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  1. Article ; Online: Integrated clinical management tools for respiratory diseases: lessons from PAL in sub-Saharan Africa.

    Bateman, Eric D

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

    2016  Volume 20, Issue 4, Page(s) 429

    MeSH term(s) Africa South of the Sahara ; Humans ; Respiration Disorders ; Risk Factors
    Language English
    Publishing date 2016-04
    Publishing country France
    Document type Comment ; Journal Article
    ZDB-ID 1385624-8
    ISSN 1815-7920 ; 1027-3719
    ISSN (online) 1815-7920
    ISSN 1027-3719
    DOI 10.5588/ijtld.16.0116
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    Zs.MO 261: Show issues

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  2. Article ; Online: Asthma management in low and middle income countries: case for change.

    Mortimer, Kevin / Reddel, Helen K / Pitrez, Paulo M / Bateman, Eric D

    The European respiratory journal

    2022  Volume 60, Issue 3

    Abstract: Asthma is the most common noncommunicable disease in children, and among the most common in adults. The great majority of people with asthma live in low and middle income countries (LMICs), which have disproportionately high asthma-related morbidity and ... ...

    Abstract Asthma is the most common noncommunicable disease in children, and among the most common in adults. The great majority of people with asthma live in low and middle income countries (LMICs), which have disproportionately high asthma-related morbidity and mortality. Essential inhaled medications, particularly those containing inhaled corticosteroids (ICS), are often unavailable or unaffordable, and this explains much of the global burden of preventable asthma morbidity and mortality. Guidelines developed for LMICs are generally based on the outdated assumption that patients with asthma symptoms <1-3 times per week do not need (or benefit from) ICS. Even when ICS are prescribed, many patients manage their asthma with oral or inhaled short-acting β
    MeSH term(s) Adolescent ; Adult ; Child ; Humans ; Administration, Inhalation ; Adrenal Cortex Hormones/therapeutic use ; Anti-Asthmatic Agents/therapeutic use ; Asthma/drug therapy ; Developing Countries ; Formoterol Fumarate/therapeutic use ; Health Status Disparities
    Chemical Substances Adrenal Cortex Hormones ; Anti-Asthmatic Agents ; Formoterol Fumarate (W34SHF8J2K)
    Language English
    Publishing date 2022-09-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.03179-2021
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    Zs.MO 292: Show issues

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  3. Article ; Online: Treatment adherence in asthmatic patients: the last frontier?

    Bateman, Eric D

    The Journal of allergy and clinical immunology

    2014  Volume 134, Issue 6, Page(s) 1269–1270

    MeSH term(s) Anti-Asthmatic Agents/therapeutic use ; Asthma/drug therapy ; Humans ; Medication Adherence ; Nebulizers and Vaporizers/utilization ; Professional-Patient Relations
    Chemical Substances Anti-Asthmatic Agents
    Language English
    Publishing date 2014-12
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2014.08.004
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  4. Article ; Online: Reply to: Cause or consequence?

    Bateman, Eric D / Price, David B / Wang, Hao-Chien / Schonffeldt, Patricia / Catanzariti, Angelina / van der Valk, Ralf J P / Beekman, Maarten J H I

    The European respiratory journal

    2022  Volume 59, Issue 6

    MeSH term(s) Asthma ; Cross-Sectional Studies ; Humans ; Prescriptions
    Language English
    Publishing date 2022-06-09
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00103-2022
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  5. Article ; Online: Tiotropium Respimat increases the risk of mortality: con.

    Bateman, Eric D

    The European respiratory journal

    2013  Volume 42, Issue 3, Page(s) 590–593

    MeSH term(s) Bronchodilator Agents/adverse effects ; Humans ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Scopolamine Derivatives/adverse effects ; Tiotropium Bromide
    Chemical Substances Bronchodilator Agents ; Scopolamine Derivatives ; Tiotropium Bromide (XX112XZP0J)
    Language English
    Publishing date 2013-09
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/09031936.00042213
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  6. Article ; Online: Genetic and T2 biomarkers linked to the efficacy of HDM sublingual immunotherapy in asthma.

    Hoof, Ilka / Bønnelykke, Klaus / Stranzl, Thomas / Brand, Stephanie / Li, Xingnan / Shamji, Mohamed H / Meyers, Deborah A / Bateman, Eric D / Bleecker, Eugene / Andersen, Peter Sejer

    Thorax

    2024  Volume 79, Issue 4, Page(s) 332–339

    Abstract: Background: Hypersensitivity to house dust mite (HDM) allergens is a common cause of allergic asthma symptoms and can be effectively treated with allergy immunotherapy (AIT).: Objective: To investigate whether genetic and type 2 (T2) inflammatory ... ...

    Abstract Background: Hypersensitivity to house dust mite (HDM) allergens is a common cause of allergic asthma symptoms and can be effectively treated with allergy immunotherapy (AIT).
    Objective: To investigate whether genetic and type 2 (T2) inflammatory biomarkers correlate with disease severity in subjects with allergic asthma, and whether this can be modified by AIT.
    Methods: MITRA (NCT01433523) was a phase III, randomised, double-blind, placebo-controlled trial of HDM sublingual immunotherapy (SLIT)-tablets in adults with HDM allergic asthma. Post hoc analyses of the study population (N=742) evaluated associations between T2 inflammatory (blood eosinophils, eosinophil cationic protein (ECP), total IgE and tryptase) and genetic (single-nucleotide polymorphisms, SNP) biomarkers (n=582) for the primary study endpoint (time to first moderate/severe asthma exacerbation). SNP associations were verified in HDM-positive subgroup from an independent 3-year Severe Asthma Research Programme (SARP3) subject cohort.
    Results: An increased asthma exacerbation risk in subjects homozygous for SNP rs7216389 (chromosomal locus 17q12-21) was reduced (p
    Conclusions: HDM SLIT-tablet AIT is efficacious in HDM-sensitised asthma subjects with a genetic asthma predisposition and/or an underlying T2 endotype.
    Trial registration number: NCT01433523.
    MeSH term(s) Adult ; Animals ; Humans ; Sublingual Immunotherapy/adverse effects ; Tryptases/therapeutic use ; Pyroglyphidae ; Treatment Outcome ; Hypersensitivity ; Asthma/therapy ; Asthma/drug therapy ; Antigens, Dermatophagoides/therapeutic use ; Tablets/therapeutic use ; Biomarkers ; Allergens
    Chemical Substances Tryptases (EC 3.4.21.59) ; Antigens, Dermatophagoides ; Tablets ; Biomarkers ; Allergens
    Language English
    Publishing date 2024-03-15
    Publishing country England
    Document type Randomized Controlled Trial ; Clinical Trial, Phase III ; Journal Article
    ZDB-ID 204353-1
    ISSN 1468-3296 ; 0040-6376
    ISSN (online) 1468-3296
    ISSN 0040-6376
    DOI 10.1136/thorax-2023-220707
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  7. Article ; Online: Efficacy and safety of high-dose ciclesonide for the treatment of severe asthma.

    Bateman, Eric D

    Expert review of respiratory medicine

    2013  Volume 7, Issue 4, Page(s) 339–348

    Abstract: Asthma severity is classified according to the level of treatment required to control symptoms. Inhaled corticosteroids are the recommended first-line therapy for the treatment of persistent asthma, and when asthma remains uncontrolled, one option is to ... ...

    Abstract Asthma severity is classified according to the level of treatment required to control symptoms. Inhaled corticosteroids are the recommended first-line therapy for the treatment of persistent asthma, and when asthma remains uncontrolled, one option is to increase the inhaled corticosteroids dose. However, there is a concomitant risk of increasing local and systemic adverse events, which may impact patient adherence and physician prescribing practices. Ciclesonide is delivered as a prodrug, has high peripheral lung deposition and high protein-binding capabilities, and is rapidly eliminated from the systemic circulation. This article reviews the use of high-dose ciclesonide in patients with severe asthma and considers whether the pharmacology of ciclesonide translates into it being an efficacious and well-tolerated option for patients requiring a step-up in their asthma treatment.
    MeSH term(s) Administration, Inhalation ; Animals ; Anti-Asthmatic Agents/administration & dosage ; Anti-Asthmatic Agents/adverse effects ; Anti-Asthmatic Agents/pharmacokinetics ; Asthma/diagnosis ; Asthma/drug therapy ; Asthma/physiopathology ; Drug Administration Schedule ; Glucocorticoids/administration & dosage ; Glucocorticoids/adverse effects ; Glucocorticoids/pharmacokinetics ; Humans ; Pregnenediones/administration & dosage ; Pregnenediones/adverse effects ; Pregnenediones/pharmacokinetics ; Prodrugs/administration & dosage ; Prodrugs/adverse effects ; Prodrugs/pharmacokinetics ; Severity of Illness Index ; Treatment Outcome
    Chemical Substances Anti-Asthmatic Agents ; Glucocorticoids ; Pregnenediones ; Prodrugs ; ciclesonide (S59502J185)
    Language English
    Publishing date 2013-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2479146-5
    ISSN 1747-6356 ; 1747-6348
    ISSN (online) 1747-6356
    ISSN 1747-6348
    DOI 10.1586/17476348.2013.814385
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  8. Article ; Online: Correction to: Global asthma prevalence in adults: findings from the cross-sectional world health survey.

    To, Teresa / Stanojevic, Sanja / Moores, Ginette / Gershon, Andrea S / Bateman, Eric D / Cruz, Alvaro A / Boulet, Louis-Philippe

    BMC public health

    2021  Volume 21, Issue 1, Page(s) 1809

    Language English
    Publishing date 2021-10-08
    Publishing country England
    Document type Published Erratum
    ISSN 1471-2458
    ISSN (online) 1471-2458
    DOI 10.1186/s12889-021-11859-6
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  9. Article ; Online: A Practical Guide to Implementing SMART in Asthma Management.

    Reddel, Helen K / Bateman, Eric D / Schatz, Michael / Krishnan, Jerry A / Cloutier, Michelle M

    The journal of allergy and clinical immunology. In practice

    2021  Volume 10, Issue 1S, Page(s) S31–S38

    Abstract: The use of a single inhaler containing the combination of an inhaled corticosteroid (ICS) and formoterol, a specific long-acting bronchodilator, for both maintenance and quick relief therapy (single maintenance and reliever therapy [SMART or MART]) is ... ...

    Abstract The use of a single inhaler containing the combination of an inhaled corticosteroid (ICS) and formoterol, a specific long-acting bronchodilator, for both maintenance and quick relief therapy (single maintenance and reliever therapy [SMART or MART]) is recommended by both the Global Initiative for Asthma and the National Asthma Education and Prevention Program Coordinating Committee in steps 3 and 4 of asthma management. This article provides practical advice about implementing SMART in clinical practice based on evidence and clinical experience. Fundamental to SMART is that ICS-formoterol provides quick relief of asthma symptoms similar to that of short-acting β
    MeSH term(s) Administration, Inhalation ; Adolescent ; Adult ; Asthma/drug therapy ; Bronchodilator Agents/therapeutic use ; Budesonide/therapeutic use ; Child ; Drug Combinations ; Ethanolamines/therapeutic use ; Formoterol Fumarate/therapeutic use ; Humans ; Treatment Outcome
    Chemical Substances Bronchodilator Agents ; Drug Combinations ; Ethanolamines ; Budesonide (51333-22-3) ; Formoterol Fumarate (W34SHF8J2K)
    Language English
    Publishing date 2021-10-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2021.10.011
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  10. Article ; Online: As-Needed Budesonide-Formoterol in Mild Asthma.

    Bateman, Eric D / Reddel, Helen K / FitzGerald, J Mark

    The New England journal of medicine

    2018  Volume 379, Issue 9, Page(s) 898

    MeSH term(s) Asthma/drug therapy ; Bronchodilator Agents ; Budesonide ; Drug Combinations ; Ethanolamines ; Formoterol Fumarate ; Humans
    Chemical Substances Bronchodilator Agents ; Drug Combinations ; Ethanolamines ; Budesonide (51333-22-3) ; Formoterol Fumarate (W34SHF8J2K)
    Language English
    Publishing date 2018-09-07
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1808073
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