LIVIVO - Search results -

Search results

Result 1 - 10 of total 67

Search options

Article ; Online: Perceptions of conflicting information about long-term medications: a qualitative in-depth interview study of patients with chronic diseases in the Swiss ambulatory care system.

Santos, Beatriz / Blondon, Katherine S / Sottas, Marie / Carpenter, Delesha / Backes, Claudine / Van Gessel, Elisabeth / Schneider, Marie P

BMJ open

2023 Volume 13, Issue 11, Page(s) e070468

Abstract: Objective: Patients with multiple long-term conditions visit various healthcare professionals and are exposed to medication information from various sources causing an increased risk of patients perceiving contradictory medication information. The aims ... ...

Abstract	Objective: Patients with multiple long-term conditions visit various healthcare professionals and are exposed to medication information from various sources causing an increased risk of patients perceiving contradictory medication information. The aims of this study are to: (1) characterise conflicting medication information perceived by patients with long-term conditions, (2) better understand the related impact on patients' medication self-management and healthcare system navigation and (3) explore ways in which such events could be prevented. Design: This study was conducted through qualitative semistructured interviews. Data were analysed using thematic analysis. Setting: Community pharmacies and medical centres in Geneva, Switzerland. Participants: This study included outpatients from April 2019 to February 2020. Patients were included after participating in a quantitative survey of perceived conflicting information about medications for long-term diseases. Methods: Semistructured audiotaped interviews of 20 to 60 min following a pre-established interview guide to explore participants' perceptions of conflicting information. Interviews were transcribed verbatim, and a thematic analysis was conducted with inductive and deductive coding using MAXQDA (2018, Release 18.2.3). Results: Twenty-two patients were interviewed, until data saturation, mentioning indication or need for a medication as the main topic of conflicting information between two healthcare professionals. Perceived conflicting information often resulted from insufficient information provided and poor communication leading to confusion, doubts and medication non-adherence. Patients expected more information and more interprofessional communication on their medications. As a result of conflicting information, most participants learnt or were learning to take an active role and become partners of the healthcare providers. Conclusion: The need to strengthen and improve communication and interprofessional collaborative practice among healthcare professionals and with the patient is emerging to increase the quality and consistency of information about medications, and consequently, to ensure better use and experience of medications.
MeSH term(s)	Humans ; Switzerland ; Qualitative Research ; Surveys and Questionnaires ; Chronic Disease ; Ambulatory Care
Language	English
Publishing date	2023-11-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2022-070468
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Perceptions of conflicting information about long-term medications

Katherine S Blondon / Beatriz Santos / Elisabeth Van Gessel / Claudine Backes / Delesha Carpenter / Marie P Schneider / Marie Sottas

BMJ Open, Vol 13, Iss

a qualitative in-depth interview study of patients with chronic diseases in the Swiss ambulatory care system

2023 Volume 11

Abstract: Objective Patients with multiple long-term conditions visit various healthcare professionals and are exposed to medication information from various sources causing an increased risk of patients perceiving contradictory medication information. The aims of ...

Abstract	Objective Patients with multiple long-term conditions visit various healthcare professionals and are exposed to medication information from various sources causing an increased risk of patients perceiving contradictory medication information. The aims of this study are to: (1) characterise conflicting medication information perceived by patients with long-term conditions, (2) better understand the related impact on patients’ medication self-management and healthcare system navigation and (3) explore ways in which such events could be prevented.Design This study was conducted through qualitative semistructured interviews. Data were analysed using thematic analysis.Setting Community pharmacies and medical centres in Geneva, Switzerland.Participants This study included outpatients from April 2019 to February 2020. Patients were included after participating in a quantitative survey of perceived conflicting information about medications for long-term diseases.Methods Semistructured audiotaped interviews of 20 to 60 min following a pre-established interview guide to explore participants’ perceptions of conflicting information. Interviews were transcribed verbatim, and a thematic analysis was conducted with inductive and deductive coding using MAXQDA (2018, Release 18.2.3).Results Twenty-two patients were interviewed, until data saturation, mentioning indication or need for a medication as the main topic of conflicting information between two healthcare professionals. Perceived conflicting information often resulted from insufficient information provided and poor communication leading to confusion, doubts and medication non-adherence. Patients expected more information and more interprofessional communication on their medications. As a result of conflicting information, most participants learnt or were learning to take an active role and become partners of the healthcare providers.Conclusion The need to strengthen and improve communication and interprofessional collaborative practice among healthcare professionals and ...
Keywords	Medicine ; R
Subject code	150
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Patients' perceptions of conflicting information on chronic medications: a prospective survey in Switzerland.

Santos, Beatriz / Blondon, Katherine S / Van Gessel, Elisabeth / Cerutti, Bernard / Backes, Claudine / Locher, Sophie / Guignard, Bertrand / Bonnabry, Pascal / Carpenter, Delesha / Schneider, Marie P

BMJ open

2022 Volume 12, Issue 11, Page(s) e060083

Abstract: ... conflicting information (p<0.01). Consequently, 65% of the participants modified their navigation ...

Abstract	Objective: The number of patients with chronic diseases and subsequent visits to various healthcare professionals has been rising over the past decades, exposing patients to potential risks of receiving conflicting medication information. This study aims to investigate the prevalence of conflicting information on medications perceived by chronic patients in Switzerland and to understand its impact on patients' medication self-management and navigation in the healthcare system. Participants: This cross-sectional study included adult patients taking at least one prescribed medication for at least 6 months, who had visited at least two physicians in the past 3 months. Main outcome measures: Data on patients' perceptions of conflicting information were collected in person through a 17-item questionnaire available on paper and electronically with four domains: (1) whether the patient had perceived any conflicting information, (2) categories of conflicting information, (3) impact and (4) sources involved in the conflicting information. Results: Of the 405 included patients, 47% perceived conflicting information related to one or more medication topics including indication, schedule, dosage, risk, severity or duration of side effects. Patients who perceived conflicting information were prescribed more drugs than those perceiving no conflicting information (p<0.01). Consequently, 65% of the participants modified their navigation of the healthcare system and 34% reported medication non-adherence. General practitioners (82%), specialist physicians (74%) and pharmacists (49%) were the healthcare professionals most often involved in conflicting information. Experience with the medication, its package insert and significant others were more frequently involved in conflicting information than internet or social media. Conclusion: Nearly half the patients in our study perceived conflicting information in the outpatient healthcare system, which can decrease medication effectiveness and pose safety issues. This issue is widely overlooked and unaddressed. Consistency of information among healthcare providers in partnership with patients should be reinforced through guidelines and new models of interprofessional care.
MeSH term(s)	Adult ; Humans ; Cross-Sectional Studies ; Switzerland ; Prospective Studies ; Pharmacists ; Surveys and Questionnaires ; Medication Adherence
Language	English
Publishing date	2022-11-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2021-060083
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Patients’ perceptions of conflicting information on chronic medications

Pascal Bonnabry / Bertrand Guignard / Bernard Cerutti / Katherine S Blondon / Beatriz Santos / Elisabeth Van Gessel / Claudine Backes / Sophie Locher / Delesha Carpenter / Marie P Schneider

BMJ Open, Vol 12, Iss

a prospective survey in Switzerland

2022 Volume 11

Abstract: ... conflicting information (p<0.01). Consequently, 65% of the participants modified their navigation ...

Abstract	Objective The number of patients with chronic diseases and subsequent visits to various healthcare professionals has been rising over the past decades, exposing patients to potential risks of receiving conflicting medication information. This study aims to investigate the prevalence of conflicting information on medications perceived by chronic patients in Switzerland and to understand its impact on patients’ medication self-management and navigation in the healthcare system.Participants This cross-sectional study included adult patients taking at least one prescribed medication for at least 6 months, who had visited at least two physicians in the past 3 months.Main outcome measures Data on patients’ perceptions of conflicting information were collected in person through a 17-item questionnaire available on paper and electronically with four domains: (1) whether the patient had perceived any conflicting information, (2) categories of conflicting information, (3) impact and (4) sources involved in the conflicting information.Results Of the 405 included patients, 47% perceived conflicting information related to one or more medication topics including indication, schedule, dosage, risk, severity or duration of side effects. Patients who perceived conflicting information were prescribed more drugs than those perceiving no conflicting information (p<0.01). Consequently, 65% of the participants modified their navigation of the healthcare system and 34% reported medication non-adherence. General practitioners (82%), specialist physicians (74%) and pharmacists (49%) were the healthcare professionals most often involved in conflicting information. Experience with the medication, its package insert and significant others were more frequently involved in conflicting information than internet or social media.Conclusion Nearly half the patients in our study perceived conflicting information in the outpatient healthcare system, which can decrease medication effectiveness and pose safety issues. This issue is widely ...
Keywords	Medicine ; R
Subject code	150
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: ZMPSTE24

Spear, Eric D / Hsu, Erh-Ting / Nie, Laiyin / Carpenter, Elisabeth P / Hrycyna, Christine A / Michaelis, Susan

Disease models & mechanisms

2018 Volume 11, Issue 7

Abstract: The human zinc metalloprotease ZMPSTE24 is an integral membrane protein crucial for the final step in the biogenesis of the nuclear scaffold protein lamin A, encoded ... ...

Abstract	The human zinc metalloprotease ZMPSTE24 is an integral membrane protein crucial for the final step in the biogenesis of the nuclear scaffold protein lamin A, encoded by
MeSH term(s)	Alleles ; Amino Acid Motifs ; Biosynthetic Pathways ; Humans ; Lamin Type A/biosynthesis ; Lamin Type A/metabolism ; Membrane Proteins/chemistry ; Membrane Proteins/genetics ; Metalloendopeptidases/chemistry ; Metalloendopeptidases/genetics ; Mutation, Missense/genetics ; Progeria/genetics ; Proteasome Endopeptidase Complex/metabolism ; Protein Stability ; Proteolysis ; SEC Translocation Channels/metabolism ; Saccharomyces cerevisiae/metabolism ; Substrate Specificity ; Ubiquitin/metabolism ; Ubiquitination
Chemical Substances	Lamin Type A ; Membrane Proteins ; SEC Translocation Channels ; Ubiquitin ; prelamin A ; Metalloendopeptidases (EC 3.4.24.-) ; ZMPSTE24 protein, human (EC 3.4.24.84) ; Proteasome Endopeptidase Complex (EC 3.4.25.1)
Language	English
Publishing date	2018-07-13
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2451104-3
ISSN	1754-8411 ; 1754-8403
ISSN (online)	1754-8411
ISSN	1754-8403
DOI	10.1242/dmm.033670
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Site specificity determinants for prelamin A cleavage by the zinc metalloprotease ZMPSTE24.

Babatz, Timothy D / Spear, Eric D / Xu, Wenxin / Sun, Olivia L / Nie, Laiyin / Carpenter, Elisabeth P / Michaelis, Susan

The Journal of biological chemistry

2020 Volume 296, Page(s) 100165

Abstract: The integral membrane zinc metalloprotease ZMPSTE24 is important for human health and longevity. ZMPSTE24 performs a key proteolytic step in maturation of prelamin A, the farnesylated precursor of the nuclear scaffold protein lamin A. Mutations in the ... ...

Abstract	The integral membrane zinc metalloprotease ZMPSTE24 is important for human health and longevity. ZMPSTE24 performs a key proteolytic step in maturation of prelamin A, the farnesylated precursor of the nuclear scaffold protein lamin A. Mutations in the genes encoding either prelamin A or ZMPSTE24 that prevent cleavage cause the premature aging disease Hutchinson-Gilford progeria syndrome (HGPS) and related progeroid disorders. ZMPSTE24 has a novel structure, with seven transmembrane spans that form a large water-filled membrane chamber whose catalytic site faces the chamber interior. Prelamin A is the only known mammalian substrate for ZMPSTE24; however, the basis of this specificity remains unclear. To define the sequence requirements for ZMPSTE24 cleavage, we mutagenized the eight residues flanking the prelamin A scissile bond (TRSY↓LLGN) to all other 19 amino acids, creating a library of 152 variants. We also replaced these eight residues with sequences derived from putative ZMPSTE24 cleavage sites from amphibian, bird, and fish prelamin A. Cleavage of prelamin A variants was assessed using an in vivo yeast assay that provides a sensitive measure of ZMPSTE24 processing efficiency. We found that residues on the C-terminal side of the cleavage site are most sensitive to changes. Consistent with other zinc metalloproteases, including thermolysin, ZMPSTE24 preferred hydrophobic residues at the P1' position (Leu647), but in addition, showed a similar, albeit muted, pattern at P2'. Our findings begin to define a consensus sequence for ZMPSTE24 that helps to clarify how this physiologically important protease functions and may ultimately lead to identifying additional substrates.
MeSH term(s)	Amino Acid Sequence ; Catalytic Domain ; Humans ; Lamin Type A/chemistry ; Lamin Type A/genetics ; Lamin Type A/metabolism ; Membrane Proteins/chemistry ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Metalloendopeptidases/chemistry ; Metalloendopeptidases/genetics ; Metalloendopeptidases/metabolism ; Mutation ; Proteolysis ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Substrate Specificity ; Zinc/metabolism
Chemical Substances	Lamin Type A ; Membrane Proteins ; Recombinant Proteins ; prelamin A ; Metalloendopeptidases (EC 3.4.24.-) ; ZMPSTE24 protein, human (EC 3.4.24.84) ; Zinc (J41CSQ7QDS)
Language	English
Publishing date	2020-12-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.RA120.015792
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uc I Zs.108: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Further evidence for a non-cortical origin of mirror movements after stroke.

Calautti, Cinzia / Jones, P Simon / Naccarato, Marcello / Sharma, Nikhil / Carpenter, T Adrian / Warburton, Elisabeth A / Baron, Jean-Claude

Brain : a journal of neurology

2018 Volume 142, Issue 1, Page(s) e1

MeSH term(s)	Humans ; Longitudinal Studies ; Movement Disorders ; Stroke
Language	English
Publishing date	2018-12-31
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	80072-7
ISSN	1460-2156 ; 0006-8950
ISSN (online)	1460-2156
ISSN	0006-8950
DOI	10.1093/brain/awy308
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui II Zs.26: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Asymmetric mechanosensitivity in a eukaryotic ion channel.

Clausen, Michael V / Jarerattanachat, Viwan / Carpenter, Elisabeth P / Sansom, Mark S P / Tucker, Stephen J

Proceedings of the National Academy of Sciences of the United States of America

2017 Volume 114, Issue 40, Page(s) E8343–E8351

Abstract: Living organisms perceive and respond to a diverse range of mechanical stimuli. A variety of mechanosensitive ion channels have evolved to facilitate these responses, but the molecular mechanisms underlying their exquisite sensitivity to different forces ...

Abstract	Living organisms perceive and respond to a diverse range of mechanical stimuli. A variety of mechanosensitive ion channels have evolved to facilitate these responses, but the molecular mechanisms underlying their exquisite sensitivity to different forces within the membrane remains unclear. TREK-2 is a mammalian two-pore domain (K2P) K
MeSH term(s)	Cell Membrane/physiology ; Humans ; Ion Channel Gating/physiology ; Lipid Bilayers/metabolism ; Mechanotransduction, Cellular/physiology ; Potassium Channels, Tandem Pore Domain/genetics ; Potassium Channels, Tandem Pore Domain/metabolism
Chemical Substances	KCNK10 protein, human ; Lipid Bilayers ; Potassium Channels, Tandem Pore Domain
Language	English
Publishing date	2017--03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.1708990114
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1148: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Norfluoxetine inhibits TREK-2 K2P channels by multiple mechanisms including state-independent effects on the selectivity filter gate.

Proks, Peter / Schewe, Marcus / Conrad, Linus J / Rao, Shanlin / Rathje, Kristin / Rödström, Karin E J / Carpenter, Elisabeth P / Baukrowitz, Thomas / Tucker, Stephen J

The Journal of general physiology

2021 Volume 153, Issue 8

Abstract: The TREK subfamily of two-pore domain K+ (K2P) channels are inhibited by fluoxetine and its metabolite, norfluoxetine (NFx). Although not the principal targets of this antidepressant, TREK channel inhibition by NFx has provided important insights into ... ...

Abstract	The TREK subfamily of two-pore domain K+ (K2P) channels are inhibited by fluoxetine and its metabolite, norfluoxetine (NFx). Although not the principal targets of this antidepressant, TREK channel inhibition by NFx has provided important insights into the conformational changes associated with channel gating and highlighted the role of the selectivity filter in this process. However, despite the availability of TREK-2 crystal structures with NFx bound, the precise mechanisms underlying NFx inhibition remain elusive. NFx has previously been proposed to be a state-dependent inhibitor, but its binding site suggests many possible ways in which this positively charged drug might inhibit channel activity. Here we show that NFx exerts multiple effects on single-channel behavior that influence both the open and closed states of the channel and that the channel can become highly activated by 2-APB while remaining in the down conformation. We also show that the inhibitory effects of NFx are unrelated to its positive charge but can be influenced by agonists which alter filter stability, such as ML335, as well as by an intrinsic voltage-dependent gating process within the filter. NFx therefore not only inhibits channel activity by altering the equilibrium between up and down conformations but also can directly influence filter gating. These results provide further insight into the complex allosteric mechanisms that modulate filter gating in TREK K2P channels and highlight the different ways in which filter gating can be regulated to permit polymodal regulation.
MeSH term(s)	Binding Sites ; Fluoxetine/analogs & derivatives ; Fluoxetine/pharmacology ; Ion Channel Gating ; Potassium Channels, Tandem Pore Domain/metabolism
Chemical Substances	Potassium Channels, Tandem Pore Domain ; Fluoxetine (01K63SUP8D) ; norfluoxetine (K8D70XE2F4)
Language	English
Publishing date	2021-05-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3118-5
ISSN	1540-7748 ; 0022-1295
ISSN (online)	1540-7748
ISSN	0022-1295
DOI	10.1085/jgp.202012812
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uc I Zs.150: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2

Li, Huanyu Z. / Pike, Ashley C.W. / Chi, Gamma / Hansen, Jesper S. / Lee, Sarah G. / Rodstrom, Karin E.J. / Bushell, Simon R. / Speedman, David / Evans, Adam / Wang, Dong / He, Didi / Shrestha, Leela / Nasrallah, Chady / Burgess-Brown, Nicola A. / Dafforn, Timonthy R. / Carpenter, Elisabeth P. / Sauer, David B.

bioRxiv

Abstract: Proline is widely known as the only proteogenic amino acid with a secondary amine. In addition to its crucial role in protein structure, the secondary amino acid modulates neurotransmission and regulates the kinetics of signaling proteins. To understand ... ...

Abstract	Proline is widely known as the only proteogenic amino acid with a secondary amine. In addition to its crucial role in protein structure, the secondary amino acid modulates neurotransmission and regulates the kinetics of signaling proteins. To understand the structural basis of proline import, we solved the structure of the proline transporter SIT1 in complex with the COVID-19 viral receptor ACE2 by cryo-electron microscopy. The structure of pipecolate-bound SIT1 reveals the specific sequence requirements for proline transport in the SLC6 family and how this protein excludes amino acids with extended side chains. By comparing apo and substrate-bound SIT1 states, we also identify the structural changes which link substrate release and opening of the cytoplasmic gate, and provide an explanation for how a missense mutation in the transporter causes iminoglycinuria.
Keywords	covid19
Language	English
Publishing date	2023-05-18
Publisher	Cold Spring Harbor Laboratory
Document type	Article ; Online
DOI	10.1101/2023.05.17.541173
Database	COVID19

Full text online

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

Kategorien

Inter-library loan at ZB MED