids in the pretreatment biopsy samples, we could not identify a single predictive factor that could identify those patients that respond to drug injections. The good clinical response to therapy is associated with the simultaneous reduction of myofibroblasts in the keloid. This study demonstrates that myofibroblasts are reduced in number in those keloids that were responsive to therapy, and that both 5-FU and TAC injections are useful for keloid treatment.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Double-Blind Method ; Female ; Fluorouracil/therapeutic use ; Glucocorticoids/therapeutic use ; Humans ; Immunosuppressive Agents/therapeutic use ; Injections, Intralesional ; Keloid/drug therapy ; Keloid/metabolism ; Keloid/pathology ; Male ; Middle Aged ; Treatment Outcome ; Triamcinolone/therapeutic use ; Young Adult
Chemical Substances	Glucocorticoids ; Immunosuppressive Agents ; Triamcinolone (1ZK20VI6TY) ; Fluorouracil (U3P01618RT)
Language	English
Publishing date	2020-03-17
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	1174873-4
ISSN	1524-475X ; 1067-1927
ISSN (online)	1524-475X
ISSN	1067-1927
DOI	10.1111/wrr.12803
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Zs.A 3890: Show issues

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Article: Assessing the conservation priority of freshwater lake sites based on taxonomic, functional and environmental uniqueness

Heino, Jani / García Girón, Jorge / Hämäläinen, Heikki / Hellsten, Seppo / Ilmonen, Jari / Karjalainen, Juha / Mäkinen, Teemu / Nyholm, Kristiina / Ropponen, Janne / Takolander, Antti / Tolonen, Kimmo T.

Diversity & distributions. 2022 Sept., v. 28, no. 9

2022

Abstract: ... uniqueness” approach, we used distance‐based methods to calculate measures of taxonomic (LCBD–t), functional ... in the studied part of the lake. RESULTS: Relationships between taxonomic (LCBD–t), functional (LCBD–f) and ... environmental (LCEH) uniqueness were generally weak, and only the relationship between macrophyte LCBD–t and ...

Abstract	AIM: We propose a novel approach that considers taxonomic uniqueness, functional uniqueness and environmental uniqueness and show how it can be used in guiding conservation planning. We illustrate the approach using data for lake biota and environment. LOCATION: Lake Puruvesi, Finland. METHODS: We sampled macrophytes and macroinvertebrates from the same 18 littoral sites. By adapting the original “ecological uniqueness” approach, we used distance‐based methods to calculate measures of taxonomic (LCBD–t), functional (LCBD–f) and environmental (LCEH) uniqueness for each site. We also considered the numbers and locations of the sites needed to protect up to 70% of total variation in taxonomic, functional or environmental features in the studied part of the lake. RESULTS: Relationships between taxonomic (LCBD–t), functional (LCBD–f) and environmental (LCEH) uniqueness were generally weak, and only the relationship between macrophyte LCBD–t and LCBD–f was statistically significant. Overall, however, if the whole biotic dataset was considered, macroinvertebrate LCBD–f values showed a consistent positive relationship with macrophyte LCBD–f. Depending on the measure of site uniqueness, between one‐third to one half of the sites could help protect up to 70% of the ecological uniqueness of the studied part of Lake Puruvesi. MAIN CONCLUSIONS: Although the dataset examined originated from a large lake system, the approach we proposed here can be applied in different ecosystems and at various spatial scales. An important consideration is that a set of sites has been sampled using the same methods, resulting in species and environmental matrices that can be analysed using the methodological approach proposed here. This framework can be easily applied to grid‐based data, sets of islands or sets of forest fragments. We suggest that the approach based on taxonomic, functional and environmental uniqueness will be a useful tool in guiding nature conservation and ecosystem management, especially if associated with meta‐system ideas or network thinking.
Keywords	data collection ; ecosystem management ; forests ; freshwater lakes ; littoral zone ; macroinvertebrates ; macrophytes ; natural resources conservation ; Finland
Language	English
Dates of publication	2022-09
Size	p. 1966-1978.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	2020139-4
ISSN	1472-4642 ; 1366-9516
ISSN (online)	1472-4642
ISSN	1366-9516
DOI	10.1111/ddi.13598
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Extraprostatic extension (pT3a) in prostate biopsy is an under-recognized feature indicating high risk disease.

Tolonen, Teemu T / Riikonen, Jarno / Tammela, Teuvo L J / Koivusalo, Laura / Haapasalo, Hannu / Kujala, Paula / Kaipia, Antti

Annals of diagnostic pathology

2018 Volume 35, Page(s) 80–84

MeSH term(s)	Adenocarcinoma/pathology ; Adult ; Aged ; Aged, 80 and over ; Biopsy, Large-Core Needle ; Carcinoma, Small Cell/pathology ; Humans ; Leiomyosarcoma/pathology ; Male ; Middle Aged ; Neoplasm Staging ; Prostatic Neoplasms/pathology
Language	English
Publishing date	2018-06-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	1440011-x
ISSN	1532-8198 ; 1092-9134
ISSN (online)	1532-8198
ISSN	1092-9134
DOI	10.1016/j.anndiagpath.2018.06.001
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Zs.A 5463: Show issues

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Article ; Online: Expected impact of MRI-targeted biopsy interreader variability among uropathologists on ProScreen prostate cancer screening trial: a pre-trial validation study.

Hietikko, Ronja / Mirtti, Tuomas / Kilpeläinen, Tuomas P / Tolonen, Teemu / Räisänen-Sokolowski, Anne / Nordling, Stig / Hannus, Jill / Laurila, Marita / Taari, Kimmo / Tammela, Teuvo L J / Autio, Reija / Natunen, Kari / Auvinen, Anssi / Rannikko, Antti

World journal of urology

2024 Volume 42, Issue 1, Page(s) 217

Abstract: Purpose: Prostate cancer (PCa) histology, particularly the Gleason score, is an independent prognostic predictor in PCa. Little is known about the inter-reader variability in grading of targeted prostate biopsy based on magnetic resonance imaging (MRI). ...

Abstract	Purpose: Prostate cancer (PCa) histology, particularly the Gleason score, is an independent prognostic predictor in PCa. Little is known about the inter-reader variability in grading of targeted prostate biopsy based on magnetic resonance imaging (MRI). The aim of this study was to assess inter-reader variability in Gleason grading of MRI-targeted biopsy among uropathologists and its potential impact on a population-based randomized PCa screening trial (ProScreen). Methods: From June 2014 to May 2018, 100 men with clinically suspected PCa were retrospectively selected. All men underwent prostate MRI and 86 underwent targeted prostate of the prostate. Six pathologists individually reviewed the pathology slides of the prostate biopsies. The five-tier ISUP (The International Society of Urological Pathology) grade grouping (GG) system was used. Fleiss' weighted kappa (κ) and Model-based kappa for associations were computed to estimate the combined agreement between individual pathologists. Results: GG reporting of targeted prostate was highly consistent among the trial pathologists. Inter-reader agreement for cancer (GG1-5) vs. benign was excellent (Model-based kappa 0.90, Fleiss' kappa κ = 0.90) and for clinically significant prostate cancer (csPCa) (GG2-5 vs. GG0 vs. GG1), it was good (Model-based kappa 0.70, Fleiss' kappa κ 0.67). Conclusions: Inter-reader agreement in grading of MRI-targeted biopsy was good to excellent, while it was fair to moderate for MRI in the same cohort, as previously shown. Importantly, there was wide consensus by pathologists in assigning the contemporary GG on MRI-targeted biopsy suggesting high reproducibility of pathology reporting in the ProScreen trial.
MeSH term(s)	Male ; Humans ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/pathology ; Early Detection of Cancer ; Reproducibility of Results ; Retrospective Studies ; Prostate-Specific Antigen ; Biopsy ; Magnetic Resonance Imaging/methods ; Neoplasm Grading ; Image-Guided Biopsy
Chemical Substances	Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2024-04-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	380333-8
ISSN	1433-8726 ; 0724-4983
ISSN (online)	1433-8726
ISSN	0724-4983
DOI	10.1007/s00345-024-04898-2
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Zs.A 1832: Show issues

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Article ; Online: Digital image analysis of the tissue surface areas of site-designated and bilaterally pooled prostate biopsies.

Koivusalo, Laura / Kaipia, Antti / Kujala, Paula / Isola, Jorma / Tolonen, Teemu T

Histology and histopathology

2017 Volume 33, Issue 4, Page(s) 399–405

Abstract: Initial reports about the length of bilaterally pooled biopsies showed alarming tissue loss compared to individual biopsies, but the current understanding of "noodle biopsies" and better embedding techniques may have improved their quality. Here, we ... ...

Abstract	Initial reports about the length of bilaterally pooled biopsies showed alarming tissue loss compared to individual biopsies, but the current understanding of "noodle biopsies" and better embedding techniques may have improved their quality. Here, we implemented digital image analysis to study the differences in tissue surface areas between individual and pooled cores. Prostate biopsy reports from 1242 consecutive patients were reviewed. Urologist-dependent bias on the biopsy quality was eliminated by identifying four urologists who submitted equally individual and bilaterally pooled biopsies. Digital image analysis was applied to the tissue surface areas of 936 virtual slides containing 1440 biopsy cores (12 cores per patient x 120 patients) taken by the four urologists. The median (range) surface areas were 73.8 mm² (40.1-102.5) for the site-designated (n=57) and 77.1 mm² (49.5-119.2) for the bilaterally pooled biopsies (n=63) (p=0.19). For three urologists, the median surface areas were 69.5 mm² (60.4-93.2), 75.5 mm² (48.2-98.7) and 78.2 mm² (47.1-92.7) for the site-designated and 79.2 mm² (49.5-116.4), 69.3mm² (49.6-119.2) and 79.2 mm² (55.1-96.7) for the pooled biopsies, respectively (p=0.58-0.75). For one urologist, the median surface area was marginally higher for the pooled biopsies, 68.1 mm² (40.1-102.5) vs. 81.6 mm² (62.7-108.8) (p=0.03). In conclusion, the histological yields of individual and pooled prostate biopsies were practically equal. The results should not be considered as a recommendation to increasingly submit unspecified bilateral cores but to encourage pathology laboratories to embed and cut all received prostate biopsies with special attention, regardless of submission type.
MeSH term(s)	Aged ; Biopsy, Needle/methods ; Humans ; Image Interpretation, Computer-Assisted ; Male ; Middle Aged ; Prostatic Neoplasms/pathology ; Retrospective Studies ; Surgical Oncology/methods
Language	English
Publishing date	2017-10-23
Publishing country	Spain
Document type	Journal Article
ZDB-ID	83911-5
ISSN	1699-5848 ; 0213-3911
ISSN (online)	1699-5848
ISSN	0213-3911
DOI	10.14670/HH-11-940
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Zs.B 3013: Show issues

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Article ; Online: Laser desorption tissue imaging with Differential Mobility Spectrometry.

Lepomäki, Maiju / Anttalainen, Anna / Vuorinen, Artturi / Tolonen, Teemu / Kontunen, Anton / Karjalainen, Markus / Vehkaoja, Antti / Roine, Antti / Oksala, Niku

Experimental and molecular pathology

2022 Volume 125, Page(s) 104759

Abstract: Pathological gross examination of breast carcinoma samples is sometimes laborious. A tissue pre-mapping method could indicate neoplastic areas to the pathologist and enable focused sampling. Differential Mobility Spectrometry (DMS) is a rapid and ... ...

Abstract	Pathological gross examination of breast carcinoma samples is sometimes laborious. A tissue pre-mapping method could indicate neoplastic areas to the pathologist and enable focused sampling. Differential Mobility Spectrometry (DMS) is a rapid and affordable technology for complex gas mixture analysis. We present an automated tissue laser analysis system for imaging approaches (iATLAS), which utilizes a computer-controlled laser evaporator unit coupled with a DMS gas analyzer. The system is demonstrated in the classification of porcine tissue samples and three human breast carcinomas. Tissue samples from eighteen landrace pigs were classified with the system based on a pre-designed matrix (spatial resolution 1-3 mm). The smoke samples were analyzed with DMS, and tissue classification was performed with several machine learning approaches. Porcine skeletal muscle (n = 1030), adipose tissue (n = 1329), normal breast tissue (n = 258), bone (n = 680), and liver (n = 264) were identified with 86% cross-validation (CV) accuracy with a convolutional neural network (CNN) model. Further, a panel tissue that comprised all five tissue types was applied as an independent validation dataset. In this test, 82% classification accuracy with CNN was achieved. An analogous procedure was applied to demonstrate the feasibility of iATLAS in breast cancer imaging according to 1) macroscopically and 2) microscopically annotated data with 10-fold CV and SVM (radial kernel). We reached a classification accuracy of 94%, specificity of 94%, and sensitivity of 93% with the macroscopically annotated data from three breast cancer specimens. The microscopic annotation was applicable to two specimens. For the first specimen, the classification accuracy was 84% (specificity 88% and sensitivity 77%). For the second, the classification accuracy was 72% (specificity 88% and sensitivity 24%). This study presents a promising method for automated tissue imaging in an animal model and lays foundation for breast cancer imaging.
MeSH term(s)	Animals ; Breast/pathology ; Breast Neoplasms/pathology ; Female ; Humans ; Ion Mobility Spectrometry ; Lasers ; Spectrum Analysis ; Swine
Language	English
Publishing date	2022-03-23
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	207655-x
ISSN	1096-0945 ; 0014-4800
ISSN (online)	1096-0945
ISSN	0014-4800
DOI	10.1016/j.yexmp.2022.104759
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Zs.A 183: Show issues

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Article ; Online: ImmunoMembrane: a publicly available web application for digital image analysis of HER2 immunohistochemistry.

Tuominen, Vilppu J / Tolonen, Teemu T / Isola, Jorma

Histopathology

2012 Volume 60, Issue 5, Page(s) 758–767

Abstract: Aims: Assessment of the human epidermal growth factor receptor 2 (HER2) with immunohistochemistry (IHC) is routine practice in clinical pathology laboratories. Visual classification of the staining reaction (usually into 0/1+, 2+ or 3+) is subjective ... ...

Abstract	Aims: Assessment of the human epidermal growth factor receptor 2 (HER2) with immunohistochemistry (IHC) is routine practice in clinical pathology laboratories. Visual classification of the staining reaction (usually into 0/1+, 2+ or 3+) is subjective and prone to significant inter- and intra-observer variation. In this study, we describe ImmunoMembrane, an easy-to-use HER2 IHC analysis software, which is freely available as a web application, requiring no download or installation. Methods and results: ImmunoMembrane uses colour deconvolution for stain separation and a customized algorithm for cell membrane segmentation. A quantitative score (IM-score, 0-20 points) is generated according to the membrane staining intensity and completeness. Specimens are classified into 0/1+, 2+ or 3+ based on IM-score cut-offs defined using a training set. The classification and membrane segmentation are presented as a pseudo-coloured overlay image. With a validation set (144 HercepTest(®) -stained whole tissue sections), ImmunoMembrane matched well with the pathologist's visual classification (weighted kappa κ(w) =0.80), as well as fluorescence in-situ hybridization (FISH) (IHC disagreement 3.5%, n=144) and chromogenic in-situ hybridization (CISH) (IHC disagreement 2.8%, n=144). Conclusions: We anticipate that publicly available web applications, such as ImmunoMembrane, will accelerate the adoption of automated image analysis in clinical diagnostics of HER2 IHC. ImmunoMembrane is freely accessible at: http://jvsmicroscope.uta.fi/immunomembrane/.
MeSH term(s)	Algorithms ; Biomarkers, Tumor/metabolism ; Breast Neoplasms/diagnosis ; Breast Neoplasms/metabolism ; Chromogenic Compounds ; DNA, Neoplasm/analysis ; Female ; Genetic Markers ; Humans ; Image Processing, Computer-Assisted ; Immunohistochemistry/methods ; In Situ Hybridization, Fluorescence ; Receptor, ErbB-2/genetics ; Receptor, ErbB-2/metabolism ; Reproducibility of Results ; Software ; Tissue Array Analysis
Chemical Substances	Biomarkers, Tumor ; Chromogenic Compounds ; DNA, Neoplasm ; Genetic Markers ; ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1)
Language	English
Publishing date	2012-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	131914-0
ISSN	1365-2559 ; 0309-0167
ISSN (online)	1365-2559
ISSN	0309-0167
DOI	10.1111/j.1365-2559.2011.04142.x
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Article: Optimized JPEG 2000 Compression for Efficient Storage of Histopathological Whole-Slide Images.

Helin, Henrik / Tolonen, Teemu / Ylinen, Onni / Tolonen, Petteri / Näpänkangas, Juha / Isola, Jorma

Journal of pathology informatics

2018 Volume 9, Page(s) 20

Abstract: Background: Whole slide images (WSIs, digitized histopathology glass slides) are large data files whose long-term storage remains a significant cost for pathology departments. Currently used WSI formats are based on lossy image compression alogrithms, ... ...

Abstract	Background: Whole slide images (WSIs, digitized histopathology glass slides) are large data files whose long-term storage remains a significant cost for pathology departments. Currently used WSI formats are based on lossy image compression alogrithms, either using JPEG or its more efficient successor JPEG 2000. While the advantages of the JPEG 2000 algorithm (JP2) are commonly recognized, its compression parameters have not been fully optimized for pathology WSIs. Methods: We defined an optimized parametrization for JPEG 2000 image compression, designated JP2-WSI, to be used specifically with histopathological WSIs. Our parametrization is based on allowing a very high degree of compression on the background part of the WSI while using a conventional amount of compression on the tissue-containing part of the image, resulting in high overall compression ratios. Results: When comparing the compression power of JP2-WSI to the commonly used fixed 35:1 compression ratio JPEG 2000 and the default image formats of proprietary Aperio, Hamamatsu, and 3DHISTECH scanners, JP2-WSI produced the smallest file sizes and highest overall compression ratios for all 17 slides tested. The image quality, as judged by visual inspection and peak signal-to-noise ratio (PSNR) measurements, was equal to or better than the compared image formats. The average file size by JP2-WSI amounted to 15, 9, and 16 percent, respectively, of the file sizes of the three commercial scanner vendors' proprietary file formats (3DHISTECH MRXS, Aperio SVS, and Hamamatsu NDPI). In comparison to the commonly used 35:1 compressed JPEG 2000, JP2-WSI was three times more efficient. Conclusions: JP2-WSI allows very efficient and cost-effective data compression for whole slide images without loss of image information required for histopathological diagnosis.
Language	English
Publishing date	2018-05-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2579241-6
ISSN	2153-3539 ; 2229-5089
ISSN (online)	2153-3539
ISSN	2229-5089
DOI	10.4103/jpi.jpi_69_17
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Article ; Online: Breast density and the likelihood of malignant MRI-detected lesions in women diagnosed with breast cancer.

Sassi, Antti / Salminen, Annukka / Jukkola, Arja / Tervo, Maija / Mäenpää, Niina / Turtiainen, Saara / Tiainen, Leena / Liimatainen, Timo / Tolonen, Teemu / Huhtala, Heini / Rinta-Kiikka, Irina / Arponen, Otso

European radiology

2023 Volume 33, Issue 11, Page(s) 8080–8088

Abstract: Objectives: To assess whether mammographic breast density in women diagnosed with breast cancer correlates with the total number of incidental magnetic resonance imaging (MRI)-detected lesions and the likelihood of the lesions being malignant.: ... ...

Abstract	Objectives: To assess whether mammographic breast density in women diagnosed with breast cancer correlates with the total number of incidental magnetic resonance imaging (MRI)-detected lesions and the likelihood of the lesions being malignant. Methods: Patients diagnosed with breast cancer meeting the EUSOBI and EUSOMA criteria for preoperative breast MRI routinely undergo mammography and ultrasound before MRI at our institution. Incidental suspicious breast lesions detected in MRI are biopsied. We included patients diagnosed with invasive breast cancers between 2014 and 2019 who underwent preoperative breast MRI. One reader retrospectively determined breast density categories according to the 5 Results: Of 946 patients with 973 malignant primary breast tumors, 166 (17.5%) had a total of 175 (18.0%) incidental MRI-detected lesions (82 (46.9%) malignant and 93 (53.1%) benign). High breast density according to BI-RADS was associated with higher incidence of all incidental enhancing lesions in preoperative breast MRIs: 2.66 (95% confidence interval: 1.03-6.86) higher for BI-RADS density category B, 2.68 (1.04-6.92) for category C, and 3.67 (1.36-9.93) for category D compared to category A (p < 0.05). However, high breast density did not predict higher incidence of malignant incidental lesions (p = 0.741). Incidental MRI-detected lesions in the contralateral breast were more likely benign (p < 0.001): 18 (27.3%)/48 (72.7%) vs. 64 (58.7%)/45 (41.3%) malignant/benign incidental lesions in contralateral vs. ipsilateral breasts. Conclusion: Women diagnosed with breast cancer who have dense breasts have more incidental MRI-detected lesions, but higher breast density does not translate to increased likelihood of malignant incidental lesions. Clinical relevance statement: Dense breasts should not be considered as an indication for preoperative breast MRI in women diagnosed with breast cancer. Key points: • The role of preoperative MRI of patients with dense breasts diagnosed with breast cancer is under debate. • Women with denser breasts have a higher incidence of all MRI-detected incidental breast lesions, but the incidence of malignant MRI-detected incidental lesions is not higher than in women with fatty breasts. • High breast density alone should not indicate preoperative breast MRI.
MeSH term(s)	Female ; Humans ; Breast Neoplasms/diagnosis ; Breast Density ; Retrospective Studies ; Breast/diagnostic imaging ; Breast/pathology ; Mammography/methods ; Magnetic Resonance Imaging/methods
Language	English
Publishing date	2023-08-30
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-023-10072-w
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Zs.A 3300: Show issues

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Article: Miniaturized, high numerical aperture confocal fluorescence detection enhanced with pyroelectric droplet accumulation for sub-attomole analyte diagnosis.

Nie, Yunfeng / Sanna, Uusitalo / Sipola, Teemu / Kokkonen, Annukka / Päkkilä, Inka / Sumen, Juha / Rahkamaa-Tolonen, Katariina / Tkachenko, Volodymyr / Vespini, Veronica / Coppola, Sara / Ferraro, Pietro / Grilli, Simonetta / Ottevaere, Heidi

Biomedical optics express

2023 Volume 14, Issue 12, Page(s) 6138–6150

Abstract: To meet the growing demand for early fatal disease screening among large populations, current fluorescence detection instruments aiming at point-of-care diagnosis have the tendency to be low cost and high sensitivity, with a high potential for the ... ...

Abstract	To meet the growing demand for early fatal disease screening among large populations, current fluorescence detection instruments aiming at point-of-care diagnosis have the tendency to be low cost and high sensitivity, with a high potential for the analysis of low-volume, multiplex analytes with easy operation. In this work, we present the development of a miniaturized, high numerical aperture confocal fluorescence scanner for sub-micro-liter fluid diagnosis. It is enhanced with high-rate analyte accumulation using a pyroelectro-hydrodynamic dispensing system for generating tiny, stable sample droplets. The simplified confocal fluorescence scanner (numerical aperture 0.79, working distance 7.3 mm) uses merely off-the-shelf mass-production optical components. Experimental results show that it can achieve a high-sensitive, cost-efficient detection for sub-micro-liter, low-abundant (0.04 µL, 0.67 attomoles) fluid diagnosis, promising for point-of-care diagnosis.
Language	English
Publishing date	2023-11-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2572216-5
ISSN	2156-7085
ISSN	2156-7085
DOI	10.1364/BOE.504757
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Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito